Succinonitrile, tetramethyl-

RTECS #

WN4025000

CAS #

3333-52-6
See: NMAM or OSHA Methods

Updated

September 2013

Molecular Weight

136.22

Molecular Formula

C₈H₁₂N₂

Synonyms

2,2,3,3-Tetramethylbutanedinitrile
Butanedinitrile, tetramethyl- (9CI)
CP 75475
Tetramethyl succinonitrile
Tetramethyl succinonitrile (ACGIH:OSHA)
Tetramethylbutanedinitrile
Tetramethylsuccinic acid dinitrile
Tetramethylsuccinodinitrile
Tetramethylsuccinonitrile
Tetramethylsukcinonitril (Czech)
TMSN

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
intraperitoneal/hamster	9944 µg/kg (8D pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)	FAATDF 3,41,1983

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
inhalation/cat	Lethal concentration: >281 mg/m³/2H		ATXKA8 16,367,1957
inhalation/mouse	Lowest published lethal concentration: 125 mg/m³/2H	Behavioral: Convulsions or effect on seizure threshold	ATXKA8 16,367,1957
inhalation/rat	Lowest published lethal concentration: 60 ppm/2H		FEPRA7 8,205,1949
intraperitoneal/mouse	lethal dose (50 percent kill): 17710 µg/kg	Behavioral: Convulsions or effect on seizure threshold	JPETAB 223,635,1982
intraperitoneal/rat	lethal dose (50 percent kill): 17500 µg/kg		ATXKA8 16,367,1957
intravenous/mouse	lethal dose (50 percent kill): 18 mg/kg		CSLNX* NX#00002
intravenous/rabbit	lethal dose (50 percent kill): 20 mg/kg		FEPRA7 8,205,1949
oral/guinea pig	lethal dose (50 percent kill): 17500 µg/kg		ATXKA8 16,367,1957
oral/rabbit	lowest published lethal dose: 25 mg/kg	Behavioral: Convulsions or effect on seizure threshold	ATXKA8 16,367,1957
oral/rat	lethal dose (50 percent kill): 27 mg/kg	Behavioral: Somnolence (general depressed activity) Behavioral: Tremor Lung, Thorax, or Respiration: Pulmonary emboli	NTIS** OTS0555206
skin/rabbit	lowest published lethal dose: 79400 µg/kg	Behavioral: Somnolence (general depressed activity) Behavioral: Muscle weakness Lung, Thorax, or Respiration: Pulmonary emboli	NTIS** OTS0555206
subcutaneous/Dog	lowest published lethal dose: 20 mg/kg		FEPRA7 8,205,1949
subcutaneous/guinea pig	lethal dose (50 percent kill): 23 mg/kg		FEPRA7 8,205,1949
subcutaneous/mouse	lowest published lethal dose: 30 mg/kg	Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Other changes	ATXKA8 16,367,1957
subcutaneous/rabbit	lowest published lethal dose: 30 mg/kg	Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Other changes	ATXKA8 16,367,1957
subcutaneous/rat	lethal dose (50 percent kill): 30 mg/kg		FEPRA7 8,205,1949

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
oral/rat	lowest published toxic dose: 270 mg/kg/90D- continuous	Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in bladder weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain	FAATDF 7,41,1986

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 0.5 ppm (skin)	DTLVS* TLV/BEI,2013

Standards and Regulations

Organization	Standard	Reference
Mine Safety and Health Administration (MSHA) STANDARD-air	time-weighted average 0.5 ppm (3 mg/m³) (skin)	DTLVS* 3,254,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 0.5 ppm (2.8 mg/m³), JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 0.5 ppm (3 mg/m³);KZW 2 ppm (12 mg/m³), skin, 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 0.5 ppm (2.8 mg/m³), Skin, MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 0.5 ppm (3 mg/m³), skin, MAY2011
Occupational Exposure Limit-FINLAND	time-weighted average 0.1 ppm (0.5 mg/m³), skin, NOV2011
Occupational Exposure Limit-FRANCE	VME 0.5 ppm (3 mg/m³), Skin, FEB2006
Occupational Exposure Limit-ICELAND	time-weighted average 0.5 ppm (3 mg/m³), skin, NOV2011
Occupational Exposure Limit-KOREA	time-weighted average 0.5 ppm (3 mg/m³), skin, 2006
Occupational Exposure Limit-MEXICO	time-weighted average 0.5 ppm (3 mg/m³);short term exposure limit 2 ppm (9 mg/m³) (skin), 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 0.5 ppm (2.8 mg/m³), skin, JAN2002
Occupational Exposure Limit-PERU	time-weighted average 0,5 ppm (2,8 mg/m³), JUL2005
Occupational Exposure Limit-SWITZERLAND	MAK-week 0.5 ppm (3 mg/m³), KZG-week 1 ppm (6 mg/m³), skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 3 mg/m³, Skin, 2003
Occupational Exposure Limit-THE PHILIPPINES	time-weighted average 0.5 ppm (3 mg/m³), Skin, JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 0.5 ppm (3 mg/m³) (skin)	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	8H time-weighted average 0.5 ppm (3 mg/m³) (skin)	CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 0.5 ppm (3 mg/m³) (skin)	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 0.5 ppm (3 mg/m³) (skin)	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO TETRAMETHYL SUCCINONITRILE-air	10H time-weighted average 0.5 ppm (Sk)	NIOSH* DHHS #92-100,1992

Status in Federal Agencies

Organization	Reference
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health