Succinonitrile
RTECS #
WN3850000
CAS #
Updated
July 2016
Molecular Weight
80.10
Molecular Formula
C4H4N2
Synonyms
Butanedinitrile
Deprelin
Dinile
Ethane, 1,2-dicyano-
Ethylene cyanide
Ethylene dicyanide
s-Dicyanoethane
Succinic acid dinitrile
Succinic dinitrile
Succinodinitrile
Sukcinonitril (Czech)
Suxil
USAF A-9442
Deprelin
Dinile
Ethane, 1,2-dicyano-
Ethylene cyanide
Ethylene dicyanide
s-Dicyanoethane
Succinic acid dinitrile
Succinic dinitrile
Succinodinitrile
Sukcinonitril (Czech)
Suxil
USAF A-9442
Reproductive Effects Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| intraperitoneal/hamster | 365 mg/kg (8D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Central nervous system | FAATDF 3,41,1983 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/rat | Lowest published lethal concentration: 730 mg/m3/4H | Behavioral: Somnolence (general depressed activity) Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Acute pulmonary edema | NTIS** OTS0570875 |
| intraperitoneal/mouse | lethal dose (50 percent kill): 63110 µg/kg | Kidney, Ureter, and Bladder: Other changes in urine composition | BCPCA6 27,1135,1978 |
| intraperitoneal/rat | lethal dose (50 percent kill): 835.5 mg/kg/24H | Behavioral: Convulsions or effect on seizure threshold Behavioral: Muscle weakness Lung, Thorax, or Respiration: Respiratory depression | FCTOD7 59,595,2013 |
| oral/mouse | lethal dose (50 percent kill): 129 mg/kg | ARTODN 57,88,1985 | |
| oral/rat | lethal dose (50 percent kill): 450 mg/kg | 38MKAJ 2C,4879,1982 | |
| oral/rat | lethal dose (50 percent kill): 488.7 mg/kg | Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Respiratory depression | FCTOD7 47,2314,2009 |
| oral/rat | lethal dose (50 percent kill): 378.5 mg/kg/24H | Behavioral: Convulsions or effect on seizure threshold Behavioral: Muscle weakness Lung, Thorax, or Respiration: Respiratory depression | FCTOD7 59,595,2013 |
| subcutaneous/Dog | lowest published lethal dose: 150 mg/kg | Behavioral: Convulsions or effect on seizure threshold Gastrointestinal: Nausea or vomiting | AIPTAK 3,77,1897 |
| subcutaneous/frog | lowest published lethal dose: 1 gm/kg | AIPTAK 3,77,1897 | |
| subcutaneous/pigeon | lowest published lethal dose: 2200 mg/kg | Behavioral: Convulsions or effect on seizure threshold Gastrointestinal: Nausea or vomiting | AIPTAK 3,77,1897 |
| subcutaneous/rabbit | lowest published lethal dose: 36 mg/kg | Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change | AIPTAK 3,77,1897 |
| subcutaneous/rat | lethal dose (50 percent kill): 755.2 mg/kg/24H | Behavioral: Convulsions or effect on seizure threshold Behavioral: Muscle weakness Lung, Thorax, or Respiration: Respiratory depression | FCTOD7 59,595,2013 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| TOXICOLOGY REVIEW | MUREAV 726,91,2011 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO SUCCINONITRILE-air | 10H time-weighted average 6 ppm | NIOSH* DHHS #92-100,1992 |
| National Occupational Exposure Survey 1983 | Hazard Code X5846; Number of Industries 1; Total Number of Facilities 44; Number of Occupations 3; Total Number of Employees Exposed 1440 |
Status in Federal Agencies
| Organization | Reference |
|---|---|
| EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
| EPA TSCA Section 8(d) unpublished health/safety studies | |
| EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 |
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health