Succinic acid, mercapto-, diethyl ester, S-ester with O,O-dimethylphosphorodithioate

RTECS #

WM8400000

CAS #

121-75-5
See: NMAM or OSHA Methods

Updated

December 2018

Molecular Weight

330.38

Molecular Formula

C₁₀H₁₉O₆PS₂

Synonyms

((Dimethoxyphosphinothioyl)thio)butanedioic acid diethyl ester
1,2-Di(ethoxycarbonyl)ethyl O,O-dimethyl phosphorodithioate
American cyanamid 4,049
Carbethoxy malathion
Carbetovur
Carbetox
Carbofos
Carbophos
Chemathion
Cimexan
Compound 4049
Cythion
Detmol MA
Detmol MA 96%
Dicarboethoxyethyl O,O-dimethyl phosphorodithioate
Diethyl ((dimethoxyphosphinothioyl)thio)butanedioate
Diethyl (dimethoxyphosphinothioylthio)succinate
Diethyl mercaptosuccinate S-ester with O,O-dimethylphosphorodithioate
Diethyl mercaptosuccinate, O,O-dimethyl dithiophosphate, S-ester
Diethyl mercaptosuccinate, O,O-dimethyl phosphorodithioate
Diethyl mercaptosuccinate, O,O-dimethyl thiophosphate
Diethyl mercaptosuccinic acid O,O-dimethyl phosphorodithioate
Dithiophosphate de O,O-dimethyle et de S-(1,2-dicarboethoxyethyle) (French)
EL 4049
Emmatos
Emmatos Extra
ENT 17,034
Ethiolacar
Etiol
Experimental insecticide 4049
Extermathion
Forthion
Fosfothion
Fosfotion
Fosfotion 550
Fyfanon
Hilthion
Hilthion 25WDP
Insecticide No. 4049
Karbofos
Kop-thion
Kypfos
Latka 4049 (Czech)
Malacide
Malafor
Malagran
Malakill
Malamar
Malamar 50
Malaphele
Malaphos
Malasol
Malaspray
Malathion
Malathion (ACGIH:OSHA)
Malathion E50
Malathion LV concentrate
Malathion ULV concentrate
Malathon
Malathyl LV concentrate & ULV concentrate
Malation (Polish)
Malatol
Malatox
Maldison
Malmed
Malphos
Maltox
Maltox MLT
Mercaptosuccinic acid diethyl ester
Mercaptothion
Mercaptotion (Spanish)
Moscarda
NCI-C00215
O,O-Dimethyl S-(1,2-bis(ethoxycarbonyl)ethyl)dithiophosphate
O,O-Dimethyl S-(1,2-dicarbethoxyethyl) dithiophosphate
O,O-Dimethyl S-(1,2-dicarbethoxyethyl) thiothionophosphate
O,O-Dimethyl S-(1,2-dicarbethoxyethyl)phosphorodithioate
O,O-Dimethyl S-1,2-di(ethoxycarbamyl)ethyl phosphorodithioate
O,O-Dimethyldithiophosphate diethylmercaptosuccinate
O,O-Dimethyl-S-1,2-(dicarbaethoxyaethyl)-dithiophosphat (German)
O,O-Dimethyl-S-1,2-dikarbetoxylethylditiofosfat (Czech)
O,O-Dwumetylo-S-1,2-bis(karboetoksyetylo)-dwutiofosforan (Polish)
Oleophosphothion
Ortho malathion
Phosphorodithioic acid, O,O-dimethyl ester, S-ester with diethyl mercaptosuccinate
Phosphothion
Prentox malathion 95% spray
Prioderm
S-(1,2-Bis(aethoxy-carbonyl)-aethyl)-O,O-dimethyl-dithiophosphat (German)
S-(1,2-Bis(carbethoxy)ethyl) O,O-dimethyl dithiophosphate
S-(1,2-Bis(ethoxycarbonyl)ethyl) O,O-dimethyl phosphorodithioate
S-(1,2-Bis(ethoxy-carbonyl)-ethyl)-O,O-dimethyl-dithiofosfaat (Dutch)
S-(1,2-Bis(etossi-carbonil)-etil)-O,O-dimetil-ditiofosfato (Italian)
S-(1,2-Di(ethoxycarbonyl)ethyl) dimethyl phosphorothiolothionate
S-(1,2-Dicarbethoxyethyl) O,O-dimethyldithiophosphate
S-1,2-Bis(ethoxycarbonyl)ethyl-O,O-dimethyl thiophosphate
Sadofos
Sadophos
SF 60
Siptox I
Sumitox
TAK
TM-4049
Vegfru malatox
Vetiol
Zithiol

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
Cytogenetic Analysis	multiple/other fish	200 nL/L	JFIBA9 26,13,1985
Cytogenetic Analysis	lymphocyte/human	50 mg/L	CYTOAN 54,191,1989
Cytogenetic Analysis	leukocyte/human	2 mg/L	MUREAV 301,13,1993
Cytogenetic Analysis	oral/mouse	14 mg/kg/7D-continuous	FCTOD7 33,309,1995
Cytogenetic Analysis	skin/mouse	500 mg/kg	MUREAV 204,283,1988
Cytogenetic Analysis	intraperitoneal/hamster	240 mg/kg	ARTODN 58,152,1986
Cytogenetic Analysis	lung/hamster	76 mg/L	GMCRDC 27,95,1981
Cytogenetic Analysis	ovary/hamster	303 mg/L	EMMUEG 10(Suppl 10),1,1987
Cytogenetic Analysis	lymphocyte/mammal (species unspecified)	25 mg/L	CUSCAM 57,280,1988
Cytogenetic Analysis	oral/mouse	121 mg/kg/12W	MUREAV 513,1,2002
Cytogenetic Analysis	intraperitoneal/mouse	5 mg/kg	MUREAV 514,223,2002
Cytogenetic Analysis	oral/mouse	5 mg/kg	MUREAV 514,223,2002
Cytogenetic Analysis	oral/mouse	10 mg/kg/5D	MUREAV 514,223,2002
Cytogenetic Analysis	intraperitoneal/rat	25 mg/kg/5D- intermittent	MUREAV 725,78,2011
DNA Damage	intraperitoneal/rat	12.5 mg/kg/5D- intermittent	MUREAV 725,78,2011
DNA Damage	lymphocyte/rat	0.26 mg/L/2H	MUREAV 761,10,2014
DNA Damage	lymphocyte/rat	0.26 mg/L/4H	MUREAV 761,10,2014
DNA Damage	intraperitoneal/rat	199.9 mg/kg	TXCYAC 253,8,2008
DNA Damage	/Escherichia coli	100 mg/L	MUREAV 52,161,1978
DNA inhibition	lymphocyte/human	70 mg/L	HUGEDQ 53,375,1980
Dominant Lethal Test	oral/Drosophila melanogaster	2500 ng/L	FCTOD7 33,309,1995
micronucleus test	lymphocyte/human	75 mg/L	MUREAV 388,85,1997
mutation in microorganisms	/Salmonella typhimurium	10 mg/L (+enzymatic activation step)	CYGEDX 15(3),64,1981
mutation in microorganisms	/Bacillus subtilis	1 nmol/plate (-enzymatic activation step)	MSERDS 5,93,1981
mutation in microorganisms	/Other microorganisms	100 mg/L (-enzymatic activation step)	CYGEDX 15(3),64,1981
other mutation test systems	lymphocyte/human	70 mg/L	ENVRAL 41,372,1986
other mutation test systems	leukocyte/human	20 µg/L	MUREAV 301,13,1993
other mutation test systems	lymphocyte/human	10 mg/L	HUGEDQ 56,189,1980
other mutation test systems	skin/mouse	1 gm/kg	MUREAV 204,283,1988
other mutation test systems	lymphocyte/mammal (species unspecified)	50 mg/L	CUSCAM 57,280,1988
sister chromatid exchange	oral/mouse	10 mg/kg/5D	MUREAV 514,223,2002
sister chromatid exchange	oral/mouse	121 mg/kg/12W	MUREAV 513,1,2002
sister chromatid exchange	intraperitoneal/mouse	5 mg/kg	MUREAV 514,223,2002
sister chromatid exchange	ovary/hamster	300 µmol/L	JTEHD6 8,939,1981
sister chromatid exchange	lung/hamster	40 mg/L	MUREAV 88,307,1981
sister chromatid exchange	lymphocyte/human	20 mg/L	CYTOAN 54,191,1989
sister chromatid exchange	fibroblast/human	5 mg/L	MUREAV 67,167,1979
sister chromatid exchange	leukocyte/human	20 mg/L	MUREAV 301,13,1993
specific locus test	oral/Drosophila melanogaster	4 µg/L	FCTOD7 33,309,1995
sperm morphology	intraperitoneal/mouse	5 mg/kg	MUREAV 514,223,2002
sperm morphology	sperm/human	50 µmol/L/1H	REPTED 22,508,2006
Unscheduled DNA Synthesis	lymphocyte/human	10 mg/L	HUGEDQ 56,189,1980

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
oral/rat	5550 mg/kg (91D prior to copulation/1-20D pregnant)	Reproductive: Specific developmental abnormalities: Body wall	JTEHD6 14,267,1984
oral/rat	43920 mg/kg (multigenerations)	Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) Reproductive: Effects on newborn: Other postnatal measures or effects	NATUAS 192,464,1961
oral/rat	191 mg/kg (9D pregnant)	Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)	JFMAAQ 54,452,1967
oral/rat	283 mg/kg (9D pregnant)	Reproductive: Specific developmental abnormalities: Urogenital system	JFMAAQ 54,452,1967
oral/rabbit	540 mg/kg (28-30D pregnant)	Reproductive: Other effects to embryo or fetus	MSCREJ 17,743,1989
oral/rat	20 mg/kg (11-17D pregnant)	Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)	FATOAO 52,87,1989
oral/rat	40 mg/kg (11-17D pregnant)	Reproductive: Effects on newborn: Other postnatal measures or effects	FATOAO 52,87,1989
subcutaneous/mouse	420 mg/kg (1-21D after birth)	Reproductive: Effects on newborn: Biochemical and metabolic	NRTXDN 27,1101,2006
unreported route/rat	40 mg/kg (11-17D pregnant)	Reproductive: Effects on newborn: Biochemical and metabolic Reproductive: Effects on newborn: Behavioral Reproductive: Effects on newborn: Delayed effects	FATOAO 54,80,1991
unreported route/rat	80 mg/kg (2D male)	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct	BECTA6 15,458,1976

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
In Vitro/Chicken, neurons	Inhibitor Concentration (50 percent kill): 5423 µmol/L/21H	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	TIVIEQ 7,653,1993
In Vitro/Chicken, neurons	Inhibitor Concentration (10 percent kill): 1927 µmol/L/21H	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	TIVIEQ 7,653,1993
In Vitro/Chicken, neurons	Inhibitor Concentration (50 percent kill): 3448 µmol/L/20H	In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.	TIVIEQ 7,653,1993
In Vitro/Chicken, neurons	Inhibitor Concentration (10 percent kill): 1851 µmol/L/20H	In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.	TIVIEQ 7,653,1993
In Vitro/Human, endocrine tumor	Inhibitor Concentration Low: 13 µmol/L/48H	Endocrine: Other changes	TXAPA9 272,757,2013
In Vitro/Human, leukemia cells	Inhibitor Concentration (50 percent kill): 206.36 µmol/L/72H	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	FCTOD7 107,150,2017
In Vitro/Human, liver	Inhibitor Concentration (10 percent kill): 0.62 mmol/L/24H	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	TIVIEQ 8,47,1994
In Vitro/Human, liver	Inhibitor Concentration (50 percent kill): 1.58 mmol/L/24H	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	TIVIEQ 8,47,1994
In Vitro/Human, liver tumor	Inhibitor Concentration (10 percent kill): 0.8 mmol/L/24H	In Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.) In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	TIVIEQ 8,47,1994
In Vitro/Human, liver tumor	Inhibitor Concentration (50 percent kill): 2.59 mmol/L/24H	In Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.) In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	TIVIEQ 8,47,1994
In Vitro/Human, neuroblastoma	Inhibitor Concentration (50 percent kill): 1.3 mmol/L/60M	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	TXAPA9 245,191,2010
In Vitro/Human, skin	Inhibitor Concentration (50 percent kill): 47.4 mg/L/48H	In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.	TIVIEQ 27,1347,2013
In Vitro/jrd	Inhibitor Concentration Low: 10 µmol/L/24H	Endocrine: Estrogenic	TXAPA9 272,453,2013
In Vitro/jrd	Inhibitor Concentration Low: 100 µmol/L/24H	In Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.)	TXAPA9 272,453,2013
In Vitro/Mouse, fibroblast	Inhibitor Concentration (50 percent kill): 103 mg/L/48H	In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.	TIVIEQ 27,1347,2013
In Vitro/Mouse, fibroblast	Inhibitor Concentration (50 percent kill): 63.7 mg/L/24H	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	TIVIEQ 27,1347,2013
In Vitro/Mouse, fibroblast	Inhibitor Concentration (10 percent kill): 0.27 mmol/L/24H	In Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.) In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	TIVIEQ 8,47,1994
In Vitro/Mouse, fibroblast	Inhibitor Concentration (50 percent kill): 1.09 mmol/L/24H	In Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.) In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	TIVIEQ 8,47,1994
In Vitro/ntd	Inhibitor Concentration Low: 50 µg/L	In Vitro Toxicity Studies: Cell proliferation: DNA incorporation, mitotic index etc. Reproductive: Maternal effects: Oogenesis	TIVIEQ 32,63,2016
In Vitro/paa	Inhibitor Concentration Low: 75.4 µmol/L/44H	In Vitro Toxicity Studies: Other assays	TIVIEQ 27,1416,2013
In Vitro/pha	Inhibitor Concentration Low: 10 µmol/L/2H	In Vitro Toxicity Studies: Cell protein synthesis	NETEEC 32,58,2011
In Vitro/Rat, endocrine tumor	Inhibitor Concentration Low: 10 µmol/L/6D	Endocrine: Other changes In Vitro Toxicity Studies: Cell protein synthesis	TXAPA9 284,292,2015
In Vitro/Rat, liver	Inhibitor Concentration (50 percent kill): 132000 mg/L/24H	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	TIVIEQ 27,1347,2013
In Vitro/Rat, liver	Inhibitor Concentration (10 percent kill): 0.33 mmol/L/24H	In Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.) In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	TIVIEQ 8,47,1994
In Vitro/Rat, liver	Inhibitor Concentration (50 percent kill): 1.02 mmol/L/24H	In Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.) In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	TIVIEQ 8,47,1994
In Vitro/Rat, lung	Inhibitor Concentration (50 percent kill): 0.16 gm/L/24H	In Vitro Toxicity Studies: Cell membrane integrity (prelabeled cells): release of radioactive isotopes ([51Cr], [3H]-thymidine, [3H]-proline, [35S]- or [75Se]-methionine, 5-[125I]-2-deoxy-uridine) or fluorescent dyes (bis-carboxyethyl-carboxyfluorescein (BCECF) or calcein-AM)	TIVIEQ 7,111,1993
In Vitro/Rat, lung	Inhibitor Concentration (50 percent kill): 0.42 gm/L/24H	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	TIVIEQ 7,111,1993
In Vitro/Rat, lung	Inhibitor Concentration (10 percent kill): 0.05 gm/L/24H	In Vitro Toxicity Studies: Cell membrane integrity (prelabeled cells): release of radioactive isotopes ([51Cr], [3H]-thymidine, [3H]-proline, [35S]- or [75Se]-methionine, 5-[125I]-2-deoxy-uridine) or fluorescent dyes (bis-carboxyethyl-carboxyfluorescein (BCECF) or calcein-AM)	TIVIEQ 7,111,1993
In Vitro/Rat, lung	Inhibitor Concentration (75 percent kill): 0.34 gm/L/24H	In Vitro Toxicity Studies: Cell membrane integrity (prelabeled cells): release of radioactive isotopes ([51Cr], [3H]-thymidine, [3H]-proline, [35S]- or [75Se]-methionine, 5-[125I]-2-deoxy-uridine) or fluorescent dyes (bis-carboxyethyl-carboxyfluorescein (BCECF) or calcein-AM)	TIVIEQ 7,111,1993
In Vitro/Rat, lung	Inhibitor Concentration (10 percent kill): 0.07 gm/L/24H	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	TIVIEQ 7,111,1993
In Vitro/Rat, lung	Inhibitor Concentration (75 percent kill): 1.3 gm/L/24H	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	TIVIEQ 7,111,1993
inhalation/cat	Lowest published lethal concentration: 10 mg/m³/4H		85GMAT -,56,1982
inhalation/rat	lethal concentration (50 percent kill): 43790 µg/m³/4H		GISAAA 56(2),80,1991
intraarterial/cat	lowest published lethal dose: 1820 µg/kg		14KTAK -,693,1964
intraperitoneal/Dog	lethal dose (50 percent kill): 1857 mg/kg		TXAPA9 15,244,1969
intraperitoneal/guinea pig	lethal dose (50 percent kill): 271 mg/kg		AEPPAE 236,202,1959
intraperitoneal/hamster	lethal dose (50 percent kill): 2400 mg/kg		ARTODN 58,152,1986
intraperitoneal/mouse	lethal dose (50 percent kill): 193 mg/kg		PSEBAA 129,699,1968
intraperitoneal/rat	lethal dose (50 percent kill): 250 mg/kg		ARZNAD 22,1926,1972
intraperitoneal/rat	lowest published toxic dose: 250 mg/kg	Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects	TOLED5 187,137,2009
intravenous/man	lowest published toxic dose: 14 µL/kg	Vascular: Other changes Skin: After systemic exposure: Dermatitis, other	JJAMA* 16,367,1992
intravenous/mouse	lethal dose (50 percent kill): 184 mg/kg		BLLIAX 38,151,1958
intravenous/rat	lethal dose (50 percent kill): 50 mg/kg		ARZNAD 5,626,1955
oral/cattle	lethal dose (50 percent kill): 53 mg/kg	Peripheral Nerve and Sensation: Fasciculations Behavioral: Convulsions or effect on seizure threshold Behavioral: Rigidity (includes catalepsy)	IVEJAC 56,650,1979
oral/chicken	lethal dose (50 percent kill): 600 mg/kg	Behavioral: Food intake (animal)	IJEBA6 9,455,1971
oral/chicken	lethal dose (50 percent kill): 1000 mg/kg		HBPTO* 2,957,2001
oral/domestic animal	lethal dose (50 percent kill): 500 mg/kg		85DPAN -,-,1971/1976
oral/duck	lethal dose (50 percent kill): 1485 µg/kg		DOEAAH 35,25,1979
oral/guinea pig	lethal dose (50 percent kill): 570 mg/kg		ARZNAD 5,626,1955
oral/man	lowest published lethal dose: 471 mg/kg	Behavioral: Coma Vascular: BP lowering not characterized in autonomic section Lung, Thorax, or Respiration: Dyspnea	ATXKA8 23,11,1967
oral/mouse	lethal dose (50 percent kill): 190 mg/kg		85GMAT -,56,1982
oral/rabbit	lowest published lethal dose: 1200 mg/kg	Lung, Thorax, or Respiration: Respiratory stimulation	AEHA** 99-002-74/1976
oral/rat	lethal dose (50 percent kill): 644 mg/kg	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	FATOAO 53,64,1990
oral/rat	lethal dose (50 percent kill): 290 mg/kg		85GMAT -,56,1982
oral/rat	lowest published toxic dose: 100 mg/kg	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	TOSCF2 92,235,2006
oral/rat	lowest published toxic dose: 500 mg/kg	Behavioral: Alteration of classical conditioning Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	TOSCF2 92,235,2006
oral/rat	lowest published toxic dose: 400 mg/kg	Gastrointestinal: Changes in structure or function of exocrine pancreas Liver: Other changes Endocrine: Hyperglycemia	FCLPH* 22(Suppl 1),36,2008
oral/rat	lowest published toxic dose: 100 mg/kg	Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects	TXCYAC 250,27,2008
oral/rat	lethal dose (50 percent kill): 450 mg/kg	Behavioral: Muscle contraction or spasticity Lung, Thorax, or Respiration: Respiratory stimulation Endocrine: Hyperglycemia	TPKVAL 7,122,1965
oral/rat	lowest published toxic dose: 360 mg/kg	Lung, Thorax, or Respiration: Respiratory depression Blood: Hemorrhage Blood: Methemoglobinemia- Carboxhemoglobinemia	TPKVAL 7,122,1965
oral/wild bird	lethal dose (50 percent kill): 400 mg/kg		AECTCV 12,355,1983
oral/woman	lowest published lethal dose: 246 mg/kg	Vascular: BP lowering not characterized in autonomic section Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion Skin: After systemic exposure: Dermatitis, other	AEHLAU 33,240,1978
oral/woman	lowest published toxic dose: 300 µL/kg	Behavioral: Coma Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Lung, Thorax, or Respiration: Cyanosis	HETOEA 13,271,1994
oral/woman	lowest published lethal dose: 8 mL/kg	Lung, Thorax, or Respiration: Acute pulmonary edema Lung, Thorax, or Respiration: Other changes Gastrointestinal: Other changes	FSINDR 95,89,1998
oral/woman	lowest published toxic dose: 200 µL/kg	Behavioral: Coma Gastrointestinal: Changes in structure or function of exocrine pancreas Lung, Thorax, or Respiration: Respiratory depression	IJMDAI 30,855,1994
skin/guinea pig	lethal dose (50 percent kill): 6700 mg/kg		AMCYC* 8/1966
skin/mouse	lethal dose (50 percent kill): 2330 mg/kg		ABCHA6 27,684,1963
skin/rabbit	lethal dose (50 percent kill): 4100 mg/kg		28ZEAL 5,142,1976
skin/rat	lethal dose (50 percent kill): >4444 mg/kg		PMJMAQ -,155,1957
subcutaneous/guinea pig	lethal dose (50 percent kill): 450 mg/kg	Eye: Lacrimation Behavioral: Muscle contraction or spasticity Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	TPKVAL 7,122,1965
subcutaneous/guinea pig	lethal dose (50 percent kill): 450 mg/kg	Behavioral: Muscle contraction or spasticity Lung, Thorax, or Respiration: Respiratory stimulation Endocrine: Hyperglycemia	TPKVAL 7,122,1965
subcutaneous/guinea pig	lowest published toxic dose: 112.5 mg/kg	Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Metabolism (intermediary): Other proteins	TPKVAL 7,122,1965
subcutaneous/mouse	lowest published toxic dose: 1000 mg/kg	Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	NRTXDN 29,184,2008
subcutaneous/mouse	lethal dose (50 percent kill): 221 mg/kg	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Reactivates cholinesterase	OIZAAV 71,6099,1959
subcutaneous/rabbit	lethal dose (50 percent kill): 280 mg/kg	Kidney, Ureter, and Bladder: Urine volume increased Endocrine: Hyperglycemia Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	TPKVAL 7,122,1965
subcutaneous/rabbit	lethal dose (50 percent kill): 280 mg/kg	Eye: Lacrimation Behavioral: Muscle contraction or spasticity Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	TPKVAL 7,122,1965
subcutaneous/rat	lethal dose (50 percent kill): 400 mg/kg	Behavioral: Muscle contraction or spasticity Lung, Thorax, or Respiration: Respiratory stimulation Endocrine: Hyperglycemia	TPKVAL 7,122,1965
subcutaneous/rat	lethal dose (50 percent kill): 400 mg/kg	Eye: Lacrimation Behavioral: Muscle contraction or spasticity Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	TPKVAL 7,122,1965
Tank with water/Zebrafish	lowest published toxic concentration: 0.01 µmol/L/3D	Reproductive: Effects on newborn: Behavioral	NETOX* 49,50,2015
Tank with water/Zebrafish	lowest published toxic concentration: 1 µmol/L/3D	Reproductive: Specific developmental abnormalities: Central nervous system	NETOX* 49,50,2015
Tank with water/Zooplankton	lethal concentration (50 percent kill): 1.42 µg/L/24H		CMSHAF 144,599,2016
unreported route/cattle	lethal dose (50 percent kill): 53 mg/kg	Behavioral: Convulsions or effect on seizure threshold Behavioral: Excitement Behavioral: Change in motor activity (specific assay)	IJLAA4 49,314,1979
unreported route/mammal (species unspecified)	lethal dose (50 percent kill): 500 mg/kg		30ZDA9 -,357,1971
unreported route/mammal (species unspecified)	lowest published toxic dose: 715 mg/kg	Immunological Including Allergic: Decrease in cellular immune response Blood: Changes in cell count (unspecified)	HBPTO* 1,773,2001
unreported route/mammal (species unspecified)	lowest published toxic dose: 0.25 mg/kg	Immunological Including Allergic: Decrease in cellular immune response	HBPTO* 1,773,2001
unreported route/mouse	lethal dose (50 percent kill): 375 mg/kg		GISAAA 50(3),4,1985
unreported route/rat	lethal dose (50 percent kill): 124 mg/kg		HBPTO* 1,786,2001

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/rat	lowest published toxic concentration: 2300 µg/m³/4H/13W- intermittent	Endocrine: Other changes Blood: Changes in other cell count (unspecified) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	GISAAA 41(8),93,1976
intraperitoneal/rat	lowest published toxic dose: 1050 mg/kg/7D- intermittent	Brain and Coverings: Other degenerative changes Behavioral: Somnolence (general depressed activity) Biochemical: Metabolism (intermediary): Lipids including transport	PHTOEH 61,12,1987
intraperitoneal/rat	lowest published toxic dose: 150 mg/kg/3D- intermittent	Brain and Coverings: Other degenerative changes Behavioral: Alteration of classical conditioning Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases	TOSCF2 97,140,2007
intraperitoneal/rat	lowest published toxic dose: 4725 mg/kg/5W- intermittent	Lung, Thorax, or Respiration: Fibrosis (interstitial) Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion Blood: Changes in leukocyte (WBC) count	RJENT* 2,85,2008
intraperitoneal/rat	lowest published toxic dose: 300 mg/kg/3D- intermittent	Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases	BCLPT* 102,365,2008
multiple/non-mammalian species	lowest published toxic dose: 500 mg/m³/7D- continuous	Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other hydrolases	TXCYAC 212,107,2005
oral/Dog	lowest published toxic dose: 210 mg/kg/12W- continuous	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	FCTXAV 6,185,1968
oral/Dog	lowest published toxic dose: 175 mg/kg/4W- continuous	Blood: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	JPETAB 121,96,1957
oral/domestic animal	lowest published toxic dose: 150 mg/kg/6D- intermittent	Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion Blood: Hemorrhage Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	VHTODE 41,287,1999
oral/human	lowest published toxic dose: 19.04 mg/kg/56D- intermittent	Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	HBPTO* 1,59,2001
oral/mouse	lowest published toxic dose: 504 mg/kg/12W- continuous	Endocrine: Changes in spleen weight Immunological Including Allergic: Decrease in cellular immune response Immunological Including Allergic: Decrease in humoral immune response	IJEBA6 36,273,1998
oral/mouse	lowest published toxic dose: 1500 mg/kg/15D- intermittent	Blood: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes	BECTA6 63,575,1999
oral/mouse	lowest published toxic dose: 75.6 mg/kg/30D- intermittent	Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects	FCTOD7 70,222,2014
oral/rabbit	lowest published toxic dose: 368 mg/kg/21W- intermittent	Immunological Including Allergic: Decrease in cellular immune response Immunological Including Allergic: Decrease in humoral immune response	IJEBA6 36,273,1998
oral/rat	lowest published toxic dose: 288 mg/kg/90D- intermittent	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	HBPTO* 1,59,2001
oral/rat	lowest published toxic dose: 3285 mg/kg/730D- intermittent	Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	HBPTO* 1,59,2001
oral/rat	lowest published toxic dose: 900 mg/kg/90D- intermittent	Nutritional and Gross Metabolic: Weight loss or decreased weight gain	JDGRAX 18,145,1989
oral/rat	lowest published toxic dose: 462 mg/kg/22W- continuous	Endocrine: Changes in spleen weight Immunological Including Allergic: Decrease in cellular immune response Immunological Including Allergic: Decrease in humoral immune response	IJEBA6 36,273,1998
oral/rat	lowest published toxic dose: 2250 mg/kg/45D- intermittent	Gastrointestinal: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases Biochemical: Metabolism (intermediary): Amino acids (including renal excretion)	BECTA6 33,289,1984
oral/rat	lowest published toxic dose: 1050 mg/kg/21D- intermittent	Liver: Other changes Biochemical: Metabolism (intermediary): Amino acids (including renal excretion)	AECTCV 14,459,1985
oral/rat	lowest published toxic dose: 3358 mg/kg/14D- continuous	Behavioral: Fluid intake Blood: Change in clotting factors	JEPOEC 6(1),51,1985
oral/rat	lowest published toxic dose: 3200 mg/kg/32D- intermittent	Behavioral: Food intake (animal) Liver: Other changes Liver: Changes in liver weight	TXCYAC 223,9,2006
oral/rat	lowest published toxic dose: 140 mg/kg/2W- intermittent	Endocrine: Change in gonadotropins Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	BECTA6 18,231,1977
oral/rat	lowest published toxic dose: 168 mg/kg/4W- continuous	Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase Biochemical: Metabolism (intermediary): Lipids including transport	CBCPAI 137,29,2004
oral/rat	lowest published toxic dose: 168 mg/kg/4W- continuous	Liver: Other changes Endocrine: Hyperglycemia Biochemical: Metabolism (intermediary): Glycolytic	CBCPAI 137,343,2004
oral/rat	lowest published toxic dose: 4200 mg/kg/28D- intermittent	Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects	ARTODN 82,543,2008
oral/rat	lowest published toxic dose: 756 mg/kg/4W- intermittent	Liver: Hepatitis (hepatocellular necrosis), diffuse Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects Biochemical: Metabolism (intermediary): Lipids including transport	FCTOD7 48,633,2010
oral/rat	lowest published toxic dose: 756 mg/kg/4W- intermittent	Endocrine: Change in gonadotropins Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)	FCTOD7 47,1903,2009
oral/rat	lowest published toxic dose: 3200 mg/kg/32D- intermittent	Liver: Multiple effects Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects	FCLPH* 21(Suppl 1),98,2007
oral/rat	lowest published toxic dose: 3200 mg/kg/32D- intermittent	Brain and Coverings: Other degenerative changes Endocrine: Other changes Biochemical: Metabolism (intermediary): Lipids including transport	FCTOD7 48,1473,2010
skin/rat	lowest published toxic dose: 1332 mg/kg/30D- intermittent	Brain and Coverings: Other degenerative changes	TOXID9 78,86,2004
skin/rat	lowest published toxic dose: 1332 mg/kg/30D- intermittent	Brain and Coverings: Other degenerative changes Behavioral: Change in motor activity (specific assay)	JTEHF8 67,331,2004
subcutaneous/guinea pig	lowest published toxic dose: 18900 mg/kg/24W- intermittent	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	TPKVAL 7,122,1965
subcutaneous/guinea pig	lowest published toxic dose: 1125 mg/kg/10D- intermittent	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	TPKVAL 7,122,1965
subcutaneous/mouse	lowest published toxic dose: 4200 mg/kg/21D- intermittent	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	NRTXDN 27,1101,2006
subcutaneous/rabbit	lowest published toxic dose: 11760 mg/kg/24W- intermittent	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	TPKVAL 7,122,1965
subcutaneous/rabbit	lowest published toxic dose: 2100 mg/kg/30D- intermittent	Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	TPKVAL 7,122,1965
subcutaneous/rat	lowest published toxic dose: 1000 mg/kg/10D- intermittent	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	TPKVAL 7,122,1965
subcutaneous/rat	lowest published toxic dose: 16800 mg/kg/24W- intermittent	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	TPKVAL 7,122,1965
unreported route/rabbit	lowest published toxic dose: 1750 mg/kg/5W- intermittent	Immunological Including Allergic: Decrease in humoral immune response	HBPTO* 1,773,2001
unreported route/rat	lowest published toxic dose: 5.6 gm/kg/14D- intermittent	Brain and Coverings: Other degenerative changes Lung, Thorax, or Respiration: Bronchiolar constriction, including asthma Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	HBPTO* 2,1035,2001

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 1 mg/m³ (inhal, vapor, skin)	DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-Not classifiable as a human carcinogen	DTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)	Cancer Review:Animal Sufficient Evidence	IMEMDT 112,107,2015
International Agency for Research on Cancer (IARC)	Cancer Review:Animal Inadequate Evidence	IMEMDT 30,103,1983
International Agency for Research on Cancer (IARC)	Cancer Review:Human No Adequate Data	IMEMDT 30,103,1983
International Agency for Research on Cancer (IARC)	Cancer Review:Human Limited Evidence	IMEMDT 112,107,2015
International Agency for Research on Cancer (IARC)	Cancer Review:Group 3	IMSUDL 7,56,1987
International Agency for Research on Cancer (IARC)	Cancer Review:Group 2A	IMEMDT 112,107,2015
TOXICOLOGY REVIEW		AQMOAC #73-19,1973
TOXICOLOGY REVIEW		RREVAH 46,1,1973
TOXICOLOGY REVIEW		CNDQA8 10(3),43,1975
TOXICOLOGY REVIEW		PMDCAY 10,85,1974
TOXICOLOGY REVIEW		DTTIAF 80,485,1973
TOXICOLOGY REVIEW		RREVAH 63,1,1976
TOXICOLOGY REVIEW		JTCTDW 38,47,2000
TOXICOLOGY REVIEW		MUREAV 562,77,2004
TOXICOLOGY REVIEW		MUTAEX 21,93,2006
TOXICOLOGY REVIEW		NETOX* 26,531,2005
TOXICOLOGY REVIEW		NRTXDN 27,628,2006
TOXICOLOGY REVIEW		MUTAEX 20,389,2005
TOXICOLOGY REVIEW		CCATAR 366,1,2006
TOXICOLOGY REVIEW		ENTOX* -,588,2005
TOXICOLOGY REVIEW		ENTOX* -,306,2005
TOXICOLOGY REVIEW		ENTOX* -,308,2005
TOXICOLOGY REVIEW		MUREAV 584,1,2005
TOXICOLOGY REVIEW		REPTED 23,260,2007
TOXICOLOGY REVIEW		JTPAE7 19,1,2006
TOXICOLOGY REVIEW		ITODC* -,355,2004
TOXICOLOGY REVIEW		MUREAV 543,251,2003
TOXICOLOGY REVIEW		HTOPA* 1,501,2002
TOXICOLOGY REVIEW		MUREAV 674,137,2009
TOXICOLOGY REVIEW		FEREAC 74,22478,2009
TOXICOLOGY REVIEW		HETOEA 26,321,2007
TOXICOLOGY REVIEW		FCTOD7 47,2906,2009
TOXICOLOGY REVIEW		FEREAC 74,47451,2009
TOXICOLOGY REVIEW		MUTAEX 23,271,2008
TOXICOLOGY REVIEW		NBREV* 9,479,1985
TOXICOLOGY REVIEW		MUTAEX 26,19,2011
TOXICOLOGY REVIEW		MUREAV 721,27,2011
TOXICOLOGY REVIEW		NRTXDN 33,575,2012
TOXICOLOGY REVIEW		TXAPA9 258,309,2012
TOXICOLOGY REVIEW		NETEEC 33,608,2011
TOXICOLOGY REVIEW		TOLED5 201,152,2011
TOXICOLOGY REVIEW		TOLED5 202,36,2011
TOXICOLOGY REVIEW		NRTXDN 42,24,2014
TOXICOLOGY REVIEW		NRTXDN 39,158,2013
TOXICOLOGY REVIEW		TOLED5 210,110,2012
TOXICOLOGY REVIEW		TXCYAC 307,42,2013
TOXICOLOGY REVIEW		TXCYAC 307,123,2013
TOXICOLOGY REVIEW		TXCYAC 307,136,2013
TOXICOLOGY REVIEW		TOLED5 230,146,2014
TOXICOLOGY REVIEW		TXAPA9 268,157,2013
TOXICOLOGY REVIEW		MUREAV 802,1,2016
TOXICOLOGY REVIEW		MUREAV 770,183,2016
TOXICOLOGY REVIEW		MUTAEX 32,491,2017
TOXICOLOGY REVIEW		REPTED 71,71,2017
TOXICOLOGY REVIEW		FCTOD7 105,456,2017
TOXICOLOGY REVIEW		RTOPDW 58,395,2010
TOXICOLOGY REVIEW		RTOPDW 59,364,2011

Standards and Regulations

Organization	Standard	Reference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION		FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES	Supported	RBREV* -,128,1998
Mine Safety and Health Administration (MSHA) STANDARD-air	time-weighted average 10 mg/m³ (skin)	DTLVS* 3,148,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-ARAB Republic of Egypt	time-weighted average 10 mg/m³, Skin, JAN1993
Occupational Exposure Limit-AUSTRALIA	time-weighted average 10 mg/m³, JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 10 mg/m³, inhal, 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 1 mg/m³ (vapor, aerosol), Skin, MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 5 mg/m³, skin, MAY2011
Occupational Exposure Limit-FINLAND	time-weighted average 10 mg/m³, short term exposure limit 20 mg/m³, skin, NOV2011
Occupational Exposure Limit-FRANCE	VME 10 mg/m³, Skin, FEB2006
Occupational Exposure Limit-GERMANY	MAK 15 mg/m³, inhal, 2011
Occupational Exposure Limit-ICELAND	time-weighted average 5 mg/m³, skin, NOV2011
Occupational Exposure Limit-JAPAN	Occupational Exposure Limit 10 mg/m³, skin, MAY2012
Occupational Exposure Limit-KOREA	time-weighted average 10 mg/m³, skin, 2006
Occupational Exposure Limit-MEXICO	time-weighted average 10 mg/m³ (skin), 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 10 mg/m³, skin, JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 5 mg/m³, JAN1999
Occupational Exposure Limit-PERU	time-weighted average 1 mg/m³, JUL2005
Occupational Exposure Limit-POLAND	MAC(time-weighted average) 1 mg/m³, MAC(short term exposure limit) 10 mg/m³, JAN1999
Occupational Exposure Limit-RUSSIA	time-weighted average 0.5 mg/m³, short term exposure limit 1.5 mg/m³, Skin, JUN2003
Occupational Exposure Limit-SWITZERLAND	MAK-week 10 mg/m³, inhal, skin, JAN2011
Occupational Exposure Limit-THAILAND	time-weighted average 15 mg/m³, JAN1993
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 10 mg/m³, Skin, 2003
Occupational Exposure Limit-THE PHILIPPINES	time-weighted average 15 mg/m³, Skin, JAN1993
Occupational Exposure Limit-TURKEY	time-weighted average 15 mg/m³, Skin, JAN1993
Occupational Exposure Limit-UNITED KINGDOM	time-weighted average 10 mg/m³, skin, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 15 mg/m³ (skin), total dust	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	8H time-weighted average 15 mg/m³ (skin)	CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 15 mg/m³ (skin), total dust	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 15 mg/m³ (skin), total dust	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO MALATHION-air	10H time-weighted average 10 mg/m³ (Sk)	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code 80046; Number of Industries 15; Total Number of Facilities 2146; Number of Occupations 18; Total Number of Employees Exposed 19170; Total Number of Female Employees Exposed 1909
National Occupational Hazard Survey 1974	Hazard Code 80046; Number of Industries 13; Total Number of Facilities 1609; Number of Occupations 14; Total Number of Employees Exposed 17242

Status in Federal Agencies

Organization	Reference
ATSDR TOXICOLOGY PROFILE (NTIS** PB2004/100003)
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay; E coli polA without S9
EPA GENETOX PROGRAM 1988, Negative: Carcinogenicity-mouse/rat; Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast; TRP reversion
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Positive/dose response: In vitro SCE-human
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);no evidence:rat	NCITR* NCI-TR-192,1979
NIOSH Analytical Method, 1994: Organophosphorus pesticides, 5600
On EPA IRIS database
OSHA ANALYTICAL METHOD #ID-62

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health