Styrene, methyl-
RTECS #
WL5075000
CAS #
Updated
October 2017
Molecular Weight
118.19
Molecular Formula
C9H10
Synonyms
3- and 4-Vinyl toluene (mixed isomers)
Ethenylmethylbenzene
Methylstyrene
Methylvinylbenzene
NCI-C56406
Toluene, vinyl- (mixed isomers)
Tolylethylene
Vinyl toluene
Vinyl toluene (ACGIH:OSHA)
Vinyl toluene (mixed isomers)
Vinyltoluene
Ethenylmethylbenzene
Methylstyrene
Methylvinylbenzene
NCI-C56406
Toluene, vinyl- (mixed isomers)
Tolylethylene
Vinyl toluene
Vinyl toluene (ACGIH:OSHA)
Vinyl toluene (mixed isomers)
Vinyltoluene
Skin and Eye Irritation and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| eye /rabbit | 90 mg | mild | AMIHAB 14,387,1956 |
| skin /rabbit | 100% | moderate | AMIHAB 14,387,1956 |
Mutation Data and Reference
| System Test | Route/Organism/Tissue | Dose | Reference |
|---|---|---|---|
| micronucleus test | intraperitoneal/mouse | 200 mg/kg | TOLED5 8,247,1981 |
| mutation in mammalian somatic cells | lymphocyte/mouse | 60 mg/L | EMMUEG 12,85,1988 |
Reproductive Effects Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| intraperitoneal/rat | 3750 mg/kg (1-15D pregnant) | Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | SWEHDO 7(Suppl 4),66,1981 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/human | lowest published toxic concentration: 400 ppm | Olfaction: Other olfaction effects Eye: Other eye effects | AMIHAB 14,387,1956 |
| inhalation/mouse | lowest published toxic concentration: 2 ppm/6M | Lung, Thorax, or Respiration: Respiratory depression | TOLED5 9,137,1981 |
| inhalation/mouse | lethal concentration (50 percent kill): 29500 mg/m3/4H | VCVGH* -,207,1990 | |
| inhalation/mouse | lethal concentration (50 percent kill): 3020 mg/m3/4H | Lung, Thorax, or Respiration: Acute pulmonary edema Gastrointestinal: Other changes Blood: Hemorrhage | HYSAAV 34(7-9),334,1969 |
| intraperitoneal/rat | lethal dose (50 percent kill): 1038 mg/kg | VCVGH* -,207,1990 | |
| intraperitoneal/rat | lethal dose (16 percent kill): 747 mg/kg | VCVGH* -,207,1990 | |
| intraperitoneal/rat | lethal dose (84 percent kill): 1761 mg/kg | VCVGH* -,207,1990 | |
| intraperitoneal/rat | lethal dose (50 percent kill): 2324 mg/kg | Eye: Lacrimation Behavioral: Somnolence (general depressed activity) Skin and Appendages: Other: Hair | ATDAEI 1,77,1990 |
| oral/mouse | lethal dose (50 percent kill): 3160 mg/kg | Lung, Thorax, or Respiration: Acute pulmonary edema Gastrointestinal: Other changes Blood: Hemorrhage | HYSAAV 34(7-9),334,1969 |
| oral/rat | lethal dose (50 percent kill): 2255 mg/kg | Eye: Lacrimation Behavioral: Somnolence (general depressed activity) Skin and Appendages: Other: Hair | ATDAEI 1,77,1990 |
| skin/mouse | lowest published lethal dose: 4500 mg/kg | GISAAA 34(9),40,1969 | |
| skin/rat | lowest published lethal dose: 4500 mg/kg | GISAAA 34(9),40,1969 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/guinea pig | lowest published toxic concentration: 29 mg/m3/4H/16W- intermittent | Behavioral: Excitement | NTIS** OTS0572508 |
| inhalation/mouse | lowest published toxic concentration: 200 ppm/6H/15D- intermittent | Lung, Thorax, or Respiration: Other changes Liver: Hepatitis (hepatocellular necrosis), diffuse Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | NTPTR* NTP-TR-375,1990 |
| inhalation/mouse | lowest published toxic concentration: 160 ppm/6H/13W- intermittent | Olfaction: Other olfaction effects Lung, Thorax, or Respiration: Other changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NTPTR* NTP-TR-375,1990 |
| inhalation/mouse | lowest published toxic concentration: 618 mg/kg/103W- intermittent | Lung, Thorax, or Respiration: Tumors Tumorigenic: Active as anti-cancer agent | NTIS** PB90-260035 |
| inhalation/mouse | lowest published toxic concentration: 618 mg/kg/103W- intermittent | Liver: Tumors Blood: Lymphoma including Hodgkin's disease Tumorigenic: Active as anti-cancer agent | NTIS** PB90-260035 |
| inhalation/mouse | lowest published toxic concentration: 200 ppm/15D- intermittent | Lung, Thorax, or Respiration: Other changes Liver: Hepatitis (hepatocellular necrosis), zonal Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | HPV132 -,-,2002 |
| inhalation/mouse | lowest published toxic concentration: 25 ppm/103W- intermittent | Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Nutritional and Gross Metabolic: Weight loss or decreased weight gain | HPV132 -,-,2002 |
| inhalation/rat | lowest published toxic concentration: 400 ppm/15D- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | HPV132 -,-,2002 |
| inhalation/rat | lowest published toxic concentration: 1300 ppm/15D- intermittent | Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Liver: Hepatitis (hepatocellular necrosis), zonal Nutritional and Gross Metabolic: Weight loss or decreased weight gain | HPV132 -,-,2002 |
| inhalation/rat | lowest published toxic concentration: 1000 ppm/13W- intermittent | Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes primarily in glomeruli | HPV132 -,-,2002 |
| inhalation/rat | lowest published toxic concentration: 5000 mg/m3/6H/100D- intermittent | Blood: Hemorrhage Blood: Luekopenia Blood: Changes in leukocyte (WBC) count | VCVGH* -,207,1990 |
| inhalation/rat | lowest published toxic concentration: 1300 ppm/6H/15D- intermittent | Eye: Lacrimation Liver: Other changes Liver: Changes in liver weight | NTPTR* NTP-TR-375,1990 |
| inhalation/rat | lowest published toxic concentration: 332 ppm/6H/21W- intermittent | Peripheral Nerve and Sensation: Recording from afferent nerve Peripheral Nerve and Sensation: Recording from peripheral motor nerve | TOLED5 30,27,1986 |
| inhalation/rat | lowest published toxic concentration: 1000 ppm/6H/13W- intermittent | Eye: Lacrimation Liver: Changes in liver weight | NTPTR* NTP-TR-375,1990 |
| inhalation/rat | lowest published toxic concentration: 100 ppm/6H/15W- intermittent | Peripheral Nerve and Sensation: Recording from peripheral motor nerve | ATSUDG 5,100,1982 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 50 ppm;short term exposure limit 100 ppm | DTLVS* TLV/BEI,2013 |
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Not classifiable as a human carcinogen | DTLVS* TLV/BEI,2013 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Human Inadequate Evidence | IMEMDT 60,373,1994 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Animal Lack Carcinogenicity | IMEMDT 60,373,1994 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Group 3 | IMEMDT 60,373,1994 |
| TOXICOLOGY REVIEW | MUREAV 543,201,2003 | |
| TOXICOLOGY REVIEW | MUREAV 584,1,2005 | |
| TOXICOLOGY REVIEW | MUREAV 721,27,2011 | |
| TOXICOLOGY REVIEW | TOLED5 204,148,2011 | |
| TOXICOLOGY REVIEW | MUREAV 802,1,2016 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 100 ppm (480 mg/m3) | DTLVS* 3,278,1971 |
| Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
| Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
| Occupational Exposure Limit-AUSTRALIA | time-weighted average 50 ppm (242 mg/m3), short term exposure limit 100 ppm (483 mg/m3), JUL2008 | |
| Occupational Exposure Limit-AUSTRIA | MAK-TMW 100 ppm (480 mg/m3);KZW 100 ppm (480 mg/m3), 2007 | |
| Occupational Exposure Limit-BELGIUM | time-weighted average 50 ppm (246 mg/m3), short term exposure limit 100 ppm(490 mg/m3), MAR2002 | |
| Occupational Exposure Limit-DENMARK | time-weighted average 25 ppm (120 mg/m3), MAY2011 | |
| Occupational Exposure Limit-FINLAND | time-weighted average 10 ppm (49 mg/m3), NOV2011 | |
| Occupational Exposure Limit-FRANCE | VME 50 ppm (240 mg/m3), FEB2006 | |
| Occupational Exposure Limit-GERMANY | MAK 100 ppm (490 mg/m3), 2011 | |
| Occupational Exposure Limit-ICELAND | time-weighted average 25 ppm (120 mg/m3), skin, NOV2011 | |
| Occupational Exposure Limit-KOREA | time-weighted average 50 ppm (240 mg/m3), 2006 | |
| Occupational Exposure Limit-MEXICO | time-weighted average 50 ppm (240 mg/m3);short term exposure limit 100 ppm (485 mg/m3), 2004 | |
| Occupational Exposure Limit-NEW ZEALAND | time-weighted average 50 ppm (242 mg/m3), short term exposure limit 100 ppm (483 mg/m3), JAN2002 | |
| Occupational Exposure Limit-PERU | time-weighted average 50 ppm (242 mg/m3); short term exposure limit 100 ppm (483 mg/m3), JUL2005 | |
| Occupational Exposure Limit-POLAND | MAC(time-weighted average) 100 mg/m3, MAC(short term exposure limit) 300 mg/m3, JAN1999 | |
| Occupational Exposure Limit-RUSSIA | time-weighted average 50 mg/m3, short term exposure limit 150 mg/m3, JUN2003 | |
| Occupational Exposure Limit-SWEDEN | time-weighted average 10 ppm (50 mg/m3);short term exposure limit 30 ppm (150 mg/m3), Skin, JUN2005 | |
| Occupational Exposure Limit-SWITZERLAND | MAK-week 50 ppm (240 mg/m3), KZG-week 100 ppm (480 mg/m3), JAN2011 | |
| Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 50 mg/m3, Skin, 2003 | |
| Occupational Exposure Limit-THE PHILIPPINES | time-weighted average 100 ppm (480 mg/m3), JAN1993 | |
| Occupational Exposure Limit-TURKEY | time-weighted average 100 ppm (480 mg/m3), JAN1993 | |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 100 ppm (480 mg/m3) | CFRGBR 29,1926.55,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 100 ppm (480 mg/m3) | CFRGBR 41,50-204.50,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 100 ppm (480 mg/m3) | CFRGBR 29,1910.1000,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 100 ppm (480 mg/m3) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO VINYL TOLUENE-air | 10H time-weighted average 100 ppm | NIOSH* DHHS #92-100,1992 |
| National Occupational Exposure Survey 1983 | Hazard Code 76510; Number of Industries 24; Total Number of Facilities 2028; Number of Occupations 31; Total Number of Employees Exposed 25353; Total Number of Female Employees Exposed 3889 | |
| National Occupational Hazard Survey 1974 | Hazard Code 76510; Number of Industries 61; Total Number of Facilities 7016; Number of Occupations 59; Total Number of Employees Exposed 73140 |
Status in Federal Agencies
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health