Silicic acid, tetramethyl ester
RTECS #
VV9800000
CAS #
Updated
December 2018
Molecular Weight
152.25
Molecular Formula
C4H12O4Si
Synonyms
Methyl silicate
Methyl silicate (ACGIH)
Silicic acid, methyl ester of ortho-
Tetramethoxysilane
Tetramethyl silicate
Tetramethylsilikat (Czech)
TL 190
Methyl silicate (ACGIH)
Silicic acid, methyl ester of ortho-
Tetramethoxysilane
Tetramethyl silicate
Tetramethylsilikat (Czech)
TL 190
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/mouse | Lowest published lethal concentration: 1 gm/m3/10M | Eye: Other eye effects Musculoskeletal: Other changes | NDRC** NDCrc-132,MAY1942 |
| inhalation/rat | Lowest published lethal concentration: 250 ppm/4H | AMIHBC 4,119,1951 | |
| intraperitoneal/mouse | lethal dose (50 percent kill): 250 mg/kg | CBCCT* 2,56,1950 | |
| intraperitoneal/rat | lethal dose (50 percent kill): 100 mg/kg | 85JCAE -,1222,1986 | |
| intravenous/rabbit | lowest published lethal dose: 100 mg/kg | Lung, Thorax, or Respiration: Acute pulmonary edema Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) | 30ZNA5 3,935,1968 |
| oral/mammal (species unspecified) | lethal dose (50 percent kill): 1 gm/kg | GISAAA 39(4),86,1974 | |
| oral/rat | lowest published lethal dose: 700 mg/kg | Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) | 30ZNA5 3,935,1968 |
| skin/rabbit | lethal dose (50 percent kill): 17 mL/kg | AMIHBC 4,119,1951 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/rat | lowest published toxic concentration: 30 ppm/6H/28D- intermittent | Behavioral: Food intake (animal) Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases | NTIS** OTS0523612 |
| inhalation/rat | lowest published toxic concentration: 20 ppm/6H/5D- intermittent | Lung, Thorax, or Respiration: Other changes Blood: Hemorrhage | NTIS** OTS0523612 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 1 ppm | DTLVS* TLV/BEI,2013 |
| TOXICOLOGY REVIEW | RTOPDW 54,247,2009 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Mine Safety and Health Administration (MSHA) STANDARD | air-ceiling concentration 5 ppm (30 mg/m3) | DTLVS* 3,169,1971 |
| Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
| Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
| Occupational Exposure Limit-AUSTRALIA | time-weighted average 1 ppm (6 mg/m3), JUL2008 | |
| Occupational Exposure Limit-AUSTRIA | MAK-TMW 1 ppm (6 mg/m3);KZW 2 ppm (12 mg/m3), 2007 | |
| Occupational Exposure Limit-BELGIUM | time-weighted average 1 ppm (6 mg/m3), MAR2002 | |
| Occupational Exposure Limit-DENMARK | ceiling concentration 1 ppm (6 mg/m3), MAY2011 | |
| Occupational Exposure Limit-FINLAND | time-weighted average 5 ppm (32 mg/m3), short term exposure limit 10 ppm (63 mg/m3), NOV2011 | |
| Occupational Exposure Limit-FRANCE | VME 1 ppm (6 mg/m3), FEB2006 | |
| Occupational Exposure Limit-ICELAND | short term exposure limit 1 ppm (6 mg/m3), NOV2011 | |
| Occupational Exposure Limit-JAPAN | Occupational Exposure Limit 1 ppm (6 mg/m3), MAY2012 | |
| Occupational Exposure Limit-KOREA | time-weighted average 1 ppm (6 mg/m3), 2006 | |
| Occupational Exposure Limit-NEW ZEALAND | time-weighted average 1 ppm (6 mg/m3), JAN2002 | |
| Occupational Exposure Limit-NORWAY | time-weighted average 1 ppm (6 mg/m3), JAN1999 | |
| Occupational Exposure Limit-PERU | time-weighted average 1 ppm (6,2 mg/m3), JUL2005 | |
| Occupational Exposure Limit-SWITZERLAND | MAK-week 1 ppm (6 mg/m3), JAN2011 | |
| Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 6 mg/m3, 2003 | |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 5 ppm (30 mg/m3) | CFRGBR 29,1926.55,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 5 ppm (30 mg/m3) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METHYL SILICATE-air | 10H time-weighted average 1 ppm | NIOSH* DHHS #92-100,1992 |
Status in Federal Agencies
| Organization | Reference |
|---|---|
| EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
| EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 |
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health