Pyridine, 2-amino-
RTECS #
US1575000
CAS #
Updated
September 2013
Molecular Weight
94.13
Molecular Formula
C5H6N2
Synonyms
2-Aminopyridine
2-Aminopyridine (ACGIH:OSHA)
2-Pyridylamine
alpha-Aminopyridine
alpha-Pyridinamine
alpha-Pyridylamine
Amino-2 pyridine
2-Aminopyridine (ACGIH:OSHA)
2-Pyridylamine
alpha-Aminopyridine
alpha-Pyridinamine
alpha-Pyridylamine
Amino-2 pyridine
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/human | lowest published toxic concentration: 5 ppm/5H | Behavioral: Somnolence (general depressed activity) Behavioral: Convulsions or effect on seizure threshold Behavioral: Antipsychotic | IMSUAI 19,317,1950 |
| intracerebral/mouse | lethal dose (50 percent kill): 4 mg/kg | Behavioral: Convulsions or effect on seizure threshold | AJEBAK 36,365,1958 |
| intraperitoneal/mouse | lethal dose (50 percent kill): 25 mg/kg | USXXAM #3816470 | |
| intraperitoneal/rat | lethal dose (50 percent kill): 48 mg/kg | GISAAA 57(9-10),64,1992 | |
| intravenous/mouse | lethal dose (50 percent kill): 23 mg/kg | Behavioral: Convulsions or effect on seizure threshold | APFRAD 26,345,1968 |
| intravenous/rat | lethal dose (50 percent kill): 29 mg/kg | AEPPAE 211,367,1950 | |
| oral/mouse | lethal dose (50 percent kill): 145 mg/kg | GISAAA 57(9-10),64,1992 | |
| oral/quail | lethal dose (50 percent kill): 133 mg/kg | AECTCV 12,355,1983 | |
| oral/rat | lethal dose (50 percent kill): 200 mg/kg | 85JCAE -,838,1986 | |
| oral/wild bird | lethal dose (50 percent kill): 31600 µg/kg | AECTCV 12,355,1983 | |
| skin/guinea pig | lethal dose (50 percent kill): 500 mg/kg | 85JCAE -,838,1986 | |
| subcutaneous/mouse | lethal dose (50 percent kill): 70 mg/kg | AEPPAE 226,163,1955 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 0.5 ppm | DTLVS* TLV/BEI,2013 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 0.5 ppm (2 mg/m3) | DTLVS* 3,11,1971 |
| Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
| Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
| Occupational Exposure Limit-AUSTRALIA | time-weighted average 0.5 ppm (2 mg/m3), JUL2008 | |
| Occupational Exposure Limit-AUSTRIA | MAK-TMW 0.5 ppm (2 mg/m3), 2007 | |
| Occupational Exposure Limit-BELGIUM | time-weighted average 0.5 ppm (1.9 mg/m3), MAR2002 | |
| Occupational Exposure Limit-DENMARK | time-weighted average 0.5 ppm (2 mg/m3), MAY2011 | |
| Occupational Exposure Limit-FINLAND | time-weighted average 0.5 ppm (2 mg/m3), short term exposure limit 1.5 ppm (5.9 mg/m3), NOV2011 | |
| Occupational Exposure Limit-FRANCE | VME 0.5 ppm (2 mg/m3), FEB2006 | |
| Occupational Exposure Limit-ICELAND | time-weighted average 0.5 ppm (2 mg/m3), NOV2011 | |
| Occupational Exposure Limit-KOREA | time-weighted average 0.5 ppm (2 mg/m3), 2006 | |
| Occupational Exposure Limit-NEW ZEALAND | time-weighted average 0.5 ppm (2 mg/m3), JAN2002 | |
| Occupational Exposure Limit-PERU | time-weighted average 0.5 ppm (1.9 mg/m3), JUL2005 | |
| Occupational Exposure Limit-POLAND | MAC(time-weighted average) 2 mg/m3, JAN1999 | |
| Occupational Exposure Limit-SWITZERLAND | MAK-week 0.5 ppm (2 mg/m3), JAN2011 | |
| Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 2 mg/m3, 2003 | |
| Occupational Exposure Limit-THE PHILIPPINES | time-weighted average 0.5 ppm (2 mg/m3), JAN1993 | |
| Occupational Exposure Limit-UNITED KINGDOM | time-weighted average 0.5 ppm (2 mg/m3);short term exposure limit 2 ppm (7,8 mg/m3), OCT2007 | |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 0.5 ppm (2 mg/m3) | CFRGBR 29,1926.55,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 0.5 ppm (2 mg/m3) | CFRGBR 41,50-204.50,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 0.5 ppm (2 mg/m3) | CFRGBR 29,1910.1000,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 0.5 ppm (2 mg/m3) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 2-AMINOPYRIDINE-air | 10H time-weighted average 0.5 ppm | NIOSH* DHHS #92-100,1992 |
| National Occupational Exposure Survey 1983 | Hazard Code 05215; Number of Industries 3; Total Number of Facilities 61; Number of Occupations 4; Total Number of Employees Exposed 3159; Total Number of Female Employees Exposed 429 |
Status in Federal Agencies
| Organization | Reference |
|---|---|
| EPA TSCA Section 8(b) CHEMICAL INVENTORY |
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health