Pyrethrum
RTECS #
UR4200000
CAS #
Updated
June 2018
Molecular Weight
N/R
Molecular Formula
N/R
Synonyms
Buhach
Chrysanthemum cinerareaefolium
Cinerin I or II
Dalmation insect flowers
Firmotox
Insect powder
Jasmolin I or II
Prentox pyrethrum extract
Pyrenone
Pyrethrin I or II
Pyrethrins
Pyrethrum (ACGIH:OSHA)
Pyrethrum (insecticide)
Pyrethrum powder other than pyrethrins
Pyrocide
Pyronyl
Trieste flowers
Chrysanthemum cinerareaefolium
Cinerin I or II
Dalmation insect flowers
Firmotox
Insect powder
Jasmolin I or II
Prentox pyrethrum extract
Pyrenone
Pyrethrin I or II
Pyrethrins
Pyrethrum (ACGIH:OSHA)
Pyrethrum (insecticide)
Pyrethrum powder other than pyrethrins
Pyrocide
Pyronyl
Trieste flowers
Reproductive Effects Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| oral/rat | 500 mg/kg (6-15D pregnant) | Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) | JTEHD6 10,111,1982 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| intracerebral/mouse | lethal dose (50 percent kill): 2500 mg/kg | HBPTO* 1,114,2001 | |
| intraperitoneal/guinea pig | lowest published lethal dose: 50 mg/kg | Behavioral: Excitement Behavioral: Ataxia Lung, Thorax, or Respiration: Respiratory stimulation | PSEBAA 34,135,1936 |
| intraperitoneal/mouse | lowest published lethal dose: 25 mg/kg | Behavioral: Excitement Behavioral: Ataxia Lung, Thorax, or Respiration: Respiratory stimulation | PSEBAA 34,135,1936 |
| intraperitoneal/mouse | lethal dose (50 percent kill): 333 mg/kg | HBPTO* 1,114,2001 | |
| intraperitoneal/pig | lethal dose (50 percent kill): 102 mg/kg | HBPTO* 1,114,2001 | |
| intraperitoneal/rat | lethal dose (50 percent kill): 189 mg/kg | HBPTO* 1,114,2001 | |
| intravenous/Dog | lethal dose (50 percent kill): 7 mg/kg | WRPCA2 3,28,1964 | |
| oral/child | lowest published lethal dose: 750 mg/kg | CMEP** -,1,1956 | |
| oral/guinea pig | lowest published lethal dose: 1 gm/kg | Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion Gastrointestinal: Hypermotility, diarrhea Nutritional and Gross Metabolic: Weight loss or decreased weight gain | PSEBAA 34,135,1936 |
| oral/human | lowest published lethal dose: 1 gm/kg | 85GYAV -,142,1971 | |
| oral/mammal (species unspecified) | lethal dose (50 percent kill): 250 mg/kg | AMIHAB 14,178,1956 | |
| oral/mouse | lethal dose (50 percent kill): 370 mg/kg | Behavioral: Tremor Behavioral: Excitement Behavioral: Ataxia | EVHPAZ 14,15,1976 |
| oral/mouse | lethal dose (50 percent kill): 285 mg/kg | HBPTO* 1,114,2001 | |
| oral/pig | lethal dose (50 percent kill): 1500 mg/kg | HBPTO* 1,114,2001 | |
| oral/quail | lethal dose (50 percent kill): 2000 mg/kg | Behavioral: Altered sleep time (including change in righting reflex) Nutritional and Gross Metabolic: Weight loss or decreased weight gain | HBPTO* 1,114,2001 |
| oral/rat | lethal dose (50 percent kill): 200 mg/kg | GUCHAZ 6,442,1973 | |
| parenteral/chicken | lethal dose (50 percent kill): 1565 mg/kg | HBPTO* 1,114,2001 | |
| skin/rabbit | lethal dose (50 percent kill): 300 mg/kg | EVHPAZ 14,109,1976 | |
| skin/rat | lethal dose (50 percent kill): 1350 mg/kg | YKYUA6 37,1481,1986 | |
| subcutaneous/frog | lethal dose (50 percent kill): 5.8 mg/kg | HBPTO* 1,114,2001 | |
| unreported route/domestic bird | lethal dose (50 percent kill): 5620 ppm | HBPTO* 1,114,2001 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| oral/rat | lowest published toxic dose: 4600 mg/kg/23D- intermittent | Liver: Changes in liver weight Biochemical: Metabolism (intermediary): Lipids including transport | TXAPA9 24,298,1973 |
| oral/rat | lowest published toxic dose: 2800 mg/kg/7D- continuous | Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes | TOXID9 72,89,2003 |
| oral/rat | lowest published toxic dose: 1050 mg/kg/7D- continuous | Liver: Other changes Liver: Changes in liver weight Endocrine: Changes in thyroid weight | TOXID9 72,89,2003 |
| oral/rat | lowest published toxic dose: 2800 mg/kg/7D- continuous | Endocrine: Evidence of thyroid hypofunction Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) | TOXID9 72,89,2003 |
| oral/rat | lowest published toxic dose: 2954 mg/kg/7D- continuous | Endocrine: Other changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases | TXAPA9 214,253,2006 |
| oral/rat | lowest published toxic dose: 5908 mg/kg/14D- continuous | Endocrine: Changes in thyroid weight | TXAPA9 214,253,2006 |
| oral/rat | lowest published toxic dose: 95.2 mg/kg/14D- continuous | Endocrine: Other changes | TXAPA9 214,253,2006 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 5 mg/m3 | DTLVS* TLV/BEI,2013 |
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Not classifiable as a human carcinogen | DTLVS* TLV/BEI,2013 |
| TOXICOLOGY REVIEW | TOLED5 134,3,2002 | |
| TOXICOLOGY REVIEW | BPCEM* 17,237,2003 | |
| TOXICOLOGY REVIEW | FCTOD7 47,1406,2009 | |
| TOXICOLOGY REVIEW | MUTAEX 26,231,2011 | |
| TOXICOLOGY REVIEW | TXCYAC 307,3,2013 | |
| TOXICOLOGY REVIEW | TIVIEQ 34,321,2016 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION | FEREAC 54,7740,1989 | |
| Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES | Cancelled | RBREV* -,205,1998 |
| Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 5 mg/m3 | DTLVS* 3,219,1971 |
| Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
| Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
| Occupational Exposure Limit-ARAB Republic of Egypt | time-weighted average 5 mg/m3, JAN1993 | |
| Occupational Exposure Limit-AUSTRALIA | time-weighted average 5 mg/m3, JUL2008 | |
| Occupational Exposure Limit-BELGIUM | time-weighted average 1 mg/m3, MAR2002 | |
| Occupational Exposure Limit-DENMARK | time-weighted average 1 mg/m3, MAY2011 | |
| Occupational Exposure Limit-EC | time-weighted average 1 mg/m3, FEB2006 | |
| Occupational Exposure Limit-FRANCE | VME 5 mg/m3, FEB2006 | |
| Occupational Exposure Limit-HUNGARY | time-weighted average 5 mg/m3, short term exposure limit 20 mg/m3, SEP2000 | |
| Occupational Exposure Limit-ICELAND | time-weighted average 1 mg/m3, NOV2011 | |
| Occupational Exposure Limit-KOREA | time-weighted average 5 mg/m3, 2006 | |
| Occupational Exposure Limit-MEXICO | time-weighted average 5 mg/m3;short term exposure limit 10 mg/m3, 2004 | |
| Occupational Exposure Limit-NEW ZEALAND | time-weighted average 5 mg/m3, sen, JAN2002 | |
| Occupational Exposure Limit-NORWAY | time-weighted average 5 mg/m3, JAN1999 | |
| Occupational Exposure Limit-PERU | time-weighted average 5 mg/m3, JUL2005 | |
| Occupational Exposure Limit-SWEDEN | time-weighted average 5 mg/m3, JUN2005 | |
| Occupational Exposure Limit-SWITZERLAND | MAK-week 5 mg/m3, inhal, sen, JAN2011 | |
| Occupational Exposure Limit-THAILAND | time-weighted average 5 mg/m3, JAN1993 | |
| Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 5 mg/m3, 2003 | |
| Occupational Exposure Limit-TURKEY | time-weighted average 5 mg/m3, JAN1993 | |
| Occupational Exposure Limit-UNITED KINGDOM | time-weighted average 1 mg/m3, OCT2007 | |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 5 mg/m3 | CFRGBR 29,1926.55,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 5 mg/m3 | CFRGBR 41,50-204.50,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 5 mg/m3 | CFRGBR 29,1910.1000,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 5 mg/m3 | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PYRETHRUM-air | 10H time-weighted average 5 mg/m3 | NIOSH* DHHS #92-100,1992 |
| National Occupational Exposure Survey 1983 | Hazard Code 65070; Number of Industries 7; Total Number of Facilities 1031; Number of Occupations 11; Total Number of Employees Exposed 11296; Total Number of Female Employees Exposed 1537 | |
| National Occupational Hazard Survey 1974 | Hazard Code 65070; Number of Industries 10; Total Number of Facilities 1081; Number of Occupations 7; Total Number of Employees Exposed 4375 |
Status in Federal Agencies
| Organization | Reference |
|---|---|
| EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 | |
| NIOSH Analytical Method, 1994: Pyrethrum, 5008 | |
| OSHA ANALYTICAL METHOD #ID-70 |
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health