Propene, 1,3-dichloro-
RTECS #
UC8310000
CAS #
Updated
March 2018
Molecular Weight
110.97
Molecular Formula
C3H4Cl2
Synonyms
1,3-Dichloro-2-propene
1,3-Dichloropropene
1,3-Dichloropropene (ACGIH)
1,3-Dichloropropene, technical grade
1,3-Dichloropropene-1
1,3-Dichloropropylene
3-Chloroallyl chloride
3-Chloropropenyl chloride
alpha,gamma-Dichloropropylene
alpha-Chloroallyl chloride
D-D 92
DD 95
Dorlone II
gamma-Chloroallyl chloride
NCI-C03985
RCRA waste number U084
Telone
Telone II
Telone II soil fumigant
1,3-Dichloropropene
1,3-Dichloropropene (ACGIH)
1,3-Dichloropropene, technical grade
1,3-Dichloropropene-1
1,3-Dichloropropylene
3-Chloroallyl chloride
3-Chloropropenyl chloride
alpha,gamma-Dichloropropylene
alpha-Chloroallyl chloride
D-D 92
DD 95
Dorlone II
gamma-Chloroallyl chloride
NCI-C03985
RCRA waste number U084
Telone
Telone II
Telone II soil fumigant
Mutation Data and Reference
System Test | Route/Organism/Tissue | Dose | Reference |
---|---|---|---|
Cytogenetic Analysis | ovary/hamster | 49100 µg/L | EMMUEG 13,60,1989 |
DNA Damage | intraperitoneal/mouse | 150 mg/kg | MUREAV 419,13,1998 |
mutation in mammalian somatic cells | lymphocyte/mouse | 3 mg/L | SCIEAS 236,933,1987 |
mutation in microorganisms | /Salmonella typhimurium | 33 µg/plate (+enzymatic activation step) | ENMUDM 5(Suppl 1),3,1983 |
mutation in microorganisms | /Salmonella typhimurium | 10 µmol/plate (-enzymatic activation step) | ENMUDM 2,59,1980 |
mutation in microorganisms | /Salmonella typhimurium | 0.004 µmol/L/3D (-enzymatic activation step) | MUREAV 572,98,2005 |
mutation in microorganisms | /Salmonella typhimurium | 50 mg/L/2H (-enzymatic activation step) | EMMUEG 44,329,2004 |
mutation in microorganisms | /Salmonella typhimurium | 100 mg/L/2H (+enzymatic activation step) | EMMUEG 44,329,2004 |
other mutation test systems | /Escherichia coli | 1 mmol/L | MUREAV 203,81,1988 |
sex chromosome loss and nondisjunction | oral/Drosophila melanogaster | 5750 ppm | ENMUDM 7,325,1985 |
sister chromatid exchange | ovary/hamster | 900 nmol/L | CNJGA8 22,681,1980 |
Tumorigenic Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/mouse | lowest published toxic concentration: 60 ppm/6H/5D/2Y | Tumorigenic: Neoplastic by RTECS criteria Lung, Thorax, or Respiration: Tumors | FAATDF 12,418,1989 |
oral/mouse | lowest published toxic dose: 31200 mg/kg/2Y- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Gastrointestinal: Tumors Kidney, Ureter, and Bladder: Bladder tumors | NTPTR* NTP-TR-269,1985 |
oral/mouse | lowest published toxic dose: 15600 mg/kg/104W- intermittent | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Lung, Thorax, or Respiration: Tumors Gastrointestinal: Tumors | NTIS** PB85-230449/AS |
oral/mouse | lowest published toxic dose: 31200 mg/kg/104W- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Gastrointestinal: Tumors | NTIS** PB85-230449/AS |
oral/mouse | lowest published toxic dose: 15600 mg/kg/104W- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Kidney, Ureter, and Bladder: Bladder tumors | NTIS** PB85-230449/AS |
oral/rat | lowest published toxic dose: 15600 mg/kg/2Y- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Gastrointestinal: Tumors Liver: Tumors | NTPTR* NTP-TR-269,1985 |
oral/rat | lowest published toxic dose: 15600 mg/kg/104W- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Gastrointestinal: Tumors | NTIS** PB85-230449/AS |
oral/rat | lowest published toxic dose: 7800 mg/kg/104W- intermittent | Tumorigenic: Neoplastic by RTECS criteria Liver: Tumors | NTIS** PB85-230449/AS |
oral/rat | lowest published toxic dose: 7800 mg/kg/104W- intermittent | Tumorigenic: Neoplastic by RTECS criteria Lung, Thorax, or Respiration: Tumors Gastrointestinal: Tumors | NTIS** PB85-230449/AS |
Acute Toxicity Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/guinea pig | Lowest published lethal concentration: 400 ppm/7H | AIHAAP 38,217,1977 | |
inhalation/human | lowest published toxic concentration: 1500 ppm | Lung, Thorax, or Respiration: Cough | VCVGH* -,474,1990 |
inhalation/mammal (species unspecified) | lethal concentration (50 percent kill): 3.88 gm/m3/4H | FEREAC 65,1869,2000 | |
inhalation/mouse | lethal concentration (50 percent kill): 3220 mg/m3/2H | VCVGH* -,473,1990 | |
inhalation/rat | Lowest published lethal concentration: 1000 ppm/2H | Eye: Lacrimation | AIHAAP 38,217,1977 |
intraperitoneal/mouse | lowest published toxic dose: 100 mg/kg | Blood: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases | CRTOEC 13,1096,2000 |
intraperitoneal/mouse | lowest published lethal dose: 700 mg/kg | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases | TOXID9 1,90,2001 |
intraperitoneal/mouse | lowest published lethal dose: 700 mg/kg | TOXID9 1,90,2001 | |
intraperitoneal/rat | lethal dose (50 percent kill): 175 mg/kg | TOXID9 5,2,1985 | |
oral/mammal (species unspecified) | lethal dose (50 percent kill): 224 mg/kg | FEREAC 65,1869,2000 | |
oral/mouse | lethal dose (50 percent kill): 640 mg/kg | ENTOX* -,11,2005 | |
oral/rat | lethal dose (50 percent kill): 470 mg/kg | ENTOX* -,11,2005 | |
skin/rabbit | lethal dose (50 percent kill): 333 mg/kg | FEREAC 65,1869,2000 | |
skin/rat | lethal dose (50 percent kill): 775 mg/kg | FMCHA2 -,C103,1991 |
Other Multiple Dose Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/mouse | lowest published toxic concentration: 90 ppm/6H/13W- intermittent | Lung, Thorax, or Respiration: Other changes Liver: Changes in liver weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain | FAATDF 11,207,1988 |
inhalation/rat | lowest published toxic concentration: 90 ppm/6H/13W- intermittent | Lung, Thorax, or Respiration: Other changes Kidney, Ureter, and Bladder: Changes in bladder weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain | FAATDF 11,207,1988 |
oral/Dog | lowest published toxic dose: 3731 mg/kg/13W- continuous | Blood: Microcytosis with or without anemia Blood: Changes in erythrocyte (RBC) count Nutritional and Gross Metabolic: Weight loss or decreased weight gain | RTOPDW 30,233,1999 |
oral/Dog | lowest published toxic dose: 5460 mg/kg/1Y- continuous | Blood: Microcytosis with or without anemia Blood: Changes in bone marrow not included in above Nutritional and Gross Metabolic: Weight loss or decreased weight gain | RTOPDW 30,233,1999 |
oral/mouse | lowest published toxic dose: 1365 mg/kg/13W- continuous | Cardiac: Changes in heart weight Liver: Changes in liver weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain | FAATDF 32,224,1996 |
oral/rat | lowest published toxic dose: 455 mg/kg/26W- intermittent | Gastrointestinal: Changes in structure or function of exocrine pancreas Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other hydrolases | GISAAA 39(1),94,1974 |
oral/rat | lowest published toxic dose: 1365 mg/kg/13W- continuous | Gastrointestinal: Alteration in gastric secretion Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic: Weight loss or decreased weight gain | FAATDF 32,224,1996 |
unreported route/rat | lowest published toxic dose: 750 mg/kg/30D- intermittent | Liver: Other changes Liver: Tumors Tumorigenic: Increased incidence of tumors in susceptible strains | TOXID9 78,115,2004 |
unreported route/rat | lowest published toxic dose: 1500 mg/kg/60D- intermittent | Liver: Other changes Liver: Tumors Tumorigenic: Increased incidence of tumors in susceptible strains | TOXID9 78,115,2004 |
Reviews
Organization | Standard | Reference |
---|---|---|
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 1 ppm (skin) | DTLVS* TLV/BEI,2013 |
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Confirmed animal carcinogen | DTLVS* TLV/BEI,2013 |
International Agency for Research on Cancer (IARC) | Cancer Review:Animal Sufficient Evidence | IMEMDT 41,113,1986 |
International Agency for Research on Cancer (IARC) | Cancer Review:Animal Sufficient Evidence | IMEMDT 71,933,1999 |
International Agency for Research on Cancer (IARC) | Cancer Review:Human Inadequate Evidence | IMEMDT 41,113,1986 |
International Agency for Research on Cancer (IARC) | Cancer Review:Human No Adequate Data | IMEMDT 71,933,1999 |
International Agency for Research on Cancer (IARC) | Cancer Review:Group 2B | IMEMDT 71,933,1999 |
TOXICOLOGY REVIEW | MUREAV 543,201,2003 | |
TOXICOLOGY REVIEW | MUREAV 567,347,2004 | |
TOXICOLOGY REVIEW | ENTOX* -,11,2005 | |
TOXICOLOGY REVIEW | MUREAV 584,1,2005 | |
TOXICOLOGY REVIEW | BCLPT* 96,131,2005 | |
TOXICOLOGY REVIEW | FEREAC 73,8212,2008 | |
TOXICOLOGY REVIEW | MUREAV 654,114,2008 | |
TOXICOLOGY REVIEW | HUTOX* -,561,1996 | |
TOXICOLOGY REVIEW | MUREAV 802,1,2016 |
Standards and Regulations
Organization | Standard | Reference |
---|---|---|
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION | FEREAC 54,7740,1989 | |
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES | Supported | RBREV* -,151,1998 |
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
Occupational Exposure Limit-AUSTRALIA | time-weighted average 1 ppm (4.5 mg/m3), Carcinogen, JUL2008 | |
Occupational Exposure Limit-AUSTRIA | TRK-TMW 0.11 ppm (0.5 mg/m3);KZW 0.44 ppm (2 mg/m3), skin, sen, 2007 | |
Occupational Exposure Limit-BELGIUM | time-weighted average 1 ppm (4.6 mg/m3), Skin, MAR2002 | |
Occupational Exposure Limit-DENMARK | time-weighted average 1 ppm (5 mg/m3), skin, carc, MAY2011 | |
Occupational Exposure Limit-ICELAND | time-weighted average 1 ppm (5 mg/m3), skin, NOV2011 | |
Occupational Exposure Limit-KOREA | time-weighted average 1 ppm (5 mg/m3), skin, 2006 | |
Occupational Exposure Limit-NEW ZEALAND | time-weighted average 1 ppm (4.5 mg/m3), skin, JAN2002 | |
Occupational Exposure Limit-NORWAY | time-weighted average 1 ppm (5 mg/m3), JAN1999 | |
Occupational Exposure Limit-PERU | time-weighted average 1 ppm (4.6 mg/m3), JUL2005 | |
Occupational Exposure Limit-RUSSIA | short term exposure limit 5 mg/m3, JUN2003 | |
Occupational Exposure Limit-SWITZERLAND | MAK-week 0.11 ppm (0.5 mg/m3), carc 2, skin, sen, JAN2011 | |
Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 5 mg/m3, 2003 |
NIOSH Documentation and Surveillance
Organization | Standard | Reference |
---|---|---|
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 1,3-DICHLOROPROPENE-air | 8H Carcinogen time-weighted average 1 ppm (Sk) | NIOSH* DHHS #95-121,1995 |
National Occupational Exposure Survey 1983 | Hazard Code X3912; Number of Industries 3; Total Number of Facilities 48; Number of Occupations 14; Total Number of Employees Exposed 2162; Total Number of Female Employees Exposed 33 |
Status in Federal Agencies
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health