2-Propanone, 1,1,1,3,3,3-hexafluoro-
RTECS #
UC2450000
CAS #
Updated
December 2018
Molecular Weight
166.03
Molecular Formula
C3F6O
Synonyms
6FK
Acetone, hexafluoro-
Hexafluoroacetone
Hexafluoroacetone (ACGIH)
NCI-C56440
Acetone, hexafluoro-
Hexafluoroacetone
Hexafluoroacetone (ACGIH)
NCI-C56440
Reproductive Effects Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/rat | 12 ppm/6H (30D male) | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct | TXCYAC 67,249,1991 |
skin/rat | 100 mg/kg (6-15D pregnant) | Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) | FAATDF 2,73,1982 |
skin/rat | 55 mg/kg (6-16D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | TXAPA9 41,195,1977 |
Acute Toxicity Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/Dog | Lowest published lethal concentration: 30600 mg/m3/45M | Vascular: BP lowering not characterized in autonomic section | VCVGK* -,437,1994 |
inhalation/rat | lethal concentration (50 percent kill): 275 ppm/3H | TXAPA9 6,341,1964 | |
inhalation/rat | lethal concentration (50 percent kill): 5520 mg/m3/30M | Brain and Coverings: Other degenerative changes Lung, Thorax, or Respiration: Other changes | VCVGK* -,437,1994 |
inhalation/rat | lethal concentration (50 percent kill): 1690 mg/m3/3H | Brain and Coverings: Other degenerative changes Lung, Thorax, or Respiration: Other changes | VCVGK* -,437,1994 |
oral/rat | lethal dose (50 percent kill): 191 mg/kg | TXAPA9 6,341,1964 | |
skin/rat | lowest published toxic dose: 39 mg/kg | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) | VCVGK* -,437,1994 |
skin/rat | lowest published toxic dose: 13 mg/kg | Reproductive: Paternal effects: Testes, epididymis, sperm duct | VCVGK* -,437,1994 |
Other Multiple Dose Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
skin/rat | lowest published toxic dose: 117 mg/kg/3D- intermittent | Reproductive: Paternal effects: Testes, epididymis, sperm duct | VCVGK* -,437,1994 |
Reviews
Organization | Standard | Reference |
---|---|---|
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 0.1 ppm (skin) | DTLVS* TLV/BEI,2013 |
TOXICOLOGY REVIEW | RTOPDW 54,247,2009 |
Standards and Regulations
Organization | Standard | Reference |
---|---|---|
Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 0.1 ppm (0.7 mg/m3) | DTLWS* 3,20,1973 |
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
Occupational Exposure Limit-AUSTRALIA | time-weighted average 0.1 ppm (0.68 mg/m3), JUL2008 | |
Occupational Exposure Limit-AUSTRIA | MAK-TMW 0.1 ppm (0.7 mg/m3);KZW 0.2 ppm (1.4 mg/m3), skin, 2007 | |
Occupational Exposure Limit-BELGIUM | time-weighted average 0.1 ppm (0.69 mg/m3), Skin, MAR2002 | |
Occupational Exposure Limit-DENMARK | time-weighted average 0.1 ppm (0.7 mg/m3), MAY2011 | |
Occupational Exposure Limit-FINLAND | time-weighted average 0.1 ppm (0.69 mg/m3), short term exposure limit 0.3 ppm (2.1 mg/m3), skin, NOV2011 | |
Occupational Exposure Limit-FRANCE | VME 0.1 ppm (0.7 mg/m3), FEB2006 | |
Occupational Exposure Limit-ICELAND | time-weighted average 0.1 ppm (0.7 mg/m3), NOV2011 | |
Occupational Exposure Limit-KOREA | time-weighted average 0.1 ppm (0.7 mg/m3), skin, 2006 | |
Occupational Exposure Limit-MEXICO | time-weighted average 0.1 ppm (0.7 mg/m3);short term exposure limit 0.3 ppm (skin), 2004 | |
Occupational Exposure Limit-NEW ZEALAND | time-weighted average 0.1 ppm (0.68 mg/m3), skin, JAN2002 | |
Occupational Exposure Limit-NORWAY | time-weighted average 0.1 ppm (0.7 mg/m3), JAN1999 | |
Occupational Exposure Limit-PERU | time-weighted average 0,1 ppm (0,68 mg/m3), JUL2005 | |
Occupational Exposure Limit-RUSSIA | short term exposure limit 2 mg/m3, Skin, JUN2003 | |
Occupational Exposure Limit-SWITZERLAND | MAK-week 0.1 ppm (0.7 mg/m3), skin, JAN2011 | |
Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 0.05 mg/m3, 2003 |
NIOSH Documentation and Surveillance
Organization | Standard | Reference |
---|---|---|
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO HEXAFLUOROACETONE-air | 10H time-weighted average 0.1 ppm (Sk) | NIOSH* DHHS #92-100,1992 |
National Occupational Hazard Survey 1974 | Hazard Code 83899; Number of Industries 1; Total Number of Facilities 14; Number of Occupations 1; Total Number of Employees Exposed 141 |
Status in Federal Agencies
Organization | Reference |
---|---|
EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 |
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health