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Propane, 1,2-epoxy-3-phenoxy-

RTECS #
TZ3675000
CAS #
122-60-1
See: NMAM or OSHA Methods
Updated
December 2018
Molecular Weight
150.19
Molecular Formula
C9H10O2
Synonyms
(Phenoxymethyl)oxirane
1,2-Epoxy-3-phenoxypropane
2,3-Epoxypropylphenyl ether
3-Phenoxy-1,2-epoxypropane
Ageflex PGE
Benzene, (2,3-epoxypropoxy)-
Ether, 2,3-epoxypropyl phenyl
Ether, phenylglycidyl
Fenyl-glycidylether (Czech)
Glycidyl phenyl ether
Heloxy WC-63
Oxirane, (phenoxymethyl)-
PGE (OSHA)
Phenol glycidyl ether
Phenol-glycidaether (German)
Phenoxypropene oxide
Phenoxypropylene oxide
Phenyl 2,3-epoxypropyl ether
Phenyl glycidyl ether
Phenyl glycidyl ether (ACGIH:OSHA)
Phenylglycydyl ether

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 111 mg mildAMIHAB 14,250,1956
eye /rabbit 250 µg/24H severe85JCAE -,776,1986
skin /rabbit 10 mg/24H open irritation test severeAMIHBC 10,61,1954
skin /rabbit 20 mg/24H moderate85JCAE -,776,1986

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA Damage/Escherichia coli1 µmol/LARTODN 46,277,1980
host-mediated assaySalmonella typhimurium/mouse2500 mg/kgMUREAV 67,9,1979
morphological transformembryo/hamster6250 µg/LMUREAV 67,9,1979
mutation in microorganisms/Klebsiella pneumoniae100 µmol/L (-enzymatic activation step)MUREAV 89,269,1981
mutation in microorganisms/Salmonella typhimurium33 µg/plate (+enzymatic activation step)MUREAV 172,105,1986
mutation in microorganisms/Salmonella typhimurium500 µg/plate (-enzymatic activation step)MUREAV 67,9,1979
mutation in microorganisms/Escherichia coli20 µmol/L (-enzymatic activation step)ARTODN 46,277,1980
other mutation test systems/Escherichia coli300 µmol/LMUREAV 231,205,1990
sister chromatid exchangelung/hamster400 µmol/LMUREAV 249,55,1991

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 11 ppm/6H (19D male)Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)TXAPA9 64,204,1982

Tumorigenic Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 12 ppm/6H/2Y- intermittentTumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors
AJPAA4 111,140,1983
inhalation/rat lowest published toxic concentration: 1092 mg/kg/2Y- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Olfaction: Tumors
TOXID9 72,27,2003
inhalation/rat lowest published toxic concentration: 728 mg/kg/2Y- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Olfaction: Tumors
TOXID9 72,27,2003

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lethal concentration (50 percent kill): >100 ppm/4HLung, Thorax, or Respiration: Acute pulmonary edemaAMIHAB 14,250,1956
inhalation/rat lethal concentration (50 percent kill): >100 ppm/8HLung, Thorax, or Respiration: Acute pulmonary edemaAMIHAB 14,250,1956
oral/mouse lethal dose (50 percent kill): 1400 mg/kgBrain and Coverings: Recordings from specific areas of CNS

Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia
AMIHAB 14,250,1956
oral/rat lethal dose (50 percent kill): 3850 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Change in motor activity (specific assay)

Behavioral: Ataxia
AMIHAB 14,250,1956
skin/rabbit lethal dose (50 percent kill): 1500 µL/kgAMIHBC 10,61,1954
subcutaneous/mouse lethal dose (50 percent kill): 760 mg/kgAutonomic Nervous System: Smooth muscle relaxant (mechanism undefined, spasmolytic)ARZNAD 15,1355,1965

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 5 ppm/6H/90D- intermittentSkin and Appendages: Other: HairJTEHD6 3,859,1977
inhalation/rat lowest published toxic concentration: 728 mg/kg/2Y- intermittentOlfaction: Other olfaction effectsTOXID9 72,27,2003

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.1 ppm (skin, sen)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Confirmed animal carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 47,237,1989
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 71,1525,1999
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 71,1525,1999
International Agency for Research on Cancer (IARC)Cancer Review:Group 2BIMEMDT 71,1525,1999
TOXICOLOGY REVIEWAJOGAH 113,130,1972
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWMUREAV 654,114,2008
TOXICOLOGY REVIEWMUTAEX 25,3,2010
TOXICOLOGY REVIEWFCTOD7 55,596,2013
TOXICOLOGY REVIEWMUREAV 802,1,2016
TOXICOLOGY REVIEWRTOPDW 55,43,2009

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 10 ppm (62 mg/m3)DTLVS* 3,206,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 1 ppm (6.1 mg/m3), JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 0.1 ppm (0.6 mg/m3), Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.1 ppm (0.6 mg/m3), skin, carc, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 0.5 ppm (3.1 mg/m3), skin, NOV2011
Occupational Exposure Limit-FRANCEVME 1 ppm (6 mg/m3), C2 Carcinogen, FEB2006
Occupational Exposure Limit-ICELANDtime-weighted average 0.1 ppm (0.6 mg/m3), short term exposure limit 1 ppm (5 mg/m3), skin, sen, NOV2011
Occupational Exposure Limit-JAPAN2B carc, MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 1 ppm (6 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 10 ppm (60 mg/m3) (skin), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 1 ppm (6.1 mg/m3), skin, sen, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 1 ppm (5 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 0.1 ppm (0.61 mg/m3), JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 0.6 mg/m3, MAC(short term exposure limit) 3 mg/m3, JAN1999
Occupational Exposure Limit-SWEDENtime-weighted average 10 ppm (60 mg/m3);short term exposure limit 15 ppm (90 mg/m3), Sen, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 1 ppm (6 mg/m3), carc 2, skin, sen, JAN2011
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 10 ppm (62 mg/m3), JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 10 ppm (60 mg/m3), JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 10 ppm (60 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 10 ppm (60 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 10 ppm (60 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 10 ppm (60 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PHENYL GLYCIDYL ETHER-airCarcinogen ceiling concentration 1 ppm/15MNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 57280; Number of Industries 15; Total Number of Facilities 355; Number of Occupations 18; Total Number of Employees Exposed 10551; Total Number of Female Employees Exposed 4108
National Occupational Hazard Survey 1974Hazard Code 57280; Number of Industries 13; Total Number of Facilities 434; Number of Occupations 12; Total Number of Employees Exposed 8533

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Positive: SHE-focus assay
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULEFEREAC 47,26992,82
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Phenyl glycidyl ether, 1619
NIOSH CURRENT INTELLIGENCE BULLETIN 29, 1978
Page last reviewed: November 16, 2018