Phosphoryl chloride
RTECS #
TH4897000
CAS #
Updated
September 2013
Molecular Weight
153.32
Molecular Formula
Cl3OP
Synonyms
Fosforoxychlorid (Czech)
Oxychlorid fosforecny (Czech)
Phosphorus oxychloride
Phosphorus oxychloride (ACGIH)
Phosphorus oxytrichloride
Phosphoryl trichloride
Trichlorophosphine oxide
Trichlorophosphorus oxide
Oxychlorid fosforecny (Czech)
Phosphorus oxychloride
Phosphorus oxychloride (ACGIH)
Phosphorus oxytrichloride
Phosphoryl trichloride
Trichlorophosphine oxide
Trichlorophosphorus oxide
Acute Toxicity Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/guinea pig | lethal concentration (50 percent kill): 53 ppm/4H | Eye: Other eye effects Behavioral: Irritability Lung, Thorax, or Respiration: Dyspnea | AIHAAP 25,470,1964 |
inhalation/mammal (species unspecified) | lowest published toxic concentration: 0.48 mg/m3 | Lung, Thorax, or Respiration: Cough | VCVN5* -,72,1993 |
inhalation/mouse | Lowest published lethal concentration: 48 mg/m3/36M | VCVN5* -,72,1993 | |
inhalation/mouse | Lowest published lethal concentration: 5.7 mg/m3/4H | VCVN5* -,72,1993 | |
inhalation/mouse | lethal concentration (50 percent kill): 404 mg/m3/2H | WDZAEK 6,98,1992 | |
inhalation/rat | lethal concentration (50 percent kill): 32 ppm/4H | 28ZPAK -,17,1972 | |
inhalation/rat | Lowest published lethal concentration: 5.7 mg/m3/4H | VCVN5* -,72,1993 | |
inhalation/rat | Lowest published lethal concentration: 48 mg/m3/36M | VCVN5* -,72,1993 | |
inhalation/rat | lethal concentration (50 percent kill): 0.071 gm/m3 | TPKVAL 13,107,1973 | |
inhalation/rat | lowest published toxic concentration: 0.006 gm/m3 | Lung, Thorax, or Respiration: Respiratory depression | TPKVAL 13,107,1973 |
inhalation/rat | lowest published toxic concentration: 0.001 gm/m3 | Skin: After systemic exposure: Dermatitis, irritative | TPKVAL 13,107,1973 |
inhalation/rat | lowest published toxic concentration: 10 mg/m3/4H | Nutritional and Gross Metabolic: Changes in: Metabolic acidosis | TPKVAL 14,112,1975 |
inhalation/rat | Lowest published lethal concentration: 0.056 gm/m3 | Eye: Lacrimation Eye: Corneal damage Behavioral: Somnolence (general depressed activity) | TPKVAL 13,107,1973 |
inhalation/rat | Lowest published lethal concentration: 0.089 gm/m3 | TPKVAL 13,107,1973 | |
ocular/rabbit | lowest published toxic dose: 100 pph | Behavioral: Excitement Lung, Thorax, or Respiration: Acute pulmonary edema Lung, Thorax, or Respiration: Respiratory depression | TPKVAL 13,107,1973 |
oral/mouse | lethal dose (50 percent kill): 327 mg/kg | WDZAEK 6,98,1992 | |
oral/rat | lowest published lethal dose: 580 mg/kg | TPKVAL 13,107,1973 | |
oral/rat | lethal dose (16 percent kill): 250 mg/kg | Lung, Thorax, or Respiration: Respiratory depression Gastrointestinal: Ulceration or bleeding from stomach Liver: Other changes | TPKVAL 13,107,1973 |
oral/rat | lethal dose (50 percent kill): 380 mg/kg | TPKVAL 13,107,1973 | |
oral/rat | lethal dose (50 percent kill): 36 mg/kg | Gastrointestinal: Other changes Liver: Other changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NTIS** OTS0534840 |
skin/rabbit | lowest published lethal dose: 1 gm/kg | Behavioral: Muscle weakness Liver: Other changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NTIS** OTS0534840 |
Other Multiple Dose Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/guinea pig | lowest published toxic concentration: 1 mg/m3/122D- intermittent | Musculoskeletal: Osteoporosis | TPKVAL 14,112,1975 |
inhalation/mammal (species unspecified) | lowest published toxic concentration: 1340 µg/m3/17W- intermittent | Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Musculoskeletal: Osteoporosis Immunological Including Allergic: Other immediate (humoral): uticaria, allergic rhinitis, serum sickness (multiple organ involvement) | JHEMA2 21,387,1977 |
inhalation/rat | lowest published toxic concentration: 1 mg/m3/30D- intermittent | Kidney, Ureter, and Bladder: Other changes in urine composition | TPKVAL 14,112,1975 |
inhalation/rat | lowest published toxic concentration: 1 mg/m3/122D- intermittent | Musculoskeletal: Osteoporosis | TPKVAL 14,112,1975 |
inhalation/rat | lowest published toxic concentration: 1 mg/m3/91D- intermittent | Nutritional and Gross Metabolic: Changes in: Ca | TPKVAL 14,112,1975 |
inhalation/rat | lowest published toxic concentration: 4 mg/m3/50D- intermittent | Lung, Thorax, or Respiration: Other changes | WDZAEK 6,98,1992 |
oral/mouse | lowest published toxic dose: 480 mg/kg/60D- intermittent | Liver: Other changes Kidney, Ureter, and Bladder: Other changes Blood: Other changes | WDZAEK 6,98,1992 |
oral/rat | lowest published toxic dose: 480 mg/kg/60D- intermittent | Liver: Other changes Kidney, Ureter, and Bladder: Other changes Blood: Other changes | WDZAEK 6,98,1992 |
Reviews
Organization | Standard | Reference |
---|---|---|
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 0.1 ppm | DTLVS* TLV/BEI,2013 |
Standards and Regulations
NIOSH Documentation and Surveillance
Organization | Standard | Reference |
---|---|---|
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PHOSPHORUS OXYCHLORIDE-air | 10H time-weighted average 0.1 ppm;short term exposure limit 0.5 ppm | NIOSH* DHHS #92-100,1992 |
National Occupational Exposure Survey 1983 | Hazard Code 81931; Number of Industries 9; Total Number of Facilities 165; Number of Occupations 29; Total Number of Employees Exposed 12587; Total Number of Female Employees Exposed 2945 | |
National Occupational Hazard Survey 1974 | Hazard Code 81931; Number of Industries 7; Total Number of Facilities 155; Number of Occupations 22; Total Number of Employees Exposed 7258 |
Status in Federal Agencies
Organization | Reference |
---|---|
EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
EPA TSCA Section 8(d) unpublished health/safety studies | |
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 |
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health