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Phosphoryl chloride

RTECS #
TH4897000
CAS #
10025-87-3
See: NMAM or OSHA Methods
Updated
September 2013
Molecular Weight
153.32
Molecular Formula
Cl3OP
Synonyms
Fosforoxychlorid (Czech)
Oxychlorid fosforecny (Czech)
Phosphorus oxychloride
Phosphorus oxychloride (ACGIH)
Phosphorus oxytrichloride
Phosphoryl trichloride
Trichlorophosphine oxide
Trichlorophosphorus oxide

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/guinea pig lethal concentration (50 percent kill): 53 ppm/4HEye: Other eye effects

Behavioral: Irritability

Lung, Thorax, or Respiration: Dyspnea
AIHAAP 25,470,1964
inhalation/mammal (species unspecified) lowest published toxic concentration: 0.48 mg/m3Lung, Thorax, or Respiration: CoughVCVN5* -,72,1993
inhalation/mouse Lowest published lethal concentration: 48 mg/m3/36MVCVN5* -,72,1993
inhalation/mouse Lowest published lethal concentration: 5.7 mg/m3/4HVCVN5* -,72,1993
inhalation/mouse lethal concentration (50 percent kill): 404 mg/m3/2HWDZAEK 6,98,1992
inhalation/rat lethal concentration (50 percent kill): 32 ppm/4H28ZPAK -,17,1972
inhalation/rat Lowest published lethal concentration: 5.7 mg/m3/4HVCVN5* -,72,1993
inhalation/rat Lowest published lethal concentration: 48 mg/m3/36MVCVN5* -,72,1993
inhalation/rat lethal concentration (50 percent kill): 0.071 gm/m3TPKVAL 13,107,1973
inhalation/rat lowest published toxic concentration: 0.006 gm/m3Lung, Thorax, or Respiration: Respiratory depressionTPKVAL 13,107,1973
inhalation/rat lowest published toxic concentration: 0.001 gm/m3Skin: After systemic exposure: Dermatitis, irritativeTPKVAL 13,107,1973
inhalation/rat lowest published toxic concentration: 10 mg/m3/4HNutritional and Gross Metabolic: Changes in: Metabolic acidosisTPKVAL 14,112,1975
inhalation/rat Lowest published lethal concentration: 0.056 gm/m3Eye: Lacrimation

Eye: Corneal damage

Behavioral: Somnolence (general depressed activity)
TPKVAL 13,107,1973
inhalation/rat Lowest published lethal concentration: 0.089 gm/m3TPKVAL 13,107,1973
ocular/rabbit lowest published toxic dose: 100 pphBehavioral: Excitement

Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Respiratory depression
TPKVAL 13,107,1973
oral/mouse lethal dose (50 percent kill): 327 mg/kgWDZAEK 6,98,1992
oral/rat lowest published lethal dose: 580 mg/kgTPKVAL 13,107,1973
oral/rat lethal dose (16 percent kill): 250 mg/kgLung, Thorax, or Respiration: Respiratory depression

Gastrointestinal: Ulceration or bleeding from stomach

Liver: Other changes
TPKVAL 13,107,1973
oral/rat lethal dose (50 percent kill): 380 mg/kgTPKVAL 13,107,1973
oral/rat lethal dose (50 percent kill): 36 mg/kgGastrointestinal: Other changes

Liver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0534840
skin/rabbit lowest published lethal dose: 1 gm/kgBehavioral: Muscle weakness

Liver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0534840

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/guinea pig lowest published toxic concentration: 1 mg/m3/122D- intermittentMusculoskeletal: OsteoporosisTPKVAL 14,112,1975
inhalation/mammal (species unspecified) lowest published toxic concentration: 1340 µg/m3/17W- intermittentLung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Musculoskeletal: Osteoporosis

Immunological Including Allergic: Other immediate (humoral): uticaria, allergic rhinitis, serum sickness (multiple organ involvement)
JHEMA2 21,387,1977
inhalation/rat lowest published toxic concentration: 1 mg/m3/30D- intermittentKidney, Ureter, and Bladder: Other changes in urine compositionTPKVAL 14,112,1975
inhalation/rat lowest published toxic concentration: 1 mg/m3/122D- intermittentMusculoskeletal: OsteoporosisTPKVAL 14,112,1975
inhalation/rat lowest published toxic concentration: 1 mg/m3/91D- intermittentNutritional and Gross Metabolic: Changes in: CaTPKVAL 14,112,1975
inhalation/rat lowest published toxic concentration: 4 mg/m3/50D- intermittentLung, Thorax, or Respiration: Other changesWDZAEK 6,98,1992
oral/mouse lowest published toxic dose: 480 mg/kg/60D- intermittentLiver: Other changes

Kidney, Ureter, and Bladder: Other changes

Blood: Other changes
WDZAEK 6,98,1992
oral/rat lowest published toxic dose: 480 mg/kg/60D- intermittentLiver: Other changes

Kidney, Ureter, and Bladder: Other changes

Blood: Other changes
WDZAEK 6,98,1992

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.1 ppmDTLVS* TLV/BEI,2013

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.1 ppm (0.63 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 0.2 ppm (1 mg/m3);KZW 0.8 ppm (4 mg/m3), 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 0.1 ppm (0.64 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.1 ppm (0.6 mg/m3), MAY2011
Occupational Exposure Limit-FINLANDshort term exposure limit 0.5 ppm (2.4 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVME 0.1 ppm (0.6 mg/m3), FEB2006
Occupational Exposure Limit-GERMANYMAK 0.2 ppm (1.3 mg/m3), 2011
Occupational Exposure Limit-ICELANDtime-weighted average 0.1 ppm (0.6 mg/m3), NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 0.1 ppm (0.6 mg/m3), short term exposure limit 0.5 ppm (3 mg/m3), 2006
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.1 ppm (0.63 mg/m3), JAN2002
Occupational Exposure Limit-PERUtime-weighted average 0,1 ppm (0,63 mg/m3), JUL2005
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.05 mg/m3, Skin, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 0.1 ppm (0.6 mg/m3);short term exposure limit 0.2 ppm (1.2 mg/m3), JUN2005
Occupational Exposure Limit-SWITZERLANDceiling concentration 0.1 ppm (0.6 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.6 mg/m3, 2003
Occupational Exposure Limit-TURKEYtime-weighted average 0.5 ppm (3 mg/m3), JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 0.2 ppm (1.3 mg/m3);short term exposure limit 0.6 ppm (3.8 mg/m3), OCT2007

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PHOSPHORUS OXYCHLORIDE-air10H time-weighted average 0.1 ppm;short term exposure limit 0.5 ppmNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 81931; Number of Industries 9; Total Number of Facilities 165; Number of Occupations 29; Total Number of Employees Exposed 12587; Total Number of Female Employees Exposed 2945
National Occupational Hazard Survey 1974Hazard Code 81931; Number of Industries 7; Total Number of Facilities 155; Number of Occupations 22; Total Number of Employees Exposed 7258

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
Page last reviewed: November 16, 2018