Phosphorothioic acid, O,O-dimethyl O-(4-(methylthio)-m-tolyl) ester
RTECS #
TF9625000
CAS #
Updated
June 2017
Molecular Weight
278.34
Molecular Formula
C10H15O3PS2
Synonyms
4-Methylmercapto-3-methylphenyl dimethyl thiophosphate
B 29493
BAY 29493
Baycid
Bayer 29493
Bayer 9007
Bayer S-1752
Baytex
ENT 25,540
Entex
Fenthion
Fenthion (ACGIH)
Fenthion 4E
Fenthion-methyl
Lebaycid
m-Cresol, 4-(methylthio)-, O-ester with O,O-dimethyl phosphorothioate
Mercaptophos
MPP (pesticide)
NCI-C08651
O,O-Dimethyl O-(3-methyl-4-methylmercaptophenyl)phosphorothioate
O,O-Dimethyl O-(4-(methylthio)-m-tolyl) phosphorothioate
O,O-Dimethyl O-(4-methylthio-3-methylphenyl) phosphorothioate
O,O-Dimethyl O-3-methyl-4-methylthiophenyl phosphorothioate
O,O-Dimethyl O-4-(methylmercapto)-3-methylphenyl phosphorothioate
O,O-Dimethyl-O-(3-methyl-4-methylthio-fenyl)-monothiofosfaat (Dutch)
O,O-Dimethyl-O-(3-methyl-4-methylthiophenyl)-monothiophosphat (German)
O,O-Dimethyl-O-(3-methyl-4-methylthio-phenyl)-thionophosphat (German)
O,O-Dimethyl-O-4-(methylmercapto)-3-methylphenyl thiophosphate
O,O-Dimetil-O-(3-metil-4-metiltio-fenil)-monotiofosfato (Italian)
OMS 2
Phosphorothioic acid O,O-dimethyl O-(3-methyl-4-(methylthio)phenyl) ester
Queletox
S 1752
Spotton
Sulfidophos
Talodex
Thiophosphate de O,O-dimethyle et de O-(3-methyl-4-methylthiophenyle) (French)
Tiguvon
B 29493
BAY 29493
Baycid
Bayer 29493
Bayer 9007
Bayer S-1752
Baytex
ENT 25,540
Entex
Fenthion
Fenthion (ACGIH)
Fenthion 4E
Fenthion-methyl
Lebaycid
m-Cresol, 4-(methylthio)-, O-ester with O,O-dimethyl phosphorothioate
Mercaptophos
MPP (pesticide)
NCI-C08651
O,O-Dimethyl O-(3-methyl-4-methylmercaptophenyl)phosphorothioate
O,O-Dimethyl O-(4-(methylthio)-m-tolyl) phosphorothioate
O,O-Dimethyl O-(4-methylthio-3-methylphenyl) phosphorothioate
O,O-Dimethyl O-3-methyl-4-methylthiophenyl phosphorothioate
O,O-Dimethyl O-4-(methylmercapto)-3-methylphenyl phosphorothioate
O,O-Dimethyl-O-(3-methyl-4-methylthio-fenyl)-monothiofosfaat (Dutch)
O,O-Dimethyl-O-(3-methyl-4-methylthiophenyl)-monothiophosphat (German)
O,O-Dimethyl-O-(3-methyl-4-methylthio-phenyl)-thionophosphat (German)
O,O-Dimethyl-O-4-(methylmercapto)-3-methylphenyl thiophosphate
O,O-Dimetil-O-(3-metil-4-metiltio-fenil)-monotiofosfato (Italian)
OMS 2
Phosphorothioic acid O,O-dimethyl O-(3-methyl-4-(methylthio)phenyl) ester
Queletox
S 1752
Spotton
Sulfidophos
Talodex
Thiophosphate de O,O-dimethyle et de O-(3-methyl-4-methylthiophenyle) (French)
Tiguvon
Mutation Data and Reference
| System Test | Route/Organism/Tissue | Dose | Reference |
|---|---|---|---|
| mutation in microorganisms | /Salmonella typhimurium | 333 µg/plate (-enzymatic activation step) | ENMUDM 8(Suppl 7),1,1986 |
| sister chromatid exchange | lung/hamster | 40 mg/L | ENMUDM 4,621,1982 |
Reproductive Effects Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| intraperitoneal/mouse | 40 mg/kg (11D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) Reproductive: Specific developmental abnormalities: Musculoskeletal system | TXAPA9 24,324,1973 |
| oral/rat | 10 mg/kg (6-15D pregnant) | Reproductive: Other effects on female | TIHEEC 14,869,1998 |
| oral/mouse | 1050 mg/kg (multigenerations) | Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated) Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4) | TXAPA9 26,29,1973 |
Tumorigenic Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| oral/mouse | lowest published toxic dose: 1730 mg/kg/103W- continuous | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Skin and Appendages: Tumors | NCITR* NCI-TR-103,1979 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| In Vitro/Rat, neurons | Inhibitor Concentration Low: 40 µmol/L/1H | In Vitro Toxicity Studies: Other assays | NRTXDN 44,204,2014 |
| inhalation/guinea pig | Lowest published lethal concentration: 1 gm/m3/2H | 85GYAV -,27,1971 | |
| inhalation/mouse | Lowest published lethal concentration: 1 gm/m3/2H | 85GYAV -,27,1971 | |
| inhalation/rabbit | Lowest published lethal concentration: 1 gm/m3/2H | 85GYAV -,27,1971 | |
| inhalation/rat | lethal concentration (50 percent kill): 800 mg/m3/4H | 85INA8 6,646,1991 | |
| intracerebral/mouse | lethal dose (50 percent kill): 50 mg/kg | PCBPBS 8,302,1978 | |
| intramuscular/Dog | lethal dose (50 percent kill): 40 mg/kg | VMRVAN (2-3),273,1967 | |
| intramuscular/domestic animal | lethal dose (50 percent kill): 46 mg/kg | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Reactivates cholinesterase | VETNAL 54(12),94,1978 |
| intramuscular/mammal (species unspecified) | lethal dose (50 percent kill): 46200 µg/kg | Behavioral: Somnolence (general depressed activity) Behavioral: Food intake (animal) Behavioral: Muscle contraction or spasticity | VETNAL 54(12),94,1978 |
| intraperitoneal/chicken | lethal dose (50 percent kill): 20 mg/kg | EQSFAP 3,173,1974 | |
| intraperitoneal/guinea pig | lethal dose (50 percent kill): 310 mg/kg | TXAPA9 6,86,1964 | |
| intraperitoneal/mouse | lowest published toxic dose: 300 mg/kg | Brain and Coverings: Other degenerative changes | TOLED5 135,89,2002 |
| intraperitoneal/mouse | lethal dose (50 percent kill): 125 mg/kg | TXAPA9 6,86,1964 | |
| intraperitoneal/rat | lethal dose (50 percent kill): 260 mg/kg | TXAPA9 6,86,1964 | |
| intravenous/mouse | lethal dose (50 percent kill): 320 mg/kg | CSLNX* NX#00142 | |
| oral/chicken | lethal dose (50 percent kill): 20 mg/kg | EQSFAP 3,173,1974 | |
| oral/duck | lethal dose (50 percent kill): 5900 µg/kg | DOEAAH 35,25,1979 | |
| oral/guinea pig | lethal dose (50 percent kill): 260 mg/kg | TXAPA9 6,86,1964 | |
| oral/mammal (species unspecified) | lethal dose (50 percent kill): 105 mg/kg | Behavioral: Somnolence (general depressed activity) Behavioral: Food intake (animal) Behavioral: Muscle contraction or spasticity | VETNAL 54(12),94,1978 |
| oral/man | lowest published toxic dose: 1429 µL/kg | Lung, Thorax, or Respiration: Other changes Kidney, Ureter, and Bladder: Other changes Skin and Appendages: Other: Sweating | JJAMA* 14,789,1990 |
| oral/man | lowest published toxic dose: 3571 µL/kg | Eye: Miosis (pupilliary constriction) Behavioral: General anesthetic Behavioral: Convulsions or effect on seizure threshold | YAKUD5 32,1456,1990 |
| oral/man | lowest published toxic dose: 643 µL/kg | Peripheral Nerve and Sensation: Fasciculations Behavioral: Ataxia Cardiac: Pulse rate decreased with fall in BP | HETOEA 14,600,1995 |
| oral/man | lowest published toxic dose: 257 mg/kg | Cardiac: Pulse rate increased without fall in BP Gastrointestinal: Hypermotility, diarrhea Gastrointestinal: Nausea or vomiting | JTCTDW 19,425,1982 |
| oral/mouse | lethal dose (50 percent kill): 88100 µg/kg | HOEKAN 30,53,1980 | |
| oral/pigeon | lethal dose (50 percent kill): 1780 µg/kg | ASTTA8 (680),157,1979 | |
| oral/quail | lethal dose (50 percent kill): 11 mg/kg | TXAPA9 20,57,1971 | |
| oral/rabbit | lethal dose (50 percent kill): 150 mg/kg | Behavioral: Muscle weakness Gastrointestinal: Changes in structure or function of salivary glands Kidney, Ureter, and Bladder: Other changes | BWHOA6 29,205,1963 |
| oral/rabbit | lowest published toxic dose: 150 mg/kg | Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Lung, Thorax, or Respiration: Emphysema Blood: Hemorrhage | JTCTDW 46,711,2008 |
| oral/rat | lethal dose (50 percent kill): 180 mg/kg | KSKZAN 16(2),59,1978 | |
| oral/wild bird | lethal dose (50 percent kill): 1300 µg/kg | TXAPA9 21,315,1972 | |
| oral/woman | lowest published toxic dose: 525 mg/kg | Eye: Miosis (pupilliary constriction) Behavioral: Muscle contraction or spasticity Lung, Thorax, or Respiration: Respiratory depression | HETOEA 9,187,1990 |
| oral/woman | lowest published toxic dose: 1200 µL/kg | Behavioral: Coma Cardiac: Pulse rate decreased with fall in BP Gastrointestinal: Hypermotility, diarrhea | HETOEA 14,600,1995 |
| skin/duck | lethal dose (50 percent kill): 44 mg/kg | TXAPA9 47,451,1979 | |
| skin/mouse | lethal dose (50 percent kill): 500 mg/kg | OYYAA2 1,74,1967 | |
| skin/rat | lethal dose (50 percent kill): 330 mg/kg | Behavioral: Tremor Behavioral: Convulsions or effect on seizure threshold Behavioral: Excitement | TXAPA9 2,88,1960 |
| subcutaneous/mouse | lethal dose (50 percent kill): 144 mg/kg | OYYAA2 1,74,1967 | |
| subcutaneous/rat | lowest published toxic dose: 0.8 gm/kg | Brain and Coverings: Other degenerative changes Lung, Thorax, or Respiration: Other changes Liver: Other changes | BCLPT* 100,308,2007 |
| subcutaneous/rat | lowest published toxic dose: 0.8 gm/kg | Cardiac: Cardiomyopathy including infarction Biochemical: Metabolism (intermediary): Other proteins Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | JTCTDW 46,67,2008 |
| subcutaneous/rat | lowest published toxic dose: 0.8 gm/kg | Gastrointestinal: Changes in structure or function of exocrine pancreas Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects | JTCTDW 46,141,2008 |
| unreported route/human | lowest published lethal dose: 50 mg/kg | 85INA8 5,267,1986 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| intraperitoneal/rat | lowest published toxic dose: 1200 mg/kg/60D- continuous | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | TXAPA9 6,86,1964 |
| oral/domestic bird | lowest published toxic dose: 7500 µg/kg/5D- continuous | Behavioral: Food intake (animal) Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | AECTCV 11,617,1982 |
| oral/rat | lowest published toxic dose: 172 mg/kg/6D- intermittent | Peripheral Nerve and Sensation: Structural change in nerve or sheath Blood: Changes in bone marrow not included in above Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | ZYYZEW 2,126,1988 |
| skin/chicken | lowest published toxic dose: 35 mg/kg/7D- intermittent | Behavioral: Ataxia Nutritional and Gross Metabolic: Weight loss or decreased weight gain Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases | JTEHD6 21,455,1987 |
| skin/chicken | lowest published toxic dose: 24 mg/kg/24W- intermittent | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Musculoskeletal: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | VHTODE 41,302,1999 |
| skin/rat | lowest published toxic dose: 380 mg/kg/19D- intermittent | Brain and Coverings: Other degenerative changes Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | BWHOA6 29,205,1963 |
| skin/rat | lowest published toxic dose: 3225 mg/kg/43W- intermittent | Brain and Coverings: Other degenerative changes | TXAPA9 104,440,1990 |
| skin/rat | lowest published toxic dose: 365 mg/kg/5D- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | BWHOA6 29,205,1963 |
| subcutaneous/rat | lowest published toxic dose: 5200 mg/kg/1Y- intermittent | Eye: Retinal changes pigmentary deposition, retinitis, other) Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | ENVRAL 30,453,1983 |
| subcutaneous/rat | lowest published toxic dose: 260 mg/kg/13W- intermittent | Eye: Retinal changes pigmentary deposition, retinitis, other) | TOXID9 15,26,1995 |
| unreported route/rat | lowest published toxic dose: 3000 mg/kg/40W- intermittent | Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | HBPTO* 1,878,2001 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 0.05 mg/m3 (inhal, vapor, skin) | DTLVS* TLV/BEI,2013 |
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Not classifiable as a human carcinogen | DTLVS* TLV/BEI,2013 |
| TOXICOLOGY REVIEW | RREVAH 46,1,1973 | |
| TOXICOLOGY REVIEW | CNDQA8 10(3),43,1975 | |
| TOXICOLOGY REVIEW | RREVAH 63,1,1976 | |
| TOXICOLOGY REVIEW | MUTAEX 21,93,2006 | |
| TOXICOLOGY REVIEW | ENTOX* -,325,2005 | |
| TOXICOLOGY REVIEW | ENTOX* -,306,2005 | |
| TOXICOLOGY REVIEW | ENTOX* -,308,2005 | |
| TOXICOLOGY REVIEW | MUREAV 584,1,2005 | |
| TOXICOLOGY REVIEW | HETOEA 26,321,2007 | |
| TOXICOLOGY REVIEW | FCTOD7 47,2906,2009 | |
| TOXICOLOGY REVIEW | FCTOD7 47,2926,2009 | |
| TOXICOLOGY REVIEW | NTAPM* -,629,1995 | |
| TOXICOLOGY REVIEW | TOLED5 190,107,2009 | |
| TOXICOLOGY REVIEW | MUREAV 721,27,2011 | |
| TOXICOLOGY REVIEW | TXAPA9 258,309,2012 | |
| TOXICOLOGY REVIEW | TOLED5 230,434,2014 | |
| TOXICOLOGY REVIEW | TXAPA9 268,157,2013 | |
| TOXICOLOGY REVIEW | MUREAV 802,1,2016 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION | FEREAC 54,7740,1989 | |
| Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES | Supported | RBREV* -,120,1998 |
| Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
| Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
| Occupational Exposure Limit-AUSTRALIA | time-weighted average 0.2 mg/m3, JUL2008 | |
| Occupational Exposure Limit-AUSTRIA | MAK-TMW 0.2 mg/m3;KZW 2 mg/m3, inhal, skin, 2007 | |
| Occupational Exposure Limit-BELGIUM | time-weighted average 0.2 mg/m3, Skin, MAR2002 | |
| Occupational Exposure Limit-DENMARK | time-weighted average 0.1 mg/m3, skin, MAY2011 | |
| Occupational Exposure Limit-GERMANY | MAK 0.2 mg/m3, inhal, 2011 | |
| Occupational Exposure Limit-ICELAND | time-weighted average 0.1 mg/m3, skin, NOV2011 | |
| Occupational Exposure Limit-JAPAN | Occupational Exposure Limit 0.2 mg/m3, skin, MAY2012 | |
| Occupational Exposure Limit-KOREA | time-weighted average 0.2 mg/m3, skin, 2006 | |
| Occupational Exposure Limit-NEW ZEALAND | time-weighted average 0.2 mg/m3, skin, JAN2002 | |
| Occupational Exposure Limit-PERU | time-weighted average 0,2 mg/m3, JUL2005 | |
| Occupational Exposure Limit-POLAND | MAC(time-weighted average) 0.2 mg/m3, JAN1999 | |
| Occupational Exposure Limit-SWITZERLAND | MAK-week 0.1 mg/m3, KZG-week 0.2 mg/m3, inhal, skin, JAN2011 | |
| Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 0.1 mg/m3, 2003 |
NIOSH Documentation and Surveillance
Status in Federal Agencies
| Organization | Reference |
|---|---|
| EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay; E coli polA without S9 | |
| EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal | |
| EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test | |
| EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast; TRP reversion | |
| EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis | |
| NCI Carcinogenesis Bioassay (feed);clear evidence:mouse | NCITR* NCI-TR-103,1979 |
| NCI Carcinogenesis Bioassay (feed);no evidence:rat | NCITR* NCI-TR-103,1979 |
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health