Phosphorothioic acid, O,O-dimethyl ester, O,O-diester with 4,4'-thiodiphenol
RTECS #
TF6890000
CAS #
Updated
December 2017
Molecular Weight
466.48
Molecular Formula
C16H20O6P2S3
Synonyms
Abaphos
Abate
Abate (OSHA)
Abathion
AC 52160
American cyanamid AC 52,160
American cyanamid CL-52160
American cyanamid E.I. 52,160
Biothion
CL 52160
Difenthos
Difos
Ecopro 1707
EI 52160
ENT 27,165
Experimental insecticide 52160
Nephis 1G
O,O'-(Thiodi-4,1-phenylene)bis(O,O-dimethyl phosphorothioate)
O,O'-(Thiodi-p-phenylene) O,O,O',O'-tetramethyl bis(phosphorothioate)
O,O,O',O'-Tetramethyl O,O'-thiodi-p-phenylene phosphorothioate
O,O-Dimethyl phosphorothioate O,O-diester with 4,4'-thiodiphenol
OMS 786
Phenol, 4,4'-thiodi-, O,O-diester with O,O-dimethyl phosphorothioate
Phosphorothioic acid, O,O'-(thiodi-4,1-phenylene) O,O,O',O'-tetramethyl ester
Procida
Swebate
Temefos
Temephos
Temephos (ACGIH:OSHA)
Tetramethyl-O,O'-thiodi-p-phenylene phosphorothioate
Abate
Abate (OSHA)
Abathion
AC 52160
American cyanamid AC 52,160
American cyanamid CL-52160
American cyanamid E.I. 52,160
Biothion
CL 52160
Difenthos
Difos
Ecopro 1707
EI 52160
ENT 27,165
Experimental insecticide 52160
Nephis 1G
O,O'-(Thiodi-4,1-phenylene)bis(O,O-dimethyl phosphorothioate)
O,O'-(Thiodi-p-phenylene) O,O,O',O'-tetramethyl bis(phosphorothioate)
O,O,O',O'-Tetramethyl O,O'-thiodi-p-phenylene phosphorothioate
O,O-Dimethyl phosphorothioate O,O-diester with 4,4'-thiodiphenol
OMS 786
Phenol, 4,4'-thiodi-, O,O-diester with O,O-dimethyl phosphorothioate
Phosphorothioic acid, O,O'-(thiodi-4,1-phenylene) O,O,O',O'-tetramethyl ester
Procida
Swebate
Temefos
Temephos
Temephos (ACGIH:OSHA)
Tetramethyl-O,O'-thiodi-p-phenylene phosphorothioate
Skin and Eye Irritation and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| skin /rabbit | 500 mg/24H | mild | TXAPA9 21,369,1972 |
Mutation Data and Reference
| System Test | Route/Organism/Tissue | Dose | Reference |
|---|---|---|---|
| micronucleus test | other cell types/human | 10 µmol/L/48H | TIVIEQ 29,779,2015 |
Reproductive Effects Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| skin/rabbit | 2132 mg/kg (6-18D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | NTIS** AD-A134-545 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| In Vitro/Human, liver tumor | Inhibitor Concentration Low: 0.5 µmol/L | In Vitro Toxicity Studies: Other assays | TIVIEQ 29,779,2015 |
| In Vitro/Human, lymphocyte | Inhibitor Concentration Low: 10 µmol/L/48H | In Vitro Toxicity Studies: Cell proliferation: DNA incorporation, mitotic index etc. In Vitro Toxicity Studies: Apoptosis in vitro | TIVIEQ 29,779,2015 |
| In Vitro/Human, lymphocyte | Inhibitor Concentration Low: 0.5 µmol/L | In Vitro Toxicity Studies: Other assays | TIVIEQ 29,779,2015 |
| intraperitoneal/mouse | lethal dose (50 percent kill): 683 mg/kg | Behavioral: Altered sleep time (including change in righting reflex) Behavioral: Tremor Behavioral: Ataxia | TOIZAG 16,297,1969 |
| intraperitoneal/rat | lethal dose (50 percent kill): 912 mg/kg | Behavioral: Somnolence (general depressed activity) Behavioral: Tremor Gastrointestinal: Changes in structure or function of salivary glands | TOIZAG 16,297,1969 |
| oral/duck | lethal dose (50 percent kill): 79 mg/kg | TXAPA9 20,57,1971 | |
| oral/mammal (species unspecified) | lethal dose (50 percent kill): 4700 mg/kg | JAVMA4 152,282,1968 | |
| oral/mouse | lethal dose (50 percent kill): 223 mg/kg | ARSIM* 20,1,1966 | |
| oral/pigeon | lethal dose (50 percent kill): 50 mg/kg | TXAPA9 20,57,1971 | |
| oral/quail | lethal dose (50 percent kill): 75 mg/kg | AECTCV 12,355,1983 | |
| oral/rabbit | lethal dose (50 percent kill): 313 mg/kg | VETNAL 60(11),63,1984 | |
| oral/rat | lethal dose (50 percent kill): 1 gm/kg | GUCHAZ 6,493,1973 | |
| oral/wild bird | lethal dose (50 percent kill): 32 mg/kg | TXAPA9 20,57,1971 | |
| skin/rabbit | lethal dose (50 percent kill): 970 mg/kg | AMCYC* 8/1966 | |
| skin/rat | lethal dose (50 percent kill): 1370 mg/kg | WRPCA2 9,119,1970 | |
| subcutaneous/chicken | Lethal dose: >1 gm/kg | Behavioral: Muscle weakness | AEHLAU 14,283,1967 |
| subcutaneous/rat | lethal dose (50 percent kill): 2302 mg/kg | Behavioral: Somnolence (general depressed activity) | TOIZAG 16,297,1969 |
| unreported route/mammal (species unspecified) | lethal dose (50 percent kill): 4 gm/kg | 30ZDA9 -,338,1971 | |
| unreported route/rat | lethal dose (50 percent kill): 8600 mg/kg | TSPMA6 37(1),45,1977 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| oral/chicken | lowest published toxic dose: 1668 mg/kg/16W- continuous | Behavioral: Muscle weakness | AEHLAU 14,283,1967 |
| oral/Dog | lowest published toxic dose: 387 mg/kg/18W- continuous | Blood: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | AEHLAU 14,283,1967 |
| oral/rabbit | lowest published toxic dose: 18483 mg/kg/44W- intermittent | Liver: Changes in liver weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | GISAAA 41(10),101,1976 |
| oral/rat | lowest published toxic dose: 14850 mg/kg/99D- continuous | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | AEHLAU 14,283,1967 |
| oral/rat | lowest published toxic dose: 18483 mg/kg/44W- intermittent | Liver: Changes in liver weight Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases | GISAAA 41(10),101,1976 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 1 mg/m3 (inhal, vapor, skin) | DTLVS* TLV/BEI,2013 |
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Not classifiable as a human carcinogen | DTLVS* TLV/BEI,2013 |
| TOXICOLOGY REVIEW | RREVAH 46,1,1973 | |
| TOXICOLOGY REVIEW | TOLED5 230,434,2014 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION | FEREAC 54,7740,1989 | |
| Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES | Supported | RBREV* -,152,1998 |
| Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 10 mg/m3 | DTLVS* 3,1,1971 |
| Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
| Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
| Occupational Exposure Limit-AUSTRALIA | time-weighted average 10 mg/m3, JUL2008 | |
| Occupational Exposure Limit-BELGIUM | time-weighted average 1 mg/m3, Skin, MAR2002 | |
| Occupational Exposure Limit-FRANCE | VME 10 mg/m3, FEB2006 | |
| Occupational Exposure Limit-KOREA | time-weighted average 10 mg/m3, 2006 | |
| Occupational Exposure Limit-MEXICO | time-weighted average 10 mg/m3;short term exposure limit 20 mg/m3, 2004 | |
| Occupational Exposure Limit-NEW ZEALAND | time-weighted average 10 mg/m3, JAN2002 | |
| Occupational Exposure Limit-PERU | time-weighted average 10 mg/m3, JUL2005 | |
| Occupational Exposure Limit-RUSSIA | short term exposure limit 0.5 mg/m3, Skin, JUN2003 | |
| Occupational Exposure Limit-SWITZERLAND | MAK-week 10 mg/m3, inhal, JAN2011 | |
| Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 10 mg/m3, 2003 | |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 15 mg/m3, total dust | CFRGBR 29,1926.55,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 5 mg/m3, respirable fraction | CFRGBR 29,1926.55,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 15 mg/m3, total dust | CFRGBR 29,1910.1000,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 5 mg/m3, respirable fraction | CFRGBR 29,1910.1000,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 15 mg/m3, total dust | CFRGBR 29,1915.1000,1993 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 5 mg/m3, respirable fraction | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO TEMEPHOS, respirable fraction-air | 10H time-weighted average 5 mg/m3 | NIOSH* DHHS #92-100,1992 |
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO TEMEPHOS, total dust-air | 10H time-weighted average 10 mg/m3 | NIOSH* DHHS #92-100,1992 |
Status in Federal Agencies
| Organization | Reference |
|---|---|
| EPA TSCA Section 8(b) CHEMICAL INVENTORY |
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health