Phosphorodithioic acid, O-ethyl O-(4-(methylthio)phenyl) S-propyl ester

RTECS #

TE4165000

CAS #

35400-43-2
See: NMAM or OSHA Methods

Updated

September 2013

Molecular Weight

322.46

Molecular Formula

C₁₂H₁₉O₂PS₃

Synonyms

BAY-NTN-9306
Bolstar
Helothion
NTN 9306
O-Ethyl O-(4-(methylmercapto)phenyl)-S-n-propylphosphorothionothiolate
O-Ethyl O-(4-(methylthio)phenyl) S-propyl phosphorodithioate
O-Ethyl O-(4-(methylthio)phenyl)phosphorodithioic acid S-propyl ester
Sulprofos
Sulprofos (ACGIH)

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
oral/rat	300 mg/kg (6-15D pregnant)	Reproductive: Other effects on female Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)	NNGADV 12,775,1987
oral/rabbit	390 mg/kg (6-18D pregnant)	Reproductive: Other effects on female	NNGADV 12,775,1987

Acute Toxicity Data and References

Route/Organism	Dose	Reference
inhalation/rat	lethal concentration (50 percent kill): >661 mg/m³/4H	NNGADV 12,775,1987
intraperitoneal/mouse	lethal dose (50 percent kill): 280 mg/kg	NNGADV 12,775,1987
intraperitoneal/rat	lethal dose (50 percent kill): 160 mg/kg	NNGADV 12,775,1987
oral/chicken	lethal dose (50 percent kill): 65 mg/kg	85INA8 6,1473,1991
oral/mouse	lethal dose (50 percent kill): 490 mg/kg	NNGADV 12,775,1987
oral/rat	lethal dose (50 percent kill): 65 mg/kg	85ARAE 1,205,1977
skin/mouse	lethal dose (50 percent kill): 5 gm/kg	NNGADV 12,775,1987
skin/rabbit	lethal dose (50 percent kill): 820 mg/kg	FMCHA2 -,C47,1991
skin/rat	lethal dose (50 percent kill): 2500 mg/kg	NNGADV 12,775,1987
subcutaneous/mouse	lethal dose (50 percent kill): >1 gm/kg	NNGADV 12,775,1987
subcutaneous/rat	lethal dose (50 percent kill): 490 mg/kg	NNGADV 12,775,1987

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
oral/chicken	lowest published toxic dose: 29610 µg/kg/45D- intermittent	Brain and Coverings: Other degenerative changes Behavioral: Ataxia Musculoskeletal: Other changes	EVMJB9 49,115,1989
oral/Dog	lowest published toxic dose: 455 mg/kg/13W- continuous	Kidney, Ureter, and Bladder: Changes in bladder weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases	NNGADV 12,775,1987
oral/Dog	lowest published toxic dose: 1825 mg/kg/2Y- continuous	Brain and Coverings: Other degenerative changes Blood: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	NNGADV 12,775,1987
oral/mouse	lowest published toxic dose: 2079 mg/kg/99W- continuous	Blood: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	NNGADV 12,775,1987
oral/rat	lowest published toxic dose: 54600 µg/kg/13W- continuous	Blood: Normocytic anemia Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	NNGADV 12,775,1987
oral/rat	lowest published toxic dose: 2628 mg/kg/2Y- continuous	Blood: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	NNGADV 12,775,1987

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 0.1 mg/m³ (inhal, vapor, skin)	DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-Not classifiable as a human carcinogen	DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEW		HETOEA 26,321,2007

Standards and Regulations

Organization	Standard	Reference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION		FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES	Cancelled	RBREV* -,150,1998
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 1 mg/m³, JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 1 mg/m³;KZW 2 mg/m³, 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 1 mg/m³, MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 1 mg/m³, MAY2011
Occupational Exposure Limit-FRANCE	VME 1 mg/m³, FEB2006
Occupational Exposure Limit-ICELAND	time-weighted average 1 mg/m³, NOV2011
Occupational Exposure Limit-KOREA	time-weighted average 1 mg/m³, 2006
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 1 mg/m³, JAN2002
Occupational Exposure Limit-PERU	time-weighted average 1 mg/m³, JUL2005
Occupational Exposure Limit-SWITZERLAND	MAK-week 1 mg/m³, inhal, JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 1 mg/m³, 2003

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO SULPROFOS-air	10H time-weighted average 1 mg/m³	NIOSH* DHHS #92-100,1992

Status in Federal Agencies

Organization	Reference
NIOSH Analytical Method, 1994: Organophosphorus pesticides, 5600
On EPA IRIS database

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health