Phosphorodithioic acid, O,O-diethyl S-(ethylthio)methyl ester

RTECS #

TD9450000

CAS #

298-02-2
See: NMAM or OSHA Methods

Updated

September 2018

Molecular Weight

260.39

Molecular Formula

C₇H₁₇O₂PS₃

Synonyms

AC 3911
Agrimet
American cyanamid 3,911
Dithiophosphate de O,O-diethyle et d'ethylthiomethyle (French)
EI3911
ENT 24,042
Experimental insecticide 3911
Foraat (Dutch)
Geomet
Granutox
L 11/6
Methanethiol, (ethylthio)-, S-ester with O,O-diethyl phosphorodithioate
O,O-Diaethyl-S-(aethylthio-methyl)-dithiophosphat (German)
O,O-Diethyl ethylthiomethyl phosphorodithioate
O,O-Diethyl S-(ethylthio)methyl phosphorodithioate
O,O-Diethyl S-ethylmercaptomethyl dithiophosphonate
O,O-Diethyl S-ethylthiomethyl dithiophosphonate
O,O-Diethyl S-ethylthiomethyl thiothionophosphate
O,O-Diethyl-S-(ethylthio-methyl)-dithiofosfaat (Dutch)
O,O-Dietil-S-(etiltio-metil)-ditiofosfato (Italian)
Phorat (German)
Phorate
Phorate (ACGIH)
Phorate-10G
Rampart
RCRA waste number P094
Thimenox
Thimet
Timet
Vegfru
Vergfru foratox
VUAgT 182

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
skin /human	1%/48H		CODEDG 17,212,1987

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
Cytogenetic Analysis	intraperitoneal/rat	180 µg/kg	NULSAK 33,14,1990
Cytogenetic Analysis	ovary/hamster	40 mg/L	MUREAV 188,241,1987
Cytogenetic Analysis	embryo/human	50 µmol/L/72H	MUREAV 744,125,2012
DNA Damage	oral/rat	12.88 mg/kg/14D	TXAPA9 259,54,2012
micronucleus test	intraperitoneal/rat	750 µg/kg/5D-continuous	MUREAV 188,45,1987
micronucleus test	intraperitoneal/mouse	750 µg/kg	MUREAV 155,131,1985
sister chromatid exchange	lymphocyte/human	2 mg/L	MUREAV 102,89,1982
sister chromatid exchange	other cell types/rat	50 mg/L	MUREAV 188,311,1987
sister chromatid exchange	ovary/hamster	40 mg/L	MUREAV 188,311,1987

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
intraperitoneal/gerbil	2500 µg/kg (1D male)	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct	IJEBA6 18,1001,1980

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
In Vitro/Human, embryonic cells	Inhibitor Concentration Low: 100 µmol/L/72H	In Vitro Toxicity Studies: Other assays	FCTOD7 49,1787,2011
In Vitro/Human, embryonic cells	Inhibitor Concentration Low: 500 µmol/L/72H	In Vitro Toxicity Studies: Cell Viability (cell death), unspecified assay Biochemical: Metabolism (intermediary): Effect on mitochondrial function	FCTOD7 49,1787,2011
inhalation/rat	lethal concentration (50 percent kill): 11 mg/m³/1H		NTIS** PB277-077
intraperitoneal/gerbil	lethal dose (50 percent kill): 1866 µg/kg	Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Bronchiolar constriction, including asthma Gastrointestinal: Hypermotility, diarrhea	JAMPA2 28,234,1981
intraperitoneal/mouse	lethal dose (50 percent kill): 2100 µg/kg		AEPPAE 236,202,1959
intraperitoneal/rat	lethal dose (50 percent kill): 1980 µg/kg		AEPPAE 236,202,1959
intravenous/rat	lethal dose (50 percent kill): 1200 µg/kg		NTIS** PB277-077
oral/duck	lethal dose (50 percent kill): 600 µg/kg		DOEAAH 35,25,1979
oral/mouse	lethal dose (50 percent kill): 2250 µg/kg		AEPPAE 236,202,1959
oral/quail	lethal dose (50 percent kill): 7 mg/kg	Behavioral: Convulsions or effect on seizure threshold Behavioral: Ataxia Lung, Thorax, or Respiration: Dyspnea	EESADV 8,551,1984
oral/rat	lethal dose (50 percent kill): 1 mg/kg		DOEAAH 35,25,1979
oral/wild bird	lethal dose (50 percent kill): 1 mg/kg		TXAPA9 21,315,1972
skin/duck	lethal dose (50 percent kill): 203 mg/kg		TXAPA9 47,451,1979
skin/guinea pig	lethal dose (50 percent kill): 20 mg/kg		PCOC** -,895,1966
skin/rabbit	lethal dose (50 percent kill): 3.1 mg/kg		USXXAM #6193990
skin/rat	lethal dose (50 percent kill): 2.5 mg/kg		USXXAM #6193990
skin/rat	lethal dose (50 percent kill): 2500 µg/kg	Behavioral: Tremor Behavioral: Convulsions or effect on seizure threshold Behavioral: Excitement	TXAPA9 2,88,1960

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
oral/rat	lowest published toxic dose: 2.576 mg/kg/14D- intermittent	Cardiac: Other changes Liver: Other changes Kidney, Ureter, and Bladder: Changes primarily in glomeruli	TXAPA9 259,54,2012

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 0.05 mg/m³ (inhal, vapor, skin)	DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-Not classifiable as a human carcinogen	DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEW		RREVAH 46,1,1973
TOXICOLOGY REVIEW		MUTAEX 21,93,2006
TOXICOLOGY REVIEW		FEREAC 73,6867,2008
TOXICOLOGY REVIEW		FEREAC 73,53732,2008
TOXICOLOGY REVIEW		TOLED5 190,107,2009
TOXICOLOGY REVIEW		MUREAV 721,27,2011
TOXICOLOGY REVIEW		TXAPA9 258,309,2012
TOXICOLOGY REVIEW		TXAPA9 268,157,2013
TOXICOLOGY REVIEW		FCTOD7 105,456,2017

Standards and Regulations

Organization	Standard	Reference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION		FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES	Supported	RBREV* -,142,1998
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 0.05 mg/m³, short term exposure limit 0.2 mg/m³, JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 0.05 mg/m³;KZW 0.1 mg/m³, skin, 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 0.05 mg/m³, short term exposure limit 0.2 mg/m³, Skin, MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 0.05 mg/m³, skin, MAY2011
Occupational Exposure Limit-FRANCE	VME 0.05 mg/m³, Skin, FEB2006
Occupational Exposure Limit-ICELAND	time-weighted average 0.05 mg/m³, skin, NOV2011
Occupational Exposure Limit-KOREA	time-weighted average 0.05 mg/m³, short term exposure limit 0.2 mg/m³, skin, 2006
Occupational Exposure Limit-MEXICO	time-weighted average 0.05 mg/m³;short term exposure limit 0.2 mg/m³ (skin), 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 0.05 mg/m³, short term exposure limit 0.2 ppm, skin, JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 0.05 mg/m³, JAN1999
Occupational Exposure Limit-PERU	time-weighted average 0,05 mg/m³; short term exposure limit 0,2 mg/m³, JUL2005
Occupational Exposure Limit-SWITZERLAND	MAK-week 0.05 mg/m³, inhal, skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 0.05 mg/m³, Skin, 2003
Occupational Exposure Limit-UNITED KINGDOM	time-weighted average 0.05 mg/m³;short term exposure limit 0.2 mg/m³, skin, OCT2007

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PHORATE-air	10H time-weighted average 0.05 mg/m³;short term exposure limit 0.2 mg/m³ (Sk)	NIOSH* DHHS #92-100,1992

Status in Federal Agencies

Organization	Reference
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay; E coli polA without S9
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast; TRP reversion
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis
NIOSH Analytical Method, 1994: Organophosphorus pesticides, 5600
On EPA IRIS database

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health