Phosphoric acid, dibutyl ester

RTECS #

TB9605000

CAS #

107-66-4
See: NMAM or OSHA Methods

Updated

September 2013

Molecular Weight

210.24

Molecular Formula

C₈H₁₉O₄P

Synonyms

Dibutyl acid phosphate
Dibutyl hydrogen phosphate
Dibutyl phosphate
Dibutyl phosphate (ACGIH:OSHA)
Di-n-butyl phosphate
DP 4 (coupling agent)
HDBP

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
eye /rabbit	100 µL	severe	HPV341 -,-,2001
skin /rabbit	500 µL/8H	severe	HPV341 -,-,2001

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
oral/rat	39000 mg/kg (14D pre-3D after birth)	Reproductive: Other effects on female Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)	HPV341 -,-,2001

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
oral/rat	lethal dose (50 percent kill): 3200 mg/kg		HPV341 -,-,2001

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
oral/rat	lowest published toxic dose: 4400 mg/kg/44D- continuous	Behavioral: Food intake (animal) Kidney, Ureter, and Bladder: Inflammation, necrosis or scarring of bladder	HPV341 -,,2001
oral/rat	lowest published toxic dose: 13200 mg/kg/44D- continuous	Behavioral: Food intake (animal) Gastrointestinal: Ulceration or bleeding from stomach Kidney, Ureter, and Bladder: Inflammation, necrosis or scarring of bladder	HPV341 -,,2001
oral/rat	lowest published toxic dose: 44000 mg/kg/44D- continuous	Gastrointestinal: Ulceration or bleeding from stomach Kidney, Ureter, and Bladder: Inflammation, necrosis or scarring of bladder Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	HPV341 -,,2001
oral/rat	lowest published toxic dose: 39000 mg/kg/39D- continuous	Gastrointestinal: Gastritis Kidney, Ureter, and Bladder: Inflammation, necrosis or scarring of bladder Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	HPV341 -,,2001

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 5 mg/m³ (inhal, vapor)	DTLVS* TLV/BEI,2013

Standards and Regulations

Organization	Standard	Reference
Mine Safety and Health Administration (MSHA) STANDARD-air	time-weighted average 1 ppm (5 mg/m³)	DTLVS* 3,75,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 1 ppm (8.6 mg/m³), short term exposure limit 2 ppm (17 mg/m³), JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 0.6 ppm (5 mg/m³);KZW 1.2 ppm (10 mg/m³), 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 1 ppm (8.7 mg/m³), short term exposure limit 2 ppm (17 mg/m³), MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 1 ppm (8.6 mg/m³), MAY2011
Occupational Exposure Limit-FINLAND	time-weighted average 1 ppm (8.7 mg/m³), short term exposure limit 3 ppm (26 mg/m³), NOV2011
Occupational Exposure Limit-FRANCE	VME 1 ppm (5 mg/m³), FEB2006
Occupational Exposure Limit-ICELAND	time-weighted average 1 ppm (8.6 mg/m³), NOV2011
Occupational Exposure Limit-KOREA	time-weighted average 1 ppm (5 mg/m³), short term exposure limit 2 ppm (10 mg/m³), 2006
Occupational Exposure Limit-MEXICO	time-weighted average 1 ppm (5 mg/m³);short term exposure limit 2 ppm (10 mg/m³), 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 1 ppm (8.6 mg/m³); short term exposure limit 2 ppm (17 mg/m³), JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 1 ppm (5 mg/m³), JAN1999
Occupational Exposure Limit-PERU	time-weighted average 1 ppm (8,6 mg/m³); short term exposure limit 2 ppm (17,2 mg/m³), JUL2005
Occupational Exposure Limit-SWITZERLAND	MAK-week 1 ppm (8.5 mg/m³), JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 5 mg/m³, 2003
Occupational Exposure Limit-THE PHILIPPINES	time-weighted average 1 ppm (5 mg/m³), JAN1993
Occupational Exposure Limit-UNITED KINGDOM	time-weighted average 1 ppm (8.7 mg/m³);short term exposure limit 2 ppm (17 mg/m³), OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 1 ppm (5 mg/m³)	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	8H time-weighted average 1 ppm (5 mg/m³)	CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 1 ppm (5 mg/m³)	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 1 ppm (5 mg/m³)	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DIBUTYL PHOSPHATE-air	10H time-weighted average 1 ppm;short term exposure limit 2 ppm	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code 23865; Number of Industries 2; Total Number of Facilities 76; Number of Occupations 2; Total Number of Employees Exposed 1321
National Occupational Hazard Survey 1974	Hazard Code 23865; Number of Industries 1; Total Number of Facilities 13; Number of Occupations 1; Total Number of Employees Exposed 13

Status in Federal Agencies

Organization	Reference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Dibutyl phosphate, 5017

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health