Phosphoric acid, 1,2-dibromo-2,2-dichloroethyl dimethyl ester

RTECS #

TB9450000

CAS #

300-76-5; 53095-31-1
See: NMAM or OSHA Methods

Updated

December 2016

Molecular Weight

380.80

Molecular Formula

C₄H₇Br₂Cl₂O₄P

Synonyms

1,2-Dibromo-2,2-dichloroethyl dimethyl phosphate
Alvora
Arthodibrom
Bromchlophos
Bromex (insecticide)
Dibrom
Dibromfos
Dimethyl 1,2-dibromo-2,2-dichloroethyl phosphate
Dimethyl-1,2-dibromo-2,2-dichloroethyl phosphate (OSHA)
ENT 24988
Ethanol, 1,2-dibromo-2,2-dichloro-, dimethyl phosphate
Flibol Ex
Fosforan O-1,2-dwubromo-2,2-dwuchloroetylo-O,O-dwumetylowy (Polish)
Hibrom
Naled
Naled (ACGIH)
Naledu (Polish)
O-(1,2-Dibrom-2,2-dichlor-aethyl)-O,O-dimethyl-phosphat (German)
O-(1,2-Dibromo-2,2-dicloro-etil)-O,O-dimetil-fosfato (Italian)
O-(1,2-Dibroom-2,2-dichloor-ethyl)-O,O-dimethyl-fosfaat (Dutch)
O,O-Dimethyl O-2,2-dichloro-1,2-dibromoethyl phosphate
O,O-Dimethyl-O-(1,2-dibrom-2,2-dichlor-aethyl)-phosphat (German)
O,O-Dimethyl-O-(1,2-dibromo-2,2-dichloroethyl)phosphate
OMS 75
Ortho 4355
Phosphate de O,O-dimethyle et de O-(1,2-dibromo-2,2-dichlorethyle) (French)
RE-4355

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
skin /man	42 mg/21D- intermittent open irritation test		TXAPA9 21,369,1972
skin /rabbit	500 mg/24H	severe	TXAPA9 21,369,1972

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
mutation in microorganisms	/Salmonella typhimurium	9800 µg/plate (+enzymatic activation step)	MUREAV 28,405,1975
mutation in microorganisms	/Salmonella typhimurium	50 µg/plate (-enzymatic activation step)	JAFCAU 29,268,1981
mutation in microorganisms	/Bacillus subtilis	300 µg/plate (+enzymatic activation step)	JAFCAU 29,268,1981

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
inhalation/mouse	Lethal concentration: >1500 mg/m³/6H		85JFAN A289,1983
intraperitoneal/mouse	lethal dose (50 percent kill): 84 mg/kg		85GMAT -,56,1982
intraperitoneal/rat	lethal dose (50 percent kill): 35 mg/kg		BECTA6 19,113,1978
oral/duck	lethal dose (50 percent kill): 52 mg/kg		DOEAAH 35,25,1979
oral/mammal (species unspecified)	lethal dose (50 percent kill): 430 mg/kg		HPBIA9 21,53,1975
oral/mouse	lethal dose (50 percent kill): 222 mg/kg	Eye: Other eye effects Behavioral: Convulsions or effect on seizure threshold Gastrointestinal: Changes in structure or function of salivary glands	BECTA6 19,113,1978
oral/rat	lethal dose (50 percent kill): 92 mg/kg	Behavioral: Tremor Gastrointestinal: Changes in structure or function of salivary glands Gastrointestinal: Hypermotility, diarrhea	ATDAEI 1,90,1990
skin/mouse	lethal dose (50 percent kill): 600 mg/kg		JPIFAN (8),24,1971
skin/rabbit	lethal dose (50 percent kill): 1100 mg/kg		ENTOX* -,180,2005
skin/rat	lethal dose (50 percent kill): 800 mg/kg		ENTOX* -,180,2005

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
oral/rat	lowest published toxic dose: 1350 mg/kg/9W- intermittent	Nutritional and Gross Metabolic: Body temperature decrease Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	RPZHAW 20,463,1969
skin/mouse	lowest published toxic dose: 1 pph/3D- intermittent	Immunological Including Allergic: Increased immune response	TXCYAC 261,152,2009

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 0.1 mg/m³ (inhal, vapor, skin, sen)	DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-Not classifiable as a human carcinogen	DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEW		DTTIAF 80,485,1973
TOXICOLOGY REVIEW		MUREAV 567,347,2004
TOXICOLOGY REVIEW		MUTAEX 21,93,2006
TOXICOLOGY REVIEW		ENTOX* -,180,2005
TOXICOLOGY REVIEW		TXAPA9 268,157,2013

Standards and Regulations

Organization	Standard	Reference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION		FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES	Supported	RBREV* -,135,1998
Mine Safety and Health Administration (MSHA) STANDARD-air	time-weighted average 3 mg/m³	DTLVS* 3,73,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 3 mg/m³, JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 3 mg/m³;KZW 12 mg/m³, inhal, skin, 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 3 mg/m³, Skin, MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 3 mg/m³, MAY2011
Occupational Exposure Limit-FINLAND	time-weighted average 3 mg/m³, short term exposure limit 6 mg/m³, skin, NOV2011
Occupational Exposure Limit-FRANCE	VME 3 mg/m³, Skin, FEB2006
Occupational Exposure Limit-GERMANY	MAK 1 mg/m³, inhal, skin, 2011
Occupational Exposure Limit-ICELAND	time-weighted average 3 mg/m³, NOV2011
Occupational Exposure Limit-KOREA	time-weighted average 3 mg/m³, skin, 2006
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 3 mg/m³, skin, JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 3 mg/m³, JAN1999
Occupational Exposure Limit-PERU	time-weighted average 0,1 mg/m³, JUL2005
Occupational Exposure Limit-RUSSIA	short term exposure limit 0.5 mg/m³, Skin, JUN2003
Occupational Exposure Limit-SWITZERLAND	MAK-week 0.1 mg/m³, skin, sen, JAN2011
Occupational Exposure Limit-THAILAND	time-weighted average 3 mg/m³, JAN1993
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 3 mg/m³, 2003
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 3 mg/m³	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	8H time-weighted average 3 mg/m³	CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 3 mg/m³	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 3 mg/m³	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO THE CHEMICAL-air	10H time-weighted average 3 mg/m³ (Sk)	NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974	Hazard Code 26420; Number of Industries 1; Total Number of Facilities 16; Number of Occupations 1; Total Number of Employees Exposed 16

Status in Federal Agencies

Organization	Reference
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health