Phosphonothioic acid, phenyl-, O-ethyl O-(p-nitrophenyl)ester

RTECS #

TB1925000

CAS #

2104-64-5; 65580-81-6
See: NMAM or OSHA Methods

Updated

December 2015

Molecular Weight

323.32

Molecular Formula

C₁₄H₁₄NO₄PS

Synonyms

Benzenephosphonic acid, thiono-, ethyl-p-nitrophenyl ester
ENT 17,798
EPN
EPN (ACGIH:OSHA)
EPN 300
Ethoxy-4-nitrophenoxyphenylphosphine sulfide
Ethyl p-nitrophenyl benzenethionophosphonate
Ethyl p-nitrophenyl benzenethiophosphate
Ethyl p-nitrophenyl benzenethiophosphonate
Ethyl p-nitrophenyl phenylphosphonothioate
Ethyl p-nitrophenyl thionobenzenephosphate
Ethyl p-nitrophenyl thionobenzenephosphonate
IN-9663-90
O-(4-Nitrophenyl) O-ethyl phenyl thiophosphonate
O-Aethyl-O-(4-nitro-phenyl)-phenyl-monothiophosphonat (German)
O-Ethyl O-(4-nitrophenyl) phenylphosphonothioate
O-Ethyl O-(4-nitrophenyl)benzenethionophosphonate
O-Ethyl O-p-nitrophenyl phenylphosphonothiolate
O-Ethyl O-p-nitrophenyl phenylphosphorothioate
O-Ethyl phenyl p-nitrophenyl thiophosphonate
O-Ethyl-O-((4-nitro-fenyl)-fenyl)-monothiofosfonaat (Dutch)
O-Ethyl-O-p-nitrofenylester kyseliny fenylthiofosfonove (Czech)
O-Etil-O-((4-nitro-fenil)-fenil)-monotiofosfonato (Italian)
OMS 219
Phenol, p-nitro-, O-ester with O-ethyl phenyl phosphonothioate
Phenylphosphonothioate, O-ethyl-O-p-nitrophenyl-
Phenylphosphonothioic acid O-ethyl O-p-nitrophenyl ester
Phenylthiophosphonate de O-ethyle et O-4-nitrophenyle (French)
PIN
Santox

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
eye /rabbit	100 µL	moderate	NTIS** OTS0540535
skin /rabbit	500 µL	moderate	NTIS** OTS0540536

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
oral/mouse	132 mg/kg (6-16D pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)	JPFCD2 20,373,1985

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
inhalation/rat	lethal concentration (50 percent kill): 106 mg/m³/1H	Peripheral Nerve and Sensation: Fasciculations Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Dyspnea	NTIS** OTS0570820
intraperitoneal/chicken	lethal dose (50 percent kill): 17 mg/kg		BECTA6 18,534,1977
intraperitoneal/Dog	lowest published lethal dose: 35 mg/kg		JPETAB 112,29,1954
intraperitoneal/guinea pig	lethal dose (10 percent kill): 14 mg/kg		TXAPA9 8,259,1966
intraperitoneal/mouse	lethal dose (50 percent kill): 8400 µg/kg		IJBBBQ 15,336,1978
intraperitoneal/rabbit	lowest published lethal dose: 20 mg/kg		JPETAB 112,29,1954
intraperitoneal/rat	lethal dose (50 percent kill): 7200 µg/kg		APCRAW 4,117,1961
oral/chicken	lethal dose (50 percent kill): 5 mg/kg		JPFCD2 17,611,1982
oral/Dog	lethal dose (50 percent kill): 20 mg/kg		PCOC** -,478,1966
oral/duck	lethal dose (50 percent kill): 3 mg/kg		TXAPA9 20,57,1971
oral/mouse	lethal dose (50 percent kill): 12200 µg/kg		ABCHA6 26,257,1962
oral/pigeon	lethal dose (50 percent kill): 4210 µg/kg		ASTTA8 (680),157,1979
oral/quail	lethal dose (50 percent kill): 5 mg/kg		TXAPA9 20,57,1971
oral/rat	lethal dose (50 percent kill): 7 mg/kg		JPETAB 112,29,1954
oral/wild bird	lethal dose (50 percent kill): 2370 µg/kg		ASTTA8 (680),157,1979
skin/cat	lethal dose (50 percent kill): 45 mg/kg	Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral: Ataxia	TOLED5 1000(Sp Iss 1),141,1980
skin/duck	lethal dose (50 percent kill): 400 mg/kg		TXAPA9 47,451,1979
skin/mouse	lethal dose (50 percent kill): 348 mg/kg		ABCHA6 26,257,1962
skin/rabbit	lethal dose (50 percent kill): 30 mg/kg	Behavioral: Somnolence (general depressed activity) Gastrointestinal: Other changes	AFDOAQ 16,3,1952
skin/rat	lethal dose (50 percent kill): 25 mg/kg	Behavioral: Tremor Behavioral: Convulsions or effect on seizure threshold Behavioral: Excitement	TXAPA9 2,88,1960
subcutaneous/mouse	lethal dose (50 percent kill): 22900 µg/kg		TOIZAG 25,635,1978
unreported route/rat	lethal dose (50 percent kill): 7 mg/kg		JPETAB 128,289,1960

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
oral/chicken	lowest published toxic dose: 90 mg/kg/90D- intermittent	Behavioral: Ataxia Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	TXAPA9 45,685,1978
oral/Dog	lowest published toxic dose: 35 mg/kg/4W- continuous	Blood: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	JPETAB 121,96,1957
oral/rat	lowest published toxic dose: 84 mg/kg/8W- continuous	Blood: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	JPETAB 121,96,1957
oral/rat	lowest published toxic dose: 2700 mg/kg/30D- continuous	Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	JPETAB 112,29,1954
skin/cat	lowest published toxic dose: 180 mg/kg/90D- intermittent	Spinal Cord: Demyelination Nutritional and Gross Metabolic: Weight loss or decreased weight gain	TXAPA9 68,54,1983
skin/chicken	lowest published toxic dose: 90 mg/kg/90D- intermittent	Behavioral: Ataxia	JTEHD6 16,85,1985

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 0.1 mg/m³ (inhal, skin)	DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-Not classifiable as a human carcinogen	DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEW		AQMOAC #73-19,1973
TOXICOLOGY REVIEW		TXAPA9 47,451,1979
TOXICOLOGY REVIEW		TXCYAC 307,136,2013

Standards and Regulations

Organization	Standard	Reference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION		FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES	Cancelled	RBREV* -,116,1998
Mine Safety and Health Administration (MSHA) STANDARD-air	time-weighted average 0.5 mg/m³ (skin)	DTLVS* 3,99,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 0.5 mg/m³, JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 0.5 mg/m³;KZW 5 mg/m³, inhal, skin, 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 0.1 mg/m³, Skin, MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 0.1 mg/m³, skin, MAY2011
Occupational Exposure Limit-FRANCE	VME 0.5 mg/m³, Skin, FEB2006
Occupational Exposure Limit-GERMANY	MAK 0.5 mg/m³, inhal, skin, 2011
Occupational Exposure Limit-ICELAND	time-weighted average 0.1 mg/m³, skin, NOV2011
Occupational Exposure Limit-KOREA	time-weighted average 0.5 mg/m³, skin, 2006
Occupational Exposure Limit-MEXICO	time-weighted average 0.5 mg/m³;short term exposure limit 2 mg/m³, 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 0.5 mg/m³, skin, JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 0.5 mg/m³, JAN1999
Occupational Exposure Limit-PERU	time-weighted average 0,1 mg/m³, JUL2005
Occupational Exposure Limit-SWITZERLAND	MAK-week 0.5 mg/m³, inhal, skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 0.1 mg/m³, Skin, 2003
Occupational Exposure Limit-THE PHILIPPINES	time-weighted average 0.5 mg/m³, Skin, JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 0.5 mg/m³ (skin)	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	8H time-weighted average 0.5 mg/m³ (skin)	CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 0.5 mg/m³ (skin)	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 0.5 mg/m³ (skin)	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO EPN-air	10H time-weighted average 0.5 mg/m³ (Sk)	NIOSH* DHHS #92-100,1992

Status in Federal Agencies

Organization	Reference
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: EPN, 5012
On EPA IRIS database

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health