3-Pentanone
RTECS #
SA8050000
CAS #
Updated
March 2019
Molecular Weight
86.15
Molecular Formula
C5H10O
Synonyms
DEK
Diethyl ketone
Diethyl ketone (ACGIH)
Diethylcetone (French)
Dimethylacetone
Metacetone
Methacetone
Pentanone-3
Propione
Diethyl ketone
Diethyl ketone (ACGIH)
Diethylcetone (French)
Dimethylacetone
Metacetone
Methacetone
Pentanone-3
Propione
Skin and Eye Irritation and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
eye /rabbit | 50 mg | moderate | UCDS** 4/25/1958 |
eye /rabbit | 100 mg/24H | moderate | 85JCAE -,282,1986 |
skin /rabbit | 410 mg open irritation test | mild | UCDS** 4/25/1958 |
skin /rabbit | 500 mg/24H | mild | 85JCAE -,282,1986 |
Mutation Data and Reference
System Test | Route/Organism/Tissue | Dose | Reference |
---|---|---|---|
gene conversion and mitotic recombination | /Saccharomyes cerevisiae | 14800 ppm | MUREAV 149,339,1985 |
sex chromosome loss and nondisjunction | /Saccharomyes cerevisiae | 14800 ppm | MUREAV 149,339,1985 |
Acute Toxicity Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/rat | Lowest published lethal concentration: 8000 ppm/4H | AMIHBC 10,61,1954 | |
intraperitoneal/rat | lowest published lethal dose: 1250 mg/kg | JIHTAB 27,1,1945 | |
intraperitoneal/rat | lowest published toxic dose: 302 mg/kg | Behavioral: Anticonvulsant | BJPCBM 158,872,2009 |
intravenous/mouse | lethal dose (50 percent kill): 513 mg/kg | JPMSAE 67,566,1978 | |
oral/mouse | lethal dose (50 percent kill): 3100 mg/kg | Behavioral: General anesthetic Behavioral: Ataxia | MTPEEI (4),41,1997 |
oral/mouse | lethal dose (50 percent kill): 3200 mg/kg | VCVGK* -,422,1994 | |
oral/rat | lethal dose (50 percent kill): 2140 mg/kg | UCDS** 4/25/1958 | |
skin/rabbit | lethal dose (50 percent kill): 20 mL/kg | AMIHBC 10,61,1954 | |
skin/rat | lethal dose (50 percent kill): 2100 mg/kg | VCVGK* -,422,1994 |
Reviews
Organization | Standard | Reference |
---|---|---|
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 200 ppm;short term exposure limit 300 ppm | DTLVS* TLV/BEI,2013 |
TOXICOLOGY REVIEW | FEREAC 75,8575,2010 | |
TOXICOLOGY REVIEW | RTOPDW 60,120,2011 |
Standards and Regulations
NIOSH Documentation and Surveillance
Organization | Standard | Reference |
---|---|---|
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DIETHYL KETONE-air | 10H time-weighted average 200 ppm | NIOSH* DHHS #92-100,1992 |
Status in Federal Agencies
Organization | Reference |
---|---|
EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
EPA TSCA Section 8(d) unpublished health/safety studies | |
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 |
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health