1,2-Oxathiolane 2,2-dioxide

RTECS #

RP5425000

CAS #

1120-71-4
See: NMAM or OSHA Methods

Updated

March 2019

Molecular Weight

122.15

Molecular Formula

C₃H₆O₃S

Synonyms

1,3-Propane sultone
1-Propanesulfonic acid-3-hydroxy-gamma-sultone
3-Hydroxy-1-propanesulfonic acid gamma-sultone
3-Hydroxy-1-propanesulphonic acid sultone
gamma-Propane sultone
Propane sultone
Propane sultone (ACGIH)
Propanesultone
RCRA waste number U193

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
skin /rabbit	500 mg	mild	34ZIAG -,498,1969

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
Cytogenetic Analysis	lymphocyte/human	1 mmol/L	TOLED5 28,139,1985
Cytogenetic Analysis	fibroblast/hamster	125 mg/L/24H	MUREAV 48,337,1977
Cytogenetic Analysis	lung/hamster	10 mg/L	ATSUDG 4,41,1980
DNA adduct	/Escherichia coli	10 µmol/L	MUREAV 89,95,1981
DNA Damage	/Bacillus subtilis	50 nmol/L	CNREA8 41,4368,1981
DNA Damage	fibroblast/human	5 mg/L	CBINA8 22,185,1978
DNA Damage	mammary gland/human	10 mg/L/24H (-enzymatic activation step)	MUREAV 588,47,2005
DNA Damage	intraperitoneal/mouse	200 mg/kg	MUREAV 467,83,2000
DNA Damage	other cell types/human	1 mmol/L/4H	EMMUEG 57,171,2016
DNA Damage	intravenous/rat	31 mg/kg	TCMUD8 7,175,1987
DNA Damage	oral/rat	240 mg/kg/3D- intermittent	MUREAV 831,62,2018
DNA inhibition	skin/mouse	2 mmol/kg	CNREA8 33,769,1973
DNA inhibition	oral/mouse	20 gm/kg	ARGEAR 51,605,1981
DNA repair	/Other microorganisms	610 µg/plate	BIZNAT 95,463,1976
DNA repair	/Escherichia coli	500 µg/disc	JJIND8 62,873,1979
gene conversion and mitotic recombination	/Saccharomyes cerevisiae	1000 ppm	JJIND8 62,901,1979
host-mediated assay	Salmonella typhimurium/mouse	12 mg/kg	JJIND8 62,911,1979
micronucleus test	intraperitoneal/mouse	18 mg/kg/48H- intermittent	MUREAV 389,3,1997
micronucleus test	oral/rat	240 mg/kg/3D- intermittent	MUREAV 831,62,2018
morphological transform	embryo/rat	5 mg/L	JNCIAM 51,799,1973
morphological transform	fibroblast/mouse	30 µg/L	CRNGDP 3,377,1982
morphological transform	embryo/mouse	50 mg/L	TOLED5 9,301,1981
morphological transform	intraperitoneal/hamster	1 gm/kg	ARPAAQ 95,380,1973
morphological transform	kidney/hamster	80 µg/L	BJCAAI 37,873,1978
morphological transform	embryo/hamster	1 mg/L	IJCNAW 19,642,1977
morphological transform	other cell types/human	7500 µg/L	CNREA8 41,5096,1981
mutation in mammalian somatic cells	fibroblast/human	30 mg/L	CNREA8 41,1620,1981
mutation in microorganisms	/Schizosaccharomyces pombe	7900 µmol/L (-enzymatic activation step)	CBINA8 14,195,1976
mutation in microorganisms	/Escherichia coli	1 gm/L (-enzymatic activation step)	ATXKA8 28,93,1971
mutation in microorganisms	/Salmonella typhimurium	5 µg/plate (+enzymatic activation step)	JJIND8 62,893,1979
mutation in microorganisms	/Salmonella typhimurium	70 µg/plate (-enzymatic activation step)	PNASA6 72,5135,1975
mutation in microorganisms	/Serratia marcescens	25 mg/L (-enzymatic activation step)	ATXKA8 30,67,1972
mutation in microorganisms	/Other microorganisms	1600 mg/L (-enzymatic activation step)	MOPMA3 6,667,1970
other mutation test systems	/Bacillus subtilis	50 mmol/L	JOBAAY 136,854,1978
other mutation test systems	/Salmonella typhimurium	16 mg/L	MUREAV 192,239,1987
sister chromatid exchange	lymphocyte/human	500 µmol/L	TOLED5 28,139,1985
specific locus test	oral/rat	60 mg/kg/3D- intermittent	MUREAV 831,62,2018
specific locus test	oral/rat	420 mg/kg/14D- intermittent	MUREAV 721,163,2011
specific locus test	oral/rat	240 mg/kg/3D	MUREAV 782,24,2015
specific locus test	oral/rat	300 mg/kg	MUREAV 811,75,2016
specific locus test	other cell types/mouse	160 µmol/L/24H	EMMUEG 59,18,2018
Unscheduled DNA Synthesis	skin/mouse	2 mmol/kg	CNREA8 33,769,1973
Unscheduled DNA Synthesis	fibroblast/human	200 µmol/L/2H	33AQAA -,103,1976

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
intravenous/rat	80 mg/kg (15D pregnant)	Reproductive: Effects on embryo or fetus: Fetal death	IARCCD 4,45,1973

Tumorigenic Data and References

Route/Organism	Dose	Effect	Reference
intravenous/rat	lowest published toxic dose: 20 mg/kg (15D pregnant)	Tumorigenic: Carcinogenic by RTECS criteria Reproductive: Tumorigenic effects: Transplacental tumorigenesis Brain and Coverings: Tumors	IARCCD 4,45,1973
oral/rat	lowest published toxic dose: 7840 mg/kg/60W- intermittent	Tumorigenic: Carcinogenic by RTECS criteria Brain and Coverings: Tumors Skin and Appendages: Tumors	NATUAS 230,460,1971
oral/rat	toxic dose: 1100 mg/kg/37W- intermittent	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Peripheral Nerve and Sensation: Peripheral nerve tumors	ZEKBAI 75,69,1970
oral/rat	toxic dose: 12 gm/kg/60W- continuous	Tumorigenic: Carcinogenic by RTECS criteria Brain and Coverings: Tumors Skin and Appendages: Tumors	JJIND8 67,75,1981
oral/rat	toxic dose: 13 gm/kg/32W- continuous	Tumorigenic: Carcinogenic by RTECS criteria Brain and Coverings: Tumors Skin and Appendages: Tumors	JJIND8 67,75,1981
skin/mouse	lowest published toxic dose: 1000 mg/kg	Tumorigenic: Carcinogenic by RTECS criteria Lung, Thorax, or Respiration: Tumors Blood: Lymphoma including Hodgkin's disease	TXCYAC 6,139,1976
skin/mouse	toxic dose: 50 mg/kg/1W- intermittent	Tumorigenic: Carcinogenic by RTECS criteria Skin and Appendages: Tumors Tumorigenic: Tumors at site of application	TXAPA9 37,93,1976
subcutaneous/mouse	lowest published toxic dose: 756 mg/kg/63W- intermittent	Tumorigenic: Neoplastic by RTECS criteria Tumorigenic: Tumors at site of application	JNCIAM 46,143,1971
subcutaneous/rat	lowest published toxic dose: 10 mg/kg	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Tumorigenic: Tumors at site of application	ZEKBAI 75,69,1970
subcutaneous/rat	toxic dose: 166 mg/kg	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Lung, Thorax, or Respiration: Tumors	INTSAO 66,161,1981
subcutaneous/rat	toxic dose: 559 mg/kg/17W- intermittent	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Lung, Thorax, or Respiration: Tumors	INTSAO 66,161,1981
subcutaneous/rat	toxic dose: 434 mg/kg/15W- intermittent	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Lung, Thorax, or Respiration: Tumors	INTSAO 66,161,1981

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
inhalation/rat	Lowest published lethal concentration: 2140 mg/m³/6H	Eye: Lacrimation Vascular: Regional or general arteriolar or venous dilation Skin and Appendages: Other: Hair	NTIS** OTS0555330
intraperitoneal/mouse	lethal dose (50 percent kill): 100 mg/kg	Eye: Other eye effects Behavioral: Somnolence (general depressed activity) Skin and Appendages: Other: Hair	NTIS** OTS0555330
intraperitoneal/rat	lethal dose (50 percent kill): 100 mg/kg	Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Dyspnea Gastrointestinal: Hypermotility, diarrhea	NTIS** OTS0555330
oral/mouse	lethal dose (50 percent kill): 400 mg/kg	Behavioral: Somnolence (general depressed activity) Behavioral: Convulsions or effect on seizure threshold Skin and Appendages: Other: Hair	NTIS** OTS0555330
oral/rat	lethal dose (50 percent kill): 100 mg/kg	Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Dyspnea Gastrointestinal: Hypermotility, diarrhea	NTIS** OTS0555330
skin/mouse	lowest published lethal dose: 1000 gm/kg		TXCYAC 6,139,1976
subcutaneous/rat	lethal dose (50 percent kill): 135 mg/kg		ZEKBAI 75,69,1970

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-Control as low as possible (skin)	DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-Confirmed animal carcinogen	DTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)	Cancer Review:Animal Sufficient Evidence	IMEMDT 4,253,1974
International Agency for Research on Cancer (IARC)	Cancer Review:Animal Sufficient Evidence	IMEMDT 71,1095,1999
International Agency for Research on Cancer (IARC)	Cancer Review:Human No Adequate Data	IMEMDT 4,253,1974
International Agency for Research on Cancer (IARC)	Cancer Review:Human No Adequate Data	IMEMDT 71,1095,1999
International Agency for Research on Cancer (IARC)	Cancer Review:Group 2B	IMEMDT 71,1095,1999
TOXICOLOGY REVIEW		TOLED5 151,251,2004
TOXICOLOGY REVIEW		MUREAV 627,10,2007
TOXICOLOGY REVIEW		MUREAV 584,1,2005
TOXICOLOGY REVIEW		MUREAV 783,23,2015
TOXICOLOGY REVIEW		MUREAV 769,34,2014
TOXICOLOGY REVIEW		MUREAV 802,1,2016
TOXICOLOGY REVIEW		MUREAV 811,3,2016
TOXICOLOGY REVIEW		REPTED 71,71,2017

Standards and Regulations

Organization	Standard	Reference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	Carcinogen, JUL2008
Occupational Exposure Limit-JAPAN	2B carc, MAY2012
Occupational Exposure Limit-SWEDEN	Group B Carcinogen, JUN2005
Occupational Exposure Limit-SWITZERLAND	carc 2, JAN2011

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PROPANE SULTONE-air	Carcinogen lowest feasible concentration	NIOSH* DHHS #92-100,1992

Status in Federal Agencies

Organization	Reference
EPA GENETOX PROGRAM 1988, Inconclusive: SHE-clonal assay
EPA GENETOX PROGRAM 1988, Positive/dose response: In vitro SCE-nonhuman
EPA GENETOX PROGRAM 1988, Positive/dose response: In vitro UDS-human fibroblast
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-RLV F344 rat embryo
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-SA7/SHE; Host-mediated assay
EPA GENETOX PROGRAM 1988, Positive: E coli polA without S9; Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae gene conversion; S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Positive: S pombe-reversion
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP 14th Report on Carcinogens,2016:Reasonably anticipated to be human carcinogen
On EPA IRIS database

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health