2-Norbornene, 5-ethylidene-

RTECS #

RB9450000

CAS #

16219-75-3
See: NMAM or OSHA Methods

Updated

December 2018

Molecular Weight

120.21

Molecular Formula

C₉H₁₂

Synonyms

5-Ethylidene-2-norbornene
5-Ethylidenebicyclo(2.2.1)hept-2-ene
Bicyclo(2.2.1)hept-2-ene, 5-ethylidene- (9CI)
Ethylidene norbornene
Ethylidene norbornene (ACGIH)

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
skin /rabbit	445 mg open irritation test	mild	UCDS** 11/28/1967

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
inhalation/rat	100 ppm/6H (6-15D pregnant)	Reproductive: Other effects on female Reproductive: Specific developmental abnormalities: Musculoskeletal system	IOMTE3 4,371,1995

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
inhalation/Dog	lethal concentration (50 percent kill): 15600 mg/m³/90M		VCVGH* -,104,1990
inhalation/Dog	lowest published toxic concentration: 10500 mg/m³/30M	Behavioral: Convulsions or effect on seizure threshold Skin: After topical application: Primary irritation	VCVGH* -,104,1990
inhalation/Dog	lowest published toxic concentration: 6200 mg/m³/90M	Behavioral: Convulsions or effect on seizure threshold	VCVGH* -,104,1990
inhalation/guinea pig	lethal concentration (50 percent kill): 2896 ppm/4H	Eye: Lacrimation Behavioral: Convulsions or effect on seizure threshold	TXAPA9 20,250,1971
inhalation/human	lowest published toxic concentration: 6 ppm/30M	Olfaction: Other olfaction effects Eye: Conjunctiva irritation Taste: Change in function	TXAPA9 20,250,1971
inhalation/human	lowest published toxic concentration: 27 mg/m³/30M	Eye: Conjunctiva irritation	VCVGH* -,104,1990
inhalation/mouse	lethal concentration (50 percent kill): 10900 mg/m³/2H		VCVGH* -,104,1990
inhalation/mouse	lethal concentration (50 percent kill): 732 ppm/4H	Behavioral: Muscle weakness	TXAPA9 20,250,1971
inhalation/rabbit	lethal concentration (50 percent kill): 3104 ppm/4H	Olfaction: Ulcerated nasal septum	TXAPA9 20,250,1971
inhalation/rat	lethal concentration (50 percent kill): 3520 mg/m³/4H		VCVGH* -,104,1990
inhalation/rat	lethal concentration (50 percent kill): 1246 ppm/4H	Behavioral: Muscle weakness	TXAPA9 20,250,1971
intraperitoneal/rat	lethal dose (50 percent kill): 2830 µL/kg		NTIS** OTS0536403
oral/mouse	lethal dose (50 percent kill): 3040 mg/kg		VCVGH* -,104,1990
oral/rat	lethal dose (50 percent kill): 2830 µL/kg		AIHAAP 30,470,1969
skin/rabbit	lethal dose (50 percent kill): 5.66 mL/kg		VCVGH* -,104,1990

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/Dog	lowest published toxic concentration: 61 ppm/7H/89D- intermittent	Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases	NTIS** OTS0536403
inhalation/rat	lowest published toxic concentration: 52 ppm/6H/9D- intermittent	Kidney, Ureter, and Bladder: Changes in kidney weight Endocrine: Evidence of thyroid hyperfunction	JJATDK 17,197,1997
inhalation/rat	lowest published toxic concentration: 359 ppm/6H/66D- intermittent	Kidney, Ureter, and Bladder: Other changes in urine composition	JJATDK 17,197,1997
inhalation/rat	lowest published toxic concentration: 149 ppm/6H/66D- intermittent	Behavioral: Food intake (animal) Behavioral: Fluid intake Liver: Changes in liver weight	JJATDK 17,197,1997
inhalation/rat	lowest published toxic concentration: 359 ppm/6H/9D- intermittent	Nutritional and Gross Metabolic: Weight loss or decreased weight gain	JJATDK 17,197,1997
inhalation/rat	lowest published toxic concentration: 24.8 ppm/6H/66D- intermittent	Nutritional and Gross Metabolic: Weight loss or decreased weight gain	JJATDK 17,197,1997
inhalation/rat	lowest published toxic concentration: 50 ppm/6H/9D- intermittent	Endocrine: Other changes	JAPTO* 17,197,1997
inhalation/rat	lowest published toxic concentration: 150 ppm/6H/9D- intermittent	Liver: Other changes Endocrine: Changes in thyroid weight	JAPTO* 17,197,1997
inhalation/rat	lowest published toxic concentration: 359 ppm/6H/9D- intermittent	Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in kidney weight Blood: Normocytic anemia	JAPTO* 17,197,1997
inhalation/rat	lowest published toxic concentration: 50 ppm/6H/9D- intermittent	Endocrine: Changes in thyroid weight	JAPTO* 17,197,1997
inhalation/rat	lowest published toxic concentration: 359 ppm/6H/9D- intermittent	Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in kidney weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain	JAPTO* 17,197,1997
inhalation/rat	lowest published toxic concentration: 4.9 ppm/6H/14W- intermittent	Kidney, Ureter, and Bladder: Changes in kidney weight	JAPTO* 17,197,1997
inhalation/rat	lowest published toxic concentration: 24.8 ppm/6H/14W- intermittent	Endocrine: Other changes Blood: Normocytic anemia Nutritional and Gross Metabolic: Weight loss or decreased weight gain	JAPTO* 17,197,1997
inhalation/rat	lowest published toxic concentration: 149 ppm/6H/14W- intermittent	Behavioral: Food intake (animal) Behavioral: Fluid intake Liver: Changes in liver weight	JAPTO* 17,197,1997
inhalation/rat	lowest published toxic concentration: 4.9 ppm/6H/14W- intermittent	Eye: Other eye effects	JAPTO* 17,197,1997
inhalation/rat	lowest published toxic concentration: 24.8 ppm/6H/14W- intermittent	Blood: Changes in erythrocyte (RBC) count	JAPTO* 17,197,1997
inhalation/rat	lowest published toxic concentration: 149 ppm/6H/14W- intermittent	Behavioral: Food intake (animal) Behavioral: Fluid intake Kidney, Ureter, and Bladder: Changes in kidney weight	JAPTO* 17,197,1997
inhalation/rat	lowest published toxic concentration: 90 ppm/7H/88D- intermittent	Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Nutritional and Gross Metabolic: Weight loss or decreased weight gain	TXAPA9 20,250,1971
inhalation/rat	lowest published toxic concentration: 350 ppm/6H/11D- intermittent	Endocrine: Changes in thyroid weight Blood: Changes in erythrocyte (RBC) count Nutritional and Gross Metabolic: Weight loss or decreased weight gain	NTIS** OTS0536403
oral/rat	lowest published toxic dose: 4200 mg/kg/14D- continuous	Liver: Changes in liver weight Endocrine: Evidence of thyroid hyperfunction Nutritional and Gross Metabolic: Weight loss or decreased weight gain	NTIS** OTS0538294-1

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-ceiling concentration 5 ppm	DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEW		FCTOD7 47,1287,2009
TOXICOLOGY REVIEW		RTOPDW 54,247,2009

Standards and Regulations

Organization	Standard	Reference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	ceiling concentration 5 ppm (25 mg/m³), JUL2008
Occupational Exposure Limit-BELGIUM	time-weighted average 5 ppm (25 mg/m³), MAR2002
Occupational Exposure Limit-DENMARK	ceiling concentration 5 ppm (25 mg/m³), MAY2011
Occupational Exposure Limit-FINLAND	short term exposure limit 5 ppm (25 mg/m³), NOV2011
Occupational Exposure Limit-FRANCE	VLE 5 ppm (25 mg/m³), FEB2006
Occupational Exposure Limit-ICELAND	short term exposure limit 5 ppm (25 mg/m³), NOV2011
Occupational Exposure Limit-KOREA	ceiling concentration 5 ppm (25 mg/m³), 2006
Occupational Exposure Limit-MEXICO	peak 5 ppm (25 mg/m³), 2004
Occupational Exposure Limit-NEW ZEALAND	ceiling concentration 5 ppm (25 mg/m³), JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 5 ppm (25 mg/m³), JAN1999
Occupational Exposure Limit-PERU	short term exposure limit 5 ppm (25 mg/m³), JUL2005
Occupational Exposure Limit-RUSSIA	short term exposure limit 10 mg/m³, Skin, JUN2003
Occupational Exposure Limit-SWITZERLAND	MAK-week 5 ppm (25 mg/m³), JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-C 25 mg/m³, 2003

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ETHYLIDENE NORBORNENE-air	ceiling concentration 5 ppm	NIOSH* DHHS #95-121,1995
National Occupational Hazard Survey 1974	Hazard Code M3889; Number of Industries 1; Total Number of Facilities 22; Number of Occupations 20; Total Number of Employees Exposed 1988

Status in Federal Agencies

Organization	Reference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health