5-Norbornene-2,3-dimethanol, 1,4,5,6,7,7-hexachloro-, cyclic sulfite
RTECS #
RB9275000
CAS #
Updated
March 2019
Molecular Weight
406.91
Molecular Formula
C9H6Cl6O3S
Synonyms
1,2,3,4,7,7-Hexachlorobicyclo(2.2.1)hepten-5,6-bioxymethylenesulfite
1,4,5,6,7,7-Hexachloro-5-norbornene-2,3-dimethanol cyclic sulfite
6,7,8,9,10,10-Hexachloro-1,5,5a,6,9,9a-hexahydro-6,9-methano-2,4,3-benzodioxathiepin-3-oxide
6,9-Methano-2,4,3-benzodioxathiepin, 6,7,8,9,10,10-hexahydro-
alpha,beta-1,2,3,4,7,7-Hexachlorobicyclo(2.2.1)-2-heptene-5,6-bisoxymethylene sulfite
Benzoepin
Beosit
BIO 5,462
Chlorthiepin
Crisulfan
Devisulphan
Endocel
Endosulfan
Endosulfan (ACGIH:OSHA)
Endosulphan
Endotaf
ENT 23,979
FMC 5462
Goldenleaf tobacco spray
Hexachlorohexahydromethano 2,4,3-benzodioxathiepin-3-oxide
Hildan
HOE 2,671
Insectophene
Kop-thiodan
Malix
NCI-C00566
NIA 5462
Niagara 5,462
OMS 570
Rasayansulfan
RCRA waste number P050
SD-4314
Sulfurous acid, cyclic ester with 1,4,5,6,7,7-hexachloro-5-norbornene-2,3-dimethanol
Thifor
Thimul
Thiodan
Thiodan 35
Thiofor
Thiomul
Thionate
Thionex
Thiosulfan
Thiosulfan tionel
Thiotox
Thiotox (insecticide)
Tiovel
1,4,5,6,7,7-Hexachloro-5-norbornene-2,3-dimethanol cyclic sulfite
6,7,8,9,10,10-Hexachloro-1,5,5a,6,9,9a-hexahydro-6,9-methano-2,4,3-benzodioxathiepin-3-oxide
6,9-Methano-2,4,3-benzodioxathiepin, 6,7,8,9,10,10-hexahydro-
alpha,beta-1,2,3,4,7,7-Hexachlorobicyclo(2.2.1)-2-heptene-5,6-bisoxymethylene sulfite
Benzoepin
Beosit
BIO 5,462
Chlorthiepin
Crisulfan
Devisulphan
Endocel
Endosulfan
Endosulfan (ACGIH:OSHA)
Endosulphan
Endotaf
ENT 23,979
FMC 5462
Goldenleaf tobacco spray
Hexachlorohexahydromethano 2,4,3-benzodioxathiepin-3-oxide
Hildan
HOE 2,671
Insectophene
Kop-thiodan
Malix
NCI-C00566
NIA 5462
Niagara 5,462
OMS 570
Rasayansulfan
RCRA waste number P050
SD-4314
Sulfurous acid, cyclic ester with 1,4,5,6,7,7-hexachloro-5-norbornene-2,3-dimethanol
Thifor
Thimul
Thiodan
Thiodan 35
Thiofor
Thiomul
Thionate
Thionex
Thiosulfan
Thiosulfan tionel
Thiotox
Thiotox (insecticide)
Tiovel
Mutation Data and Reference
| System Test | Route/Organism/Tissue | Dose | Reference |
|---|---|---|---|
| Cytogenetic Analysis | unreported route/mouse | 1 mg/kg | TGANAK 16(1),45,1982 |
| Cytogenetic Analysis | oral/mouse | 32 mg/kg | IMSCE2 14,1125,1986 |
| Cytogenetic Analysis | intraperitoneal/hamster | 8 mg/kg | ARTODN 58,152,1986 |
| DNA Damage | ovary/hamster | 1 µmol/L/3H | EMMUEG 47,682,2006 |
| DNA Damage | lymphocyte/human | 0.05 µmol/L/3H | EMMUEG 47,682,2006 |
| DNA Damage | other cell types/human | 80 µmol/L/1D | MUTAEX 31,43,2016 |
| DNA Damage | other cell types/human | 30 µmol/L/7D | MUTAEX 31,43,2016 |
| Dominant Lethal Test | intraperitoneal/mouse | 83 mg/kg/5D-continuous | MUREAV 242,1,1990 |
| micronucleus test | other cell types/human | 30 µmol/L/14D | MUTAEX 31,43,2016 |
| micronucleus test | multiple/frog | 5 µg/L/48H-continuous | MUREAV 587,67,2005 |
| mutation in mammalian somatic cells | lymphocyte/mouse | 18600 µg/L | EMMUEG 12,85,1988 |
| mutation in microorganisms | /Saccharomyes cerevisiae | 100 mg/L (-enzymatic activation step) | TGANAK 18,455,1984 |
| mutation in microorganisms | /Salmonella typhimurium | 1 µg/plate/30M | EMMUEG 47,682,2006 |
| sex chromosome loss and nondisjunction | oral/Drosophila melanogaster | 200 ppm/48H | MUREAV 136,115,1984 |
| sister chromatid exchange | lymphocyte/human | 1 µmol/L | ARTODN 52,221,1983 |
| sperm morphology | oral/rat | 75 mg/kg/10D- intermittent | MUREAV 585,50,2005 |
| sperm morphology | intraperitoneal/mouse | 83 mg/kg/5D-continuous | MUREAV 242,1,1990 |
Reproductive Effects Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| intraperitoneal/rat | 66 mg/kg (1-22D pregnant) | Reproductive: Effects on newborn: Biochemical and metabolic | BDERB* 86,1,2009 |
| oral/rat | 26.23 mg/kg (1-22D preg/21D after birth) | Reproductive: Effects on newborn: Delayed effects | TOLED5 197,106,2010 |
| oral/rat | 226.44 mg/kg (1-22D preg/15D after birth) | Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Effects on newborn: Biochemical and metabolic Reproductive: Effects on newborn: Other postnatal measures or effects | TOLED5 196S,S314,2010 |
| oral/mouse | 151.2 µg/kg (multigeneration) | Reproductive: Effects on newborn: Physical Reproductive: Effects on newborn: Biochemical and metabolic Reproductive: Specific developmental abnormalities: Blood and lymphatic systems (including spleen and marrow) | TXCYAC 308,74,2013 |
| oral/mouse | 151.2 µg/kg (1D preg-21D after birth) | Reproductive: Maternal effects: Postpartum Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4) | TXCYAC 308,74,2013 |
| oral/rat | 26.84 mg/kg (1D preg-21D after birth) | Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Effects on newborn: Biochemical and metabolic | TXCYAC 311,35,2013 |
| oral/rat | 18.5 mg/kg (7-22D preg/21D after birth) | Reproductive: Effects on newborn: Biochemical and metabolic Reproductive: Effects on newborn: Behavioral | FCTOD7 99,135,2017 |
| oral/rat | 45 mg/kg (6-14D pregnant) | Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Specific developmental abnormalities: Musculoskeletal system | APTOA6 42,150,1978 |
| oral/rat | 600 mg/kg (60D male) | Reproductive: Paternal effects: Testes, epididymis, sperm duct Reproductive: Other effects on male | TOLED5 18(Suppl 1),139,1983 |
| oral/rat | 125 mg/kg (13W male) | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct | BECTA6 58,79,1997 |
| oral/rat | 175 mg/kg (10W male) | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct | VHTODE 37,547,1995 |
| oral/rat | 42 mg/kg (15-21D preg/1-21D after birth) | Reproductive: Effects on newborn: Physical | HETOEA 18,583,1999 |
| oral/rat | 10 mg/kg (12-22D pregnant) | Reproductive: Specific developmental abnormalities: Urogenital system Reproductive: Effects on newborn: Germ cell effects (in offspring) Reproductive: Effects on newborn: Delayed effects | ETOPFR 10,29,2001 |
| oral/rat | 150 mg/kg (30D male) | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) | BECTA6 70,285,2003 |
| oral/rat | 450 mg/kg (30D male) | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) | BECTA6 70,285,2003 |
| oral/rat | 6.2 mg/kg (multigenerations) | Reproductive: Specific developmental abnormalities: Endocrine system Reproductive: Specific developmental abnormalities: Urogenital system Reproductive: Effects on newborn: Other neonatal measures or effects | FEREAC 69,10443,2004 |
| oral/rat | 32 mg/kg (21D pre-21D after birth) | Reproductive: Paternal effects: Testes, epididymis, sperm duct | HETOEA 22,171,2003 |
| oral/rat | 257 mg/kg (1D preg-21D after birth) | Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) | TOLED5 176,58,2008 |
| oral/rat | 25.6 mg/kg (1D preg-21D after birth) | Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | TOLED5 176,58,2008 |
| oral/rat | 220.3 mg/kg (1D preg-15D after birth) | Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | TOLED5 176,58,2008 |
| oral/rat | 22 mg/kg (1D preg-15D after birth) | Reproductive: Effects on newborn: Biochemical and metabolic | TOLED5 176,58,2008 |
| oral/rat | 15 mg/kg (6-20D pregnant) | Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on embryo or fetus: Fetal death Reproductive: Specific developmental abnormalities: Central nervous system | JAPTO* 27,143,2007 |
| oral/rat | 257 mg/kg (1D preg-21D after birth) | Reproductive: Effects on newborn: Biochemical and metabolic | TOXID9 -,245,2009 |
| oral/rat | 15 mg/kg (6-20D pregnant) | Reproductive: Maternal effects: Uterus, cervix, vagina Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) | JAPTO* 27,589,2007 |
| oral/rat | 15 mg/kg (6-20D pregnant) | Reproductive: Specific developmental abnormalities: Hepatobiliary system Reproductive: Specific developmental abnormalities: Urogenital system | JAPTO* 28,901,2008 |
| oral/rat | 120 mg/kg (15D preg-22D after birth) | Reproductive: Effects on newborn: Other postnatal measures or effects | BDERB* 86,1,2009 |
| oral/rat | 84 mg/kg (6-19D pregnant) | Reproductive: Other effects on female Reproductive: Specific developmental abnormalities: Musculoskeletal system Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | BDERB* 86,1,2009 |
| oral/rat | 125 mg/kg (1D preg-28D after birth) | Reproductive: Other effects on female Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | BDERB* 86,1,2009 |
| oral/rabbit | 92 mg/kg (6-28D pregnant) | Reproductive: Other effects on female | BDERB* 86,1,2009 |
| oral/rat | 263.16 mg/kg (1D preg-21D after birth) | Reproductive: Other effects on female Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) Reproductive: Effects on newborn: Biochemical and metabolic | BDERB* 86,1,2009 |
Tumorigenic Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| oral/mouse | lowest published toxic dose: 330 mg/kg/78W- intermittent | Tumorigenic: Neoplastic by RTECS criteria Lung, Thorax, or Respiration: Tumors | NTIS** PB223-159 |
| subcutaneous/mouse | lowest published toxic dose: 2 mg/kg | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Lung, Thorax, or Respiration: Tumors Liver: Tumors | NTIS** PB223-159 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| In Vitro/Human, endothelium | Inhibitor Concentration Low: 40 µmol/L/48H | In Vitro Toxicity Studies: Other assays | TOLED5 269,33,2017 |
| In Vitro/Human, endothelium | Inhibitor Concentration Low: 60 µmol/L/48H | In Vitro Toxicity Studies: Apoptosis in vitro In Vitro Toxicity Studies: Other assays | TOLED5 269,33,2017 |
| In Vitro/Human, liver | Inhibitor Concentration Low: 10 µmol/L/24H | In Vitro Toxicity Studies: Other assays | TIVIEQ 26,718,2012 |
| In Vitro/Human, liver tumor | Inhibitor Concentration Low: 50 µmol/L/48H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 28,1507,2014 |
| In Vitro/Human, liver tumor | Inhibitor Concentration Low: 50 µmol/L/24H | In Vitro Toxicity Studies: Cell proliferation: DNA incorporation, mitotic index etc. Biochemical: Metabolism (intermediary): Effect on mitochondrial function | TIVIEQ 28,1507,2014 |
| In Vitro/Human, liver tumor | Inhibitor Concentration Low: 20 µmol/L/4H | In Vitro Toxicity Studies: Other assays | TIVIEQ 28,1507,2014 |
| In Vitro/Human, liver tumor | Inhibitor Concentration Low: 20 µmol/L/72H | In Vitro Toxicity Studies: Cell morphology: overgrowth of cell appendixes etc. | FCTOD7 50,3963,2012 |
| In Vitro/Human, liver tumor | Inhibitor Concentration (50 percent kill): 40 µmol/L/24H | In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc. | TXCYAC 292,23,2012 |
| In Vitro/Human, liver tumor | Inhibitor Concentration Low: 30 µmol/L/4H | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphokinase | TXCYAC 292,23,2012 |
| In Vitro/Human, liver tumor | Inhibitor Concentration (50 percent kill): 100.5 µmol/L/24H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TXCYAC 300,19,2012 |
| In Vitro/Human, liver tumor | Inhibitor Concentration (50 percent kill): 73.3 µmol/L/48H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TXCYAC 300,19,2012 |
| In Vitro/Human, liver tumor | Inhibitor Concentration (50 percent kill): 68.9 µmol/L/72H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TXCYAC 300,19,2012 |
| In Vitro/Human, liver tumor | Inhibitor Concentration (50 percent kill): 20 µmol/L/48H | In Vitro Toxicity Studies: Cell morphology: overgrowth of cell appendixes etc. In Vitro Toxicity Studies: Other assays | TXCYAC 300,19,2012 |
| In Vitro/jrd | Inhibitor Concentration (50 percent kill): 1.3 µmol/L/6D | Endocrine: Estrogenic | FCTOD7 62,82,2013 |
| In Vitro/Mouse, liver | Inhibitor Concentration Low: 1 µmol/L/24H | In Vitro Toxicity Studies: Other assays | TIVIEQ 26,718,2012 |
| In Vitro/Non-mammalian species, fibroblast | Inhibitor Concentration (50 percent kill): 0.07 mmol/L/24H | In Vitro Toxicity Studies: Cell counting | TIVIEQ 7,537,1993 |
| In Vitro/Non-mammalian species, liver | Inhibitor Concentration Low: 100 µmol/L/120H | In Vitro Toxicity Studies: Cell Viability (cell death), unspecified assay | FCTOD7 73,157,2014 |
| In Vitro/Rat, neurons | Inhibitor Concentration Low: 40 µmol/L/1H | In Vitro Toxicity Studies: Other assays | NRTXDN 44,204,2014 |
| inhalation/cat | lethal concentration (50 percent kill): 90 mg/m3/4H | 85GMAT -,72,1982 | |
| inhalation/rat | lethal concentration (50 percent kill): 80 mg/m3/4H | JOCMA7 9,35,1967 | |
| inhalation/rat | lethal concentration (50 percent kill): 0.16 gm/m3/4H | FEREAC 69,10443,2004 | |
| inhalation/rat | lethal concentration (50 percent kill): 12.6 mg/m3/4H | Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Dyspnea Nutritional and Gross Metabolic: Weight loss or decreased weight gain | BDERB* 86,1,2009 |
| intraperitoneal/hamster | lethal dose (50 percent kill): 80 mg/kg | ARTODN 58,152,1986 | |
| intraperitoneal/mouse | lethal dose (50 percent kill): 7 mg/kg | Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Respiratory depression Lung, Thorax, or Respiration: Respiratory stimulation | BECTA6 15,708,1976 |
| intraperitoneal/rat | lethal dose (50 percent kill): 8 mg/kg | Behavioral: Change in motor activity (specific assay) Gastrointestinal: Nausea or vomiting Gastrointestinal: Contraction (isolated tissue) | RREVAH 22,1,1968 |
| intravenous/rat | lowest published toxic dose: 5.7 mg/kg | Behavioral: Convulsions or effect on seizure threshold Gastrointestinal: Changes in structure or function of salivary glands | NRTXDN 32,31,2011 |
| intravenous/rat | lowest published toxic dose: 1 mg/kg | Brain and Coverings: Recordings from specific areas of CNS | NRTXDN 32,31,2011 |
| intravenous/rat | lowest published toxic dose: 2 mg/kg | Brain and Coverings: Recordings from specific areas of CNS Vascular: BP elevation not characterized in autonomic section | NRTXDN 32,31,2011 |
| intravenous/rat | lowest published toxic dose: 4 mg/kg | Brain and Coverings: Changes in surface EEG Behavioral: Convulsions or effect on seizure threshold Vascular: BP elevation not characterized in autonomic section | NRTXDN 32,31,2011 |
| intravenous/woman | lowest published toxic dose: 6 µL/kg | Behavioral: Muscle weakness Liver: Liver function tests impaired Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) | JTCTDW 34,447,1996 |
| oral/cat | lethal dose (50 percent kill): 2 mg/kg | 85DPAN -,-,1971/1976 | |
| oral/Dog | lethal dose (50 percent kill): 76700 µg/kg | PEMNDP 9,332,1991 | |
| oral/domestic animal | lethal dose (50 percent kill): 26 mg/kg | Behavioral: Somnolence (general depressed activity) Behavioral: Excitement Behavioral: Muscle contraction or spasticity | VETNAL 59(12),64,1983 |
| oral/duck | lethal dose (50 percent kill): 33 mg/kg | DOEAAH 35,25,1979 | |
| oral/hamster | lethal dose (50 percent kill): 118 mg/kg | EJTXAZ 7,159,1974 | |
| oral/human | lowest published lethal dose: 0.87 gm/kg | Behavioral: Convulsions or effect on seizure threshold Liver: Liver function tests impaired Musculoskeletal: Other changes | HETOEA 28,309,2009 |
| oral/human | lowest published toxic dose: 0.4785 gm/kg | Behavioral: Convulsions or effect on seizure threshold Liver: Liver function tests impaired Musculoskeletal: Other changes | HETOEA 28,309,2009 |
| oral/human | Lethal dose: >0.5 gm/kg | HETOEA 28,309,2009 | |
| oral/man | lowest published lethal dose: 2571 mg/kg | Behavioral: Convulsions or effect on seizure threshold Liver: Fatty liver degeneration Blood: Changes in bone marrow not included in above | JTCTDW 42,927,2004 |
| oral/man | lowest published lethal dose: 429 µL/kg | Eye: Miosis (pupilliary constriction) Behavioral: Convulsions or effect on seizure threshold Kidney, Ureter, and Bladder: Urine volume decreased or anuria | YAKUD5 34,1232,1992 |
| oral/man | lowest published lethal dose: 260 mg/kg | Brain and Coverings: Changes in surface EEG Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis) | JTCTDW 36,345,1998 |
| oral/man | lowest published toxic dose: 86 mg/kg | Behavioral: Convulsions or effect on seizure threshold Behavioral: Coma Lung, Thorax, or Respiration: Cyanosis | JTCTDW 26,265,1988 |
| oral/man | lowest published lethal dose: 418 µL/kg | Olfaction: Other olfaction effects Behavioral: Convulsions or effect on seizure threshold Cardiac: Pulse rate decreased with fall in BP | AJEMEN 6,510,1988 |
| oral/mouse | lethal dose (50 percent kill): 7360 µg/kg | Behavioral: Somnolence (general depressed activity) Behavioral: Tremor | TOLED5 7,221,1981 |
| oral/rabbit | lethal dose (50 percent kill): 28 mg/kg | Behavioral: Somnolence (general depressed activity) Behavioral: Excitement Behavioral: Muscle contraction or spasticity | VETNAL 59(12),64,1983 |
| oral/rat | lethal dose (50 percent kill): 18 mg/kg | ARSIM* 20,9,1966 | |
| oral/rat | lowest published toxic dose: 3 mg/kg | Behavioral: Somnolence (general depressed activity) Behavioral: Ataxia Lung, Thorax, or Respiration: Respiratory depression | FEREAC 69,10443,2004 |
| oral/rat | lethal dose (50 percent kill): 10 mg/kg | Lung, Thorax, or Respiration: Acute pulmonary edema Gastrointestinal: Gastritis Kidney, Ureter, and Bladder: Other changes | BDERB* 86,1,2009 |
| oral/wild bird | lethal dose (50 percent kill): 35 mg/kg | TXAPA9 21,315,1972 | |
| oral/woman | lowest published toxic dose: 246 mg/kg | Behavioral: Convulsions or effect on seizure threshold Cardiac: Arrythmias (indlucing changes in conduction) Lung, Thorax, or Respiration: Acute pulmonary edema | JTCTDW 42,927,2004 |
| skin/mammal (species unspecified) | lethal dose (50 percent kill): 147 mg/kg | Behavioral: Somnolence (general depressed activity) Behavioral: Muscle contraction or spasticity | VETNAL 59(12),64,1983 |
| skin/rabbit | lethal dose (50 percent kill): 90 mg/kg | Eye: Other eye effects Skin: After systemic exposure: Dermatitis, irritative | JOCMA7 9,35,1967 |
| skin/rat | lethal dose (50 percent kill): 34 mg/kg | 85GMAT -,72,1982 | |
| skin/rat | lethal dose (50 percent kill): 74 mg/kg | Skin: After topical application: Primary irritation | BDERB* 86,1,2009 |
| subcutaneous/rabbit | lethal dose (50 percent kill): 360 mg/kg | Behavioral: Change in motor activity (specific assay) Gastrointestinal: Nausea or vomiting Gastrointestinal: Contraction (isolated tissue) | RREVAH 22,1,1968 |
| Tank with water/other fish | toxic concentration: 18.5 µg/L/96H | Vascular: Effect on gills and gill functions Endocrine: Hyperglycemia Endocrine: Other changes | EESADV 131,79,2016 |
| Tank with water/other fish | toxic concentration: 18.5 µg/L/96H | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases | EESADV 131,79,2016 |
| Tank with water/other fish | lethal concentration (50 percent kill): 0.77 µg/L/96H | Behavioral: Alteration of classical conditioning | FCTOD7 49,1898,2011 |
| Tank with water/other fish | lowest published toxic concentration: 0.0075 µg/L/96H | Behavioral: Alteration of classical conditioning | FCTOD7 49,1898,2011 |
| Tank with water/other fish | lowest published toxic concentration: 0.0025 µg/L/7D | Endocrine: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases | FCTOD7 49,1898,2011 |
| Tank with water/Zebrafish | lowest published toxic concentration: 2.4 µg/L/96H | Behavioral: Change in motor activity (specific assay) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | NRTXDN 33,469,2012 |
| unreported route/mouse | lethal dose (50 percent kill): 32 mg/kg | TGANAK 16(1),45,1982 | |
| unreported route/rat | lethal dose (50 percent kill): 40 mg/kg | 30ZDA9 -,267,1971 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/rat | lowest published toxic concentration: 8.4 mg/kg/6H/21D- intermittent | Blood: Changes in leukocyte (WBC) count Nutritional and Gross Metabolic: Weight loss or decreased weight gain | FEREAC 69,10443,2004 |
| inhalation/rat | lowest published toxic concentration: 8.4 mg/kg/6H/21D- intermittent | Kidney, Ureter, and Bladder: Renal function tests depressed Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) | FEREAC 69,10443,2004 |
| inhalation/rat | lowest published toxic concentration: 2 mg/m3/29D- intermittent | Behavioral: Somnolence (general depressed activity) Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic: Weight loss or decreased weight gain | BDERB* 86,1,2009 |
| inhalation/rat | lowest published toxic concentration: 6.5 mg/m3/9D- intermittent | Behavioral: Convulsions or effect on seizure threshold Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | BDERB* 86,1,2009 |
| intraperitoneal/mouse | lowest published toxic dose: 21.7 mg/kg/14D- intermittent | Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum | NRTXDN 28,727,2007 |
| intraperitoneal/rabbit | lowest published toxic dose: 650 mg/kg/65W- intermittent | Eye: Retinal changes pigmentary deposition, retinitis, other) Nutritional and Gross Metabolic: Weight loss or decreased weight gain Nutritional and Gross Metabolic: Conditioned vitamin deficiency | JTOTDO 6,161,1987 |
| intraperitoneal/rat | lowest published toxic dose: 35 mg/kg/5W- intermittent | Brain and Coverings: Other degenerative changes Behavioral: Aggression | BDERB* 86,1,2009 |
| intraperitoneal/rat | lowest published toxic dose: 90 mg/kg/30D- intermittent | Brain and Coverings: Other degenerative changes Behavioral: Aggression Biochemical: Metabolism (intermediary): Other | BDERB* 86,1,2009 |
| intratracheal/rat | lowest published toxic dose: 30 mg/kg/3D- intermittent | Lung, Thorax, or Respiration: Other changes Liver: Other changes Biochemical: Metabolism (intermediary): Other proteins | BECTA6 34,63,1985 |
| oral/chicken | lowest published toxic dose: 19.6 mg/kg/8W- continuous | Musculoskeletal: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases Biochemical: Metabolism (intermediary): Plasma proteins not involving coagulation | TOPADD 32,364,2004 |
| oral/chicken | lowest published toxic dose: 315 mg/kg/60D- continuous | Blood: Changes in spleen Immunological Including Allergic: Decreased immune response | TXAPA9 197,278,2004 |
| oral/chicken | lowest published toxic dose: 315 mg/kg/60D- intermittent | Endocrine: Changes in spleen weight Endocrine: Changes in thymus weight Immunological Including Allergic: Decreased immune response | TXCYAC 251,51,2008 |
| oral/Dog | lowest published toxic dose: 2745 mg/kg/0.5Y- intermittent | Gastrointestinal: Other changes | FEREAC 69,10443,2004 |
| oral/Dog | lowest published toxic dose: 638.75 mg/kg/1Y- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | FEREAC 69,10443,2004 |
| oral/Dog | lowest published toxic dose: 643.72 mg/kg/44W- intermittent | Behavioral: Convulsions or effect on seizure threshold Behavioral: Food intake (animal) Nutritional and Gross Metabolic: Weight loss or decreased weight gain | BDERB* 86,1,2009 |
| oral/mouse | lowest published toxic dose: 105 mg/kg/35D- intermittent | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct | BDERB* 86,1,2009 |
| oral/mouse | lowest published toxic dose: 45 mg/kg/15D- intermittent | Reproductive: Maternal effects: Oogenesis Related to Chronic Data: Changes in ovarian weight | BDERB* 86,1,2009 |
| oral/mouse | lowest published toxic dose: 120 mg/kg/30D- intermittent | Liver: Other changes Reproductive: Maternal effects: Uterus, cervix, vagina Biochemical: Metabolism (intermediary): Other proteins | BECTA6 71,458,2003 |
| oral/mouse | lowest published toxic dose: 664.3 mg/kg/13W- intermittent | Related to Chronic Data: Changes in uterine weight | FEREAC 69,10443,2004 |
| oral/mouse | lowest published toxic dose: 105 mg/kg/7D- continuous | Liver: Other changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | TXAPA9 148,158,1998 |
| oral/mouse | lowest published toxic dose: 1934.5 mg/kg/2Y- intermittent | Related to Chronic Data: Changes in uterine weight | FEREAC 69,10443,2004 |
| oral/mouse | lowest published toxic dose: 468.72 mg/kg/27W- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | BDERB* 86,1,2009 |
| oral/rabbit | lowest published toxic dose: 92 mg/kg/23D- intermittent | Behavioral: Convulsions or effect on seizure threshold Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | BDERB* 86,1,2009 |
| oral/rat | lowest published toxic dose: 225 mg/kg/90D- intermittent | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) | BDERB* 86,1,2009 |
| oral/rat | lowest published toxic dose: 125 mg/kg/50D- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | BDERB* 86,1,2009 |
| oral/rat | lowest published toxic dose: 144 mg/kg/24D- intermittent | Brain and Coverings: Other degenerative changes Behavioral: Alteration of operant conditioning Biochemical: Neurotransmitters or modulators (putative): Catecholamine levels in CNS | BDERB* 86,1,2009 |
| oral/rat | lowest published toxic dose: 180 mg/kg/90D- intermittent | Brain and Coverings: Other degenerative changes Behavioral: Alteration of operant conditioning | BDERB* 86,1,2009 |
| oral/rat | lowest published toxic dose: 600.6 mg/kg/13W- intermittent | Behavioral: Food intake (animal) Nutritional and Gross Metabolic: Weight loss or decreased weight gain Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases | BDERB* 86,1,2009 |
| oral/rat | lowest published toxic dose: 308 mg/kg/8W- intermittent | Behavioral: Convulsions or effect on seizure threshold Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | BDERB* 86,1,2009 |
| oral/rat | lowest published toxic dose: 75 mg/kg/15D- intermittent | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Reproductive: Paternal effects: Testes, epididymis, sperm duct Related to Chronic Data: Changes in testicular weight | FCTOD7 64,1,2014 |
| oral/rat | lowest published toxic dose: 2111.2 mg/kg/104W- intermittent | Vascular: Structural changes in vessels Liver: Other changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain | BDERB* 86,1,2009 |
| oral/rat | lowest published toxic dose: 150 mg/kg/30D- intermittent | Endocrine: Androgenic Endocrine: Other changes | TOLED5 180S,S188,2008 |
| oral/rat | lowest published toxic dose: 15 mg/kg/15D- continuous | Liver: Changes in liver weight Kidney, Ureter, and Bladder: Other changes Endocrine: Changes in spleen weight | JAPTO* 27,589,2007 |
| oral/rat | lowest published toxic dose: 2130.31 mg/kg/13W- intermittent | Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in kidney weight Reproductive: Paternal effects: Testes, epididymis, sperm duct | BDERB* 86,1,2009 |
| oral/rat | lowest published toxic dose: 2472.47 mg/kg/13W- intermittent | Liver: Other changes Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in kidney weight | BDERB* 86,1,2009 |
| oral/rat | lowest published toxic dose: 150 mg/kg/15D- intermittent | Liver: Changes in liver weight Reproductive: Paternal effects: Testes, epididymis, sperm duct Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | BDERB* 86,1,2009 |
| oral/rat | lowest published toxic dose: 15 mg/kg/15D- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | JAPTO* 27,143,2007 |
| oral/rat | lowest published toxic dose: 28 mg/kg/2W- intermittent | Gastrointestinal: Changes in structure or function of exocrine pancreas | TXCYAC 200,205,2004 |
| oral/rat | lowest published toxic dose: 42 mg/kg/3W- intermittent | Gastrointestinal: Changes in structure or function of exocrine pancreas Endocrine: Hyperglycemia Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) | TXCYAC 200,205,2004 |
| oral/rat | lowest published toxic dose: 84 mg/kg/6W- intermittent | Cardiac: Cardiomyopathy including infarction Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects | TXCYAC 202,227,2004 |
| oral/rat | lowest published toxic dose: 75 mg/kg/10D- intermittent | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Changes in testicular weight | MUREAV 585,50,2005 |
| oral/rat | lowest published toxic dose: 75 mg/kg/10D- intermittent | Endocrine: Androgenic Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects Reproductive: Paternal effects: Testes, epididymis, sperm duct | MUREAV 585,50,2005 |
| oral/rat | lowest published toxic dose: 150 mg/kg/15D- intermittent | Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in bladder weight Related to Chronic Data: Changes in testicular weight | BECTA6 18,378,1977 |
| oral/rat | lowest published toxic dose: 450 mg/kg/60D- intermittent | Lung, Thorax, or Respiration: Changes in lung weight Liver: Changes in liver weight Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | TOLED5 21,29,1984 |
| oral/rat | lowest published toxic dose: 840 mg/kg/7W- intermittent | Endocrine: Hyperglycemia Blood: Other changes Nutritional and Gross Metabolic: Changes in: Ca | TOLED5 5,119,1980 |
| oral/rat | lowest published toxic dose: 185 mg/kg/22W- continuous | Endocrine: Changes in spleen weight Immunological Including Allergic: Decrease in cellular immune response Immunological Including Allergic: Decrease in humoral immune response | ARTODN 59,279,1986 |
| oral/rat | lowest published toxic dose: 45 mg/kg/30D- intermittent | Liver: Other changes Kidney, Ureter, and Bladder: Changes in bladder weight Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) | INHEAO 22,295,1984 |
| oral/rat | lowest published toxic dose: 126 mg/kg/6W- continuous | Liver: Changes in liver weight Immunological Including Allergic: Decrease in cellular immune response Immunological Including Allergic: Decrease in humoral immune response | BECTA6 38,435,1987 |
| oral/rat | lowest published toxic dose: 136.5 mg/kg/13W- intermittent | Kidney, Ureter, and Bladder: Other changes Endocrine: Changes in spleen weight | FEREAC 69,10443,2004 |
| oral/rat | lowest published toxic dose: 2482 mg/kg/2Y- intermittent | Vascular: Structural changes in vessels Kidney, Ureter, and Bladder: Changes primarily in glomeruli Nutritional and Gross Metabolic: Weight loss or decreased weight gain | FEREAC 69,10443,2004 |
| skin/rat | lowest published toxic dose: 567 mg/kg/21D- intermittent | Related to Chronic Data: Changes in uterine weight | FEREAC 69,10443,2004 |
| subcutaneous/rat | lowest published toxic dose: 250 mg/kg/10D- intermittent | Behavioral: Excitement | NETEEC 24,797,2002 |
| subcutaneous/rat | lowest published toxic dose: 2400 µg/kg/7D- intermittent | Endocrine: Estrogenic Skin and Appendages: Other: Breast | TOLED5 281,102,2017 |
| subcutaneous/rat | lowest published toxic dose: 67.5 mg/kg/15D- intermittent | Related to Chronic Data: Changes in ovarian weight Related to Chronic Data: Changes in testicular weight Related to Chronic Data: Changes in uterine weight | BDERB* 86,1,2009 |
| unreported route/mouse | lowest published toxic dose: 52.5 mg/kg/7D- intermittent | Endocrine: Androgenic Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Metabolism (intermediary): Other | BDERB* 86,1,2009 |
| unreported route/rat | lowest published toxic dose: 150 mg/kg/10W- intermittent | Liver: Other changes Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Biochemical: Metabolism (intermediary): Lipids including transport | BDERB* 86,1,2009 |
| unreported route/rat | lowest published toxic dose: 50 mg/kg/4D- intermittent | Endocrine: Hyperglycemia Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes | HBPTO* 1,879,2001 |
| unreported route/rat | lowest published toxic dose: 50 mg/kg/4D- intermittent | Brain and Coverings: Other degenerative changes Biochemical: Metabolism (intermediary): Effect on Na-K pump | HBPTO* 1,879,2001 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 0.1 mg/m3 (skin) | DTLVS* TLV/BEI,2013 |
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Not classifiable as a human carcinogen | DTLVS* TLV/BEI,2013 |
| TOXICOLOGY REVIEW | DTTIAF 80,485,1973 | |
| TOXICOLOGY REVIEW | RREVAH 56,107,1975 | |
| TOXICOLOGY REVIEW | TXCYAC 13,115,1979 | |
| TOXICOLOGY REVIEW | ETOPFR 7,156,2002 | |
| TOXICOLOGY REVIEW | GISAAA -,18,1993 | |
| TOXICOLOGY REVIEW | MUREAV 557,109,2004 | |
| TOXICOLOGY REVIEW | TOLED5 127,29,2002 | |
| TOXICOLOGY REVIEW | MUREAV 562,77,2004 | |
| TOXICOLOGY REVIEW | MUREAV 567,109,2004 | |
| TOXICOLOGY REVIEW | MUTAEX 21,93,2006 | |
| TOXICOLOGY REVIEW | BPCEM* 16,105,2002 | |
| TOXICOLOGY REVIEW | ENTOX* -,174,2005 | |
| TOXICOLOGY REVIEW | JTEHD6 7,1,2004 | |
| TOXICOLOGY REVIEW | FEREAC 71,24615,2006 | |
| TOXICOLOGY REVIEW | REPTED 26,1,2008 | |
| TOXICOLOGY REVIEW | JTPAE7 19,1,2006 | |
| TOXICOLOGY REVIEW | SIMEJ* 47,1030,2006 | |
| TOXICOLOGY REVIEW | FCTOD7 46,813,2008 | |
| TOXICOLOGY REVIEW | MUREAV 674,3,2009 | |
| TOXICOLOGY REVIEW | MUREAV 681,80,2009 | |
| TOXICOLOGY REVIEW | HETOEA 26,321,2007 | |
| TOXICOLOGY REVIEW | MUTAEX 26,19,2011 | |
| TOXICOLOGY REVIEW | MUTAEX 21,343,2006 | |
| TOXICOLOGY REVIEW | REPTED 33,269,2012 | |
| TOXICOLOGY REVIEW | REPTED 38,1,2013 | |
| TOXICOLOGY REVIEW | TOLED5 201,152,2011 | |
| TOXICOLOGY REVIEW | TXCYAC 307,74,2013 | |
| TOXICOLOGY REVIEW | TXCYAC 307,89,2013 | |
| TOXICOLOGY REVIEW | TOLED5 230,146,2014 | |
| TOXICOLOGY REVIEW | MUREAV 767,67,2016 | |
| TOXICOLOGY REVIEW | TXAPA9 268,157,2013 | |
| TOXICOLOGY REVIEW | FCTOD7 105,456,2017 | |
| TOXICOLOGY REVIEW | FCTOD7 107,20,2017 | |
| TOXICOLOGY REVIEW | RTOPDW 54,294,2009 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION | FEREAC 54,7740,1989 | |
| Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES | Supported | RBREV* -,117,1998 |
| Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 0.1 mg/m3 (skin) | DTLVS* 3,97,1971 |
| Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
| Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
| Occupational Exposure Limit-AUSTRALIA | time-weighted average 0.1 mg/m3, JUL2008 | |
| Occupational Exposure Limit-AUSTRIA | MAK-TMW 0.1 mg/m3;KZW 0.2 mg/m3, inhal, skin, 2007 | |
| Occupational Exposure Limit-BELGIUM | time-weighted average 0.1 mg/m3, Skin, MAR2002 | |
| Occupational Exposure Limit-DENMARK | time-weighted average 0.1 mg/m3, skin, MAY2011 | |
| Occupational Exposure Limit-FINLAND | time-weighted average 0.1 mg/m3, short term exposure limit 0.3 mg/m3, skin, NOV2011 | |
| Occupational Exposure Limit-FRANCE | VME 0.1 mg/m3, Skin, FEB2006 | |
| Occupational Exposure Limit-ICELAND | time-weighted average 0.1 mg/m3, skin, NOV2011 | |
| Occupational Exposure Limit-INDIA | time-weighted average 0.1 mg/m3, Skin, JAN1993 | |
| Occupational Exposure Limit-KOREA | time-weighted average 0.1 mg/m3, skin, 2006 | |
| Occupational Exposure Limit-MEXICO | time-weighted average 0.1 mg/m3;short term exposure limit 0.3 mg/m3 (skin), 2004 | |
| Occupational Exposure Limit-NEW ZEALAND | time-weighted average 0.1 mg/m3, skin, JAN2002 | |
| Occupational Exposure Limit-NORWAY | time-weighted average 0.1 mg/m3, JAN1999 | |
| Occupational Exposure Limit-PERU | time-weighted average 0,1 mg/m3, JUL2005 | |
| Occupational Exposure Limit-RUSSIA | short term exposure limit 0.1 mg/m3, Skin, JUN2003 | |
| Occupational Exposure Limit-SWITZERLAND | MAK-week 0.1 mg/m3, inhal, skin, JAN2011 | |
| Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 0.1 mg/m3, Skin, 2003 | |
| Occupational Exposure Limit-UNITED KINGDOM | time-weighted average 0.1 mg/m3;short term exposure limit 0.3 mg/m3, skin, OCT2007 | |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 0.1 mg/m3 (skin) | CFRGBR 29,1926.55,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 0.1 mg/m3 (skin) | CFRGBR 29,1910.1000,1993 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 0.1 mg/m3 (skin) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ENDOSULFAN-air | 10H time-weighted average 0.1 mg/m3 (Sk) | NIOSH* DHHS #95-121,1995 |
| National Occupational Exposure Survey 1983 | Hazard Code 28880; Number of Industries 1; Total Number of Facilities 291; Number of Occupations 1; Total Number of Employees Exposed 3205 | |
| National Occupational Hazard Survey 1974 | Hazard Code 28880; Number of Industries 1; Total Number of Facilities 43; Number of Occupations 8; Total Number of Employees Exposed 605 |
Status in Federal Agencies
| Organization | Reference |
|---|---|
| ATSDR TOXICOLOGY PROFILE (NTIS** PB/2000/108023) | |
| EPA TSCA Section 8(d) unpublished health/safety studies | |
| EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 | |
| NCI Carcinogenesis Bioassay (feed);no evidence:mouse,rat | NCITR* NCI-TR-62,1977 |
| On EPA IRIS database |
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health