Nitrogen monoxide

RTECS #

QX0525000

CAS #

10102-43-9; 51005-21-1; 90452-29-2; 90880-94-7
See: NMAM or OSHA Methods

Updated

March 2019

Molecular Weight

30.01

Molecular Formula

Synonyms

Amidogen, oxo-
Bioxyde d'azote (French)
Nitric oxide
Nitric oxide (ACGIH:OSHA)
Nitric oxide trimer
Nitrosyl radical
Oxyde nitrique (French)
RCRA waste number P076
Stickmonoxyd (German)

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
mutation in mammalian somatic cells	inhalation/rat	27 ppm/3H-continuous	MUREAV 136,119,1984
mutation in mammalian somatic cells	fibroblast/hamster	10 ppm	MUREAV 136,119,1984
mutation in microorganisms	/Salmonella typhimurium	30 ppm (+enzymatic activation step)	MUREAV 136,119,1984

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
inhalation/Dog	Lowest published lethal concentration: 5000 ppm/25M	Lung, Thorax, or Respiration: Acute pulmonary edema Blood: Methemoglobinemia- Carboxhemoglobinemia	BJANAD 39,393,1967
inhalation/Dog	lowest published toxic concentration: 20 ppm/6H	Lung, Thorax, or Respiration: Other changes	CYLPDN 23,278,2002
inhalation/human	lowest published toxic concentration: 76 mg/m³	Behavioral: Muscle weakness	VCVN5* -,32,1993
inhalation/mouse	Lowest published lethal concentration: 320 ppm	Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Cyanosis Blood: Methemoglobinemia- Carboxhemoglobinemia	AEPPAE 181,145,1936
inhalation/mouse	lowest published toxic concentration: 6000 mg/m³/4M	Behavioral: Alteration of classical conditioning	VCVN5* -,32,1993
inhalation/mouse	Lowest published lethal concentration: 6000 mg/m³/6M		VCVN5* -,32,1993
inhalation/mouse	lowest published toxic concentration: 3000 mg/m³/6M	Behavioral: Alteration of classical conditioning	VCVN5* -,32,1993
inhalation/mouse	Lowest published lethal concentration: 3000 mg/m³/12M		VCVN5* -,32,1993
inhalation/mouse	Lowest published lethal concentration: 320 ppm/1H		TXCYAC 208,177,2005
inhalation/rabbit	Lowest published lethal concentration: 315 ppm/15M		TXCYAC 208,177,2005
inhalation/rabbit	lowest published toxic concentration: 90 ppm/8H	Eye: Corneal damage	TXCYAC 208,177,2005
inhalation/rabbit	lowest published toxic concentration: 10 pph/20M	Blood: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes	CEXPB9 27,95,2000
inhalation/rat	lowest published toxic concentration: 140 mg/m³	Blood: Methemoglobinemia- Carboxhemoglobinemia	VCVN5* -,32,1993
inhalation/rat	lethal concentration (50 percent kill): 160 mg/m³		VCVN5* -,32,1993
inhalation/rat	Lowest published lethal concentration: 797 ppm/15M		TXCYAC 208,177,2005
inhalation/rat	lethal concentration (50 percent kill): 1068 mg/kg		ENTOX* -,230,2005
inhalation/rat	lowest published toxic concentration: 10 ppm/5H	Vascular: Structural changes in vessels Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes	TOXID9 -,437,2009

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/infant	lowest published toxic concentration: 20 ppm/5D- continuous	Lung, Thorax, or Respiration: Other changes	NEJMAG 342,469,2000
inhalation/mammal (species unspecified)	lowest published toxic concentration: 50 mg/m³/6H/7W- intermittent	Blood: Normocytic anemia	VCVN5* -,33,1989
inhalation/mouse	lowest published toxic concentration: 10 ppm/2H/30W- intermittent	Lung, Thorax, or Respiration: Emphysema Blood: Pigmented or nucleated red blood cells Blood: Changes in leukocyte (WBC) count	ENVRAL 19,154,1979
inhalation/rabbit	lowest published toxic concentration: 14 mg/m³/24H/17W- continuous	Cardiac: EKG changes not diagnostic of above Blood: Changes in erythrocyte (RBC) count	VCVN5* -,33,1989
inhalation/rat	lowest published toxic concentration: 1 mg/m³/3240H-continuous	Lung, Thorax, or Respiration: Emphysema Liver: Fatty liver degeneration Kidney, Ureter, and Bladder: Changes primarily in glomeruli	VCVN5* -,33,1989
inhalation/rat	lowest published toxic concentration: 14 mg/m³/24H/17W- continuous	Cardiac: EKG changes not diagnostic of above Blood: Changes in erythrocyte (RBC) count	VCVN5* -,33,1989
inhalation/rat	lowest published toxic concentration: 200 ppm/6H/7D- intermittent	Lung, Thorax, or Respiration: Acute pulmonary edema Blood: Methemoglobinemia- Carboxhemoglobinemia	TOXID9 42,253,1998
inhalation/rat	lowest published toxic concentration: 50 mg/m³/6H/7W- intermittent	Lung, Thorax, or Respiration: Changes in lung weight Liver: Changes in liver weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain	GTPZAB 19(4),52,1975
inhalation/rat	lowest published toxic concentration: 3 mg/m³/24H/16D- continuous	Brain and Coverings: Recordings from specific areas of CNS Blood: Methemoglobinemia- Carboxhemoglobinemia Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	GISAAA 48(9),69,1983
inhalation/rat	lowest published toxic concentration: 160 ppm/6H/4W- intermittent	Blood: Methemoglobinemia- Carboxhemoglobinemia	TOXID9 42,253,1998
inhalation/rat	lowest published toxic concentration: 9.8 ppm/72W- intermittent	Lung, Thorax, or Respiration: Emphysema	TXCYAC 208,177,2005

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 25 ppm	DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEW		CTOXAO 7,145,1974
TOXICOLOGY REVIEW		XPHBAO 272,1,1941
TOXICOLOGY REVIEW		TOLED5 139,163,2003
TOXICOLOGY REVIEW		TPHSDY 23,406,2002
TOXICOLOGY REVIEW		TPHSDY 24,560,2003
TOXICOLOGY REVIEW		TPHSDY 24,609,2003
TOXICOLOGY REVIEW		TPHSDY 24,389,2003
TOXICOLOGY REVIEW		ENTOX* -,230,2005
TOXICOLOGY REVIEW		MUREAV 533,65,2003
TOXICOLOGY REVIEW		MUREAV 533,173,2003
TOXICOLOGY REVIEW		MUTAEX 19,169,2004
TOXICOLOGY REVIEW		MUTAEX 19,423,2004
TOXICOLOGY REVIEW		PAREAQ 57,217,2005
TOXICOLOGY REVIEW		MUREAV 659,15,2008
TOXICOLOGY REVIEW		JTPAE7 20,77,2007
TOXICOLOGY REVIEW		MUREAV 658,68,2008
TOXICOLOGY REVIEW		HUTOX* -,661,1996
TOXICOLOGY REVIEW		HTOPA* 1,501,2002
TOXICOLOGY REVIEW		TPHSDY 29,402,2008
TOXICOLOGY REVIEW		MUREAV 674,3,2009
TOXICOLOGY REVIEW		MUREAV 636,144,2007
TOXICOLOGY REVIEW		MUREAV 667,142,2009
TOXICOLOGY REVIEW		CEXPB9 34,933,2007
TOXICOLOGY REVIEW		MUREAV 704,152,2010
TOXICOLOGY REVIEW		MUREAV 705,40,2010
TOXICOLOGY REVIEW		MUREAV 690,3,2010
TOXICOLOGY REVIEW		EMMUEG 50,68,2009
TOXICOLOGY REVIEW		MUREAV 751,15,2012
TOXICOLOGY REVIEW		MUREAV 751,77,2012
TOXICOLOGY REVIEW		MUREAV 752,153,2012
TOXICOLOGY REVIEW		MUREAV 753,131,2013
TOXICOLOGY REVIEW		EMMUEG 55,231,2014
TOXICOLOGY REVIEW		MUREAV 764-765,72,2014
TOXICOLOGY REVIEW		MUREAV 762,76,2014
TOXICOLOGY REVIEW		MUREAV 764,64,2015
TOXICOLOGY REVIEW		MUREAV 733,92,2012
TOXICOLOGY REVIEW		MUREAV 767,8,2016
TOXICOLOGY REVIEW		FCTOD7 94,93,2016
TOXICOLOGY REVIEW		MUREAV 774,46,2017
TOXICOLOGY REVIEW		REPTED 73,105,2017
TOXICOLOGY REVIEW		MUREAV 776,32,2018
TOXICOLOGY REVIEW		TOLED5 265,106,2017
TOXICOLOGY REVIEW		MUREAV 777,64,2018
TOXICOLOGY REVIEW		RTOPDW 54,247,2009
TOXICOLOGY REVIEW		MUREAV 778,13,2018

Standards and Regulations

Organization	Standard	Reference
Mine Safety and Health Administration (MSHA) STANDARD-air	time-weighted average 25 ppm (30 mg/m³)	DTLVS* 3,182,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 25 ppm (31 mg/m³), JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 25 ppm (30 mg/m³), 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 25 ppm (31 mg/m³), MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 25 ppm (30 mg/m³), MAY2011
Occupational Exposure Limit-FINLAND	time-weighted average 25 ppm (31 mg/m³), NOV2011
Occupational Exposure Limit-FRANCE	VME 25 ppm (30 mg/m³), FEB2006
Occupational Exposure Limit-GERMANY	MAK 0.5 ppm (0.63 mg/m³), 2011
Occupational Exposure Limit-HUNGARY	time-weighted average 30 mg/m³, SEP2000
Occupational Exposure Limit-ICELAND	time-weighted average 25 ppm (30 mg/m³), NOV2011
Occupational Exposure Limit-KOREA	time-weighted average 25 ppm (30 mg/m³), 2006
Occupational Exposure Limit-MEXICO	time-weighted average 25 ppm (30 mg/m³);short term exposure limit 35 ppm (45 mg/m³), 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 25 ppm (31 mg/m³), JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 25 ppm (30 mg/m³), JAN1999
Occupational Exposure Limit-PERU	time-weighted average 25 ppm (31 mg/m³), JUL2005
Occupational Exposure Limit-POLAND	MAC(time-weighted average) 5 mg/m³, MAC(short term exposure limit) 10 mg/m³, JAN1999
Occupational Exposure Limit-SWEDEN	time-weighted average 25 ppm (30 mg/m³);short term exposure limit 50 ppm (60 mg/m³), JUN2005
Occupational Exposure Limit-SWITZERLAND	MAK-week 25 ppm (30 mg/m³), JAN2011
Occupational Exposure Limit-THAILAND	time-weighted average 25 ppm (30 mg/m³), JAN1993
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 30 mg/m³, 2003
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 25 ppm (30 mg/m³)	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	8H time-weighted average 25 ppm (30 mg/m³)	CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 25 ppm (30 mg/m³)	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 25 ppm (30 mg/m³)	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO NITRIC OXIDE-air	10H time-weighted average 25 ppm	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code 50745; Number of Industries 3; Total Number of Facilities 59; Number of Occupations 16; Total Number of Employees Exposed 14332; Total Number of Female Employees Exposed 6183
National Occupational Hazard Survey 1974	Hazard Code 50745; Number of Industries 11; Total Number of Facilities 276; Number of Occupations 11; Total Number of Employees Exposed 1354

Status in Federal Agencies

Organization	Reference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Nitric oxide and nitrogen dioxide, 6014
On EPA IRIS database
OSHA ANALYTICAL METHOD #ID-109

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health