Nitric acid
RTECS #
QU5775000
CAS #
Updated
December 2018
Molecular Weight
63.02
Molecular Formula
HNO3
Synonyms
Acide nitrique (French)
Acido nitrico (Italian)
Aqua fortis
Azotic acid
Azotowy kwas (Polish)
Hydrogen nitrate
Kyselina dusicne (Czech)
Nitric acid (ACGIH:OSHA)
Salpetersaure (German)
Salpeterzuuroplossingen (Dutch)
Acido nitrico (Italian)
Aqua fortis
Azotic acid
Azotowy kwas (Polish)
Hydrogen nitrate
Kyselina dusicne (Czech)
Nitric acid (ACGIH:OSHA)
Salpetersaure (German)
Salpeterzuuroplossingen (Dutch)
Reproductive Effects Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
oral/rat | 21150 mg/kg (1-21D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | ZHYGAM 29,667,1983 |
oral/rat | 2345 mg/kg (18D pregnant) | Reproductive: Effects on newborn: Biochemical and metabolic | ZHYGAM 29,667,1983 |
Acute Toxicity Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
In Vitro/Human, liver tumor | Inhibitor Concentration (50 percent kill): 40 mmol/L/24H | In Vitro Toxicity Studies: Cell protein synthesis | TIVIEQ 3,189,1989 |
inhalation/cat | lowest published toxic concentration: 300 mg/m3/2H | Lung, Thorax, or Respiration: Acute pulmonary edema | VCVN5* -,45,1993 |
inhalation/cat | Lowest published lethal concentration: 500 mg/m3 | VCVN5* -,45,1993 | |
inhalation/rat | lethal concentration (50 percent kill): 260 mg/m3/30M | VCVN5* -,45,1993 | |
inhalation/rat | lethal concentration (50 percent kill): 130 mg/m3/4H | VCVN5* -,45,1993 | |
inhalation/rat | lowest published toxic concentration: 460 ppm/1H | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | TOXID9 44,302,2005 |
inhalation/rat | Lowest published lethal concentration: 919 ppm/1H | TOXID9 44,302,2005 | |
oral/human | lowest published lethal dose: 430 mg/kg | YAKUD5 22,651,1980 | |
skin/rat | lowest published toxic dose: 150 mL/kg | Blood: Methemoglobinemia- Carboxhemoglobinemia | VCVN5* -,46,1993 |
unreported route/man | lowest published lethal dose: 110 mg/kg | 85DCAI 2,73,1970 |
Other Multiple Dose Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/rat | lowest published toxic concentration: 1071 µg/m3/24H/84D- continuous | Behavioral: Muscle contraction or spasticity Kidney, Ureter, and Bladder: Other changes in urine composition Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | GISAAA 38(3),6,1973 |
inhalation/rat | lowest published toxic concentration: 50 µg/m3/4H/3D- intermittent | Lung, Thorax, or Respiration: Respiratory depression | INHTE5 8,595,1996 |
Reviews
Organization | Standard | Reference |
---|---|---|
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 2 ppm;short term exposure limit 4 ppm | DTLVS* TLV/BEI,2013 |
TOXICOLOGY REVIEW | ANAEA3 35,165,1975 | |
TOXICOLOGY REVIEW | ARTODN 39,299,1978 | |
TOXICOLOGY REVIEW | NCLNA* 16,107,1998 | |
TOXICOLOGY REVIEW | RTOPDW 54,247,2009 |
Standards and Regulations
Organization | Standard | Reference |
---|---|---|
Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 2 ppm (5 mg/m3) | DTLVS* 3,181,1971 |
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
Occupational Exposure Limit-ARAB Republic of Egypt | time-weighted average 2 ppm (5 mg/m3), JAN1993 | |
Occupational Exposure Limit-AUSTRALIA | time-weighted average 2 ppm (5.2 mg/m3), short term exposure limit 4 ppm (10 mg/m3), JUL2008 | |
Occupational Exposure Limit-AUSTRIA | MAK-KZW 1 ppm (2.6 mg/m3), 2007 | |
Occupational Exposure Limit-BELGIUM | short term exposure limit 1 ppm (2.6 mg/m3), MAR2002 | |
Occupational Exposure Limit-DENMARK | time-weighted average 1 ppm (2.6 mg/m3), MAY2011 | |
Occupational Exposure Limit-EC | short term exposure limit 2.6 mg/m3 (1 ppm), FEB2006 | |
Occupational Exposure Limit-FINLAND | time-weighted average 0.5 ppm (1.3 mg/m3), short term exposure limit 1 ppm (2.6 mg/m3), NOV2011 | |
Occupational Exposure Limit-FRANCE | VME 2 ppm (5 mg/m3), VLE 4 ppm (10 mg/m3), FEB2006 | |
Occupational Exposure Limit-HUNGARY | time-weighted average 5 mg/m3, short term exposure limit 5 mg/m3, SEP2000 | |
Occupational Exposure Limit-ICELAND | short term exposure limit 1 ppm (2.6 mg/m3), NOV2011 | |
Occupational Exposure Limit-JAPAN | Occupational Exposure Limit 2 ppm (5.2 mg/m3), MAY2012 | |
Occupational Exposure Limit-KOREA | time-weighted average 2 ppm (5 mg/m3), short term exposure limit 4 ppm (10 mg/m3), 2006 | |
Occupational Exposure Limit-MEXICO | time-weighted average 2 ppm (5 mg/m3);short term exposure limit 4 ppm (10 mg/m3), 2004 | |
Occupational Exposure Limit-NEW ZEALAND | time-weighted average 2 ppm (5.2 mg/m3), short term exposure limit 4 ppm (10 mg/m3), JAN2002 | |
Occupational Exposure Limit-NORWAY | time-weighted average 2 ppm (5 mg/m3), JAN1999 | |
Occupational Exposure Limit-PERU | time-weighted average 2 ppm (5.2 mg/m3); short term exposure limit 4 ppm (10.4 mg/m3), JUL2005 | |
Occupational Exposure Limit-POLAND | MAC(time-weighted average) 5 mg/m3, MAC(short term exposure limit) 10 mg/m3, JAN1999 | |
Occupational Exposure Limit-RUSSIA | short term exposure limit 2 mg/m3, Skin, JUN2003 | |
Occupational Exposure Limit-SWEDEN | time-weighted average 2 ppm (5 mg/m3);short term exposure limit 5 ppm (13 mg/m3), JUN2005 | |
Occupational Exposure Limit-SWITZERLAND | ceiling concentration 2 ppm (5 mg/m3), JAN2011 | |
Occupational Exposure Limit-THAILAND | time-weighted average 2 ppm (5 mg/m3), JAN1993 | |
Occupational Exposure Limit-THE PHILIPPINES | time-weighted average 2 ppm (5 mg/m3), JAN1993 | |
Occupational Exposure Limit-TURKEY | time-weighted average 2 ppm (5 mg/m3), JAN1993 | |
Occupational Exposure Limit-UNITED KINGDOM | short term exposure limit 1 ppm (2.6 mg/m3), OCT2007 | |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 2 ppm (5 mg/m3) | CFRGBR 29,1926.55,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 2 ppm (5 mg/m3) | CFRGBR 41,50-204.50,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 2 ppm (5 mg/m3) | CFRGBR 29,1910.1000,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 2 ppm (5 mg/m3) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
Organization | Standard | Reference |
---|---|---|
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO NITRIC ACID-air | 10H time-weighted average 2 ppm;short term exposure limit 4 ppm | NIOSH* DHHS #92-100,1992 |
National Occupational Exposure Survey 1983 | Hazard Code 50742; Number of Industries 201; Total Number of Facilities 18239; Number of Occupations 120; Total Number of Employees Exposed 297627; Total Number of Female Employees Exposed 76316 | |
National Occupational Hazard Survey 1974 | Hazard Code 50742; Number of Industries 197; Total Number of Facilities 18088; Number of Occupations 101; Total Number of Employees Exposed 132401 |
Status in Federal Agencies
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health