1-Naphthylamine
RTECS #
QM1400000
CAS #
Updated
June 2017
Molecular Weight
143.20
Molecular Formula
C10H9N
Synonyms
1-Aminonaftalen (Czech)
1-Aminonaphthalene
1-Naftilamina (Spanish)
1-Naftylamin (Czech)
1-Naftylamine (Dutch)
1-Naphthylamin (German)
Alfanaftilamina (Italian)
alfa-Naftyloamina (Polish)
alpha-Naftalamin (Czech)
alpha-Naftylamin (Czech)
alpha-Naphthylamine (DOT:OSHA)
C.I. Azoic Diazo Component 114
Fast Garnet B Base
Fast Garnet Base B
Naphthalidam
Naphthalidine
RCRA waste number U167
1-Aminonaphthalene
1-Naftilamina (Spanish)
1-Naftylamin (Czech)
1-Naftylamine (Dutch)
1-Naphthylamin (German)
Alfanaftilamina (Italian)
alfa-Naftyloamina (Polish)
alpha-Naftalamin (Czech)
alpha-Naftylamin (Czech)
alpha-Naphthylamine (DOT:OSHA)
C.I. Azoic Diazo Component 114
Fast Garnet B Base
Fast Garnet Base B
Naphthalidam
Naphthalidine
RCRA waste number U167
Mutation Data and Reference
System Test | Route/Organism/Tissue | Dose | Reference |
---|---|---|---|
Cytogenetic Analysis | liver/rat | 25 mg/L | PMRSDJ 1,570,1981 |
Cytogenetic Analysis | fibroblast/hamster | 60 mg/L/48H | MUREAV 48,337,1977 |
DNA adduct | oral/Dog | 60 µmol/kg | EVHPAZ 49,125,1983 |
DNA Damage | intraperitoneal/mouse | 150 mg/kg | CRNGDP 2,265,1981 |
DNA Damage | oral/mouse | 400 mg/kg | MUREAV 440,1,1999 |
DNA Damage | intraperitoneal/rat | 2790 µmol/kg | CRNGDP 2,1317,1981 |
DNA Damage | liver/rat | 3 mmol/L | SinJF# 26OCT1982 |
DNA Damage | /Bacillus subtilis | 2 mg/disc | PMRSDJ 1,175,1981 |
DNA inhibition | intraperitoneal/mouse | 20 gm/kg | ARGEAR 51,605,1981 |
DNA repair | /Saccharomyes cerevisiae | 100 mg/L | PMRSDJ 1,502,1981 |
DNA repair | /Escherichia coli | 25 mg/L | JJIND8 62,873,1979 |
gene conversion and mitotic recombination | /Saccharomyes cerevisiae | 50 ppm | PMRSDJ 1,481,1981 |
host-mediated assay | Salmonella typhimurium/mouse | 167 mg/kg | JJIND8 62,911,1979 |
host-mediated assay | Escherichia coli/mouse | 33 mg/kg | MUREAV 272,161,1992 |
micronucleus test | other cell types/mouse | 229.16 mg/L/4H (+enzymatic activation step) | MUTAEX 14,403,1999 |
morphological transform | embryo/hamster | 100 mg/L | AETODY 1,241,1980 |
morphological transform | mammary gland/mouse | 1 µg/L | CNREA8 39,1784,1979 |
morphological transform | other cell types/human | 65 mg/L | ITCSAF 17,719,1981 |
morphological transform | oral/rat | 400 mg/kg | CNREA8 40,1157,1980 |
mutation in mammalian somatic cells | lymphocyte/mouse | 1700 µg/L | PMRSDJ 1,580,1981 |
mutation in microorganisms | /Salmonella typhimurium | 0.9 µmol/L/16H (+enzymatic activation step) | EMMUEG 46,126,2005 |
mutation in microorganisms | /Saccharomyes cerevisiae | 10 mg/L/16H | MUTAEX 20,105,2004 |
mutation in microorganisms | /Bacillus subtilis | 5 gm/L (-enzymatic activation step) | MUREAV 42,19,1977 |
mutation in microorganisms | /Salmonella typhimurium | 50 µg/plate (+enzymatic activation step) | PMRSDJ 1,261,1981 |
mutation in microorganisms | /Salmonella typhimurium | 10 µg/plate (-enzymatic activation step) | ENMUDM 6,497,1984 |
other mutation test systems | /Escherichia coli | 35 nmol/tube | MUREAV 147,79,1985 |
phage inhibition capacity | /Escherichia coli | 250 mg/L | CNREA8 41,532,1981 |
sex chromosome loss and nondisjunction | /Saccharomyes cerevisiae | 100 mg/L | PMRSDJ 1,468,1981 |
sister chromatid exchange | intraperitoneal/mouse | 38 mg/kg | MUREAV 108,225,1983 |
specific locus test | ovary/hamster | 10 mg/L | PMRSDJ 1,594,1981 |
sperm morphology | intraperitoneal/mouse | 1260 mg/kg/5D- intermittent | CMMUAO 5,257,1978 |
Unscheduled DNA Synthesis | liver/hamster | 50 µmol/L | ENMUDM 6,1,1984 |
Unscheduled DNA Synthesis | fibroblast/human | 10 mg/L | PMRSDJ 1,528,1981 |
Unscheduled DNA Synthesis | liver/rat | 700 µmol/L | CNREA8 42,3010,1982 |
Tumorigenic Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
intraperitoneal/rat | lowest published toxic dose: 1300 mg/kg/13W- intermittent | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Blood: Leukemia | CNREA8 28,535,1968 |
Acute Toxicity Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
In Vitro/Human, melanoma | Inhibitor Concentration (50 percent kill): 4.1 mg/L/48H | In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc. | FCTOD7 50,2084,2012 |
intraperitoneal/mouse | lethal dose (50 percent kill): 96 mg/kg | PMRSDJ 1,682,1981 | |
oral/mammal (species unspecified) | lowest published lethal dose: 4 gm/kg | JIDHAN 13,87,1931 | |
subcutaneous/rabbit | lowest published lethal dose: 300 mg/kg | Behavioral: Tremor Behavioral: Muscle weakness | XPHBAO 271,174,1941 |
Reviews
Organization | Standard | Reference |
---|---|---|
International Agency for Research on Cancer (IARC) | Cancer Review:Animal Inadequate Evidence | IMEMDT 4,87,1974 |
International Agency for Research on Cancer (IARC) | Cancer Review:Human Inadequate Evidence | IMEMDT 4,87,1974 |
International Agency for Research on Cancer (IARC) | Cancer Review:Group 3 | IMSUDL 7,260,1987 |
TOXICOLOGY REVIEW | KHZHAZ 12(2),85,1976 | |
TOXICOLOGY REVIEW | ADCSAJ 13,271,1970 | |
TOXICOLOGY REVIEW | MUREAV 567,347,2004 | |
TOXICOLOGY REVIEW | MUREAV 578,88,2005 | |
TOXICOLOGY REVIEW | MUREAV 721,27,2011 | |
TOXICOLOGY REVIEW | MUREAV 752,99,2013 | |
TOXICOLOGY REVIEW | MUTAEX 31,117,2016 | |
TOXICOLOGY REVIEW | FCTOD7 94,93,2016 |
Standards and Regulations
Organization | Standard | Reference |
---|---|---|
Mine Safety and Health Administration (MSHA) STANDARD | skin-HUMAN CARCINOGEN, NO ASSIGNED time-weighted average | DTLWS* 3,24,1973 |
Occupational Exposure Limit-AUSTRIA | TRK-TMW 0.17 ppm (1 mg/m3);KZW 0.68 ppm (4 mg/m3), inhal, skin, 2007 | |
Occupational Exposure Limit-POLAND | MAC(time-weighted average) 0 mg/m3, MAC(short term exposure limit) 0 mg/m3, JAN1999 | |
Occupational Exposure Limit-SWEDEN | Group B Carcinogen, JUN2005 | |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | see Code of Federal Regulations (CFR) 29,1926.1104 | CFRGBR 29,1926.55,1994 |
Occupational Safety and Health Administration (OSHA)-cancer suspect agent | CFRGBR 29,1910.1004,1987 |
NIOSH Documentation and Surveillance
Organization | Standard | Reference |
---|---|---|
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO alpha-NAPHTHYLAMINE-air | Carcinogen use 29 Code of Federal Regulations (CFR) 1910.1004 | NIOSH* DHHS #92-100,1992 |
National Occupational Exposure Survey 1983 | Hazard Code 84304; Number of Industries 1; Total Number of Facilities 268; Number of Occupations 5; Total Number of Employees Exposed 2132; Total Number of Female Employees Exposed 1796 | |
National Occupational Hazard Survey 1974 | Hazard Code 84304; Number of Industries 2; Total Number of Facilities 66; Number of Occupations 2; Total Number of Employees Exposed 610 |
Status in Federal Agencies
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health