Morpholine, 4-ethyl-
RTECS #
QE4025000
CAS #
Updated
September 2013
Molecular Weight
115.20
Molecular Formula
C6H13NO
Synonyms
4-Ethylmorpholine
NEM
N-Ethylmorfolin (Czech)
N-Ethylmorpholine
N-Ethylmorpholine (ACGIH:OSHA)
NEM
N-Ethylmorfolin (Czech)
N-Ethylmorpholine
N-Ethylmorpholine (ACGIH:OSHA)
Skin and Eye Irritation and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
skin /rabbit | 453 mg open irritation test | mild | UCDS** 11/3/1971 |
Mutation Data and Reference
System Test | Route/Organism/Tissue | Dose | Reference |
---|---|---|---|
mutation in microorganisms | /Salmonella typhimurium | 6667 µg/plate (-enzymatic activation step) | ENMUDM 9(Suppl 9),1,1987 |
Acute Toxicity Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
In Vitro/pzx | Inhibitor Concentration Low: 100 µmol/L/2H | In Vitro Toxicity Studies: Other assays | TXCYAC 276,27,2010 |
inhalation/mouse | lethal concentration (50 percent kill): 18000 mg/m3/2H | TPKVAL 15,116,1979 | |
inhalation/rat | Lowest published lethal concentration: 2000 ppm/4H | AMIHBC 10,61,1954 | |
intravenous/mouse | lethal dose (50 percent kill): 180 mg/kg | CSLNX* NX#04778 | |
oral/mammal (species unspecified) | lethal dose (50 percent kill): 1200 mg/kg | GISAAA 39(4),86,1974 | |
oral/mouse | lethal dose (50 percent kill): 1200 mg/kg | Lung, Thorax, or Respiration: Other changes Liver: Liver function tests impaired Blood: Other changes | TPKVAL 15,116,1979 |
oral/rat | lethal dose (50 percent kill): 1780 mg/kg | DTLWS* 4,190,1982 |
Reviews
Organization | Standard | Reference |
---|---|---|
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 5 ppm (skin) | DTLVS* TLV/BEI,2013 |
TOXICOLOGY REVIEW | CHHSA* 9,6,2002 |
Standards and Regulations
Organization | Standard | Reference |
---|---|---|
Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 20 ppm (94 mg/m3) (skin) | DTLVS* 3,113,1971 |
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
Occupational Exposure Limit-AUSTRALIA | time-weighted average 5 ppm (24 mg/m3), JUL2008 | |
Occupational Exposure Limit-AUSTRIA | MAK-TMW 5 ppm (23 mg/m3);KZW 10 ppm (46 mg/m3), skin, 2007 | |
Occupational Exposure Limit-BELGIUM | time-weighted average 5 ppm (24 mg/m3), Skin, MAR2002 | |
Occupational Exposure Limit-DENMARK | time-weighted average 5 ppm (23.5 mg/m3), skin, MAY2011 | |
Occupational Exposure Limit-FINLAND | time-weighted average 5 ppm (24 mg/m3), short term exposure limit 10 ppm (48 mg/m3), skin, NOV2011 | |
Occupational Exposure Limit-FRANCE | VME 5 ppm (23 mg/m3), Skin, FEB2006 | |
Occupational Exposure Limit-ICELAND | time-weighted average 5 ppm (23.5 mg/m3), skin, NOV2011 | |
Occupational Exposure Limit-KOREA | time-weighted average 5 ppm (23 mg/m3), skin, 2006 | |
Occupational Exposure Limit-MEXICO | time-weighted average 20 ppm (95 mg/m3) (skin), 2004 | |
Occupational Exposure Limit-NEW ZEALAND | time-weighted average 5 ppm (24 mg/m3), skin, JAN2002 | |
Occupational Exposure Limit-NORWAY | time-weighted average 5 ppm (23 mg/m3), JAN1999 | |
Occupational Exposure Limit-PERU | time-weighted average 5 ppm (24 mg/m3), JUL2005 | |
Occupational Exposure Limit-RUSSIA | time-weighted average 5 mg/m3, short term exposure limit 15 mg/m3, Skin, JUN2003 | |
Occupational Exposure Limit-SWEDEN | time-weighted average 5 ppm (25 mg/m3);short term exposure limit 10 ppm (50 mg/m3), Skin, JUN2005 | |
Occupational Exposure Limit-SWITZERLAND | MAK-week 5 ppm (25 mg/m3), skin, JAN2011 | |
Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 23 mg/m3, Skin, 2003 | |
Occupational Exposure Limit-UNITED KINGDOM | time-weighted average 5 ppm (24 mg/m3);short term exposure limit 20 ppm (96 mg/m3), skin, OCT2007 | |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 20 ppm (94 mg/m3) (skin) | CFRGBR 29,1926.55,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 20 ppm (94 mg/m3) (skin) | CFRGBR 41,50-204.50,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 20 ppm (94 mg/m3) (skin) | CFRGBR 29,1910.1000,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 20 ppm (94 mg/m3) (skin) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
Organization | Standard | Reference |
---|---|---|
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO N-ETHYLMORPHOLINE-air | 10H time-weighted average 5 ppm (Sk) | NIOSH* DHHS #92-100,1992 |
National Occupational Hazard Survey 1974 | Hazard Code 32840; Number of Industries 3; Total Number of Facilities 37; Number of Occupations 3; Total Number of Employees Exposed 967 |
Status in Federal Agencies
Organization | Reference |
---|---|
EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 |
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health