Methylamine
RTECS #
PF6300000
CAS #
Updated
September 2013
Molecular Weight
31.07
Molecular Formula
CH5N
Synonyms
Aminomethane
Carbinamine
Mercurialin
Methanamine (9CI)
Methylamine (ACGIH:OSHA)
Methylaminen (Dutch)
Metilamine (Italian)
Metyloamina (Polish)
Monomethylamine
Carbinamine
Mercurialin
Methanamine (9CI)
Methylamine (ACGIH:OSHA)
Methylaminen (Dutch)
Metilamine (Italian)
Metyloamina (Polish)
Monomethylamine
Skin and Eye Irritation and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| eye /rabbit | 40% | severe | ENTOX* 86,-,2005 |
| eye /rabbit | 5% | mild | ENTOX* 86,-,2005 |
| skin /guinea pig | 100 mg open irritation test | severe | CODEDG 6,140,1980 |
| skin /rabbit | 40% | severe | ENTOX* 86,-,2005 |
Mutation Data and Reference
| System Test | Route/Organism/Tissue | Dose | Reference |
|---|---|---|---|
| Dominant Lethal Test | inhalation/rat | 10 µg/m3 | GISAAA 46(5),7,1981 |
| mutation in mammalian somatic cells | lymphocyte/mouse | 3 mmol/L | MUREAV 174,285,1986 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/cat | lowest published toxic concentration: 0.4 gm/m3 | TPKVAL 7,56,1965 | |
| inhalation/human | lowest published toxic concentration: 0.01 gm/m3 | Behavioral: Alteration of classical conditioning | TPKVAL 7,56,1965 |
| inhalation/mammal (species unspecified) | lethal concentration (50 percent kill): 2400 mg/m3 | TPKVAL 14,80,1975 | |
| inhalation/mammal (species unspecified) | lethal concentration (50 percent kill): 3.7 gm/m3 | Eye: Conjunctiva irritation | TPKVAL 7,56,1965 |
| inhalation/mouse | lethal concentration (50 percent kill): 2400 mg/m3/2H | ENTOX* -,86,2005 | |
| inhalation/rat | lethal concentration (50 percent kill): 448 ppm/2.5H | Eye: Lacrimation Lung, Thorax, or Respiration: Dyspnea Skin: After systemic exposure: Dermatitis, irritative | JEBIDP 13,273,1992 |
| inhalation/rat | lethal concentration (50 percent kill): 448 ppm/2.5H | ENTOX* -,86,2005 | |
| intracerebral/mouse | lowest published toxic dose: 88.8 ng/kg | Brain and Coverings: Other degenerative changes Behavioral: Food intake (animal) | BJPCBM 142,381,2004 |
| intracerebral/rat | lowest published toxic dose: 78.95 µg/kg | Brain and Coverings: Other degenerative changes Behavioral: Food intake (animal) | BJPCBM 150,1003,2007 |
| intracerebral/rat | lowest published toxic dose: 315.79 µg/kg | Behavioral: Food intake (animal) Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites | BJPCBM 150,1003,2007 |
| oral/rat | lethal dose (50 percent kill): 100 mg/kg | ENTOX* -,86,2005 | |
| subcutaneous/guinea pig | lowest published lethal dose: 200 mg/kg | HBAMAK 4,1289,1935 | |
| subcutaneous/mouse | lowest published lethal dose: 2500 mg/kg | 85KYAH 11,949,1989 | |
| subcutaneous/rat | lowest published lethal dose: 200 mg/kg | HBAMAK 4,1289,1935 | |
| unreported route/mouse | lethal dose (50 percent kill): 317 mg/kg | HBPTO* 1,825,2001 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/rat | lowest published toxic concentration: 750 ppm/6H/2W- intermittent | Olfaction: Other olfaction effects Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Related to Chronic Data: Changes in testicular weight | INHTE5 2,29,1990 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 5 ppm;short term exposure limit 15 ppm | DTLVS* TLV/BEI,2013 |
| TOXICOLOGY REVIEW | CHREAY 9,389,1931 | |
| TOXICOLOGY REVIEW | ENTOX* -,86,2005 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 10 ppm (12 mg/m3) | DTLVS* 3,156,1971 |
| Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
| Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
| Occupational Exposure Limit-AUSTRALIA | time-weighted average 10 ppm (13 mg/m3), JUL2008 | |
| Occupational Exposure Limit-AUSTRIA | MAK-TMW 10 ppm (12 mg/m3);KZW 10 ppm (12 mg/m3), 2007 | |
| Occupational Exposure Limit-BELGIUM | time-weighted average 5 ppm (6.6 mg/m3), short term exposure limit 15 ppm (19 mg/m3), MAR2002 | |
| Occupational Exposure Limit-DENMARK | time-weighted average 5 ppm (6.4 mg/m3), skin, MAY2011 | |
| Occupational Exposure Limit-FINLAND | short term exposure limit 10 ppm (13 mg/m3), NOV2011 | |
| Occupational Exposure Limit-GERMANY | MAK 10 ppm (13 mg/m3), 2011 | |
| Occupational Exposure Limit-ICELAND | time-weighted average 5 ppm (6.4 mg/m3), skin, NOV2011 | |
| Occupational Exposure Limit-JAPAN | Occupational Exposure Limit 10 ppm (13 mg/m3), MAY2012 | |
| Occupational Exposure Limit-KOREA | time-weighted average 10 ppm (12 mg/m3), 2006 | |
| Occupational Exposure Limit-MEXICO | time-weighted average 10 ppm (12 mg/m3), 2004 | |
| Occupational Exposure Limit-NEW ZEALAND | time-weighted average 10 ppm (13 mg/m3), JAN2002 | |
| Occupational Exposure Limit-NORWAY | time-weighted average 10 ppm (12 mg/m3), JAN1999 | |
| Occupational Exposure Limit-PERU | time-weighted average 5 ppm (6,4 mg/m3); short term exposure limit 15 ppm (19 mg/m3), JUL2005 | |
| Occupational Exposure Limit-POLAND | MAC(time-weighted average) 5 mg/m3, MAC(short term exposure limit) 15 mg/m3, JAN1999 | |
| Occupational Exposure Limit-RUSSIA | short term exposure limit 1 mg/m3, Skin, JUN2003 | |
| Occupational Exposure Limit-SWEDEN | time-weighted average 10 ppm (13 mg/m3);short term exposure limit 20 ppm (25 mg/m3), Skin, JUN2005 | |
| Occupational Exposure Limit-SWITZERLAND | ceiling concentration 10 ppm (12 mg/m3), JAN2011 | |
| Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 6.4 mg/m3, 2003 | |
| Occupational Exposure Limit-THE PHILIPPINES | time-weighted average 10 ppm (12 mg/m3), JAN1993 | |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 10 ppm (12 mg/m3) | CFRGBR 29,1926.55,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 10 ppm (12 mg/m3) | CFRGBR 41,50-204.50,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 10 ppm (12 mg/m3) | CFRGBR 29,1910.1000,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 10 ppm (12 mg/m3) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METHYLAMINE-air | 10H time-weighted average 10 ppm | NIOSH* DHHS #92-100,1992 |
| National Occupational Exposure Survey 1983 | Hazard Code 46470; Number of Industries 6; Total Number of Facilities 197; Number of Occupations 24; Total Number of Employees Exposed 10890; Total Number of Female Employees Exposed 1411 | |
| National Occupational Hazard Survey 1974 | Hazard Code 46470; Number of Industries 5; Total Number of Facilities 175; Number of Occupations 9; Total Number of Employees Exposed 1098 |
Status in Federal Agencies
| Organization | Reference |
|---|---|
| EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
| EPA TSCA Section 8(d) unpublished health/safety studies | |
| EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 | |
| OSHA ANALYTICAL METHOD #40 |
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health