4,7-Methanoindan, 1,2,4,5,6,7,8,8-octachloro-3a,4,7,7a-tetrahydro-

RTECS #

PB9800000

CAS #

57-74-9; 39400-80-1; 53637-13-1
See: NMAM or OSHA Methods

Updated

March 2019

Molecular Weight

409.76

Molecular Formula

C₁₀H₆Cl₈

Synonyms

1,2,4,5,6,7,10,10-Octachloro-4,7,8,9-tetrahydro-4,7-methyleneindane
1,2,4,5,6,7,8,8-Octachloor-3a,4,7,7a-tetrahydro-4,7-endo-methano-indaan (Dutch)
1,2,4,5,6,7,8,8-Octachlor-2,3,3a,4,7,7a-hexahydro-4,7-methanoindane
1,2,4,5,6,7,8,8-Octachlor-3a,4,7,7a-tetrahydro-4,7-endo-methano-indan (German)
1,2,4,5,6,7,8,8-Octachloro-2,3,3a,4,7,7a-hexahydro-4,7-methano-1H-indene
1,2,4,5,6,7,8,8-Octachloro-2,3,3a,4,7,7a-hexahydro-4,7-methanoindene
1,2,4,5,6,7,8,8-Octachloro-3a,4,7,7a-hexahydro-4,7-methylene indane
1,2,4,5,6,7,8,8-Octachloro-3a,4,7,7a-tetrahydro-4,7-methanoindane
1,2,4,5,6,7,8,8-Octachloro-4,7-methano-3a,4,7,7a-tetrahydroindane
1,2,4,5,6,7,8,8-Octahydro-2,3,3a,4,7,7a-hexahydro-4,7-methanoindan
1,2,4,5,6,7,8,8-Ottochloro-3a,4,7,7a-tetraidro-4,7-endo-metano-indano (Italian)
4,7-Methano-1H-indene, 1,2,4,5,6,7,8,8-octachloro-2,3,3a,4,7,7a-hexahydro-
Aspon-chlordane
BELT
CD 68
Chloordaan (Dutch)
Chlor KIL
Chlordan
Chlordane
Chlordane (ACGIH:OSHA)
Chlorindan
Chlorodane
Chlortox
Clordan (Italian)
Clordano
Cortilan-neu
Dichlorochlordene
Dowchlor
ENT 25,552-X
ENT 9,932
HCS 3260
Kilex lindane
Kypchlor
Latka 1068 (Czech)
M 140
NCI-C00099
Octachlor
Octachloro-4,7-methanohydroindane
Octachloro-4,7-methanotetrahydroindane
Octachlorodihydrodicyclopentadiene
Octa-klor
Oktaterr
OMS 1437
Ortho-klor
RCRA waste number U036
SD 5532
Shell SD-5532
Starchlor
Synklor
TAT chlor 4
Termi-ded
Topichlor 20
Topiclor
Topiclor 20
Toxichlor
Unexan-koeder
Velsicol 1068

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
Cytogenetic Analysis	oral/mouse	10 mg/kg	MUREAV 301,33,1993
morphological transform	oral/rat	1260 mg/kg/6W	CRNGDP 9,387,1988
mutation in mammalian somatic cells	lung/hamster	10 µmol/L	CBINA8 19,369,1977
other mutation test systems	oral/mouse	35 mg/kg	MUREAV 343,157,1995
phage inhibition capacity	/Escherichia coli	3050 µmol/L	MUREAV 182,193,1987
sister chromatid exchange	multiple/other fish	54 pmol/L	MUREAV 118,61,1983
sister chromatid exchange	lymphocyte/human	10 µmol/L	ARTODN 52,221,1983
Unscheduled DNA Synthesis	fibroblast/human	1 µmol/L	MUREAV 42,161,1977

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
oral/mouse	3360 µg/kg (1-21D pregnant)	Reproductive: Specific developmental abnormalities: Endocrine system Reproductive: Effects on newborn: Biochemical and metabolic	JEPTDQ 2(2),357,1978
oral/mouse	152 mg/kg (1-19D pregnant)	Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial system	TXAPA9 62,402,1982
oral/mouse	7 mg/kg (15-21D pregnant)	Reproductive: Effects on newborn: Behavioral	BJPCBM 49,311,1973
oral/mouse	3040 µg/kg (1-19D pregnant)	Reproductive: Effects on newborn: Biochemical and metabolic	ENVRAL 35,204,1984
oral/mouse	2625 mg/kg (5W male)	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct	TOLED5 115,1,2000
unreported route/mouse	168 mg/kg (1-21D pregnant)	Reproductive: Effects on newborn: Delayed effects	APTOD9 19,A18,1980
unreported route/mouse	168 mg/kg (1-21D pregnant)	Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial system	TJADAB 19,23A,1979

Tumorigenic Data and References

Route/Organism	Dose	Effect	Reference
oral/mouse	lowest published toxic dose: 2020 mg/kg/80W- continuous	Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors	NCITR* NCI-TR-8,1977
oral/mouse	toxic dose: 3780 mg/kg/80W- continuous	Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors	NCITR* NCI-TR-8,1977

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
In Vitro/Mouse, fibroblast	Inhibitor Concentration (10 percent kill): 24 µmol/L/24H	In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.	TIVIEQ 2,1,1988
In Vitro/Mouse, fibroblast	Inhibitor Concentration (50 percent kill): 39 µmol/L/24H	In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.	TIVIEQ 2,1,1988
In Vitro/Mouse, fibroblast	Inhibitor Concentration (10 percent kill): 15 µmol/L/24H	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	TIVIEQ 2,1,1988
In Vitro/Mouse, fibroblast	Inhibitor Concentration (50 percent kill): 47 µmol/L/24H	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	TIVIEQ 2,1,1988
In Vitro/Rat, liver	Inhibitor Concentration (50 percent kill): 4 µmol/L/1H	In Vitro Toxicity Studies: Other assays	TXAPA9 247,10,2010
In Vitro/Rat, neurons	Inhibitor Concentration Low: 40 µmol/L/1H	In Vitro Toxicity Studies: Other assays	NRTXDN 44,204,2014
inhalation/cat	lethal concentration (50 percent kill): 100 mg/m³/4H	Behavioral: Somnolence (general depressed activity) Behavioral: Convulsions or effect on seizure threshold Behavioral: Excitement	GTPZAB 8(4),30,1964
inhalation/mammal (species unspecified)	lethal concentration (50 percent kill): >20 gm/m³/4H		PEMNDP 9,139,1991
intraperitoneal/mouse	lowest published lethal dose: 240 mg/kg		TXAPA9 23,288,1972
intraperitoneal/rat	lethal dose (50 percent kill): 343 mg/kg		TXAPA9 32,443,1975
intraperitoneal/rat	lowest published toxic dose: 25 mg/kg	Biochemical: Metabolism (intermediary): Other	ENDOAO 82,406,1968
intravenous/mouse	lethal dose (50 percent kill): 100 mg/kg		CSLNX* NX#04876
intravenous/rabbit	lowest published lethal dose: 10 mg/kg		AIHOAX 1,13,1950
oral/cat	lethal dose (50 percent kill): 100 mg/kg		VCVGH* -,565,1990
oral/chicken	lethal dose (50 percent kill): 220 mg/kg		PCOC** -,226,1966
oral/domestic animal	lethal dose (50 percent kill): 50 mg/kg		YKYUA6 32,471,1981
oral/duck	lethal dose (50 percent kill): 1200 mg/kg		DOEAAH 35,25,1979
oral/hamster	lethal dose (50 percent kill): 1720 mg/kg		EJTXAZ 7,159,1974
oral/human	lowest published lethal dose: 29 mg/kg	Liver: Fatty liver degeneration	CMEP** -,1,1956
oral/mammal (species unspecified)	lethal dose (50 percent kill): 180 mg/kg		PCOC** -,226,1966
oral/man	lowest published toxic dose: 3071 µg/kg	Behavioral: Coma Lung, Thorax, or Respiration: Dyspnea Gastrointestinal: Nausea or vomiting	JTCTDW 20,291,1983
oral/mouse	lethal dose (50 percent kill): 145 mg/kg		ARSIM* 20,19,1966
oral/rabbit	lethal dose (50 percent kill): 100 mg/kg		PCOC** -,226,1966
oral/rat	lethal dose (50 percent kill): 200 mg/kg		ARZNAD 17,614,1967
oral/rat	lethal dose (50 percent kill): 200 mg/kg/24H	Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Respiratory depression Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)	TAEHC* VI:34 ,1,1984
oral/woman	lowest published lethal dose: 120 µg/kg	Behavioral: Convulsions or effect on seizure threshold Behavioral: Excitement Gastrointestinal: Gastritis	CMEP** -,1,1956
skin/human	lowest published lethal dose: 428 mg/kg	Behavioral: Tremor Behavioral: Convulsions or effect on seizure threshold Behavioral: Ataxia	34ZIAG -,648,1969
skin/rabbit	lethal dose (50 percent kill): 780 mg/kg		85DPAN -,-,1971/1976
skin/rat	lethal dose (50 percent kill): 690 mg/kg		JAVMA4 157,1835,1970
unreported route/human	lowest published lethal dose: 25 mg/kg/24H		TAEHC* VI:34 ,1,1984
unreported route/man	lowest published lethal dose: 118 mg/kg		85DCAI 2,73,1970

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/rat	lowest published toxic concentration: 28200 µg/m³/8H/28D- intermittent	Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in bladder weight Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)	JTEHD6 28,327,1989
inhalation/rat	lowest published toxic concentration: 10 mg/m³/8H/90D- intermittent	Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in bladder weight Nutritional and Gross Metabolic: Changes in: Ca	JTEHD6 28,327,1989
intraperitoneal/rat	lowest published toxic dose: 125 mg/kg/5D- intermittent	Liver: Changes in liver weight Biochemical: Metabolism (intermediary): Other	ENDOAO 82,406,1968
intraperitoneal/rat	lowest published toxic dose: 500 mg/kg/10D- intermittent	Endocrine: Androgenic Endocrine: Estrogenic Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)	CLPTAT 14,727,1976
oral/rat	lowest published toxic dose: 7 mg/kg/28D- intermittent	Immunological Including Allergic: Decrease in cellular immune response	TOXID9 60,22,2001
oral/rat	lowest published toxic dose: 168 mg/kg/21D- intermittent	Endocrine: Other changes Blood: Changes in spleen	TOXID9 1,54,2001
oral/rat	lowest published toxic dose: 21 mg/kg/21D- intermittent	Liver: Other changes Liver: Changes in liver weight	TOXID9 1,54,2001
oral/rat	lowest published toxic dose: 176 mg/kg/22D- intermittent	Peripheral Nerve and Sensation: Sensory change involving peripheral nerve Behavioral: Tremor Behavioral: Convulsions or effect on seizure threshold	TOXID9 60,233,2001
oral/rat	lowest published toxic dose: 176 mg/kg/22D- intermittent	Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	TOXID9 60,233,2001
oral/rat	lowest published toxic dose: 44 mg/kg/22D- intermittent	Nutritional and Gross Metabolic: Weight loss or decreased weight gain	TOXID9 60,233,2001
oral/rat	lowest published toxic dose: 22 mg/kg/22D- intermittent	Liver: Changes in liver weight	TOXID9 60,233,2001
oral/rat	lowest published toxic dose: 44 mg/kg/22D- intermittent	Endocrine: Changes in spleen weight Endocrine: Changes in thymus weight	TOXID9 60,233,2001
oral/rat	lowest published toxic dose: 112 mg/kg/14D- intermittent	Behavioral: Convulsions or effect on seizure threshold Behavioral: Change in motor activity (specific assay) Gastrointestinal: Changes in structure or function of salivary glands	TOXID9 60,247,2001
oral/rat	lowest published toxic dose: 112 mg/kg/14D- intermittent	Endocrine: Changes in thymus weight Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	TOXID9 60,247,2001
oral/rat	lowest published toxic dose: 224 mg/kg/14D- intermittent	Lung, Thorax, or Respiration: Respiratory depression	TOXID9 60,247,2001
oral/rat	lowest published toxic dose: 28 mg/kg/14D- intermittent	Endocrine: Changes in spleen weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain	TOXID9 60,247,2001
oral/rat	lowest published toxic dose: 504 mg/kg/12W- continuous	Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	APTOD9 19,A99,1980
oral/rat	lowest published toxic dose: 410 mg/kg/39W- continuous	Liver: Other changes	AMPLAO 64,614,1957
oral/rat	lowest published toxic dose: 660 mg/kg/15D- intermittent	Behavioral: Convulsions or effect on seizure threshold Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	AMIHBC 7,197,1953
oral/rat	lowest published toxic dose: 6512 mg/kg/58W- intermittent	Liver: Changes in liver weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain	AMIHBC 7,197,1953
oral/rat	lowest published toxic dose: 5475 mg/kg/2Y- continuous	Liver: Hepatitis (hepatocellular necrosis), zonal Liver: Changes in liver weight Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	AMIHBC 6,357,1952

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 0.5 mg/m³ (skin)	DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-Confirmed animal carcinogen	DTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)	Cancer Review:Animal Sufficient Evidence	IMEMDT 20,45,1979
International Agency for Research on Cancer (IARC)	Cancer Review:Animal Limited Evidence	IMSUDL 7,146,1987
International Agency for Research on Cancer (IARC)	Cancer Review:Animal Sufficient Evidence	IMEMDT 53,115,1991
International Agency for Research on Cancer (IARC)	Cancer Review:Human Inadequate Evidence	IMEMDT 20,45,1979
International Agency for Research on Cancer (IARC)	Cancer Review:Human Inadequate Evidence	IMEMDT 53,115,1991
International Agency for Research on Cancer (IARC)	Cancer Review:Group 2B	IMEMDT 53,115,1991
TOXICOLOGY REVIEW		CNDQA8 10(3),43,1975
TOXICOLOGY REVIEW		RREVAH 56,107,1975
TOXICOLOGY REVIEW		BNYMAM 54,413,1978
TOXICOLOGY REVIEW		CTOXAO 13,231,1978
TOXICOLOGY REVIEW		MUREAV 567,109,2004
TOXICOLOGY REVIEW		NETOX* 26,531,2005
TOXICOLOGY REVIEW		ENTOX* -,540,2005
TOXICOLOGY REVIEW		ENTOX* -,334,2005
TOXICOLOGY REVIEW		MUREAV 584,1,2005
TOXICOLOGY REVIEW		HETOEA 25,413,2006
TOXICOLOGY REVIEW		JTEHD6 7,1,2004
TOXICOLOGY REVIEW		REPTED 23,260,2007
TOXICOLOGY REVIEW		ITODC* -,327,2004
TOXICOLOGY REVIEW		HTOPA* 1,501,2002
TOXICOLOGY REVIEW		TPHSDY 29,322,2008
TOXICOLOGY REVIEW		FCTOD7 46,813,2008
TOXICOLOGY REVIEW		BLREV* 3,71,1989
TOXICOLOGY REVIEW		MUREAV 682,94,2009
TOXICOLOGY REVIEW		IMEMDT 79,411,
TOXICOLOGY REVIEW		MUTAEX 23,271,2008
TOXICOLOGY REVIEW		NBREV* 5,1,1981
TOXICOLOGY REVIEW		NTAPM* -,711,1995
TOXICOLOGY REVIEW		REPTED 31,327,2011
TOXICOLOGY REVIEW		MUREAV 762,37,2014
TOXICOLOGY REVIEW		TXCYAC 307,123,2013
TOXICOLOGY REVIEW		TXAPA9 268,157,2013
TOXICOLOGY REVIEW		VETOX* ,339,2018

Standards and Regulations

Organization	Standard	Reference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION		FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES	Cancelled	RBREV* -,96,1998
Mine Safety and Health Administration (MSHA) STANDARD-air	time-weighted average 0.5 mg/m³ (skin)	DTLVS* 3,44,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-ARAB Republic of Egypt	time-weighted average 0.5 mg/m³, Skin, JAN1993
Occupational Exposure Limit-AUSTRALIA	time-weighted average 0.5 mg/m³, short term exposure limit 3 mg/m³, Carcinogen, JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 0.5 mg/m³;KZW 5 mg/m³, inhal, skin, 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 0.5 mg/m³, Skin, MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 0.5 mg/m³, skin, carc, MAY2011
Occupational Exposure Limit-FRANCE	VME 0.5 mg/m³, Skin, C3 Carcinogen, FEB2006
Occupational Exposure Limit-GERMANY	MAK 0.5 mg/m³, inhal, 2011
Occupational Exposure Limit-HUNGARY	Skin, SEP2000
Occupational Exposure Limit-ICELAND	time-weighted average 0.5 mg/m³, skin, NOV2011
Occupational Exposure Limit-JAPAN	2B carc, MAY2012
Occupational Exposure Limit-KOREA	time-weighted average 0.5 mg/m³, short term exposure limit 2 mg/m³, skin, 2006
Occupational Exposure Limit-MEXICO	time-weighted average 0.5 mg/m³;short term exposure limit 2 mg/m³ (skin), 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 0.5 mg/m³, skin, JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 0.5 mg/m³, JAN1999
Occupational Exposure Limit-PERU	time-weighted average 0.5 mg/m³, JUL2005
Occupational Exposure Limit-RUSSIA	short term exposure limit 0.01 mg/m³, Skin, JUN2003
Occupational Exposure Limit-SWITZERLAND	MAK-week 0.5 mg/m³, carc 3, inhal, skin, JAN2011
Occupational Exposure Limit-THAILAND	time-weighted average 0.5 mg/m³, JAN1993
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 0.5 mg/m³, Skin, 2003
Occupational Exposure Limit-THE PHILIPPINES	time-weighted average 0.5 mg/m³, Skin, JAN1993
Occupational Exposure Limit-TURKEY	time-weighted average 0.5 mg/m³, Skin, JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 0.5 mg/m³ (skin)	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	8H time-weighted average 0.5 mg/m³ (skin)	CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 0.5 mg/m³ (skin)	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 0.5 mg/m³ (skin)	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CHLORDANE-air	10H Carcinogen time-weighted average 0.5 mg/m³ (Sk)	NIOSH* DHHS #92-100,1992

Status in Federal Agencies

Organization	Reference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/95/100111/AS)
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);clear evidence:mouse	NCITR* NCI-TR-8,1977
NCI Carcinogenesis Bioassay (feed);no evidence:rat	NCITR* NCI-TR-8,1977
NIOSH Analytical Method, 1994: Chlordane, 5510
On EPA IRIS database
OSHA ANALYTICAL METHOD #67

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health