Methane, trichloronitro-
RTECS #
PB6300000
CAS #
Updated
December 2018
Molecular Weight
164.37
Molecular Formula
CCl3NO2
Synonyms
Acquinite
Chloorpikrine (Dutch)
Chloroform, nitro-
Chloropicrin
Chloropicrin (ACGIH:OSHA)
Chloropicrine (French)
Chlorpikrin (German)
Cloropicrina (Italian)
Dojyopicrin
Dolochlor
G 25
KLOP
Larvacide
Microlysin
NCI-C00533
Nitrochloroform
Nitrotrichloromethane (OSHA)
Pic-Clor
Picfume
Picride
Profume A
PS
Trichloornitromethaan (Dutch)
Trichlornitromethan (German)
Trichloronitromethane
Tri-clor
Tricloro-nitro-metano (Italian)
Chloorpikrine (Dutch)
Chloroform, nitro-
Chloropicrin
Chloropicrin (ACGIH:OSHA)
Chloropicrine (French)
Chlorpikrin (German)
Cloropicrina (Italian)
Dojyopicrin
Dolochlor
G 25
KLOP
Larvacide
Microlysin
NCI-C00533
Nitrochloroform
Nitrotrichloromethane (OSHA)
Pic-Clor
Picfume
Picride
Profume A
PS
Trichloornitromethaan (Dutch)
Trichlornitromethan (German)
Trichloronitromethane
Tri-clor
Tricloro-nitro-metano (Italian)
Mutation Data and Reference
| System Test | Route/Organism/Tissue | Dose | Reference |
|---|---|---|---|
| mutation in microorganisms | /Salmonella typhimurium | 50 µg/plate (-enzymatic activation step) | MUREAV 116,185,1983 |
| mutation in microorganisms | /Escherichia coli | 50 µg/plate (+enzymatic activation step) | SAIGBL 29,34,1987 |
| other mutation test systems | /Escherichia coli | 300 µg/L | MUREAV 348,147,1995 |
| sister chromatid exchange | lymphocyte/human | 8 mg/L | TCMUD8 10,21,1990 |
Tumorigenic Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| oral/mouse | lowest published toxic dose: 26 gm/kg/78W- intermittent | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Gastrointestinal: Tumors | NCITR* NCI-TR-65,1978 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| In Vitro/Human, lung | Inhibitor Concentration (50 percent kill): 111 µmol/L/24H | In Vitro Toxicity Studies: Cell counting | TIVIEQ 45,72,2017 |
| In Vitro/Human, lung | Inhibitor Concentration Low: 10 µmol/L/24H | In Vitro Toxicity Studies: Cell morphology: overgrowth of cell appendixes etc. | TIVIEQ 42,247,2017 |
| In Vitro/Human, lung fibroblast | Inhibitor Concentration Low: 16 µmol/L/6H | In Vitro Toxicity Studies: Other assays | TIVIEQ 28,209,2014 |
| In Vitro/Human, lung tumor | Inhibitor Concentration Low: 50 µmol/L/24H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. In Vitro Toxicity Studies: Apoptosis in vitro | TOLED5 226,236,2014 |
| In Vitro/Human, lung tumor | Inhibitor Concentration (50 percent kill): 112 µmol/L/24H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TOLED5 226,236,2014 |
| In Vitro/jda | Inhibitor Concentration Low: 50 µmol/L/24H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. In Vitro Toxicity Studies: Other assays | TOLED5 211,239,2012 |
| inhalation/cat | Lowest published lethal concentration: 800 mg/m3/20M | Behavioral: Food intake (animal) Lung, Thorax, or Respiration: Acute pulmonary edema Lung, Thorax, or Respiration: Dyspnea | ZGEMAZ 106,296,1939 |
| inhalation/Dog | Lowest published lethal concentration: 0.5 gm/m3/30M | Cardiac: Cardiomyopathy including infarction Lung, Thorax, or Respiration: Changes in pulmonary vascular resistance Lung, Thorax, or Respiration: Respiratory obstruction | TPKVAL 3,103,1961 |
| inhalation/guinea pig | Lowest published lethal concentration: 0.5 gm/m3/30M | Brain and Coverings: Changes in circulation Behavioral: Ataxia Behavioral: Tetany | TPKVAL 3,103,1961 |
| inhalation/guinea pig | Lowest published lethal concentration: 800 mg/m3/20M | Lung, Thorax, or Respiration: Emphysema Lung, Thorax, or Respiration: Acute pulmonary edema Lung, Thorax, or Respiration: Dyspnea | ZGEMAZ 106,296,1939 |
| inhalation/human | lowest published toxic concentration: 2 mg/m3 | Eye: Lacrimation Eye: Conjunctiva irritation Lung, Thorax, or Respiration: Other changes | ZGEMAZ 106,296,1939 |
| inhalation/human | Lowest published lethal concentration: 2000 mg/m3/10M | 34ZIAG -,169,1969 | |
| inhalation/mouse | lethal concentration (50 percent kill): 66 mg/m3/4H | Eye: Increased intraocular pressure Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Respiratory stimulation | SAIGBL 15,406,1973 |
| inhalation/mouse | Lowest published lethal concentration: 0.15 gm/m3/15M | Skin: After systemic exposure: Dermatitis, other | TPKVAL 3,103,1961 |
| inhalation/mouse | lowest published toxic concentration: 0.99 ppm/30M | Blood: Hemorrhage | TOXID9 60,426,2001 |
| inhalation/rabbit | lethal concentration (50 percent kill): 800 mg/m3/20M | FMCHA2 -,C72,1991 | |
| inhalation/rat | lethal concentration (50 percent kill): 14400 ppb/4H | Lung, Thorax, or Respiration: Other changes | NNGADV 16,63,1991 |
| inhalation/rat | lethal concentration (50 percent kill): 18.9 ppm/4H | Olfaction: Change in sensation of smell Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Other changes | TOXID9 60,426,2001 |
| inhalation/rat | lowest published toxic concentration: 10.5 ppm/4H | Gastrointestinal: Nausea or vomiting | TOXID9 60,426,2001 |
| inhalation/rat | lowest published toxic concentration: 10.5 ppm/4H | Liver: Other changes Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Metabolism (intermediary): Lipids including transport | TOXID9 60,426,2001 |
| inhalation/rat | Lowest published lethal concentration: 18 ppm/4H | Olfaction: Other olfaction effects Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation) | TOXID9 60,426,2001 |
| inhalation/rat | Lowest published lethal concentration: 23.5 ppm/4H | Olfaction: Change in sensation of smell Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Other changes | TOXID9 60,426,2001 |
| intraperitoneal/mouse | lethal dose (50 percent kill): 25 mg/kg | ENTOX* -,571,2005 | |
| intravenous/guinea pig | lethal dose (50 percent kill): 4200 µg/kg | Lung, Thorax, or Respiration: Acute pulmonary edema | AIPTAK 114,146,1958 |
| oral/rat | lethal dose (50 percent kill): 250 mg/kg | DOWCC* -,-,1972 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| oral/rat | lowest published toxic dose: 400 mg/kg/10D- intermittent | Endocrine: Changes in thymus weight Blood: Changes in leukocyte (WBC) count Nutritional and Gross Metabolic: Weight loss or decreased weight gain | DCTODJ 17,125,1994 |
| oral/rat | lowest published toxic dose: 2880 mg/kg/90D- intermittent | Gastrointestinal: Other changes Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic: Weight loss or decreased weight gain | DCTODJ 17,125,1994 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 0.1 ppm | DTLVS* TLV/BEI,2013 |
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Not classifiable as a human carcinogen | DTLVS* TLV/BEI,2013 |
| TOXICOLOGY REVIEW | MUREAV 567,347,2004 | |
| TOXICOLOGY REVIEW | ENTOX* -,571,2005 | |
| TOXICOLOGY REVIEW | MUREAV 636,242,2007 | |
| TOXICOLOGY REVIEW | MUREAV 831,1,2018 | |
| TOXICOLOGY REVIEW | RTOPDW 54,247,2009 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION | FEREAC 54,7740,1989 | |
| Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES | Supported | RBREV* -,98,1998 |
| Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 0.1 ppm (0.7 mg/m3) | DTLVS* 3,54,1971 |
| Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
| Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
| Occupational Exposure Limit-AUSTRALIA | time-weighted average 0.1 ppm (0.67 mg/m3), JUL2008 | |
| Occupational Exposure Limit-AUSTRIA | MAK-TMW 0.1 ppm (0.7 mg/m3);KZW 0.2 ppm (1.4 mg/m3), 2007 | |
| Occupational Exposure Limit-BELGIUM | time-weighted average 0.1 ppm (0.68 mg/m3), MAR2002 | |
| Occupational Exposure Limit-DENMARK | time-weighted average 0.1 ppm (0.7 mg/m3), MAY2011 | |
| Occupational Exposure Limit-FINLAND | time-weighted average 0.1 ppm (0.7 mg/m3), short term exposure limit 0.3 ppm (2.1 mg/m3), NOV2011 | |
| Occupational Exposure Limit-FRANCE | VME 0.1 ppm (0.7 mg/m3), FEB2006 | |
| Occupational Exposure Limit-GERMANY | MAK 0.1 ppm (0.68 mg/m3), 2011 | |
| Occupational Exposure Limit-ICELAND | time-weighted average 0.1 ppm (0.7 mg/m3), NOV2011 | |
| Occupational Exposure Limit-JAPAN | Occupational Exposure Limit 0.1 ppm (0.67 mg/m3), MAY2012 | |
| Occupational Exposure Limit-KOREA | time-weighted average 0.1 ppm (0.7 mg/m3), short term exposure limit 0.3 ppm (2 mg/m3), 2006 | |
| Occupational Exposure Limit-MEXICO | time-weighted average 0.1 ppm (0.7 mg/m3), 2004 | |
| Occupational Exposure Limit-NEW ZEALAND | time-weighted average 0.1 ppm (0.67 mg/m3), JAN2002 | |
| Occupational Exposure Limit-NORWAY | time-weighted average 0.1 ppm (0.7 mg/m3), JAN1999 | |
| Occupational Exposure Limit-PERU | time-weighted average 0,1 ppm (0,7 mg/m3), JUL2005 | |
| Occupational Exposure Limit-POLAND | MAC(time-weighted average) 0.5 mg/m3, MAC(short term exposure limit) 1.5 mg/m3, JAN1999 | |
| Occupational Exposure Limit-RUSSIA | short term exposure limit 0.5 mg/m3, Skin, JUN2003 | |
| Occupational Exposure Limit-SWITZERLAND | ceiling concentration 0.1 ppm (0.7 mg/m3), JAN2011 | |
| Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 0.7 mg/m3, 2003 | |
| Occupational Exposure Limit-THE PHILIPPINES | time-weighted average 0.1 ppm (0.7 mg/m3), JAN1993 | |
| Occupational Exposure Limit-TURKEY | time-weighted average 0.1 ppm (0.7 mg/m3), JAN1993 | |
| Occupational Exposure Limit-UNITED KINGDOM | time-weighted average 0.1 ppm (0.68 mg/m3);short term exposure limit 0.3 ppm (2.1 mg/m3), OCT2007 | |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 0.1 ppm (0.7 mg/m3) | CFRGBR 29,1926.55,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 0.1 ppm (0.7 mg/m3) | CFRGBR 41,50-204.50,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 0.1 ppm (0.7 mg/m3) | CFRGBR 29,1910.1000,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 0.1 ppm (0.7 mg/m3) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CHLOROPICRIN-air | 10H time-weighted average 0.1 ppm | NIOSH* DHHS #95-121,1995 |
| National Occupational Exposure Survey 1983 | Hazard Code M0419; Number of Industries 3; Total Number of Facilities 484; Number of Occupations 8; Total Number of Employees Exposed 4843; Total Number of Female Employees Exposed 939 |
Status in Federal Agencies
| Organization | Reference |
|---|---|
| EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
| EPA TSCA Section 8(d) unpublished health/safety studies | |
| EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 | |
| NCI Carcinogenesis Bioassay (gavage);inadequate studies:rat | NCITR* NCI-TR-65,1978 |
| NCI Carcinogenesis Bioassay (gavage);no evidence:mouse | NCITR* NCI-TR-65,1978 |
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health