Methane, trichlorofluoro-

RTECS #

PB6125000

CAS #

75-69-4; 83589-40-6
See: NMAM or OSHA Methods

Updated

September 2013

Molecular Weight

137.36

Molecular Formula

CCl₃F

Synonyms

Algofrene type 1
Arcton 9
Electro-CF 11
Eskimon 11
F 11
FC 11
Fluorocarbon No. 11
Fluorotrichloromethane
Fluorotrichloromethane (OSHA)
Fluorotrojchlorometan (Polish)
Freon 11
Freon 11A
Freon 11B
Freon HE
Freon MF
Frigen 11
Genetron 11
Halocarbon 11
Isceon 131
Isotron 11
Ledon 11
Methane, fluorotrichloro-
Monofluorotrichloromethane
NCI-C04637
Refrigerant 11
Trichlorofluoromethane (ACGIH:OSHA)
Trichloromonofluoromethane
Ucon flurocarbon 11
Ucon refrigerant 11

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
inhalation/Dog	lowest published toxic concentration: 16 pph/10M	Cardiac: Change in rate	AEHLAU 30,353,1975
inhalation/Dog	lowest published toxic concentration: 868500 mg/m³/10M	Cardiac: Change in rate	VCVGH* -,616,1990
inhalation/Dog	Lowest published lethal concentration: 22 pph/10M	Cardiac: Pulse rate decreased with fall in BP Cardiac: Change in conduction velocity	AEHLAU 30,353,1975
inhalation/guinea pig	lowest published toxic concentration: 145000 mg/m³/2H	Behavioral: Tremor Lung, Thorax, or Respiration: Dyspnea	VCVGH* -,616,1990
inhalation/guinea pig	lethal concentration (50 percent kill): 25 pph/30M		EJTXAZ 9,385,1976
inhalation/human	lowest published toxic concentration: 50000 ppm/30M	Eye: Conjunctiva irritation Lung, Thorax, or Respiration: Fibrosing alveolitis Liver: Other changes	EJTXAZ 9,385,1976
inhalation/mouse	lethal concentration (50 percent kill): 10 pph/30M		EJTXAZ 9,385,1976
inhalation/mouse	lowest published toxic concentration: 100 pph/10M	Cardiac: EKG changes not diagnostic of above Cardiac: Pulse rate decreased with fall in BP	JAMAAP 214,81,1970
inhalation/mouse	Lowest published lethal concentration: 346700 mg/m³/2H		VCVGH* -,616,1990
inhalation/rabbit	lowest published toxic concentration: 289500 mg/m³/2M	Cardiac: Cardiac output Vascular: BP lowering not characterized in autonomic section	VCVGH* -,616,1990
inhalation/rabbit	lethal concentration (50 percent kill): 25 pph/30M		EJTXAZ 9,385,1976
inhalation/rat	lethal concentration (50 percent kill): 13 pph/15M	Behavioral: Tremor Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Respiratory depression	HUTODJ 1,239,1982
inhalation/rat	lowest published toxic concentration: 520000 mg/m³/30M	Behavioral: General anesthetic	VCVGH* -,616,1990
inhalation/rat	Lowest published lethal concentration: 579000 mg/m³/20M		VCVGH* -,616,1990
inhalation/rat	Lowest published lethal concentration: 868000 mg/m³/4M		VCVGH* -,616,1990
intraperitoneal/mouse	lethal dose (50 percent kill): 1743 mg/kg	Behavioral: Convulsions or effect on seizure threshold	TOIZAG 18,363,1971
oral/rat	Lethal dose: >352 mg/kg		NTIS** OTS0520424
oral/rat	lowest published toxic dose: 1.25 mL/kg	Gastrointestinal: Ulceration or bleeding from stomach Blood: Hemorrhage	JTCTDW 46,325,2008

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/rat	lowest published toxic concentration: 12000 ppm/4H/10D- intermittent	Brain and Coverings: Other degenerative changes Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion	NTIS** OTS0571425

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-ceiling concentration 1000 ppm	DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-Not classifiable as a human carcinogen	DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEW		FAZMAE 18,365,1974
TOXICOLOGY REVIEW		TXCYAC 3,311,1975
TOXICOLOGY REVIEW		NYSJAM 74,1939,1974
TOXICOLOGY REVIEW		AIHAAP 29,517,1968
TOXICOLOGY REVIEW		MUREAV 543,201,2003
TOXICOLOGY REVIEW		HUTOX* -,577,1996

Standards and Regulations

Organization	Standard	Reference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION		FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES	Cancelled	RBREV* -,312,1998
Mine Safety and Health Administration (MSHA) STANDARD-air	time-weighted average 1000 ppm (5600 mg/m³)	DTLVS* 3,118,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	ceiling concentration 1000 ppm (5620 mg/m³), JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 1000 ppm (5600 mg/m³);KZW 2000 ppm (11200 mg/m³), 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 1000 ppm (5702 mg/m³), MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 500 ppm (2810 mg/m³), MAY2011
Occupational Exposure Limit-FINLAND	time-weighted average 1000 ppm (5600 mg/m³), short term exposure limit 1300 ppm (7000 mg/m³), NOV2011
Occupational Exposure Limit-FRANCE	VLE 1000 ppm (5600 mg/m³), FEB2006
Occupational Exposure Limit-GERMANY	MAK 1000 ppm (5700 mg/m³), 2011
Occupational Exposure Limit-HUNGARY	Prohibited in Hungary, SEP2000
Occupational Exposure Limit-ICELAND	time-weighted average 500 ppm (2810 mg/m³), NOV2011
Occupational Exposure Limit-JAPAN	ceiling concentration 1000 ppm (5600 mg/m³), MAY2012
Occupational Exposure Limit-KOREA	ceiling concentration 1,000 ppm (5,600 mg/m³), 2006
Occupational Exposure Limit-MEXICO	peak 1000 ppm (5600 mg/m³), 2004
Occupational Exposure Limit-NEW ZEALAND	ceiling concentration 1000 ppm (5620 mg/m³), JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 500 ppm (2800 mg/m³), JAN1999
Occupational Exposure Limit-PERU	short term exposure limit 1000 ppm (5619 mg/m³), JUL2005
Occupational Exposure Limit-POLAND	MAC(time-weighted average) 500 mg/m³, MAC(C) 5600 mg/m³, JAN1999
Occupational Exposure Limit-RUSSIA	short term exposure limit 1000 mg/m³, JUN2003
Occupational Exposure Limit-SWEDEN	time-weighted average 500 ppm (3000 mg/m³);short term exposure limit 750 ppm (4500 mg/m³), JUN2005
Occupational Exposure Limit-SWITZERLAND	MAK-week 1000 ppm (5600 mg/m³), JAN2011
Occupational Exposure Limit-THE PHILIPPINES	time-weighted average 1000 ppm (5600 mg/m³), JAN1993
Occupational Exposure Limit-TURKEY	time-weighted average 1000 ppm (5600 mg/m³), JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 1000 ppm (5600 mg/m³)	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	8H time-weighted average 1000 ppm (5600 mg/m³)	CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 1000 ppm (5600 mg/m³)	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 1000 ppm (5600 mg/m³)	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO FLUOROTRICHLOROMETHANE-air	ceiling concentration 1000 ppm	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code 33565; Number of Industries 142; Total Number of Facilities 15107; Number of Occupations 119; Total Number of Employees Exposed 267742; Total Number of Female Employees Exposed 95886
National Occupational Hazard Survey 1974	Hazard Code 33565; Number of Industries 304; Total Number of Facilities 68187; Number of Occupations 173; Total Number of Employees Exposed 785337

Status in Federal Agencies

Organization	Reference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (gavage);inadequate studies:rat	NCITR* NCI-TR-106,1978
NCI Carcinogenesis Bioassay (gavage);no evidence:mouse	NCITR* NCI-TR-106,1978
NIOSH Analytical Method, 1994: Fluorotrichloromethane, 1006
NIOSH Analytical Method, 1994: Trichlorofluoromethane, 1006
On EPA IRIS database

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health