Methanesulfenyl chloride, trichloro-

RTECS #

PB0370000

CAS #

594-42-3
See: NMAM or OSHA Methods

Updated

September 2013

Molecular Weight

185.87

Molecular Formula

CCl₄S

Synonyms

Clairsit
Mercaptan methylique perchlore (French)
Perchlormethylmerkaptan (Czech)
Perchloromethyl mercaptan
Perchloromethyl mercaptan (ACGIH:OSHA)
RCRA waste number P118
Trichloromethane sulfenyl chloride
Trichloromethanesulphenyl chloride
Trichloromethylsulfenyl chloride
Trichloromethylsulphenyl chloride

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
eye /rabbit	50 µg/24H	severe	28ZPAK -,13,1972
skin /rabbit	500 mg/24H	severe	28ZPAK -,13,1972

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
inhalation/mouse	lethal concentration (50 percent kill): 296 mg/m³/2H		85GMAT -,97,1982
inhalation/rat	lethal concentration (50 percent kill): 11 ppm/1H		TXAPA9 42,417,1977
intraperitoneal/mouse	lethal dose (50 percent kill): 10 mg/kg	Behavioral: Somnolence (general depressed activity) Gastrointestinal: Other changes Skin and Appendages: Other: Hair	NTIS** OTS0533569
intraperitoneal/rat	lethal dose (50 percent kill): 25 mg/kg	Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Dyspnea Skin and Appendages: Other: Hair	NTIS** OTS0533569
intravenous/mouse	lethal dose (50 percent kill): 56 mg/kg		CSLNX* NX#06768
oral/mouse	lethal dose (50 percent kill): 400 mg/kg	Behavioral: Somnolence (general depressed activity) Gastrointestinal: Hypermotility, diarrhea Skin and Appendages: Other: Hair	NTIS** OTS0533569
oral/rat	lethal dose (50 percent kill): 82600 µg/kg		28ZPAK -,13,1972
skin/guinea pig	lethal dose (50 percent kill): 500 µL/kg	Skin: After systemic exposure: Dermatitis, other	NTIS** OTS0533569
skin/rabbit	lethal dose (50 percent kill): 1410 mg/kg		TXAPA9 42,417,1977

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/Dog	lowest published toxic concentration: 1 ppm/8H/13W- intermittent	Eye: Lacrimation Lung, Thorax, or Respiration: Cough Gastrointestinal: Nausea or vomiting	NTIS** OTS0558749
inhalation/guinea pig	lowest published toxic concentration: 1 ppm/8H/13W- intermittent	Eye: Lacrimation Lung, Thorax, or Respiration: Respiratory stimulation Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	NTIS** OTS0558749
inhalation/rat	lowest published toxic concentration: 1 ppm/8H/13W- intermittent	Lung, Thorax, or Respiration: Other changes	NTIS** OTS0558749

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 0.1 ppm	DTLVS* TLV/BEI,2013

Standards and Regulations

Organization	Standard	Reference
Mine Safety and Health Administration (MSHA) STANDARD-air	time-weighted average 0.1 ppm (0.8 mg/m³)	DTLVS* 3,202,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 0.1 ppm (0.76 mg/m³), JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 0.1 ppm (0.8 mg/m³);KZW 0.2 ppm (1.6 mg/m³), 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 0.1 ppm (0.77 mg/m³), MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 0.1 ppm (0.8 mg/m³), MAY2011
Occupational Exposure Limit-FINLAND	short term exposure limit 0.1 ppm (0.77 mg/m³), skin, NOV2011
Occupational Exposure Limit-FRANCE	VME 0.1 ppm (0.8 mg/m³), FEB2006
Occupational Exposure Limit-ICELAND	time-weighted average 0.1 ppm (0.8 mg/m³), NOV2011
Occupational Exposure Limit-KOREA	time-weighted average 0.1 ppm (0.8 mg/m³), 2006
Occupational Exposure Limit-MEXICO	time-weighted average 0.1 ppm (0.8 mg/m³), 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 0.1 ppm (0.76 mg/m³), JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 0.1 ppm (0.8 mg/m³), JAN1999
Occupational Exposure Limit-PERU	time-weighted average 0,1 ppm (0,76 mg/m³), JUL2005
Occupational Exposure Limit-RUSSIA	short term exposure limit 1 mg/m³, JUN2003
Occupational Exposure Limit-SWITZERLAND	MAK-week 0.1 ppm (0.8 mg/m³), JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 0.8 mg/m³, 2003
Occupational Exposure Limit-TURKEY	time-weighted average 0.1 ppm (0.8 mg/m³), JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 0.1 ppm (0.8 mg/m³)	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	8H time-weighted average 0.1 ppm (0.8 mg/m³)	CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 0.1 ppm (0.8 mg/m³)	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 0.1 ppm (0.8 mg/m³)	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PERCHLOROMETHYL MERCAPTAN-air	10H time-weighted average 0.1 ppm	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code 54800; Number of Industries 6; Total Number of Facilities 324; Number of Occupations 17; Total Number of Employees Exposed 9112; Total Number of Female Employees Exposed 1677

Status in Federal Agencies

Organization	Reference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8978;8EHQ-0892-9092
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health