Methane, dichlorofluoro-
RTECS #
PA8400000
CAS #
Updated
September 2013
Molecular Weight
102.92
Molecular Formula
CHCl2F
Synonyms
Algofrene type 5
Arcton 7
CFC-21
Dichlorofluoromethane
Dichlorofluoromethane (ACGIH)
Dichloromonofluoromethane (OSHA)
Dwuchlorofluorometan (Polish)
FC-21
Fluorocarbon 21
Fluorodichloromethane
Freon 21
Genetron 21
Racon 21
Refrigerant 21
Arcton 7
CFC-21
Dichlorofluoromethane
Dichlorofluoromethane (ACGIH)
Dichloromonofluoromethane (OSHA)
Dwuchlorofluorometan (Polish)
FC-21
Fluorocarbon 21
Fluorodichloromethane
Freon 21
Genetron 21
Racon 21
Refrigerant 21
Reproductive Effects Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/rat | 1 pph/6H (6-15D pregnant) | Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) | TXAPA9 45,293,1978 |
| inhalation/rat | 30 mg/m3 (1-22D pregnant) | Reproductive: Effects on embryo or fetus: Fetal death | VCVGH* -,614,1990 |
| inhalation/rat | 100 mg/m3 (1-22D pregnant) | Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Effects on embryo or fetus: Fetal death | VCVGH* -,614,1990 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/Dog | lowest published toxic concentration: 1 pph/10M | Behavioral: Excitement Cardiac: EKG changes not diagnostic of above Kidney, Ureter, and Bladder: Incontinence | EPASR* #86-890000758 |
| inhalation/guinea pig | Lowest published lethal concentration: 10 pph/1H | FLCRAP 1,197,1967 | |
| inhalation/guinea pig | Lowest published lethal concentration: 260400 mg/m3/5M | VCVGH* -,614,1990 | |
| inhalation/mouse | lowest published toxic concentration: 868000 mg/m3 | Behavioral: Convulsions or effect on seizure threshold Gastrointestinal: Nausea or vomiting | VCVGH* -,614,1990 |
| inhalation/mouse | lethal concentration (50 percent kill): 800000 mg/m3/4H | VCVGH* -,614,1990 | |
| inhalation/mouse | lethal concentration (50 percent kill): >800 gm/m3/2H | Behavioral: Tremor Behavioral: Ataxia Lung, Thorax, or Respiration: Other changes | GTPZAB 20(11),38,1976 |
| inhalation/rat | lethal concentration (50 percent kill): 49900 ppm/4H | 85INA8 5,187,1986 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/cat | lowest published toxic concentration: 1 pph/3.5H/4W- intermittent | Liver: Hepatitis (hepatocellular necrosis), zonal Liver: Fatty liver degeneration | ZAARAM 21,149,1971 |
| inhalation/Dog | lowest published toxic concentration: 1 pph/3.5H/4W- intermittent | Liver: Hepatitis (hepatocellular necrosis), zonal Liver: Fatty liver degeneration | ZAARAM 21,149,1971 |
| inhalation/Dog | lowest published toxic concentration: 5000 ppm/6H/13W- intermittent | Liver: Changes in liver weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NTIS** OTS0520832 |
| inhalation/guinea pig | lowest published toxic concentration: 1 pph/3.5H/4W- intermittent | Liver: Hepatitis (hepatocellular necrosis), zonal Liver: Fatty liver degeneration Nutritional and Gross Metabolic: Weight loss or decreased weight gain | ZAARAM 21,149,1971 |
| inhalation/rat | lowest published toxic concentration: 1 pph/6H/2W- intermittent | Liver: Other changes | TXAPA9 41(1),199,1977 |
| inhalation/rat | lowest published toxic concentration: 1000 ppm/6H/90D- intermittent | Skin and Appendages: Other: Hair Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | TXAPA9 41(1),200,1977 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 10 ppm | DTLVS* TLV/BEI,2013 |
| TOXICOLOGY REVIEW | FAZMAE 18,365,1974 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 1000 ppm (4200 mg/m3) | DTLVS* 3,81,1971 |
| Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
| Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
| Occupational Exposure Limit-AUSTRALIA | time-weighted average 10 ppm (42 mg/m3), JUL2008 | |
| Occupational Exposure Limit-AUSTRIA | MAK-TMW 10 ppm (43 mg/m3);KZW 40 ppm (172 mg/m3), 2007 | |
| Occupational Exposure Limit-BELGIUM | time-weighted average 10 ppm (43 mg/m3), MAR2002 | |
| Occupational Exposure Limit-DENMARK | time-weighted average 10 ppm (40 mg/m3), MAY2011 | |
| Occupational Exposure Limit-FINLAND | time-weighted average 10 ppm (40 mg/m3), short term exposure limit 20 ppm (80 mg/m3), NOV2011 | |
| Occupational Exposure Limit-FRANCE | VME 10 ppm (40 mg/m3), FEB2006 | |
| Occupational Exposure Limit-GERMANY | MAK 10 ppm (43 mg/m3), 2011 | |
| Occupational Exposure Limit-HUNGARY | time-weighted average 43 mg/m3, short term exposure limit 172 mg/m3, SEP2000 | |
| Occupational Exposure Limit-ICELAND | time-weighted average 10 ppm (40 mg/m3), NOV2011 | |
| Occupational Exposure Limit-KOREA | time-weighted average 10 ppm (40 mg/m3), 2006 | |
| Occupational Exposure Limit-MEXICO | time-weighted average 500 ppm (2100 mg/m3), 2004 | |
| Occupational Exposure Limit-NEW ZEALAND | time-weighted average 10 ppm (42 mg/m3), JAN2002 | |
| Occupational Exposure Limit-NORWAY | time-weighted average 10 ppm (42 mg/m3), JAN1999 | |
| Occupational Exposure Limit-PERU | time-weighted average 10 ppm (42 mg/m3), JUL2005 | |
| Occupational Exposure Limit-POLAND | MAC(time-weighted average) 40 mg/m3, MAC(short term exposure limit) 200 mg/m3, JAN1999 | |
| Occupational Exposure Limit-RUSSIA | short term exposure limit 3000 mg/m3, JUN2003 | |
| Occupational Exposure Limit-SWITZERLAND | MAK-week 10 ppm (40 mg/m3), KZG-week 20 ppm (80 mg/m3), JAN2011 | |
| Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 43 mg/m3, 2003 | |
| Occupational Exposure Limit-THE PHILIPPINES | time-weighted average 1000 ppm (4200 mg/m3), JAN1993 | |
| Occupational Exposure Limit-TURKEY | time-weighted average 1000 ppm (4200 mg/m3), JAN1993 | |
| Occupational Exposure Limit-UNITED KINGDOM | time-weighted average 10 ppm (43 mg/m3), OCT2007 | |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 1000 ppm (4200 mg/m3) | CFRGBR 29,1926.55,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 1000 ppm (4200 mg/m3) | CFRGBR 41,50-204.50,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 1000 ppm (4200 mg/m3) | CFRGBR 29,1910.1000,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 1000 ppm (4200 mg/m3) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DICHLOROMONOFLUOROMETHANE-air | 10H time-weighted average 10 ppm | NIOSH* DHHS #92-100,1992 |
| National Occupational Exposure Survey 1983 | Hazard Code 24235; Number of Industries 8; Total Number of Facilities 935; Number of Occupations 13; Total Number of Employees Exposed 12182; Total Number of Female Employees Exposed 1640 | |
| National Occupational Hazard Survey 1974 | Hazard Code 24235; Number of Industries 44; Total Number of Facilities 4131; Number of Occupations 56; Total Number of Employees Exposed 43521 |
Status in Federal Agencies
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health