Methane, chlorodifluoro-
RTECS #
PA6390000
CAS #
Updated
September 2013
Molecular Weight
86.47
Molecular Formula
CHClF2
Synonyms
Algeon 22
Algofrene 22
Algofrene type 6
Arcton 22
Arcton 4
CFC 22
Chlorodifluoromethane (ACGIH)
Daiflon 22
Difluorochloromethane
Difluoromonochloromethane
Dymel 22
Electro-CF 22
Eskimon 22
F 22
Flugene 22
Fluorocarbon-22
Forane 22
Freon 22
Frigen 22
Genetron 22
Haltron 22
HFA-22
Isceon 22
Isotron 22
Khaladon 22
Monochlorodifluoromethane
Propellant 22
R 22 (refrigerant)
R-22
Racon 22
Refrigerant R 22
Ucon 22
Algofrene 22
Algofrene type 6
Arcton 22
Arcton 4
CFC 22
Chlorodifluoromethane (ACGIH)
Daiflon 22
Difluorochloromethane
Difluoromonochloromethane
Dymel 22
Electro-CF 22
Eskimon 22
F 22
Flugene 22
Fluorocarbon-22
Forane 22
Freon 22
Frigen 22
Genetron 22
Haltron 22
HFA-22
Isceon 22
Isotron 22
Khaladon 22
Monochlorodifluoromethane
Propellant 22
R 22 (refrigerant)
R-22
Racon 22
Refrigerant R 22
Ucon 22
Mutation Data and Reference
System Test | Route/Organism/Tissue | Dose | Reference |
---|---|---|---|
mutation in microorganisms | /Salmonella typhimurium | 33 pph/24H-continuous (+/-enzymatic activation step) | TOLED5 2,1,1978 |
Reproductive Effects Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/rat | 50000 ppm/5H (56D male) | Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands | FAATDF 1,266,1981 |
inhalation/rat | 5 ppm (6-15D pregnant) | Reproductive: Specific developmental abnormalities: Eye, ear | NTIS** OTS0520838 |
inhalation/rat | 50000 ppm/6H (6-15D pregnant) | Reproductive: Specific developmental abnormalities: Eye, ear | NTIS** OTS0545682 |
Acute Toxicity Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/Dog | Lowest published lethal concentration: 70 pph | Lung, Thorax, or Respiration: Other changes | TXAPA9 2,363,1960 |
inhalation/guinea pig | Lowest published lethal concentration: 30 pph/2H | Behavioral: General anesthetic Behavioral: Somnolence (general depressed activity) Behavioral: Convulsions or effect on seizure threshold | ZAARAM 21,149,1971 |
inhalation/guinea pig | lowest published toxic concentration: 584000 mg/m3/55M | Behavioral: Tremor Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Respiratory stimulation | VCVGH* -,618,1990 |
inhalation/guinea pig | lowest published toxic concentration: 1380000 mg/m3/2H | Behavioral: Tremor Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Respiratory stimulation | VCVGH* -,618,1990 |
inhalation/guinea pig | Lowest published lethal concentration: 1800000 mg/m3/18M | VCVGH* -,618,1990 | |
inhalation/mouse | lethal concentration (50 percent kill): 1000000 mg/m3/2H | VCVGH* -,618,1990 | |
inhalation/mouse | lethal concentration (50 percent kill): 1020000 mg/m3/30M | VCVGH* -,618,1990 | |
inhalation/mouse | lethal concentration (50 percent kill): 1380 gm/m3/2H | Behavioral: Somnolence (general depressed activity) Behavioral: Ataxia Lung, Thorax, or Respiration: Cyanosis | TLSMA6 75,241,1963 |
inhalation/rabbit | Lowest published lethal concentration: 1100000 mg/m3/30M | VCVGH* -,618,1990 | |
inhalation/rabbit | Lowest published lethal concentration: 1530000 mg/m3/20M | VCVGH* -,618,1990 | |
inhalation/rat | lethal concentration (50 percent kill): 35 pph/15M | Behavioral: Altered sleep time (including change in righting reflex) Behavioral: Ataxia Lung, Thorax, or Respiration: Respiratory depression | HUTODJ 1,239,1982 |
oral/rat | Lethal dose: >43200 µg/kg | GISAAA 48(8),69,1983 |
Other Multiple Dose Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/mouse | lowest published toxic concentration: 50 gm/m3/6H/43W- intermittent | Brain and Coverings: Other degenerative changes Spinal Cord: Other degenerative changes Behavioral: Alteration of classical conditioning | TLSMA6 75,231,1963 |
oral/rat | lowest published toxic dose: 2457 mg/kg/26W- intermittent | Brain and Coverings: Other degenerative changes Blood: Changes in other cell count (unspecified) Nutritional and Gross Metabolic: Weight loss or decreased weight gain | GISAAA 48(8),69,1983 |
Reviews
Organization | Standard | Reference |
---|---|---|
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 1000 ppm | DTLVS* TLV/BEI,2013 |
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Not classifiable as a human carcinogen | DTLVS* TLV/BEI,2013 |
International Agency for Research on Cancer (IARC) | Cancer Review:Animal Limited Evidence | IMEMDT 41,237,1986 |
International Agency for Research on Cancer (IARC) | Cancer Review:Animal Limited Evidence | IMEMDT 71,1339,1999 |
International Agency for Research on Cancer (IARC) | Cancer Review:Human Inadequate Evidence | IMEMDT 41,237,1986 |
International Agency for Research on Cancer (IARC) | Cancer Review:Human Inadequate Evidence | IMEMDT 71,1339,1999 |
International Agency for Research on Cancer (IARC) | Cancer Review:Group 3 | IMEMDT 71,1339,1999 |
TOXICOLOGY REVIEW | FAZMAE 18,365,1974 | |
TOXICOLOGY REVIEW | NYSJAM 74,1939,1974 | |
TOXICOLOGY REVIEW | ENTOX* -,384,2005 | |
TOXICOLOGY REVIEW | MUREAV 584,1,2005 | |
TOXICOLOGY REVIEW | HUTOX* -,683,1996 | |
TOXICOLOGY REVIEW | HUTOX* -,577,1996 |
Standards and Regulations
NIOSH Documentation and Surveillance
Organization | Standard | Reference |
---|---|---|
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CHLORODIFLUOROMETHANE-air | time-weighted average 1000 ppm;short term exposure limit 1250 ppm | NIOSH* DHHS #95-121,1995 |
National Occupational Exposure Survey 1983 | Hazard Code 80048; Number of Industries 78; Total Number of Facilities 12513; Number of Occupations 57; Total Number of Employees Exposed 157080; Total Number of Female Employees Exposed 12185 | |
National Occupational Hazard Survey 1974 | Hazard Code 80048; Number of Industries 76; Total Number of Facilities 7420; Number of Occupations 44; Total Number of Employees Exposed 56234 |
Status in Federal Agencies
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health