Methanamine, N,N-dimethyl-
RTECS #
PA0350000
CAS #
Updated
December 2017
Molecular Weight
59.13
Molecular Formula
C3H9N
Synonyms
Dimethylmethaneamine
N,N-Dimethylmethanamine
Trimethylamine
Trimethylamine (ACGIH)
N,N-Dimethylmethanamine
Trimethylamine
Trimethylamine (ACGIH)
Reproductive Effects Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| intraperitoneal/mouse | 4430 mg/kg (6-15D pregnant) | Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) Reproductive: Effects on newborn: Physical | CJPPA3 71,185,1993 |
| intraperitoneal/mouse | 2960 mg/kg (6-15D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | CJPPA3 71,185,1993 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/mammal (species unspecified) | lethal concentration (50 percent kill): 19 gm/m3 | TPKVAL 14,80,1975 | |
| inhalation/mouse | lethal concentration (50 percent kill): 19 gm/m3 | Behavioral: Somnolence (general depressed activity) Behavioral: Excitement Behavioral: Muscle contraction or spasticity | GTPZAB 11(4),26,1967 |
| inhalation/rat | Lowest published lethal concentration: 3500 ppm/4H | TOXID9 4,68,1984 | |
| intraperitoneal/mouse | lethal dose (50 percent kill): 946 mg/kg | YKKZAJ 97,1117,1977 | |
| intravenous/mouse | lethal dose (50 percent kill): 90 mg/kg | MPHEAE 16,529,1967 | |
| intravenous/rabbit | lowest published lethal dose: 160 mg/kg | CRSBAW 83,481,1920 | |
| oral/pig | lowest published lethal dose: 1 gm/kg | Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change Behavioral: Food intake (animal) | INHTE5 2,41,1990 |
| oral/rat | lethal dose (50 percent kill): 500 mg/kg | INHTE5 2,41,1990 | |
| rectal/rabbit | lowest published lethal dose: 800 mg/kg | CRSBAW 83,481,1920 | |
| subcutaneous/frog | lowest published lethal dose: 2 gm/kg | Cardiac: Pulse rate decreased with fall in BP Cardiac: Other changes Blood: Other changes | SAPHAO 10,201,1900 |
| subcutaneous/rabbit | lowest published lethal dose: 800 mg/kg | CRSBAW 83,481,1920 | |
| unreported route/guinea pig | lethal dose (50 percent kill): 315 mg/kg | GISAAA 46(8),79,1981 | |
| unreported route/mouse | lethal dose (50 percent kill): 460 mg/kg | GISAAA 46(8),79,1981 | |
| unreported route/rabbit | lethal dose (50 percent kill): 240 mg/kg | GISAAA 46(8),79,1981 | |
| unreported route/rat | lethal dose (50 percent kill): 535 mg/kg | GISAAA 46(8),79,1981 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/rat | lowest published toxic concentration: 75 mg/m3/5H/30W- intermittent | Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis) Endocrine: Changes in adrenal weight Blood: Changes in other cell count (unspecified) | GTPZAB 11(4),26,1967 |
| inhalation/rat | lowest published toxic concentration: 750 ppm/6H/2W- intermittent | Olfaction: Other olfaction effects Blood: Changes in erythrocyte (RBC) count Nutritional and Gross Metabolic: Weight loss or decreased weight gain | INHTE5 2,41,1990 |
| unreported route/rabbit | lowest published toxic dose: 437 mg/kg/26W- intermittent | Blood: Changes in erythrocyte (RBC) count Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Monoamine oxidase Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases | GISAAA 46(8),79,1981 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 5 ppm;short term exposure limit 15 ppm | DTLVS* TLV/BEI,2013 |
| TOXICOLOGY REVIEW | CHREAY 9,389,1931 | |
| TOXICOLOGY REVIEW | MUREAV 741,32,2012 | |
| TOXICOLOGY REVIEW | MUREAV 802,38,2016 |
Standards and Regulations
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO TRIMETHYLAMINE-air | 10H time-weighted average 10 ppm;short term exposure limit 15 ppm | NIOSH* DHHS #92-100,1992 |
| National Occupational Exposure Survey 1983 | Hazard Code 82039; Number of Industries 7; Total Number of Facilities 142; Number of Occupations 13; Total Number of Employees Exposed 5261; Total Number of Female Employees Exposed 2870 | |
| National Occupational Hazard Survey 1974 | Hazard Code 82039; Number of Industries 6; Total Number of Facilities 387; Number of Occupations 11; Total Number of Employees Exposed 3900 |
Status in Federal Agencies
| Organization | Reference |
|---|---|
| EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
| EPA TSCA Section 8(d) unpublished health/safety studies | |
| EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 |
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health