Lactonitrile, 2-methyl-
RTECS #
OD9275000
CAS #
Updated
September 2013
Molecular Weight
85.12
Molecular Formula
C4H7NO
Synonyms
2-Hydroxy-2-methylpropionitrile
2-Methyllactonitrile
Acetoncianhidrinei (Romanian)
Acetoncianidrina (Italian)
Acetoncyaanhydrine (Dutch)
Acetoncyanhydrin (German)
Acetone cyanohydrin
Acetone cyanohydrin (ACGIH)
Acetonecyanhydrine (French)
Acetonkyanhydrin (Czech)
alpha-Hydroxyisobutyronitrile
Cyanhydrine d'acetone (French)
Propanenitrile, 2-hydroxy-2-methyl-
RCRA waste number P069
USAF RH-8
2-Methyllactonitrile
Acetoncianhidrinei (Romanian)
Acetoncianidrina (Italian)
Acetoncyaanhydrine (Dutch)
Acetoncyanhydrin (German)
Acetone cyanohydrin
Acetone cyanohydrin (ACGIH)
Acetonecyanhydrine (French)
Acetonkyanhydrin (Czech)
alpha-Hydroxyisobutyronitrile
Cyanhydrine d'acetone (French)
Propanenitrile, 2-hydroxy-2-methyl-
RCRA waste number P069
USAF RH-8
Acute Toxicity Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/mouse | lethal concentration (30 percent kill): 70 mg/m3/2H | 85GMAT -,15,1982 | |
inhalation/rat | Lowest published lethal concentration: 63 ppm/4H | AIHAAP 23,95,1962 | |
intraperitoneal/mouse | lethal dose (50 percent kill): 1 mg/kg | NTIS** AD277-689 | |
intraperitoneal/rat | lowest published toxic dose: 5022 µg/kg | Behavioral: Convulsions or effect on seizure threshold Behavioral: Alteration of classical conditioning Lung, Thorax, or Respiration: Respiratory depression | NETEEC 32,289,2010 |
intraperitoneal/rat | lowest published lethal dose: 7490 µg/kg | Behavioral: Convulsions or effect on seizure threshold Behavioral: Alteration of classical conditioning Lung, Thorax, or Respiration: Respiratory depression | NETEEC 32,289,2010 |
oral/guinea pig | lethal dose (50 percent kill): 9 mg/kg | NTIS** PB214-270 | |
oral/mammal (species unspecified) | lowest published toxic dose: 0.14 mg/kg | Blood: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) | TOVEFN (1),29,1994 |
oral/mouse | lethal dose (50 percent kill): 1898 µg/kg | TOVEFN (1),29,1994 | |
oral/rabbit | lethal dose (50 percent kill): 13500 µg/kg | NTIS** PB214-270 | |
oral/rat | lethal dose (50 percent kill): 5.9 mg/kg | TOVEFN (1),29,1994 | |
oral/rat | lowest published toxic dose: 20003 µg/kg | Behavioral: Convulsions or effect on seizure threshold Behavioral: Alteration of classical conditioning Lung, Thorax, or Respiration: Respiratory depression | NETEEC 32,289,2010 |
skin/guinea pig | lethal dose (50 percent kill): 150 mg/kg | AMIHBC 8,371,1953 | |
skin/rabbit | lethal dose (50 percent kill): 17 µL/kg | AIHAAP 23,95,1962 | |
subcutaneous/rat | lethal dose (50 percent kill): 8500 µg/kg | Blood: Other changes | BJIMAG 19,283,1962 |
subcutaneous/rat | lowest published lethal dose: 74361 µg/kg/24H | NETEEC 32,289,2010 | |
subcutaneous/rat | lowest published toxic dose: 61286 µg/kg/24H | Behavioral: Muscle weakness Lung, Thorax, or Respiration: Other changes | NETEEC 32,289,2010 |
unreported route/mouse | lethal dose (50 percent kill): 2900 µg/kg | GISAAA 31(6),8,1966 | |
unreported route/rat | lethal dose (50 percent kill): 13300 µg/kg | GISAAA 31(6),8,1966 |
Other Multiple Dose Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
multiple/rat | lowest published toxic dose: 209 mg/kg/3D- continuous | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | NETEEC 32,289,2010 |
oral/rat | lowest published toxic dose: 3634 mg/kg/35W- intermittent | Gastrointestinal: Ulceration or bleeding from stomach Liver: Other changes | AMPMAR 32,653,1971 |
oral/rat | lowest published toxic dose: 0.84 mg/kg/30D- intermittent | Liver: Other changes Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Blood: Other changes | TOVEFN (1),29,1994 |
oral/rat | lowest published toxic dose: 0.84 mg/kg/30D- intermittent | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases | TOVEFN (1),29,1994 |
oral/rat | lowest published toxic dose: 1.27 mg/kg/26W- intermittent | Liver: Other changes Kidney, Ureter, and Bladder: Other changes in urine composition Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) | TOVEFN (1),29,1994 |
oral/rat | lowest published toxic dose: 1.27 mg/kg/26W- intermittent | Blood: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases | TOVEFN (1),29,1994 |
oral/rat | lowest published toxic dose: 8485 mg/kg/57D- continuous | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | NETEEC 32,289,2010 |
oral/rat | lowest published toxic dose: 8444 mg/kg/57D- continuous | Brain and Coverings: Other degenerative changes Behavioral: Alteration of classical conditioning | NETEEC 32,289,2010 |
subcutaneous/rat | lowest published toxic dose: 164 mg/kg/3D- continuous | Behavioral: Alteration of classical conditioning | NETEEC 32,289,2010 |
unreported route/rabbit | lowest published toxic dose: 242 mg/kg/26W- intermittent | Liver: Liver function tests impaired Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) | GISAAA 31(6),8,1966 |
unreported route/rat | lowest published toxic dose: 242 mg/kg/26W- intermittent | Brain and Coverings: Other degenerative changes Blood: Changes in erythrocyte (RBC) count Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | GISAAA 31(6),8,1966 |
Reviews
Organization | Standard | Reference |
---|---|---|
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-ceiling concentration 5 mg(CN)/m3 (skin) | DTLVS* TLV/BEI,2013 |
Standards and Regulations
NIOSH Documentation and Surveillance
Organization | Standard | Reference |
---|---|---|
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ACETONE CYANOHYDRIN-air | ceiling concentration 1 ppm/15M | NIOSH* DHHS #92-100,1992 |
National Occupational Exposure Survey 1983 | Hazard Code X3298; Number of Industries 2; Total Number of Facilities 45; Number of Occupations 2; Total Number of Employees Exposed 1016; Total Number of Female Employees Exposed 187 |
Status in Federal Agencies
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health