Iron, tris(dimethyldithiocarbamato)-

RTECS #

NO8750000

CAS #

14484-64-1; 301-05-3; 13494-27-4; 64070-92-4
See: NMAM or OSHA Methods

Updated

June 2018

Molecular Weight

416.51

Molecular Formula

C₉H₁₈N₃S₆·Fe

Synonyms

Aafertis
Bercema fertam 50
Carbamic acid, dimethyldithio-, iron salt
Carbamodithioic acid, dimethyl-, iron complex
Dimethylcarbamodithioic acid, iron complex
Dimethylcarbamodithioic acid, iron(3+) salt
Dimethyldithiocarbamic acid, iron salt
Dimethyldithiocarbamic acid, iron(3+) salt
Eisen(III)-tris(N,N-dimethyldithiocarbamat) (German)
Eisendimethyldithiocarbamat (German)
ENT 14,689
Ferbam
Ferbam (ACGIH:OSHA)
Ferbam 50
Ferberk
Fermate
Ferradow
Ferric dimethyldithiocarbamate
Fuklasin Ultra
Fuklazin
Hexaferb
Iron dimethyldithiocarbamate
Iron, tris(dimethylcarbamodithioato-S,S')-, (OC-6-11)-
Karbam Black
Liromate
Stauffer ferbam
Trimanzone
Tris(dimethyldithiocarbamato)iron
Tris(N,N-dimethyldithiocarbamato) iron(111)
Vancide FE95

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
Cytogenetic Analysis	oral/mouse	30 mg/kg	TCMUD8 22,451,2002
DNA repair	/Bacillus subtilis	2 µg/disc	MUREAV 40,19,1976
mutation in microorganisms	/Other microorganisms	1000 ppm (-enzymatic activation step)	MMAPAP 50,233,1973
mutation in microorganisms	/Salmonella typhimurium	50 µg/plate (+enzymatic activation step)	CSHCAL 4,267,1977
mutation in microorganisms	/Salmonella typhimurium	200 µg/plate (-enzymatic activation step)	MBENDX 14,377,1986
sperm morphology	oral/mouse	5 gm/kg/5D-continuous	MUREAV 224,405,1989

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
oral/rat	1140 mg/kg (6-15D pregnant)	Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)	TXAPA9 35,83,1976
oral/rat	536 mg/kg (16-22D preg/21D after birth)	Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)	TXAPA9 35,83,1976
oral/rat	3479 mg/kg (16-22D preg/21D after birth)	Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)	TXAPA9 35,83,1976
oral/mouse	5 gm/kg (5D male)	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)	MUREAV 224,405,1989
subcutaneous/mouse	41760 µg/kg (6-14D pregnant)	Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Effects on embryo or fetus: Fetal death	NTIS** PB223-160

Tumorigenic Data and References

Route/Organism	Dose	Effect	Reference
oral/mouse	lowest published toxic dose: 3500 mg/kg/78W- intermittent	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Lung, Thorax, or Respiration: Tumors Liver: Tumors	NTIS** PB223-159
subcutaneous/mouse	lowest published toxic dose: 100 mg/kg	Tumorigenic: Carcinogenic by RTECS criteria Blood: Tumors	NTIS** PB223-159

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
In Vitro/Human, kidney	Inhibitor Concentration (20 percent kill): 17.78 µmol/L/2H	In Vitro Toxicity Studies: Cell metabolic activity: Alamar Blue assay etc.	TIVIEQ 40,66,2017
In Vitro/Human, kidney	Inhibitor Concentration (20 percent kill): 33.88 µmol/L/2H	Endocrine: Other changes	TIVIEQ 40,66,2017
intraperitoneal/guinea pig	lowest published lethal dose: 2300 mg/kg		JAPMA8 41,662,1952
intraperitoneal/mouse	lethal dose (50 percent kill): 3 gm/kg		JAPMA8 41,662,1952
intraperitoneal/rabbit	lowest published lethal dose: 1500 mg/kg		JAPMA8 41,662,1952
intraperitoneal/rat	lethal dose (50 percent kill): 2700 mg/kg		JAPMA8 41,662,1952
oral/guinea pig	lowest published lethal dose: 2 gm/kg		JAPMA8 41,662,1952
oral/mouse	lethal dose (50 percent kill): 3400 mg/kg	Behavioral: Somnolence (general depressed activity) Behavioral: Excitement Behavioral: Ataxia	JTEHD6 4,93,1978
oral/rabbit	lowest published lethal dose: 3 gm/kg		JAPMA8 41,662,1952
oral/rat	lethal dose (50 percent kill): 1130 mg/kg		FATOAO 32,356,1969

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
oral/Dog	lowest published toxic dose: 9125 mg/kg/1Y- continuous	Behavioral: Convulsions or effect on seizure threshold Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	JPETAB 118,174,1956
oral/rat	lowest published toxic dose: 45 gm/kg/30D- continuous	Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	JAPMA8 41,662,1952
oral/rat	lowest published toxic dose: 91250 mg/kg/2Y- continuous	Brain and Coverings: Other degenerative changes Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	JPETAB 118,174,1956

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 5 mg/m³	DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-Not classifiable as a human carcinogen	DTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)	Cancer Review:Animal Inadequate Evidence	IMEMDT 12,121,1976
International Agency for Research on Cancer (IARC)	Cancer Review:Human No Adequate Data	IMEMDT 12,121,1976
International Agency for Research on Cancer (IARC)	Cancer Review:Group 3	IMSUDL 7,56,1987
TOXICOLOGY REVIEW		FEREAC 72,32570,2007
TOXICOLOGY REVIEW		FEREAC 72,53449,2007
TOXICOLOGY REVIEW		HUTOX* -,561,1996
TOXICOLOGY REVIEW		HETOEA 26,321,2007

Standards and Regulations

Organization	Standard	Reference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION		FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES	Supported	RBREV* -,173,1998
Mine Safety and Health Administration (MSHA) STANDARD-air	time-weighted average 10 mg/m³	DTLVS* 3,113,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 10 mg/m³, JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 10 mg/m³, inhal, 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 1 mg(Fe)/m³, MAR2002
Occupational Exposure Limit-BELGIUM	time-weighted average 10 mg/m³, MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 5 mg/m³, MAY2011
Occupational Exposure Limit-FRANCE	VME 10 mg/m³, FEB2006
Occupational Exposure Limit-ICELAND	time-weighted average 5 mg/m³, NOV2011
Occupational Exposure Limit-KOREA	time-weighted average 10 mg/m³, 2006
Occupational Exposure Limit-MEXICO	time-weighted average 10 mg/m³;short term exposure limit 20 mg/m³, 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 10 mg/m³, JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 1 mg(Fe)/m³, JAN1999
Occupational Exposure Limit-PERU	time-weighted average 10 mg/m³, JUL2005
Occupational Exposure Limit-SWITZERLAND	MAK-week 10 mg/m³, inhal, JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 10 mg/m³, 2003
Occupational Exposure Limit-TURKEY	time-weighted average 15 mg/m³, JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 15 mg/m³, total dust	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	8H time-weighted average 15 mg/m³	CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 15 mg/m³, total dust	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 15 mg/m³, total dust	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO FERBAM-air	10H time-weighted average 10 mg/m³	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code M0362; Number of Industries 1; Total Number of Facilities 291; Number of Occupations 1; Total Number of Employees Exposed 3205
National Occupational Hazard Survey 1974	Hazard Code M0362; Number of Industries 1; Total Number of Facilities 12; Number of Occupations 1; Total Number of Employees Exposed 72

Status in Federal Agencies

Organization	Reference
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health