Glycerol
RTECS #
MA8050000
CAS #
Updated
March 2019
Molecular Weight
92.11
Molecular Formula
C3H8O3
Synonyms
1,2,3-Propanetriol
1,2,3-Trihydroxypropane
90 Technical glycerine
Citifluor AF 2
Clyzerin, wasserfrei (German)
Glycerin
Glycerin mist
Glycerin mist (ACGIH,OSHA)
Glycerin, anhydrous
Glycerin, synthetic
Glycerine
Glyceritol
Glycyl alcohol
Grocolene
MOON
Osmoglyn
Star
Synthetic glycerin
Trihydroxypropane
1,2,3-Trihydroxypropane
90 Technical glycerine
Citifluor AF 2
Clyzerin, wasserfrei (German)
Glycerin
Glycerin mist
Glycerin mist (ACGIH,OSHA)
Glycerin, anhydrous
Glycerin, synthetic
Glycerine
Glyceritol
Glycyl alcohol
Grocolene
MOON
Osmoglyn
Star
Synthetic glycerin
Trihydroxypropane
Skin and Eye Irritation and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| eye /rabbit | 500 mg/24H | mild | 85JCAE -,207,1986 |
| skin /rabbit | 500 mg/24H | mild | 85JCAE -,207,1986 |
Mutation Data and Reference
| System Test | Route/Organism/Tissue | Dose | Reference |
|---|---|---|---|
| Cytogenetic Analysis | oral/rat | 1 gm/kg | TGANAK 19,436,1985 |
| DNA inhibition | lymphocyte/human | 200 mmol/L | PNASA6 79,1171,1982 |
Reproductive Effects Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| intratesticular/rat | 280 mg/kg (2D male) | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct | CCPTAY 29,291,1984 |
| intratesticular/rat | 1600 mg/kg (1D male) | Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) | CCPTAY 29,291,1984 |
| intratesticular/rat | 862 mg/kg (1D male) | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) | LIFSAK 34,1747,1984 |
| intratesticular/monkey | 119 mg/kg (1D male) | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct | CCPTAY 39,447,1989 |
| oral/rat | 100 mg/kg (1D male) | Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) | TGANAK 19,436,1985 |
Tumorigenic Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| oral/mouse | lowest published toxic dose: 87.5 gm/kg/25W- intermittent | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Lung, Thorax, or Respiration: Tumors Tumorigenic: Facilitates action of known carcinogens | CALEDQ 229,181,2005 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| In Vitro/Human, colon tumor | Inhibitor Concentration (50 percent kill): 35.8 µmol/L/24H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | FCTOD7 74,311,2014 |
| In Vitro/Human, colon tumor | Inhibitor Concentration (50 percent kill): 21 µmol/L/48H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | FCTOD7 74,311,2014 |
| In Vitro/Human, colon tumor | Inhibitor Concentration Low: 40 µmol/L/24H | In Vitro Toxicity Studies: Cell morphology: overgrowth of cell appendixes etc. | FCTOD7 74,311,2014 |
| In Vitro/Human, colon tumor | Inhibitor Concentration Low: 50 µmol/L/24H | In Vitro Toxicity Studies: Apoptosis in vitro | FCTOD7 74,311,2014 |
| In Vitro/Human, leukemia cells | Inhibitor Concentration (5 percent kill): >25000 mg/L/30M | In Vitro Toxicity Studies: Cell counting | TIVIEQ 27,857,2013 |
| In Vitro/Human, leukemia cells | Inhibitor Concentration Low: 25000 mg/L/30M | In Vitro Toxicity Studies: Other assays | TIVIEQ 27,857,2013 |
| In Vitro/Human, liver tumor | Inhibitor Concentration (50 percent kill): 983 mmol/L/24H | In Vitro Toxicity Studies: Cell protein synthesis | TIVIEQ 3,189,1989 |
| In Vitro/Human, lung | Inhibitor Concentration (20 percent kill): >4 mmol/L | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 30,274,2015 |
| In Vitro/Human, lymphocyte | Inhibitor Concentration (30 percent kill): >200 mg/L/45H | In Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc. | TIVIEQ 29,901,2015 |
| In Vitro/Human, lymphocyte | Inhibitor Concentration (50 percent kill): >200 mg/L/45H | In Vitro Toxicity Studies: Other assays | TIVIEQ 29,901,2015 |
| In Vitro/Human, monocyte | Inhibitor Concentration (20 percent kill): >10000 µmol/L/24H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TOLED5 199,51,2010 |
| In Vitro/Human, monocyte | Inhibitor Concentration (20 percent kill): 10 mmol/L/2H | In Vitro Toxicity Studies: Other assays | TOLED5 199,51,2010 |
| In Vitro/Human, skin | Inhibitor Concentration Low: 0.01 pph/6H | In Vitro Toxicity Studies: Other assays | TIVIEQ 27,2213,2013 |
| In Vitro/Human, skin | Inhibitor Concentration (50 percent kill): >2000 µmol/L/48H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 29,688,2015 |
| In Vitro/Human, skin | Inhibitor Concentration (50 percent kill): >2000 µmol/L/48H | In Vitro Toxicity Studies: Cell metabolic activity: Alamar Blue assay etc. | TIVIEQ 29,688,2015 |
| In Vitro/Human, skin | Inhibitor Concentration (30 percent kill): >2000 µmol/L/48H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 29,688,2015 |
| In Vitro/Human, skin | Inhibitor Concentration (30 percent kill): >2000 µmol/L/48H | In Vitro Toxicity Studies: Cell metabolic activity: Alamar Blue assay etc. | TIVIEQ 29,688,2015 |
| In Vitro/jda | Inhibitor Concentration (50 percent kill): 454605 mg/L/1H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TOLED5 212,198,2012 |
| In Vitro/jkh | Inhibitor Concentration Low: 50 µmol/L/24H | In Vitro Toxicity Studies: Apoptosis in vitro | FCTOD7 74,311,2014 |
| In Vitro/jkh | Inhibitor Concentration Low: 40 µmol/L/24H | In Vitro Toxicity Studies: Cell morphology: overgrowth of cell appendixes etc. | FCTOD7 74,311,2014 |
| In Vitro/jkh | Inhibitor Concentration (50 percent kill): 34.5 µmol/L/24H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | FCTOD7 74,311,2014 |
| In Vitro/jkh | Inhibitor Concentration (50 percent kill): 23 µmol/L/48H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | FCTOD7 74,311,2014 |
| In Vitro/jzx | Inhibitor Concentration (50 percent kill): 68391.33 mg/L/48H | In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc. | TIVIEQ 25,1989,2011 |
| In Vitro/jzx | Inhibitor Concentration (50 percent kill): 55.2 pph/60M | In Vitro Toxicity Studies: Other assays | TIVIEQ 26,150,2012 |
| In Vitro/Mouse, fibroblast | Inhibitor Concentration (50 percent kill): 289 mmol/L/48H | In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc. | TIVIEQ 27,1357,2013 |
| In Vitro/paa | Inhibitor Concentration Low: 267 mmol/L/44H | In Vitro Toxicity Studies: Other assays | TIVIEQ 27,1416,2013 |
| In Vitro/Rabbit, ocular | Inhibitor Concentration (50 percent kill): 0.035 gm/L/10M | In Vitro Toxicity Studies: Cell Viability (cell death), unspecified assay | TIVIEQ 3,329,1989 |
| intramuscular/rat | lowest published toxic dose: 5 mL/kg | Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) | FCTOD7 50,2622,2012 |
| intramuscular/rat | lowest published toxic dose: 5000 mg/kg | Kidney, Ureter, and Bladder: Renal function tests depressed | EKFAE9 55,21,1992 |
| intramuscular/rat | lowest published toxic dose: 8 mL/kg | Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | TXCYAC 201,143,2004 |
| intramuscular/rat | lowest published lethal dose: 10 mg/kg | Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, and Bladder: Other changes in urine composition | NPRNAY 20,47,1978 |
| intramuscular/rat | lowest published toxic dose: 4 mL/kg | Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, and Bladder: Urine volume decreased or anuria Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases | PHMCAA 67,41,2003 |
| intramuscular/rat | lowest published toxic dose: 4000 mg/kg | Kidney, Ureter, and Bladder: Other changes Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | FCTOD7 46,710,2008 |
| intramuscular/rat | lowest published lethal dose: 10 mL/kg | Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects | CEXPB9 33,119,2006 |
| intramuscular/rat | lowest published toxic dose: 4 mL/kg | Vascular: Contraction (isolated tissue) Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, and Bladder: Other changes | JPETAB 322,461,2007 |
| intraperitoneal/mouse | lethal dose (50 percent kill): 8700 mg/kg | Behavioral: Altered sleep time (including change in righting reflex) | ARZNAD 28,1579,1978 |
| intraperitoneal/rat | lethal dose (50 percent kill): 4420 mg/kg | Behavioral: Toxic psychosis Cardiac: Other changes Kidney, Ureter, and Bladder: Other changes | RCOCB8 56,125,1987 |
| intravenous/mouse | lethal dose (50 percent kill): 4250 mg/kg | JAPMA8 39,583,1950 | |
| intravenous/rabbit | lethal dose (50 percent kill): 53 gm/kg | NIIRDN 6,215,1982 | |
| intravenous/rat | lethal dose (50 percent kill): 5566 mg/kg | ARZNAD 26,1581,1976 | |
| oral/guinea pig | lethal dose (50 percent kill): 7750 mg/kg | JIHTAB 23,259,1941 | |
| oral/human | lowest published toxic dose: 1428 mg/kg | Behavioral: Headache Gastrointestinal: Nausea or vomiting | 34ZIAG -,288,1969 |
| oral/man | lowest published toxic dose: 3.88 gm/kg | Brain and Coverings: Changes in surface EEG Behavioral: Excitement Gastrointestinal: Hypermotility, diarrhea | JTCTDW 47,312,2009 |
| oral/mouse | lethal dose (50 percent kill): 4090 mg/kg | FRZKAP (6),56,1977 | |
| oral/rabbit | lethal dose (50 percent kill): 27 gm/kg | DMDJAP 31,276,1959 | |
| oral/rat | lethal dose (50 percent kill): 12600 mg/kg | Behavioral: General anesthetic Behavioral: Muscle weakness Liver: Other changes | FEPRA7 4,142,1945 |
| oral/rat | lethal dose (50 percent kill): 12600 mg/kg | ENTOX* -,449,2005 | |
| subcutaneous/mouse | lethal dose (50 percent kill): 91 mg/kg | NIIRDN 6,215,1982 | |
| subcutaneous/rat | lethal dose (50 percent kill): 100 mg/kg | NIIRDN 6,215,1982 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| oral/mouse | lowest published toxic dose: 560 gm/kg/8W- continuous | Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi | EXLRDA 12,281,1987 |
| oral/mouse | lowest published toxic dose: 2800 mg/kg/25W- continuous | Skin and Appendages: Tumors Tumorigenic: Facilitates action of known carcinogens | CALEDQ 155,61,2000 |
| oral/rat | lowest published toxic dose: 96 gm/kg/30D- intermittent | Blood: Changes in leukocyte (WBC) count Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | GISAAA 49(10),81,1984 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| TOXICOLOGY REVIEW | INMEAF 9,-,1940 | |
| TOXICOLOGY REVIEW | TPHSDY 23,504,2002 | |
| TOXICOLOGY REVIEW | TPHSDY 24,355,2003 | |
| TOXICOLOGY REVIEW | ENTOX* -,449,2005 | |
| TOXICOLOGY REVIEW | FCTOD7 47,1287,2009 | |
| TOXICOLOGY REVIEW | REPTED 58,252,2015 | |
| TOXICOLOGY REVIEW | FCTOD7 84,133,2015 | |
| TOXICOLOGY REVIEW | RTOPDW 58,395,2010 | |
| TOXICOLOGY REVIEW | RTOPDW 59,364,2011 | |
| TOXICOLOGY REVIEW | RTOPDW 61,119,2011 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION | FEREAC 54,7740,1989 | |
| Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES | Cancelled | RBREV* -,313,1998 |
| Mine Safety and Health Administration (MSHA) STANDARD | NUISANCE PARTICULATES (mist) | DTLWS* 3,20,1973 |
| Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
| Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
| Occupational Exposure Limit-BELGIUM | time-weighted average 10 mg/m3, MAR2002 | |
| Occupational Exposure Limit-FINLAND | time-weighted average 20 mg/m3, NOV2011 | |
| Occupational Exposure Limit-FRANCE | VME 10 mg/m3, FEB2006 | |
| Occupational Exposure Limit-GERMANY | MAK 50 mg/m3, inhal, 2011 | |
| Occupational Exposure Limit-KOREA | time-weighted average 10 mg/m3 (mist), 2006 | |
| Occupational Exposure Limit-MEXICO | time-weighted average 10 mg/m3 (inhalable), 2004 | |
| Occupational Exposure Limit-NEW ZEALAND | time-weighted average 10 mg/m3 (mist), JAN2002 | |
| Occupational Exposure Limit-PERU | time-weighted average 10 mg/m3, JUL2005 | |
| Occupational Exposure Limit-SWITZERLAND | MAK-week 50 mg/m3, KZG-week 100 mg/m3, inhal, JAN2011 | |
| Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 10 mg/m3, 2003 | |
| Occupational Exposure Limit-UNITED KINGDOM | time-weighted average 10 mg/m3, OCT2007 | |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 15 mg/m3, total dust | CFRGBR 29,1926.55,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 5 mg/m3, respirable fraction | CFRGBR 29,1926.55,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 15 mg/m3, total dust | CFRGBR 29,1910.1000,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 5 mg/m3, respirable fraction | CFRGBR 29,1910.1000,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 15 mg/m3, total dust | CFRGBR 29,1915.1000,1993 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 5 mg/m3, respirable fraction | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
Status in Federal Agencies
| Organization | Reference |
|---|---|
| EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
| EPA TSCA Section 8(d) unpublished health/safety studies | |
| EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 |
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health