Formic acid, methyl ester
RTECS #
LQ8925000
CAS #
Updated
September 2013
Molecular Weight
60.06
Molecular Formula
C2H4O2
Synonyms
Formiate de methyle (French)
Methyl formate
Methyl formate (ACGIH:OSHA)
Methyl methanoate
Methyle (formiate de) (French)
Methylester kyseliny mravenci (Czech)
Methylformiaat (Dutch)
Methylformiat (German)
Metil (formiato di) (Italian)
Mravencan methylnaty (Czech)
Methyl formate
Methyl formate (ACGIH:OSHA)
Methyl methanoate
Methyle (formiate de) (French)
Methylester kyseliny mravenci (Czech)
Methylformiaat (Dutch)
Methylformiat (German)
Metil (formiato di) (Italian)
Mravencan methylnaty (Czech)
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/human | lowest published toxic concentration: 100 ppm/6H | Behavioral: Headache | HPV246 -,-,2001 |
| inhalation/rat | lethal concentration (50 percent kill): 5200 mg/m3/4H | NTIS** OTS0556791 | |
| inhalation/rat | lethal concentration (50 percent kill): >21000 mg/m3/4H | Eye: Lacrimation Behavioral: Somnolence (general depressed activity) | HPV246 -,-,2001 |
| oral/mouse | lethal dose (50 percent kill): 675 mg/kg | NTIS** OTS0556689 | |
| oral/rabbit | lethal dose (50 percent kill): 1600 mg/kg | HPV246 -,-,2001 | |
| oral/rat | lethal dose (50 percent kill): 1500 mg/kg | Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Acute pulmonary edema Gastrointestinal: Ulceration or bleeding from stomach | HPV246 -,-,2001 |
| oral/rat | lethal dose (50 percent kill): 475 mg/kg | NTIS** OTS0556689 | |
| skin/guinea pig | lethal dose (50 percent kill): >20 mL/kg | NTIS** OTS0556689 | |
| skin/rabbit | lethal dose (50 percent kill): >5 gm/kg | NTIS** OTS0556797 | |
| skin/rat | lethal dose (50 percent kill): >4 gm/kg | NTIS** OTS0556791 | |
| skin/rat | lethal dose (50 percent kill): >4000 mL/kg | Behavioral: Somnolence (general depressed activity) | HPV246 -,-,2001 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 100 ppm;short term exposure limit 150 ppm | DTLVS* TLV/BEI,2013 |
| TOXICOLOGY REVIEW | AMIHAB 20,517,1959 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 100 ppm (250 mg/m3) | DTLVS* 3,165,1971 |
| Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
| Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
| Occupational Exposure Limit-AUSTRALIA | time-weighted average 100 ppm (246 mg/m3), short term exposure limit 150 ppm (368 mg/m3), , JUL2008 | |
| Occupational Exposure Limit-AUSTRIA | MAK-TMW 50 ppm (120 mg/m3);KZW 50 ppm (120 mg/m3), skin, 2007 | |
| Occupational Exposure Limit-BELGIUM | time-weighted average 100 ppm(250 mg/m3), short term exposure limit 150 ppm(373 mg/m3), MAR2002 | |
| Occupational Exposure Limit-DENMARK | time-weighted average 50 ppm (123 mg/m3), skin, MAY2011 | |
| Occupational Exposure Limit-FINLAND | time-weighted average 50 ppm (125 mg/m3), short term exposure limit 150 ppm (370 mg/m3), NOV2011 | |
| Occupational Exposure Limit-FRANCE | VME 100 ppm (250 mg/m3), FEB2006 | |
| Occupational Exposure Limit-GERMANY | MAK 50 ppm (120 mg/m3), 2011 | |
| Occupational Exposure Limit-ICELAND | time-weighted average 50 ppm (123 mg/m3), skin, NOV2011 | |
| Occupational Exposure Limit-KOREA | time-weighted average 100 ppm (250 mg/m3), short term exposure limit 150 ppm (375 mg/m3), 2006 | |
| Occupational Exposure Limit-MEXICO | time-weighted average 100 ppm (250 mg/m3);short term exposure limit 150 ppm (375 mg/m3), 2004 | |
| Occupational Exposure Limit-NEW ZEALAND | time-weighted average 100 ppm (246 mg/m3); short term exposure limit 150 ppm (368 mg/m3), JAN2002 | |
| Occupational Exposure Limit-PERU | time-weighted average 100 ppm (266 mg/m3); short term exposure limit 150 ppm (399 mg/m3), JUL2005 | |
| Occupational Exposure Limit-SWEDEN | time-weighted average 100 ppm (250 mg/m3);short term exposure limit 150 ppm (350 mg/m3), JUN2005 | |
| Occupational Exposure Limit-SWITZERLAND | MAK-week 50 ppm (125 mg/m3), KZG-week 200 ppm (500 mg/m3), skin, JAN2011 | |
| Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 250 mg/m3, 2003 | |
| Occupational Exposure Limit-TURKEY | time-weighted average 100 ppm (250 mg/m3), JAN1993 | |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 100 ppm (250 mg/m3) | CFRGBR 29,1926.55,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 100 ppm (250 mg/m3) | CFRGBR 41,50-204.50,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 100 ppm (250 mg/m3) | CFRGBR 29,1910.1000,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 100 ppm (250 mg/m3) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METHYL FORMATE-air | 10H time-weighted average 100 ppm;short term exposure limit 150 ppm | NIOSH* DHHS #92-100,1992 |
| National Occupational Exposure Survey 1983 | Hazard Code 33850; Number of Industries 6; Total Number of Facilities 80; Number of Occupations 22; Total Number of Employees Exposed 7738; Total Number of Female Employees Exposed 1402 |
Status in Federal Agencies
| Organization | Reference |
|---|---|
| EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
| EPA TSCA Section 8(d) unpublished health/safety studies | |
| EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 |
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health