Formic acid, ethyl ester
RTECS #
LQ8400000
CAS #
Updated
September 2013
Molecular Weight
74.09
Molecular Formula
C3H6O2
Synonyms
Aethylformiat (German)
Areginal
Ethyl formate
Ethyl formate (ACGIH:OSHA)
Ethyl formic ester
Ethyl methanoate
Ethyle (formiate d') (French)
Ethylester kyseliny mravenci (Czech)
Ethylformiaat (Dutch)
Etile (formiato di) (Italian)
Formic ether
Mrowczan etylu (Polish)
Areginal
Ethyl formate
Ethyl formate (ACGIH:OSHA)
Ethyl formic ester
Ethyl methanoate
Ethyle (formiate d') (French)
Ethylester kyseliny mravenci (Czech)
Ethylformiaat (Dutch)
Etile (formiato di) (Italian)
Formic ether
Mrowczan etylu (Polish)
Skin and Eye Irritation and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| skin /rabbit | 460 mg open irritation test | mild | UCDS** 4/10/1968 |
Tumorigenic Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| skin/mouse | lowest published toxic dose: 110 gm/kg/9W- intermittent | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Skin and Appendages: Tumors | BJCAAI 9,177,1955 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/rat | Lowest published lethal concentration: 8000 ppm/4H | AMIHBC 10,61,1954 | |
| inhalation/rat | lethal concentration (50 percent kill): 28950 mg/m3 | TOVEFN (1),61,1995 | |
| inhalation/rat | lowest published toxic concentration: 300 mg/m3 | Behavioral: Change in motor activity (specific assay) Behavioral: Alteration of classical conditioning Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) | TOVEFN (1),61,1995 |
| inhalation/rat | lowest published toxic concentration: 300 mg/m3 | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Peptidases | TOVEFN (1),61,1995 |
| oral/guinea pig | lethal dose (50 percent kill): 1110 mg/kg | Behavioral: Somnolence (general depressed activity) Gastrointestinal: Gastritis | FCTXAV 2,327,1964 |
| oral/rabbit | lethal dose (50 percent kill): 2075 mg/kg | IMSUAI 41,31,1972 | |
| oral/rat | lethal dose (50 percent kill): 2699 mg/kg | Behavioral: General anesthetic Behavioral: Alteration of classical conditioning Lung, Thorax, or Respiration: Dyspnea | TOVEFN (1),61,1995 |
| oral/rat | lethal dose (50 percent kill): 1850 mg/kg | Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Dyspnea | FCTXAV 2,327,1964 |
| skin/rabbit | lethal dose (50 percent kill): >20 mL/kg | AMIHBC 10,61,1954 | |
| subcutaneous/rabbit | lowest published lethal dose: 1 gm/kg | FCTXAV 16,737,1978 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| oral/rabbit | lowest published toxic dose: 619 mg/kg/13W- intermittent | Kidney, Ureter, and Bladder: Interstitial nephritis Kidney, Ureter, and Bladder: Proteinuria Blood: Other changes | FAONAU 44A,1,1967 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-short term exposure limit 100 ppm | DTLVS* TLV/BEI,2013 |
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Not classifiable as a human carcinogen | DTLVS* TLV/BEI,2013 |
| TOXICOLOGY REVIEW | AMIHAB 20,517,1959 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 100 ppm (300 mg/m3) | DTLVS* 3,107,1971 |
| Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
| Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
| Occupational Exposure Limit-AUSTRALIA | time-weighted average 100 ppm (303 mg/m3), JUL2008 | |
| Occupational Exposure Limit-AUSTRIA | MAK-TMW 100 ppm (300 mg/m3);KZW 200 ppm (600 mg/m3), skin, 2007 | |
| Occupational Exposure Limit-BELGIUM | time-weighted average 100 ppm (307 mg/m3), MAR2002 | |
| Occupational Exposure Limit-DENMARK | time-weighted average 100 ppm (300 mg/m3), MAY2011 | |
| Occupational Exposure Limit-FINLAND | time-weighted average 100 ppm (310 mg/m3), short term exposure limit 150 ppm (460 mg/m3), NOV2011 | |
| Occupational Exposure Limit-FRANCE | VME 100 ppm (300 mg/m3), FEB2006 | |
| Occupational Exposure Limit-GERMANY | MAK 100 ppm (310 mg/m3), skin, 2011 | |
| Occupational Exposure Limit-ICELAND | time-weighted average 100 ppm (300 mg/m3), NOV2011 | |
| Occupational Exposure Limit-KOREA | time-weighted average 100 ppm (300 mg/m3), 2006 | |
| Occupational Exposure Limit-MEXICO | time-weighted average 100 ppm (300 mg/m3);short term exposure limit 150 ppm (450 mg/m3), 2004 | |
| Occupational Exposure Limit-NEW ZEALAND | time-weighted average 100 ppm (303 mg/m3), JAN2002 | |
| Occupational Exposure Limit-NORWAY | time-weighted average 50 ppm (150 mg/m3), JAN1999 | |
| Occupational Exposure Limit-PERU | time-weighted average 100 ppm (303 mg/m3), JUL2005 | |
| Occupational Exposure Limit-POLAND | MAC(time-weighted average) 100 mg/m3, MAC(short term exposure limit) 450 mg/m3, JAN1999 | |
| Occupational Exposure Limit-SWITZERLAND | ceiling concentration 100 ppm (310 mg/m3), skin, JAN2011 | |
| Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 300 mg/m3, 2003 | |
| Occupational Exposure Limit-TURKEY | time-weighted average 100 ppm (300 mg/m3), JAN1993 | |
| Occupational Exposure Limit-UNITED KINGDOM | time-weighted average 100 ppm (308 mg/m3);short term exposure limit 150 ppm (462 mg/m3), OCT2007 | |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 100 ppm (300 mg/m3) | CFRGBR 29,1926.55,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 100 ppm (300 mg/m3) | CFRGBR 41,50-204.50,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 100 ppm (300 mg/m3) | CFRGBR 29,1910.1000,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 100 ppm (300 mg/m3) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ETHYL FORMATE-air | 10H time-weighted average 100 ppm | NIOSH* DHHS #92-100,1992 |
| National Occupational Exposure Survey 1983 | Hazard Code 32610; Number of Industries 6; Total Number of Facilities 99; Number of Occupations 19; Total Number of Employees Exposed 8151; Total Number of Female Employees Exposed 1169 | |
| National Occupational Hazard Survey 1974 | Hazard Code 32610; Number of Industries 1; Total Number of Facilities 21; Number of Occupations 1; Total Number of Employees Exposed 124 |
Status in Federal Agencies
| Organization | Reference |
|---|---|
| EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
| EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 | |
| NIOSH Analytical Method, 1994: Ethyl formate, 1452 |
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health