Ferrocene

RTECS #

LK0700000

CAS #

102-54-5
See: NMAM or OSHA Methods

Updated

September 2013

Molecular Weight

186.05

Molecular Formula

C₁₀H₁₀Fe

Synonyms

Biscyclopentadienyliron
Catane
Di-2,4-cyclopentadien-1-yliron
Dicyclopentadienyl iron
Dicyclopentadienyl iron (ACGIH:OSHA)
Ferrotsen
Iron bis(cyclopentadiene)
Iron dicyclopentadienyl

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
DNA Damage	oral/rat	202.5 gm/kg/1Y- intermittent	TXCYAC 254,11,2008
heritable translocation test	parenteral/Drosophila melanogaster	100 ppm	ENMUDM 7,87,1985
mutation in microorganisms	/Salmonella typhimurium	10 µg/plate (-enzymatic activation step)	ENMUDM 5(Suppl 1),3,1983
sex chromosome loss and nondisjunction	parenteral/Drosophila melanogaster	100 ppm	ENMUDM 7,87,1985
sister chromatid exchange	ovary/hamster	130 µg/L	ENMUDM 7,1,1985

Tumorigenic Data and References

Route/Organism	Dose	Effect	Reference
intramuscular/rat	lowest published toxic dose: 5175 mg/kg/2Y- intermittent	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Tumorigenic: Tumors at site of application	NCIUS* PH43-64-886

Acute Toxicity Data and References

Route/Organism	Dose	Reference
inhalation/mammal (species unspecified)	Lethal concentration: >21700 µg/m³	STGNBT -,228,1999
intraperitoneal/mouse	lethal dose (50 percent kill): 335 mg/kg	NCIUS* PH43-64-886
intraperitoneal/rat	lethal dose (50 percent kill): 500 mg/kg	NCIUS* PH43-64-886
intravenous/mouse	lethal dose (50 percent kill): 178 mg/kg	CSLNX* NX#02382
oral/mouse	lethal dose (50 percent kill): 832 mg/kg	BJPCAL 24,352,1965
oral/rat	lethal dose (50 percent kill): 1320 mg/kg	SCCUR* -,5,1961

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/mammal (species unspecified)	lowest published toxic concentration: 15800 µg/m³/17W- intermittent	Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Kidney, Ureter, and Bladder: Other changes in urine composition Nutritional and Gross Metabolic: Changes in: Fe	STGNBT -,228,1999
inhalation/mouse	lowest published toxic concentration: 20 mg/m³/2W- intermittent	Liver: Changes in liver weight Endocrine: Changes in spleen weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain	FAATDF 17,150,1991
inhalation/rat	lowest published toxic concentration: 36 mg/m³/2W- intermittent	Liver: Changes in liver weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain	FAATDF 17,150,1991
oral/Dog	lowest published toxic dose: 54600 mg/kg/26W- intermittent	Liver: Hepatitis, fibrous (cirrhosis, post- necrotic scarring) Endocrine: Other changes Nutritional and Gross Metabolic: Changes in: Fe	TXAPA9 15,666,1969

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 10 mg(Fe)/m3	DTLVS* TLV/BEI,2013

Standards and Regulations

Organization	Standard	Reference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 0.1 mg(Fe)/m³, JUL2008
Occupational Exposure Limit-AUSTRALIA	time-weighted average 10 mg/m³, JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 5 mg/m³;KZW 10 mg/m³, inhal, 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 1 mg(Fe)/m³, MAR2002
Occupational Exposure Limit-BELGIUM	time-weighted average 10 mg/m³, MAR2002
Occupational Exposure Limit-FINLAND	time-weighted average 10 mg/m³, short term exposure limit 20 mg/m³, NOV2011
Occupational Exposure Limit-FRANCE	VME 10 mg/m³, FEB2006
Occupational Exposure Limit-KOREA	time-weighted average 10 mg/m³, 2006
Occupational Exposure Limit-MEXICO	time-weighted average 10 mg/m³;short term exposure limit 20 mg/m³, 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 10 mg/m³, JAN2002
Occupational Exposure Limit-PERU	time-weighted average 10 mg/m³, JUL2005
Occupational Exposure Limit-SWITZERLAND	MAK-week 10 mg/m³, inhal, JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 10 mg/m³, 2003
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 15 mg/m³, total dust	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 5 mg/m³, respirable fraction	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 15 mg/m³, total dust	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 5 mg/m³, respirable fraction	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 15 mg/m³, total dust	CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 5 mg/m³, respirable fraction	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DICYCLOPENTADIENYL IRON, total dust-air	time-weighted average 10 mg/m³	NIOSH* DHHS #95-121,1995
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DICYCLOPENTADIENYL IRON-air	10H time-weighted average 5 mg/m³	NIOSH* DHHS #95-121,1995
National Occupational Exposure Survey 1983	Hazard Code T2061; Number of Industries 2; Total Number of Facilities 14; Number of Occupations 3; Total Number of Employees Exposed 412; Total Number of Female Employees Exposed 328

Status in Federal Agencies

Organization	Reference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health