Ethylene, 1,1-difluoro-

RTECS #

KW0560000

CAS #

75-38-7
See: NMAM or OSHA Methods

Updated

September 2013

Molecular Weight

64.04

Molecular Formula

C₂H₂F₂

Synonyms

1,1-Difluoroethene
Ethene, 1,1-difluoro-
Halocarbon 1132A
NCI-C60208
VDF
Vinylidene difluoride
Vinylidene fluoride

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
mutation in microorganisms	/Salmonella typhimurium	50 pph/24H (-enzymatic activation step)	ARTODN 41,249,1979

Route/Organism	Dose	Effect	Reference
oral/rat	lowest published toxic dose: 1930 mg/kg/52W- intermittent	Tumorigenic: Neoplastic by RTECS criteria Ear: Tumors Skin and Appendages: Tumors	MELAAD 70,363,1979
oral/rat	lowest published toxic dose: 857 mg/kg/130W- intermittent	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Skin and Appendages: Tumors	VCVGH* -,287,1990

Route/Organism	Dose	Effect	Reference
inhalation/guinea pig	Lowest published lethal concentration: 800 ppb/4H		NTIS** OTS0523847
inhalation/rat	lethal concentration (50 percent kill): 240000 mg/m³/4H		VCVGH* -,287,1990
inhalation/rat	Lowest published lethal concentration: 128000 ppm/4H	Lung, Thorax, or Respiration: Other changes	JOCMA7 4,262,1962

Route/Organism	Dose	Effect	Reference
inhalation/mouse	lowest published toxic concentration: 40000 ppm/6H/13W- intermittent	Behavioral: Excitement Blood: Pigmented or nucleated red blood cells Skin and Appendages: Other: Hair	NTIS** OTS0522815
inhalation/rat	lowest published toxic concentration: 1500 ppm/6H/13W- intermittent	Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in bladder weight Blood: Changes in erythrocyte (RBC) count	NTIS** OTS0523847

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 500 ppm	DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-Not classifiable as a human carcinogen	DTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)	Cancer Review:Animal Inadequate Evidence	IMEMDT 39,227,1986
International Agency for Research on Cancer (IARC)	Cancer Review:Animal Inadequate Data	IMEMDT 71,1551,1999
International Agency for Research on Cancer (IARC)	Cancer Review:Human No Adequate Data	IMEMDT 39,227,1986
International Agency for Research on Cancer (IARC)	Cancer Review:Human No Adequate Data	IMEMDT 71,1551,1999
International Agency for Research on Cancer (IARC)	Cancer Review:Group 3	IMEMDT 71,1551,1999
TOXICOLOGY REVIEW		ENTOX* -,43,2005
TOXICOLOGY REVIEW		FCTOD7 47,1287,2009
TOXICOLOGY REVIEW		FCTOD7 49,1877,2011

Organization	Standard	Reference
Occupational Exposure Limit-BELGIUM	time-weighted average 500 ppm (1330 mg/m³), MAR2002

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO VINYLIDENE FLUORIDE-air	use 29 Code of Federal Regulations (CFR) 1910.1017	NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974	Hazard Code 80234; Number of Industries 2; Total Number of Facilities 41; Number of Occupations 4; Total Number of Employees Exposed 1467

Organization	Reference
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE	FEREAC 47,26992,82
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

Page last reviewed: November 16, 2018