NIOSH logo and tagline

Ether, diphenyl

Related Pages
RTECS #
KN8970000
CAS #
101-84-8
See: NMAM or OSHA Methods
Updated
December 2013
Molecular Weight
170.22
Molecular Formula
C12H10O
Synonyms
Benzene, 1,1'-oxybis- (9CI)
Benzene, phenoxy-
Biphenyl oxide
Chemcryl JK-EB
Diphenyl ether
Diphenyl oxide
Geranium crystals
Oxybisbenzene
Oxydiphenyl
Phenoxybenzene
Phenyl ether (ACGIH:OSHA)
Phenyl ether, fume
Phenyl oxide

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 10 ppm/140HTXAPA9 33,78,1975
eye /rat 10 ppm/140HTXAPA9 33,78,1975
skin /rabbit 500 mg/24H mildFCTXAV 12,707,1974

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 2000 mg/kg (6-15D pregnant)Reproductive: Other effects on femaleHPV217 -,-,2002

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
oral/rat lethal dose (50 percent kill): 2450 mg/kgBehavioral: Food intake (animal)

Behavioral: Muscle weakness

Gastrointestinal: Other changes		NTIS** 0TS0518143
oral/rat lethal dose (50 percent kill): 4000 mg/kgGastrointestinal: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes		VCVGK* -,303,1984
oral/rat lethal dose (50 percent kill): 2450 mg/kgBehavioral: Somnolence (general depressed activity)

Gastrointestinal: Gastritis

Liver: Other changes		HPV217 -,-,2002
skin/rabbit lethal dose (50 percent kill): >7940 mg/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Acute pulmonary edema		NTIS** 0TS0518143

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 150 mg/kg/5D- intermittentEndocrine: Evidence of thyroid hypofunction

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)		TOXID9 72,135,2003
oral/rat lowest published toxic dose: 93 mg/kg/31D- intermittentEndocrine: Evidence of thyroid hypofunction

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)		TOXID9 72,135,2003
oral/rat lowest published toxic dose: 930 mg/kg/31D- intermittentEndocrine: Evidence of thyroid hypofunction

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Reproductive: Other effects on male		TOXID9 72,135,2003
oral/rat lowest published toxic dose: 1860 mg/kg/31D- intermittentReproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands

Related to Chronic Data: Changes in prostate weight		TOXID9 72,135,2003
oral/rat lowest published toxic dose: 150 mg/kg/5D- intermittentLiver: Liver function tests impaired

Endocrine: Evidence of thyroid hypofunction

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)		TOXID9 72,136,2003
oral/rat lowest published toxic dose: 1200 mg/kg/20D- intermittentReproductive: Other effects on femaleTOXID9 72,136,2003
oral/rat lowest published toxic dose: 2000 mg/kg/10D- intermittentBehavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		HPV217 -,-,2002
oral/rat lowest published toxic dose: 5000 mg/kg/10D- intermittentBehavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		HPV217 -,-,2002
skin/rat lowest published toxic dose: 27.3 gm/kg/6H/13W- intermittentLiver: Changes in liver weightFCTOD7 41,259,2003
skin/rat lowest published toxic dose: 91 gm/kg/6H/13W- intermittentBrain and Coverings: Changes in brain weight

Kidney, Ureter, and Bladder: Changes in kidney weight		FCTOD7 41,259,2003
skin/rat lowest published toxic dose: 9.1 gm/kg/6H/13W- intermittentSkin: After systemic exposure: Dermatitis, otherFCTOD7 41,259,2003

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 1 ppm;short term exposure limit 2 ppm (vapor)DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWMUTAEX 25,335,2010

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 1 ppm (7 mg/m3) (vapor)DTLVS* 3,205,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 1 ppm (7 mg/m3), short term exposure limit 2 ppm (14 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 1 ppm (7 mg/m3), 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 1 ppm (7 mg/m3), (vapor), MAR2002
Occupational Exposure Limit-BELGIUMshort term exposure limit 2 ppm (14 mg/m3) (vapor), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 1 ppm (7 mg/m3), MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 1 ppm (7.1 mg/m3), short term exposure limit 3 ppm (21 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVME 1 ppm (7 mg/m3), FEB2006
Occupational Exposure Limit-GERMANYMAK 1 ppm (7.1 mg/m3), 2011
Occupational Exposure Limit-ICELANDtime-weighted average 1 ppm (7 mg/m3), NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 1 ppm (7 mg/m3), short term exposure limit 2 ppm (14 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 1 ppm (7 mg/m3);short term exposure limit 2 ppm (14 mg/m3) (vapor), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 1 ppm (7 mg/m3), short term exposure limit 2 ppm (14 mg/m3) (vapour), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 1 ppm (7 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 1 ppm (7 mg/m3); short term exposure limit 2 ppm (14 mg/m3), JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 7 mg/m3, MAC(short term exposure limit) 14 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAshort term exposure limit 5 mg/m3, JUN2003
Occupational Exposure Limit-SWITZERLANDceiling concentration 1 ppm (7 mg/m3), JAN2011
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 1 ppm (7 mg/m3), JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 1 ppm (7.1 mg/m3) (vapor), OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 1 ppm (7 mg/m3), vaporCFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 1 ppm (7 mg/m3), vaporCFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 1 ppm (7 mg/m3), vaporCFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 1 ppm (7 mg/m3), vaporCFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PHENYL ETHER, vapor-air10H time-weighted average 1 ppmNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 57210; Number of Industries 62; Total Number of Facilities 7313; Number of Occupations 70; Total Number of Employees Exposed 90789; Total Number of Female Employees Exposed 33945
National Occupational Hazard Survey 1974Hazard Code 57210; Number of Industries 17; Total Number of Facilities 561; Number of Occupations 33; Total Number of Employees Exposed 13791

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Phenyl ether, 1617
Page last reviewed: November 16, 2018
Content source: National Institute for Occupational Safety and Health