Ethanol, 2-methoxy-, acetate
RTECS #
KL5950000
CAS #
Updated
July 2016
Molecular Weight
118.15
Molecular Formula
C5H10O3
Synonyms
2-Methoxyaethylacetat (German)
2-Methoxyethanol acetate
2-Methoxyethanol, acetate
2-Methoxy-ethyl acetaat (Dutch)
2-Methoxyethyl acetate
2-Methoxyethyl acetate (ACGIH:OSHA)
2-Methoxyethyle, acetate de (French)
2-Methoxyethylester kyseliny octove (Czech)
2-Metossietilacetato (Italian)
Acetate de l'ether monomethylique de l'ethylene-glycol (French)
Acetate de methyle glycol (French)
Acetato di metil cellosolve (Italian)
Acetic acid 2-methoxyethyl ester
Aethylenglykolmethylaetheracetat (German)
EGMEA
Ethylene glycol methyl acetate (OSHA)
Ethylene glycol methyl ether acetate
Ethylene glycol monomethyl ether acetate
Glycol ether EM acetate
Glycol monomethyl ether acetate
MeCsac
Methyl cellosolve acetate
Methyl cellosolve acetate (OSHA)
Methyl cellosolye acetaat (Dutch)
Methyl glycol acetate
Methyl glycol monoacetate
Methylcelosolvacetat (Czech)
Methylglykolacetat (German)
2-Methoxyethanol acetate
2-Methoxyethanol, acetate
2-Methoxy-ethyl acetaat (Dutch)
2-Methoxyethyl acetate
2-Methoxyethyl acetate (ACGIH:OSHA)
2-Methoxyethyle, acetate de (French)
2-Methoxyethylester kyseliny octove (Czech)
2-Metossietilacetato (Italian)
Acetate de l'ether monomethylique de l'ethylene-glycol (French)
Acetate de methyle glycol (French)
Acetato di metil cellosolve (Italian)
Acetic acid 2-methoxyethyl ester
Aethylenglykolmethylaetheracetat (German)
EGMEA
Ethylene glycol methyl acetate (OSHA)
Ethylene glycol methyl ether acetate
Ethylene glycol monomethyl ether acetate
Glycol ether EM acetate
Glycol monomethyl ether acetate
MeCsac
Methyl cellosolve acetate
Methyl cellosolve acetate (OSHA)
Methyl cellosolye acetaat (Dutch)
Methyl glycol acetate
Methyl glycol monoacetate
Methylcelosolvacetat (Czech)
Methylglykolacetat (German)
Skin and Eye Irritation and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| eye /rabbit | 218 mg | mild | UCDS** 3/20/1973 |
Mutation Data and Reference
| System Test | Route/Organism/Tissue | Dose | Reference |
|---|---|---|---|
| sex chromosome loss and nondisjunction | oral/Drosophila melanogaster | 32000 ppm | MUREAV 259,147,1991 |
| sex chromosome loss and nondisjunction | /Saccharomyes cerevisiae | 56600 ppm | MUREAV 149,339,1985 |
Reproductive Effects Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| oral/mouse | 12500 mg/kg (25D male) | Reproductive: Paternal effects: Testes, epididymis, sperm duct | SAIGBL 21,29,1979 |
| oral/mouse | 50 gm/kg (25D male) | Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands | SAIGBL 21,29,1979 |
| oral/mouse | 9800 mg/kg (7-14D pregnant) | Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) | NTIS** PB86-197605 |
| oral/mouse | 9800 mg/kg (6-13D pregnant) | Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) | TCMUD8 7,29,1987 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/cat | Lowest published lethal concentration: 6 gm/m3/7H | Eye: Lacrimation Behavioral: Food intake (animal) Gastrointestinal: Changes in structure or function of salivary glands | AGGHAR 5,1,1933 |
| inhalation/human | lowest published toxic concentration: 1000 mg/m3 | Eye: Lacrimation Lung, Thorax, or Respiration: Cough Lung, Thorax, or Respiration: Other changes | AGGHAR 5,1,1933 |
| inhalation/mammal (species unspecified) | lowest published toxic concentration: 1014 mg/m3/4H | Behavioral: Alteration of classical conditioning Kidney, Ureter, and Bladder: Other changes in urine composition | TOVEFN (1),28,1996 |
| inhalation/rat | Lowest published lethal concentration: 7000 ppm/4H | JIHTAB 30,63,1948 | |
| intraperitoneal/rat | lowest published lethal dose: 1200 mg/kg | Behavioral: General anesthetic Behavioral: Muscle weakness Kidney, Ureter, and Bladder: Renal function tests depressed | JPPMAB 11,150,1959 |
| oral/guinea pig | lethal dose (50 percent kill): 1250 mg/kg | Behavioral: General anesthetic Gastrointestinal: Other changes Kidney, Ureter, and Bladder: Other changes | JIHTAB 23,259,1941 |
| oral/mouse | lethal dose (50 percent kill): 3100 mg/kg | Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Dyspnea Lung, Thorax, or Respiration: Respiratory depression | TOVEFN (1),27,1996 |
| oral/mouse | lethal dose (50 percent kill): 3100 mg/kg | Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Respiratory depression | TOVEFN (1),28,1996 |
| oral/rat | lethal dose (50 percent kill): 2900 mg/kg | TOVEFN (1),28,1996 | |
| oral/rat | lethal dose (16 percent kill): 2600 mg/kg | Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Respiratory depression | TOVEFN (1),28,1996 |
| oral/rat | lowest published lethal dose: 3200 mg/kg | TOVEFN (1),28,1996 | |
| oral/rat | lethal dose (50 percent kill): 2900 mg/kg | Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Dyspnea Lung, Thorax, or Respiration: Respiratory depression | TOVEFN (1),27,1996 |
| skin/rabbit | lethal dose (50 percent kill): 5250 µL/kg | UCDS** 3/20/1973 | |
| subcutaneous/cat | lowest published lethal dose: 3 gm/kg | Behavioral: Muscle weakness Lung, Thorax, or Respiration: Dyspnea | AGGHAR 5,1,1933 |
| subcutaneous/guinea pig | lowest published lethal dose: 5 gm/kg | Behavioral: Somnolence (general depressed activity) | AGGHAR 5,1,1933 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 0.1 ppm (skin) | DTLVS* TLV/BEI,2013 |
| TOXICOLOGY REVIEW | CRTXB2 30,307,2000 | |
| TOXICOLOGY REVIEW | FCTOD7 55,596,2013 | |
| TOXICOLOGY REVIEW | REPTED 58,252,2015 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 25 ppm (120 mg/m3) (skin) | DTLVS* 3,159,1971 |
| Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
| Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
| Occupational Exposure Limit-AUSTRALIA | time-weighted average 5 ppm (24 mg/m3), JUL2008 | |
| Occupational Exposure Limit-AUSTRIA | MAK-TMW 5 ppm (25 mg/m3);KZW 20 ppm (100 mg/m3), skin, 2007 | |
| Occupational Exposure Limit-BELGIUM | time-weighted average 5 ppm (24 mg/m3), Skin, MAR2002 | |
| Occupational Exposure Limit-DENMARK | time-weighted average 5 ppm (24 mg/m3), skin, MAY2011 | |
| Occupational Exposure Limit-FINLAND | time-weighted average 0.5 ppm (2.5 mg/m3), skin, NOV2011 | |
| Occupational Exposure Limit-FRANCE | VME 5 ppm (24 mg/m3), Skin, FEB2006 | |
| Occupational Exposure Limit-GERMANY | MAK 1 ppm (4.9 mg/m3), 2011 | |
| Occupational Exposure Limit-HUNGARY | time-weighted average 25 mg/m3, short term exposure limit 100 mg/m3, Skin, SEP2000 | |
| Occupational Exposure Limit-ICELAND | time-weighted average 5 ppm (24 mg/m3), skin, NOV2011 | |
| Occupational Exposure Limit-JAPAN | Occupational Exposure Limit 0.1 ppm (0.48 mg/m3), skin, MAY2012 | |
| Occupational Exposure Limit-KOREA | time-weighted average 5 ppm (24 mg/m3), skin, 2006 | |
| Occupational Exposure Limit-MEXICO | time-weighted average 5 ppm (16 mg/m3), 2004 | |
| Occupational Exposure Limit-NEW ZEALAND | time-weighted average 5 ppm (24 mg/m3), skin, JAN2002 | |
| Occupational Exposure Limit-NORWAY | time-weighted average 5 ppm (22 mg/m3), JAN1999 | |
| Occupational Exposure Limit-PERU | time-weighted average 5 ppm (24 mg/m3), JUL2005 | |
| Occupational Exposure Limit-POLAND | MAC(time-weighted average) 25 mg/m3, MAC(short term exposure limit) 100 mg/m3, JAN1999 | |
| Occupational Exposure Limit-RUSSIA | short term exposure limit 10 mg/m3, JUN2003 | |
| Occupational Exposure Limit-SWITZERLAND | MAK-week 1 ppm (4.9 mg/m3), KZG-week 8 ppm (39.2 mg/m3), skin, JAN2011 | |
| Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 1.5 mg/m3, Skin, 2003 | |
| Occupational Exposure Limit-THE PHILIPPINES | time-weighted average 25 ppm (120 mg/m3), Skin, JAN1993 | |
| Occupational Exposure Limit-TURKEY | time-weighted average 25 ppm (120 mg/m3), Skin, JAN1993 | |
| Occupational Exposure Limit-UNITED KINGDOM | time-weighted average 5 ppm (25 mg/m3), skin, OCT2007 | |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 25 ppm (120 mg/m3) (skin) | CFRGBR 29,1926.55,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 25 ppm (120 mg/m3) (skin) | CFRGBR 41,50-204.50,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 25 ppm (120 mg/m3) (skin) | CFRGBR 29,1910.1000,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 25 ppm (120 mg/m3) (skin) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO EGMEA-air | 10H time-weighted average 0.1 ppm (Sk) | NIOSH* DHHS #92-100,1992 |
| National Occupational Exposure Survey 1983 | Hazard Code 46935; Number of Industries 20; Total Number of Facilities 658; Number of Occupations 27; Total Number of Employees Exposed 9892; Total Number of Female Employees Exposed 2801 | |
| National Occupational Hazard Survey 1974 | Hazard Code 46935; Number of Industries 45; Total Number of Facilities 2907; Number of Occupations 49; Total Number of Employees Exposed 20492 |
Status in Federal Agencies
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health