Ethanol, 2-methoxy-

RTECS #

KL5775000

CAS #

109-86-4
See: NMAM or OSHA Methods

Updated

March 2019

Molecular Weight

76.11

Molecular Formula

C₃H₈O₂

Synonyms

2-Methoxy-aethanol (German)
2-Methoxyethanol
2-Methoxyethanol (ACGIH:OSHA)
2-Metossietanolo (Italian)
Aethylenglykol-monomethylaether (German)
Dowanol 7
Dowanol EM
EGME
Ether monomethylique de l'ethylene-glycol (French)
Ethylene glycol methyl ether
Ethylene glycol monomethyl ether
Glycol ether EM
Glycol monomethyl ether
Glycolmethyl ether
Jeffersol EM
Methoxyethanol
Methoxyhydroxyethane
Methyl cellosolve
Methyl cellosolve (OSHA)
Methyl cellosolve methyl glycol
Methyl ethoxol
Methyl glycol
Methyl oxitol
Methylcelosolv (Czech)
Methylglykol (German)
Metil cellosolve (Italian)
Metoksyetylowy alkohol (Polish)
Monomethyl ether of ethylene glycol
Poly-Solv EM
Prist

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
eye /guinea pig	10 µg	mild	JPPMAB 11,150,1959
eye /rabbit	97 mg		TXAPA9 19,276,1971
eye /rabbit	500 mg/24H	mild	85JCAE -,623,1986
skin /rabbit	483 mg/24H	mild	TXAPA9 19,276,1971

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
Cytogenetic Analysis	lymphocyte/human	150 mmol/L	MUREAV 320,125,1994
DNA Damage	oral/rat	800 mg/kg/4D- intermittent	TOXID9 44,114,2005
Dominant Lethal Test	oral/rat	500 mg/kg	ENMUDM 6,390,1984
sperm morphology	oral/rat	500 mg/kg	ENMUDM 6,390,1984
sperm morphology	oral/mouse	500 mg/kg	ENMUDM 6,390,1984

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
inhalation/rat	68 mg/kg/4H (1-19D pregnant)	Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)	FAVUAI 21,30,1989
inhalation/rat	30 ppm/6H (65D male)	Reproductive: Paternal effects: Testes, epididymis, sperm duct	FAATDF 3,49,1983
inhalation/rat	100 ppm/6H (6-17D pregnant)	Reproductive: Maternal effects: Parturition Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)	TXAPA9 69,43,1983
inhalation/rat	100 ppm/6H (6-17D pregnant)	Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)	TXAPA9 69,43,1983
inhalation/rat	30 ppm/6H (13W male)	Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)	FAATDF 3,80,1983
inhalation/mouse	1000 ppm/6H (11D male)	Reproductive: Paternal effects: Testes, epididymis, sperm duct	TXAPA9 61,368,1981
inhalation/mouse	500 ppm/7H (5D male)	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)	TXAPA9 70,303,1983
inhalation/mouse	50 ppm/6H (6-15D pregnant)	Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) Reproductive: Specific developmental abnormalities: Urogenital system	TXAPA9 75,409,1984
inhalation/mouse	50 ppm/6H (6-15D pregnant)	Reproductive: Specific developmental abnormalities: Musculoskeletal system Reproductive: Specific developmental abnormalities: Urogenital system	EVHPAZ 57,7,1984
inhalation/rabbit	300 ppm/6H (65D male)	Reproductive: Paternal effects: Testes, epididymis, sperm duct	FAATDF 3,49,1983
inhalation/rabbit	50 ppm/6H (6-18D pregnant)	Reproductive: Specific developmental abnormalities: Body wall Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system Reproductive: Specific developmental abnormalities: Urogenital system	TXAPA9 75,409,1984
inhalation/rabbit	50 ppm/6H (6-18D pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Body wall Reproductive: Specific developmental abnormalities: Musculoskeletal system	EVHPAZ 57,7,1984
inhalation/rabbit	10 ppm/6H (6-18D pregnant)	Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Specific developmental abnormalities: Musculoskeletal system	TXAPA9 75,409,1984
inhalation/rat	933 mg/m³ (6-17D pregnant)	Reproductive: Maternal effects: Parturition Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)	VCVGK* -,160,1994
intraperitoneal/rat	330 mg/kg (12D pregnant)	Reproductive: Specific developmental abnormalities: Musculoskeletal system Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system	TJADAB 29(2),54A,1984
intraperitoneal/rat	190 mg/kg (14D pregnant)	Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Specific developmental abnormalities: Urogenital system	JJATDK 4,35,1984
intraperitoneal/rat	190 mg/kg (12D pregnant)	Reproductive: Specific developmental abnormalities: Musculoskeletal system	JJATDK 4,35,1984
intraperitoneal/rat	190 mg/kg (8D pregnant)	Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)	JJATDK 4,35,1984
intravenous/mouse	250 mg/kg (8D pregnant)	Reproductive: Specific developmental abnormalities: Central nervous system	TOXID9 12,101,1992
oral/monkey	930 mg/kg (20-45D pregnant)	Reproductive: Effects on fertility: Abortion Reproductive: Effects on embryo or fetus: Fetal death	TJADAB 35,66A,1987
oral/monkey	633 mg/kg (20-45D pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)	TJADAB 35,66A,1987
oral/hamster	1562 mg/kg (25D male)	Reproductive: Paternal effects: Testes, epididymis, sperm duct	EVHPAZ 57,75,1984
oral/mouse	11200 mg/kg (7-14D pregnant)	Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)	EVHPAZ 57,141,1984
oral/guinea pig	6250 mg/kg (25D male)	Reproductive: Paternal effects: Testes, epididymis, sperm duct	EVHPAZ 57,75,1984
oral/rat	250 mg/kg (13D pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Musculoskeletal system	TXAPA9 145,415,1997
oral/mouse	175 mg/kg (11D pregnant)	Reproductive: Specific developmental abnormalities: Musculoskeletal system	TJADAB 31,48A,1985
oral/mouse	2 gm/kg (7-14D pregnant)	Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) Reproductive: Effects on embryo or fetus: Fetal death Reproductive: Specific developmental abnormalities: Central nervous system	TXCYAC 20,335,1981
oral/mouse	500 mg/kg (9D pregnant)	Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)	TXAPA9 80,108,1985
oral/mouse	250 mg/kg (11D pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Musculoskeletal system	TXAPA9 80,108,1985
oral/mouse	6250 mg/kg (25D male)	Reproductive: Paternal effects: Testes, epididymis, sperm duct	SAIGBL 21,29,1979
oral/rat	175 mg/kg (7-13D pregnant)	Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system	TJADAB 32,33,1985
oral/rat	175 mg/kg (7-13D pregnant)	Reproductive: Maternal effects: Parturition Reproductive: Effects on newborn: Biochemical and metabolic	DCTODJ 9,1,1986
oral/rat	15015 mg/kg (13W male)	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)	NTPTR* NIH-93-3349
oral/rat	100 mg/kg (1D male)	Reproductive: Paternal effects: Testes, epididymis, sperm duct	TXAPA9 69,385,1983
oral/rat	350 mg/kg (9-15D pregnant)	Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system	TXAPA9 86,197,1986
oral/rat	1000 mg/kg (6-17D pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Musculoskeletal system	VCVGK* -,160,1994
oral/mouse	1000 mg/kg (6-17D pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Musculoskeletal system	VCVGK* -,160,1994
oral/rabbit	1000 mg/kg (6-17D pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Musculoskeletal system	VCVGK* -,160,1994
oral/rat	350 mg/kg (9-15D pregnant)	Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)	TXAPA9 82,197,1986
oral/rat	350 mg/kg (9-15D pregnant)	Reproductive: Effects on embryo or fetus: Fetal death Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system	TXAPA9 82,197,1986
oral/mouse	2 gm/kg (7D male/7D prior to copulation/21D pregnant)	Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)	NTIS** #PB89152565
oral/mouse	4.45 gm/kg (7D prior to copulation/21D pregnant)	Reproductive: Maternal effects: Postpartum	NTIS** #PB86163136
oral/rat	5.5 gm/kg (21W male)	Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)	NTIS** #PB90252321/AS
oral/mouse	5.6 gm/kg (7D male/7D prior to copulation/21D pregnant)	Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)	NTIS** #PB86163136
oral/mouse	7.2 gm/kg (7D male/7D pre-1D after birth)	Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)	NTIS** #PB88192240
oral/mouse	8.4 gm/kg (7D male/7D prior to copulation)	Reproductive: Effects on fertility: Other measures of fertility	NTIS** #PB88192240
oral/mouse	11.8 gm/kg (7D male/7D prior to copulation/21D pregnant)	Reproductive: Effects on fertility: Other measures of fertility Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)	NTIS** #PB86163136
oral/mouse	14 gm/kg (14D male)	Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)	NTIS** #PB86163136
oral/mouse	14 gm/kg (14D prior to copulation)	Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)	NTIS** #PB86163136
oral/mouse	17.5 gm/kg (7D male/7D prior to copulation/21D pregnant)	Reproductive: Effects on fertility: Other measures of fertility Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)	NTIS** #PB89152565
oral/mouse	35.28 gm/kg (15W prior to copulation)	Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)	NTIS** #PB86163136
oral/rat	36.75 gm/kg (21W male/21W prior to copulation)	Reproductive: Effects on fertility: Other measures of fertility	NTIS** #PB90252321/AS
oral/mouse	43 gm/kg (15W male/15W pre-3W after birth)	Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)	NTIS** #PB89152565
oral/rat	30 mg/kg (multigenerations)	Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) Reproductive: Effects on newborn: Sex ratio	NTIS** #PB90252321
oral/rat	37.5 mg/kg (multigenerations)	Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)	NTIS** #PB90252321/AS
oral/mouse	50 mg/kg (multigenerations)	Reproductive: Specific developmental abnormalities: Urogenital system	NTIS** #PB89152565
oral/mouse	159 mg/kg (multigenerations)	Reproductive: Effects on fertility: Mating performance (e.g., # sperm positive females per # females mated; # copulations per # estrus cycles) Reproductive: Effects on fertility: Other measures of fertility Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)	NTIS** #PB86163136
oral/mouse	159 mg/kg (multigenerations)	Reproductive: Specific developmental abnormalities: Hepatobiliary system	NTIS** #PB86163136
oral/mouse	170 mg/kg (multigenerations)	Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)	NTIS** #PB89152565
oral/rat	1050 mg/kg (7D male/7D prior to copulation/21D pregnant)	Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) Reproductive: Effects on newborn: Sex ratio	NTIS** #PB90252321
oral/rat	3570 mg/kg (17W male)	Reproductive: Effects on newborn: Sex ratio	NTIS** #PB90252321
oral/mouse	19 gm/kg (7D male/7D prior to copulation/21D pregnant)	Reproductive: Effects on fertility: Other measures of fertility	NTIS** #PB88211446
oral/rat	15 mg/kg (multigenerations)	Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)	NTIS** #PB90252321
oral/mouse	200 mg/kg (multigenerations)	Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)	NTIS** #PB88211446
oral/rat	262 mg/kg (7D male/7D prior to copulation/21D pregnant)	Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)	NTIS** #PB90252321
oral/mouse	60 mg/kg (multigenerations)	Reproductive: Specific developmental abnormalities: Hepatobiliary system Reproductive: Specific developmental abnormalities: Urogenital system	NTIS** #PB88211446
oral/rat	750 mg/kg (18D prior to copulation/0-6D pregnant)	Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) Reproductive: Effects on fertility: Other measures of fertility	JTSCDR 34,SP121,2009
oral/rat	2400 mg/kg (17D prior to copulation/0-6D pregnant)	Reproductive: Maternal effects: Menstrual cycle changes or disorders Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)	JTSCDR 34,SP121,2009
oral/rat	7800 mg/kg (19D prior to copulation/0-6D pregnant)	Reproductive: Maternal effects: Menstrual cycle changes or disorders Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)	JTSCDR 34,SP121,2009
oral/rat	150 mg/kg (3D male)	Reproductive: Paternal effects: Testes, epididymis, sperm duct	TOLED5 190,193,2009
skin/rat	11592 mg/kg (6-17D pregnant)	Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated) Reproductive: Effects on embryo or fetus: Fetal death	JJATDK 6,165,1986
skin/rat	4375 mg/kg (7D male)	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)	TXAPA9 100,145,1989
skin/rat	2 gm/kg (10D pregnant)	Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)	FAATDF 15,448,1990
skin/rat	1 gm/kg (12D pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) Reproductive: Specific developmental abnormalities: Gastrointestinal system	FAATDF 15,448,1990
skin/guinea pig	65 gm/kg (65D male)	Reproductive: Paternal effects: Testes, epididymis, sperm duct	FAATDF 6,339,1986
skin/rat	2.5 mg/kg (7-16D pregnant)	Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Musculoskeletal system	VCVGK* -,159,1994
subcutaneous/mouse	1200 mg/kg (7-13D pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)	TOLED5 50,263,1990
subcutaneous/mouse	3200 mg/kg (7-14D pregnant)	Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)	TOLED5 50,263,1990
subcutaneous/mouse	250 mg/kg (8D pregnant)	Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)	TJADAB 54,219,1996
subcutaneous/rat	600 mg/kg (6-20D pregnant)	Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)	EVHPAZ 57,199,1984
subcutaneous/rat	440 mg/kg (7-17D pregnant)	Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)	TCMUD8 7,73,1987

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
In Vitro/Human, liver tumor	Inhibitor Concentration (50 percent kill): 414 mmol/L/24H	In Vitro Toxicity Studies: Cell protein synthesis	TIVIEQ 3,189,1989
In Vitro/Rat, embryo	Inhibitor Concentration Low: 200 mmol/L/48H	Reproductive: Effects on embryo or fetus: Fetal death Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Specific developmental abnormalities: Musculoskeletal system	TIVIEQ 7,777,1993
In Vitro/Rat, embryo	Inhibitor Concentration Low: 50 mmol/L/48H	Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Specific developmental abnormalities: Eye, ear	TIVIEQ 7,777,1993
In Vitro/Rat, embryo	Inhibitor Concentration Low: 50 mmol/L/48H	Reproductive: Other effects to embryo or fetus	TIVIEQ 7,777,1993
inhalation/human	lowest published toxic concentration: 25 ppm	Behavioral: Tremor Behavioral: Convulsions or effect on seizure threshold Behavioral: Change in motor activity (specific assay)	JIHTAB 20,134,1938
inhalation/mouse	lethal concentration (50 percent kill): 1480 ppm/7H	Behavioral: Analgesia Lung, Thorax, or Respiration: Dyspnea Kidney, Ureter, and Bladder: Hematuria	JIHTAB 25,157,1943
inhalation/mouse	lethal concentration (50 percent kill): 4600 ppm		ENTOX* -,63,2005
inhalation/rat	lowest published toxic concentration: 625 ppm/4H	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)	ATSUDG 7,167,1984
inhalation/rat	lowest published toxic concentration: 1000 ppm/4H	Reproductive: Paternal effects: Testes, epididymis, sperm duct Related to Chronic Data: Changes in testicular weight	ATSUDG 7,167,1984
inhalation/rat	lethal concentration (50 percent kill): 1500 ppm/7H		NPIRI* 1,57,1974
intraperitoneal/mouse	lethal dose (50 percent kill): 2147 mg/kg	Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli Blood: Changes in spleen Blood: Other changes	FEPRA7 6,342,1947
intraperitoneal/rat	lethal dose (50 percent kill): 2500 mg/kg		NPIRI* 1,57,1974
intraperitoneal/rat	lowest published toxic dose: 50 mg/kg	Reproductive: Effects on fertility: Other measures of fertility	REPTED 14,45,2000
intraperitoneal/rat	lowest published toxic dose: 150 mg/kg	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct	VCVGK* -,159,1984
intravenous/rat	lethal dose (50 percent kill): 2068 mg/kg	Blood: Other hemolysis with or without anemia	AMIHAB 14,114,1956
oral/guinea pig	lethal dose (50 percent kill): 950 mg/kg	Behavioral: General anesthetic Gastrointestinal: Other changes Kidney, Ureter, and Bladder: Other changes	JIHTAB 23,259,1941
oral/guinea pig	lowest published toxic dose: 200 mg/kg	Reproductive: Paternal effects: Testes, epididymis, sperm duct	EXMPA6 61,119,1994
oral/guinea pig	lowest published toxic dose: 300 mg/kg	Blood: Other changes	EXMPA6 61,119,1994
oral/human	lowest published lethal dose: 3380 mg/kg	Gastrointestinal: Gastritis Liver: Other changes Kidney, Ureter, and Bladder: Other changes	JIHTAB 28,267,1946
oral/human	lowest published lethal dose: 143 mg/kg		VCVGK* -,159,1984
oral/mouse	lethal dose (50 percent kill): 2800 mg/kg	Behavioral: Somnolence (general depressed activity) Liver: Other changes Kidney, Ureter, and Bladder: Other changes	VCVGK* -,159,1984
oral/mouse	lethal dose (50 percent kill): 2560 mg/kg	Behavioral: Somnolence (general depressed activity) Behavioral: Change in motor activity (specific assay) Cardiac: Other changes	GTPZAB 32(3),48,1988
oral/rabbit	lethal dose (50 percent kill): 890 mg/kg	Behavioral: General anesthetic Blood: Other hemolysis with or without anemia	AMIHAB 14,114,1956
oral/rabbit	lethal dose (50 percent kill): 890 mg/kg	Behavioral: Somnolence (general depressed activity) Liver: Other changes Kidney, Ureter, and Bladder: Other changes	VCVGK* -,159,1984
oral/rat	lethal dose (50 percent kill): 2460 mg/kg	Behavioral: Somnolence (general depressed activity) Liver: Other changes Kidney, Ureter, and Bladder: Other changes	VCVGK* -,159,1984
oral/rat	lowest published toxic dose: 250 mg/kg	Related to Chronic Data: Changes in prostate weight	REPTED 6,491,1992
oral/rat	lethal dose (50 percent kill): 2370 mg/kg	Behavioral: Altered sleep time (including change in righting reflex) Lung, Thorax, or Respiration: Other changes	VHTODE 29,361,1987
oral/rat	lowest published toxic dose: 2000 mg/kg	Reproductive: Paternal effects: Testes, epididymis, sperm duct Nutritional and Gross Metabolic: Weight loss or decreased weight gain Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases	JTSCDR 32,515,2007
oral/rat	lowest published toxic dose: 50 mg/kg	Reproductive: Paternal effects: Testes, epididymis, sperm duct Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases	JTSCDR 32,515,2007
oral/rat	lowest published toxic dose: 200 mg/kg	Blood: Normocytic anemia Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)	EXMPA6 61,119,1994
oral/rat	lowest published toxic dose: 150 mg/kg	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct	JOAND3 5,369,1984
oral/rat	lowest published toxic dose: 200 mg/kg	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)	TOXID9 44,114,2005
skin/rabbit	lethal dose (50 percent kill): 2000 mg/kg	Kidney, Ureter, and Bladder: Urine volume decreased or anuria	VCVGK* -,159,1984
skin/rabbit	lethal dose (50 percent kill): 1280 mg/kg		NPIRI* 1,57,1974

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/Dog	lowest published toxic concentration: 750 ppm/7H/12W- intermittent	Blood: Microcytosis with or without anemia Blood: Other changes	JIHTAB 25,409,1943
inhalation/Dog	lowest published toxic concentration: 2500 mg/m³/7H/60D- intermittent	Blood: Changes in spleen Blood: Microcytosis with or without anemia	VCVGK* -,160,1994
inhalation/mammal (species unspecified)	lowest published toxic concentration: 1240 mg/m³/6H/5D- intermittent	Nutritional and Gross Metabolic: Weight loss or decreased weight gain Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage) Brain and Coverings: Other degenerative changes	VCVGK* -,159,1994
inhalation/mouse	lowest published toxic concentration: 3680 mg/m³/6H/9D- intermittent	Reproductive: Paternal effects: Testes, epididymis, sperm duct	VCVGK* -,159,1994
inhalation/mouse	lowest published toxic concentration: 1000 ppm/6H/11D- intermittent	Blood: Changes in leukocyte (WBC) count Related to Chronic Data: Changes in testicular weight	TXAPA9 61,368,1981
inhalation/mouse	lowest published toxic concentration: 3680 mg/m³/6H/9D- intermittent	Spinal Cord: Other degenerative changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain	VCVGK* -,159,1994
inhalation/rabbit	lowest published toxic concentration: 300 ppm/6H/13W- intermittent	Endocrine: Changes in thymus weight Blood: Changes in erythrocyte (RBC) count Related to Chronic Data: Changes in testicular weight	FAATDF 3,49,1983
inhalation/rat	lowest published toxic concentration: 300 ppm/6H/13W- intermittent	Blood: Changes in leukocyte (WBC) count Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Changes in testicular weight	FAATDF 3,49,1983
inhalation/rat	lowest published toxic concentration: 970 mg/m³/7H/5W- intermittent	Blood: Changes in bone marrow not included in above Blood: Changes in spleen	JIHTAB 25,374,1943
inhalation/rat	lowest published toxic concentration: 1000 ppm/6H/11D- intermittent	Kidney, Ureter, and Bladder: Other changes in urine composition Blood: Changes in bone marrow not included in above Blood: Changes in leukocyte (WBC) count	TXAPA9 61,368,1981
inhalation/rat	lowest published toxic concentration: 400 ppm/6H/2W- intermittent	Brain and Coverings: Other degenerative changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects	ENVRAL 22,423,1980
inhalation/rat	lowest published toxic concentration: 3680 mg/m³/6H/9D- intermittent	Reproductive: Paternal effects: Testes, epididymis, sperm duct	VCVGK* -,159,1994
inhalation/rat	lowest published toxic concentration: 3680 mg/m³/6H/9D- intermittent	Spinal Cord: Other degenerative changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain	VCVGK* -,159,1994
inhalation/rat	lowest published toxic concentration: 1100 mg/m³/10D- intermittent	Reproductive: Paternal effects: Testes, epididymis, sperm duct Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)	VCVGK* -,160,1994
inhalation/rat	lowest published toxic concentration: 600 ppm/6H/27D- intermittent	Nutritional and Gross Metabolic: Weight loss or decreased weight gain	TOLED5 255,11,2016
inhalation/rat	lowest published toxic concentration: 600 ppm/6H/27D- intermittent	Reproductive: Paternal effects: Testes, epididymis, sperm duct Nutritional and Gross Metabolic: Weight loss or decreased weight gain	TOLED5 255,11,2016
intraperitoneal/rat	lowest published toxic dose: 450 mg/kg/16D- intermittent	Blood: Changes in other cell count (unspecified) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes	TIHEEC 9,617,1993
oral/guinea pig	lowest published toxic dose: 600 mg/kg/3D- intermittent	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)	EXMPA6 61,119,1994
oral/mouse	lowest published toxic dose: 12110 mg/kg/2W- continuous	Endocrine: Changes in thymus weight Related to Chronic Data: Changes in testicular weight	NTPTR* NIH-93-3349
oral/mouse	lowest published toxic dose: 82 gm/kg/13W- continuous	Endocrine: Effect on menstrual cycle Endocrine: Other changes Blood: Changes in spleen	NTPTR* NIH-93-3349
oral/mouse	lowest published toxic dose: 11200 mg/kg/8D- intermittent	Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	EVHPAZ 57,141,1984
oral/mouse	lowest published toxic dose: 8820 mg/kg/21W- continuous	Kidney, Ureter, and Bladder: Changes in kidney weight	NTIS** #PB88211446
oral/mouse	lowest published toxic dose: 29400 mg/kg/21W- continuous	Liver: Changes in liver weight	NTIS** #PB88211446
oral/mouse	lowest published toxic dose: 80850 mg/kg/21W- continuous	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct	NTIS** #PB88211446
oral/mouse	lowest published toxic dose: 8820 mg/kg/21W- continuous	Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	NTIS** #PB88211446
oral/mouse	lowest published toxic dose: 126000 mg/kg/15W- continuous	Reproductive: Paternal effects: Testes, epididymis, sperm duct Nutritional and Gross Metabolic: Weight loss or decreased weight gain	NTIS** #PB89152565
oral/mouse	lowest published toxic dose: 17850 mg/kg/15W- continuous	Liver: Changes in liver weight Reproductive: Paternal effects: Testes, epididymis, sperm duct	NTIS** #PB89152565
oral/mouse	lowest published toxic dose: 6300 mg/kg/15W- continuous	Liver: Changes in liver weight	NTIS** #PB88192240
oral/mouse	lowest published toxic dose: 4200 mg/kg/7D- continuous	Nutritional and Gross Metabolic: Weight loss or decreased weight gain	NTIS** #PB88192240
oral/mouse	lowest published toxic dose: 4200 mg/kg/7D- continuous	Reproductive: Paternal effects: Testes, epididymis, sperm duct Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands	NTIS** #PB88192240
oral/mouse	lowest published toxic dose: 9800 mg/kg/49D- continuous	Liver: Changes in liver weight Reproductive: Maternal effects: Ovaries, fallopian tubes	NTIS** #PB88192240
oral/mouse	lowest published toxic dose: 21665 mg/kg/28D- continuous	Nutritional and Gross Metabolic: Weight loss or decreased weight gain	NTIS** #PB86163136
oral/mouse	lowest published toxic dose: 35280 mg/kg/15W- continuous	Reproductive: Maternal effects: Menstrual cycle changes or disorders	NTIS** #PB86163136
oral/rat	lowest published toxic dose: 1400 mg/kg/1W- intermittent	Nutritional and Gross Metabolic: Weight loss or decreased weight gain	JTSCDR 25,259,2000
oral/rat	lowest published toxic dose: 2800 mg/kg/2W- intermittent	Reproductive: Paternal effects: Testes, epididymis, sperm duct Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Changes in testicular weight	JTSCDR 25,259,2000
oral/rat	lowest published toxic dose: 200 mg/kg/2D- intermittent	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)	EXMPA6 40,169,1984
oral/rat	lowest published toxic dose: 600 mg/kg/3D- intermittent	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)	EXMPA6 61,119,1994
oral/rat	lowest published toxic dose: 900 mg/kg/3D- intermittent	Reproductive: Maternal effects: Menstrual cycle changes or disorders	TXAPA9 142,328,1997
oral/rat	lowest published toxic dose: 4500 mg/kg/15D- intermittent	Kidney, Ureter, and Bladder: Changes in kidney weight	TXAPA9 142,328,1997
oral/rat	lowest published toxic dose: 1050 mg/kg/2W- continuous	Reproductive: Maternal effects: Oogenesis Reproductive: Effects on fertility: Other measures of fertility	REPTED 14,45,2000
oral/rat	lowest published toxic dose: 29484 mg/kg/13W- continuous	Endocrine: Changes in thymus weight Blood: Changes in platelet count Nutritional and Gross Metabolic: Weight loss or decreased weight gain	NTPTR* NIH-93-3349
oral/rat	lowest published toxic dose: 10206 mg/kg/21D- continuous	Endocrine: Changes in thymus weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Changes in testicular weight	FAATDF 16,830,1991
oral/rat	lowest published toxic dose: 500 mg/kg/10D- intermittent	Endocrine: Changes in thymus weight Immunological Including Allergic: Decreased immune response	TXAPA9 109,494,1991
oral/rat	lowest published toxic dose: 500 mg/kg/10D- intermittent	Reproductive: Paternal effects: Testes, epididymis, sperm duct Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)	VCVGK* -,160,1994
oral/rat	lowest published toxic dose: 4200 mg/kg/60D- intermittent	Endocrine: Changes in thymus weight Reproductive: Paternal effects: Testes, epididymis, sperm duct	HPV004 -,-,2001
oral/rat	lowest published toxic dose: 40500 mg/kg/60D- intermittent	Endocrine: Changes in thymus weight Reproductive: Paternal effects: Testes, epididymis, sperm duct Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	HPV004 -,-,2001
oral/rat	lowest published toxic dose: 4200 mg/kg/2W- intermittent	Endocrine: Changes in adrenal weight Reproductive: Maternal effects: Ovaries, fallopian tubes Reproductive: Maternal effects: Menstrual cycle changes or disorders	JTSCDR 34,SP121,2009
oral/rat	lowest published toxic dose: 2800 mg/kg/4W- intermittent	Kidney, Ureter, and Bladder: Changes in kidney weight Endocrine: Changes in adrenal weight Reproductive: Maternal effects: Menstrual cycle changes or disorders	JTSCDR 34,SP121,2009
oral/rat	lowest published toxic dose: 840 mg/kg/4W- intermittent	Endocrine: Changes in adrenal weight	JTSCDR 34,SP121,2009
oral/rat	lowest published toxic dose: 1400 mg/kg/2W- intermittent	Reproductive: Maternal effects: Uterus, cervix, vagina	JTSCDR 34,SP121,2009
oral/rat	lowest published toxic dose: 7800 mg/kg/26D- intermittent	Nutritional and Gross Metabolic: Weight loss or decreased weight gain	JTSCDR 34,SP121,2009
oral/rat	lowest published toxic dose: 3900 mg/kg/13D- intermittent	Nutritional and Gross Metabolic: Weight loss or decreased weight gain	JTSCDR 34,SP121,2009
oral/rat	lowest published toxic dose: 11200 mg/kg/28D- intermittent	Reproductive: Paternal effects: Testes, epididymis, sperm duct	TOLED5 255,11,2016
oral/rat	lowest published toxic dose: 2800 mg/kg/7D- intermittent	Behavioral: Food intake (animal)	TOLED5 255,11,2016
oral/rat	lowest published toxic dose: 2800 mg/kg/7D- intermittent	Behavioral: Food intake (animal) Nutritional and Gross Metabolic: Weight loss or decreased weight gain	TOLED5 255,11,2016
oral/rat	lowest published toxic dose: 700 mg/kg/7D- intermittent	Liver: Changes in liver weight Nutritional and Gross Metabolic: Changes in: Ca Related to Chronic Data: Changes in uterine weight	TXAPA9 82,197,1986
oral/rat	lowest published toxic dose: 1200 mg/kg/8D- intermittent	Related to Chronic Data: Changes in testicular weight	JOAND3 5,369,1984
skin/guinea pig	lowest published toxic dose: 65 gm/kg/13W- intermittent	Blood: Changes in erythrocyte (RBC) count Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Changes in testicular weight	FAATDF 6,339,1986
skin/rat	lowest published toxic dose: 3200 mg/kg/4D- intermittent	Endocrine: Changes in thymus weight Immunological Including Allergic: Decrease in humoral immune response	TXCYAC 98,215,1995
skin/rat	lowest published toxic dose: 20 gm/kg/4W- intermittent	Blood: Changes in other cell count (unspecified) Blood: Changes in leukocyte (WBC) count Related to Chronic Data: Changes in testicular weight	TXCYAC 57,209,1989
subcutaneous/rat	lowest published toxic dose: 1902.75 mg/kg/4W- intermittent	Nutritional and Gross Metabolic: Weight loss or decreased weight gain	ARTODN 82,125,2008
subcutaneous/rat	lowest published toxic dose: 3805.5 mg/kg/4W- intermittent	Blood: Luekopenia Blood: Changes in erythrocyte (RBC) count Nutritional and Gross Metabolic: Weight loss or decreased weight gain	ARTODN 82,125,2008
unreported route/rat	lowest published toxic dose: 150 mg/kg/3D- intermittent	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct Biochemical: Metabolism (intermediary): Other	TOXID9 90,219,2006

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 0.1 ppm (skin)	DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEW		FAATDF 13,747,1989
TOXICOLOGY REVIEW		CRTXB2 30,307,2000
TOXICOLOGY REVIEW		JTSCDR 25,1,2000
TOXICOLOGY REVIEW		CRTXB2 33,137,2003
TOXICOLOGY REVIEW		ENTOX* -,451,2005
TOXICOLOGY REVIEW		ENTOX* -,63,2005
TOXICOLOGY REVIEW		HUTOX* -,623,1996
TOXICOLOGY REVIEW		JTSCDR 34,SP1,2009
TOXICOLOGY REVIEW		MUREAV 721,27,2011
TOXICOLOGY REVIEW		REPTED 33,269,2012
TOXICOLOGY REVIEW		REPTED 58,252,2015
TOXICOLOGY REVIEW		RTOPDW 60,120,2011
TOXICOLOGY REVIEW		RTOPDW 61,251,2011

Standards and Regulations

Organization	Standard	Reference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION		FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES	Cancelled	RBREV* -,241,1998
Mine Safety and Health Administration (MSHA) STANDARD-air	time-weighted average 25 ppm (80 mg/m³) (skin)	DTLVS* 3,158,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 5 ppm (16 mg/m³), JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 5 ppm (15 mg/m³);KZW 20 ppm (60 mg/m³), skin, 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 5 ppm (16 mg/m³), Skin, MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 5 ppm (16 mg/m³), skin, MAY2011
Occupational Exposure Limit-FINLAND	time-weighted average 0.5 ppm (1.6 mg/m³), skin, NOV2011
Occupational Exposure Limit-FRANCE	VME 5 ppm (16 mg/m³), Skin, FEB2006
Occupational Exposure Limit-GERMANY	MAK 1 ppm (3.2 mg/m³), 2011
Occupational Exposure Limit-HUNGARY	time-weighted average 15 mg/m³, short term exposure limit 60 mg/m³, Skin, SEP2000
Occupational Exposure Limit-ICELAND	time-weighted average 5 ppm (16 mg/m³), skin, NOV2011
Occupational Exposure Limit-JAPAN	Occupational Exposure Limit 0.1 ppm (0.31 mg/m³), skin, MAY2012
Occupational Exposure Limit-KOREA	time-weighted average 5 ppm (16 mg/m³), skin, 2006
Occupational Exposure Limit-MEXICO	time-weighted average 25 ppm (80 mg/m³);short term exposure limit 35 ppm (skin), 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 5 ppm (16 mg/m³), skin, JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 5 ppm (16 mg/m³), JAN1999
Occupational Exposure Limit-PERU	time-weighted average 5 ppm (16 mg/m³), JUL2005
Occupational Exposure Limit-POLAND	MAC(time-weighted average) 15 mg/m³, MAC(short term exposure limit) 60 mg/m³, JAN1999
Occupational Exposure Limit-RUSSIA	time-weighted average 5 ppm, JUN2003
Occupational Exposure Limit-SWITZERLAND	MAK-week 1 ppm (3.2 mg/m³), KZG-week 8 ppm (25.6 mg/m³), skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 1 mg/m³, Skin, 2003
Occupational Exposure Limit-THE PHILIPPINES	time-weighted average 25 ppm (80 mg/m³), Skin, JAN1993
Occupational Exposure Limit-TURKEY	time-weighted average 25 ppm (80 mg/m³), JAN1993
Occupational Exposure Limit-UNITED KINGDOM	time-weighted average 5 ppm (16 mg/m³), skin, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 25 ppm (80 mg/m³) (skin)	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	8H time-weighted average 25 ppm (80 mg/m³) (skin)	CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 25 ppm (80 mg/m³) (skin)	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 25 ppm (80 mg/m³) (skin)	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ETHYLENEGLYCOL MONOMETHYL ETHER-air	10H time-weighted average 0.1 ppm (Sk)	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code 46240; Number of Industries 89; Total Number of Facilities 8042; Number of Occupations 86; Total Number of Employees Exposed 168180; Total Number of Female Employees Exposed 53403
National Occupational Hazard Survey 1974	Hazard Code 46240; Number of Industries 128; Total Number of Facilities 11165; Number of Occupations 102; Total Number of Employees Exposed 103424

Status in Federal Agencies

Organization	Reference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9101
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Alcohols IV, 1403
NIOSH CURRENT INTELLIGENCE BULLETIN, #39
NTP Toxicity studies, RPT# TOX-26, October 2000
On EPA IRIS database
OSHA ANALYTICAL METHOD #53
OSHA ANALYTICAL METHOD #79

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health