Ethanol, 2-isopropoxy-

RTECS #

KL5075000

CAS #

109-59-1
See: NMAM or OSHA Methods

Updated

July 2016

Molecular Weight

104.17

Molecular Formula

C₅H₁₂O₂

Synonyms

2-Isopropoxyethanol
2-Isopropoxyethanol (ACGIH)
beta-Hydroxyethyl isopropyl ether
Dowanol eipat
Ethylene glycol isopropyl ether
Ethylene glycol, monoisopropyl ether
Isopropyl cellosolve
Isopropyl glycol
Isopropyl oxitol
Isopropylethylene glycol ether
Monoisopropyl ether of ethylene glycol

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
eye /rabbit	500 mg/24H	mild	85JCAE -,627,1986
skin /rabbit	20 mg/24H	moderate	85JCAE -,627,1986

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
inhalation/mouse	lethal concentration (50 percent kill): 1930 ppm/7H	Behavioral: Analgesia Lung, Thorax, or Respiration: Dyspnea Kidney, Ureter, and Bladder: Hematuria	JIHTAB 25,157,1943
inhalation/rat	lethal concentration (50 percent kill): 3100 mg/m³/4H		85GMAT -,67,1982
intraperitoneal/mammal (species unspecified)	lowest published toxic dose: 100 mg/kg	Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)	VCVGK* -,165,1984
intraperitoneal/mouse	lethal dose (50 percent kill): 1860 mg/kg		85GMAT -,67,1982
intraperitoneal/mouse	lethal dose (50 percent kill): 1250 mg/kg	Behavioral: Ataxia Lung, Thorax, or Respiration: Respiratory depression Blood: Other hemolysis with or without anemia	VCVGK* -,165,1984
intraperitoneal/rabbit	lethal dose (50 percent kill): 800 mg/kg	Behavioral: Ataxia Lung, Thorax, or Respiration: Respiratory depression Blood: Other hemolysis with or without anemia	VCVGK* -,165,1984
intraperitoneal/rat	lethal dose (50 percent kill): 1250 mg/kg	Behavioral: Ataxia Lung, Thorax, or Respiration: Respiratory depression Blood: Other hemolysis with or without anemia	VCVGK* -,165,1984
intraperitoneal/rat	lethal dose (50 percent kill): 800 mg/kg		85GMAT -,67,1982
oral/mouse	lethal dose (50 percent kill): 4900 mg/kg		85GMAT -,67,1982
oral/rat	lethal dose (50 percent kill): 5660 µL/kg		AIHAAP 30,470,1969
skin/rabbit	lethal dose (50 percent kill): 1600 µL/kg		AIHAAP 30,470,1969
unreported route/mouse	lethal dose (50 percent kill): 1250 mg/kg	Behavioral: Somnolence (general depressed activity) Behavioral: Excitement Lung, Thorax, or Respiration: Other changes	GISAAA 41(11),7,1976
unreported route/rat	lethal dose (50 percent kill): 1250 mg/kg	Behavioral: Somnolence (general depressed activity) Behavioral: Excitement Lung, Thorax, or Respiration: Other changes	GISAAA 41(11),7,1976

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/Dog	lowest published toxic concentration: 200 ppm/6H/26W- intermittent	Cardiac: Changes in heart weight Gastrointestinal: Hypermotility, diarrhea Nutritional and Gross Metabolic: Weight loss or decreased weight gain	NTIS** OTS0556079
inhalation/guinea pig	lowest published toxic concentration: 200 ppm/6H/26W- intermittent	Liver: Liver function tests impaired Nutritional and Gross Metabolic: Weight loss or decreased weight gain	NTIS** OTS0556079
inhalation/rabbit	lowest published toxic concentration: 200 ppm/6H/26W- intermittent	Kidney, Ureter, and Bladder: Changes in bladder weight Musculoskeletal: Other changes	NTIS** OTS0556079
inhalation/rat	lowest published toxic concentration: 1000 mg/m³/4H/30D- intermittent	Kidney, Ureter, and Bladder: Other changes Blood: Changes in cell count (unspecified)	VCVGK* -,165,1994
inhalation/rat	lowest published toxic concentration: 30 mg/m³/90D- continuous	Liver: Other changes Kidney, Ureter, and Bladder: Other changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain	VCVGK* -,165,1994
inhalation/rat	lowest published toxic concentration: 1650 mg/m³/7H/5W- intermittent	Blood: Changes in spleen	JIHTAB 25,374,1943
inhalation/rat	lowest published toxic concentration: 10 mg/m³/24H/13W- continuous	Endocrine: Hypoglycemia Blood: Changes in erythrocyte (RBC) count Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases	GISAAA 41(11),7,1976
inhalation/rat	lowest published toxic concentration: 142 ppm/6H/4W- intermittent	Blood: Pigmented or nucleated red blood cells Blood: Changes in spleen Blood: Changes in erythrocyte (RBC) count	INHTE5 4,43,1992
inhalation/rat	lowest published toxic concentration: 200 ppm/6H/26W- intermittent	Endocrine: Changes in spleen weight Blood: Other changes Blood: Changes in erythrocyte (RBC) count	NTIS** OTS0556079
subcutaneous/rat	lowest published toxic dose: 1562.55 mg/kg/4W- intermittent	Blood: Changes in erythrocyte (RBC) count Nutritional and Gross Metabolic: Weight loss or decreased weight gain	ARTODN 82,125,2008

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 25 ppm (skin)	DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEW		REPTED 58,252,2015

Standards and Regulations

Organization	Standard	Reference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 25 ppm (105 mg/m³), JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 5 ppm (22 mg/m³);KZW 20 ppm (88 mg/m³), skin, 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 25 ppm (108 mg/m³), Skin, MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 5 ppm (22 mg/m³), skin, MAY2011
Occupational Exposure Limit-FRANCE	VME 25 ppm (105 mg/m³), FEB2006
Occupational Exposure Limit-GERMANY	MAK 5 ppm (22 mg/m³), 2011
Occupational Exposure Limit-ICELAND	time-weighted average 5 ppm (22 mg/m³), skin, NOV2011
Occupational Exposure Limit-KOREA	time-weighted average 25 ppm (105 mg/m³), 2006
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 25 ppm (106 mg/m³), JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 20 ppm (80 mg/m³), JAN1999
Occupational Exposure Limit-SWEDEN	time-weighted average 10 ppm (45 mg/m³);short term exposure limit 20 ppm (90 mg/m³), Skin, JUN2005
Occupational Exposure Limit-SWITZERLAND	MAK-week 5 ppm (22 mg/m³), KZG-week 40 ppm (176 mg/m³), skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 44 mg/m³, Skin, 2003

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Occupational Exposure Survey 1983	Hazard Code X7487; Number of Industries 1; Total Number of Facilities 32; Number of Occupations 5; Total Number of Employees Exposed 1357; Total Number of Female Employees Exposed 63

Status in Federal Agencies

Organization	Reference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health