Ethanol, 2-(diethylamino)-

RTECS #

KK5075000

CAS #

100-37-8
See: NMAM or OSHA Methods

Updated

December 2018

Molecular Weight

117.22

Molecular Formula

C₆H₁₅NO

Synonyms

2-(Diethylamino)ethanol
2-Diethylaminoethanol
2-Diethylaminoethanol (ACGIH:OSHA)
2-Hydroxytriethylamine
2-N-Diethylaminoethanol
beta-Diethylaminoethanol
beta-Diethylaminoethyl alcohol
DEAE
Diaethylaminoaethanol (German)
Diethylethanolamine
N,N-Diethylethanolamine
N,N-Diethyl-N-(beta-hydroxyethyl)amine
N-Diethylaminoethanol

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
eye /rabbit	5 mg	severe	UCDS** 6/11/1963
skin /rabbit	10 mg/24H open irritation test		JIHTAB 26,269,1944
skin /rabbit	500 mg open irritation test	mild	UCDS** 6/11/1963

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
In Vitro/Rabbit, ocular	Inhibitor Concentration Low: 5 pph/5M	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	TIVIEQ 25,1425,2011
inhalation/human	lowest published toxic concentration: 200 ppm	Gastrointestinal: Nausea or vomiting	34ZIAG -,216,1969
inhalation/mouse	lethal concentration (50 percent kill): 5000 mg/m³	Brain and Coverings: Recordings from specific areas of CNS Eye: Conjunctiva irritation Behavioral: Convulsions or effect on seizure threshold	GTPZAB 14(11),52,1970
inhalation/rat	Lowest published lethal concentration: 4500 mg/m³/4H	Brain and Coverings: Recordings from specific areas of CNS Eye: Conjunctiva irritation Behavioral: Convulsions or effect on seizure threshold	GTPZAB 14(11),52,1970
intramuscular/mouse	lethal dose (50 percent kill): 416 mg/kg		ARZNAD 9,31,1959
intraperitoneal/mouse	lethal dose (50 percent kill): 192 mg/kg	Behavioral: Ataxia	JPETAB 94,249,1948
intraperitoneal/rat	lethal dose (50 percent kill): 1220 mg/kg		TXAPA9 12,486,1968
intravenous/mouse	lethal dose (50 percent kill): 188 mg/kg	Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Other changes	ARZNAD 9,31,1959
oral/rat	lethal dose (50 percent kill): 1300 mg/kg		JIHTAB 26,269,1944
skin/guinea pig	lethal dose (50 percent kill): 1 mL/kg		JIHTAB 26,269,1944
skin/rabbit	lethal dose (50 percent kill): 1260 µL/kg		UCDS** 6/11/1963
subcutaneous/mouse	lethal dose (50 percent kill): 650 mg/kg	Behavioral: Convulsions or effect on seizure threshold Behavioral: Ataxia Lung, Thorax, or Respiration: Other changes	ARZNAD 9,31,1959
unreported route/mammal (species unspecified)	lowest published lethal dose: 1300 mg/kg		34ZIAG -,216,1969

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/rat	lowest published toxic concentration: 500 ppm/6H/5D- intermittent	Eye: Other eye effects Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	AIHAAP 26,479,1965
inhalation/rat	lowest published toxic concentration: 200 ppm/6H/26W- intermittent	Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	AIHAAP 26,479,1965
inhalation/rat	lowest published toxic concentration: 76 ppm/6H/14W- intermittent	Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in bladder weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain	FAATDF 18,418,1992
inhalation/rat	lowest published toxic concentration: 301 ppm/6H/2W- intermittent	Behavioral: Fluid intake Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	FAATDF 18,418,1992
oral/Dog	lowest published toxic dose: 21559 mg/kg/1Y- continuous	Brain and Coverings: Other degenerative changes Behavioral: Ataxia Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion	NTIS** OTS0530455-1
oral/Dog	lowest published toxic dose: 4875 mg/kg/39D- intermittent	Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	NTIS** OTS0536945

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 2 ppm (skin)	DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEW		FCTOD7 55,596,2013
TOXICOLOGY REVIEW		RTOPDW 55,43,2009

Standards and Regulations

Organization	Standard	Reference
Mine Safety and Health Administration (MSHA) STANDARD-air	time-weighted average 10 ppm (50 mg/m³) (skin)	DTLVS* 3,85,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 10 ppm (48 mg/m³), JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 5 ppm (24 mg/m³);KZW 5 ppm (24 mg/m³), skin, 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 2 ppm (9.7 mg/m³), Skin, MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 2 ppm (9.6 mg/m³), skin, MAY2011
Occupational Exposure Limit-FINLAND	short term exposure limit 10 ppm (49 mg/m³), skin, NOV2011
Occupational Exposure Limit-FRANCE	VME 10 ppm (50 mg/m³), Skin, FEB2006
Occupational Exposure Limit-GERMANY	MAK 5 ppm (24 mg/m³), 2011
Occupational Exposure Limit-ICELAND	time-weighted average 2 ppm (9.6 mg/m³), skin, NOV2011
Occupational Exposure Limit-KOREA	time-weighted average 10 ppm (50 mg/m³), skin, 2006
Occupational Exposure Limit-MEXICO	time-weighted average 10 ppm (50 mg/m³) (skin), 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 10 ppm (48 mg/m³), skin, JAN2002
Occupational Exposure Limit-PERU	time-weighted average 2 ppm (9.6 mg/m³), JUL2005
Occupational Exposure Limit-POLAND	time-weighted average 50 mg/m³, JAN1999
Occupational Exposure Limit-RUSSIA	short term exposure limit 5 mg/m³, Skin, JUN2003
Occupational Exposure Limit-SWEDEN	time-weighted average 2 ppm (10 mg/m³);short term exposure limit 10 ppm (50 mg/m³), Skin, JUN2005
Occupational Exposure Limit-SWITZERLAND	MAK-week 10 ppm (50 mg/m³), skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 9.6 mg/m³, Skin, 2003
Occupational Exposure Limit-THE PHILIPPINES	time-weighted average 10 ppm (50 mg/m³), Skin, JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 10 ppm (50 mg/m³)	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	8H time-weighted average 10 ppm (50 mg/m³) (skin)	CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 10 ppm (50 mg/m³) (skin)	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 10 ppm (50 mg/m³)	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 2-DIETHYLAMINOETHANOL-air	10H time-weighted average 10 ppm (Sk)	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code 24930; Number of Industries 115; Total Number of Facilities 11825; Number of Occupations 68; Total Number of Employees Exposed 106878; Total Number of Female Employees Exposed 20564
National Occupational Hazard Survey 1974	Hazard Code 24930; Number of Industries 71; Total Number of Facilities 7801; Number of Occupations 39; Total Number of Employees Exposed 23770

Status in Federal Agencies

Organization	Reference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Aminoethanol compounds I, 2007

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health