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Ethane, pentachloro-

RTECS #
KI6300000
CAS #
76-01-7
See: NMAM or OSHA Methods
Updated
April 2017
Molecular Weight
202.28
Molecular Formula
C2HCl5
Synonyms
Ethane pentachloride
NCI-C53894
Pentachloorethaan (Dutch)
Pentachloraethan (German)
Pentachlorethane (French)
Pentachloroethane
Pentacloroetano (Italian)
Pentalin
RCRA waste number U184

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislung/hamster80 mg/LMUREAV 369,243,1996
mutation in mammalian somatic cellslymphocyte/mouse70 mg/LEMMUEG 12,85,1988
mutation in microorganisms/Saccharomyes cerevisiae2500 µmol/L (+enzymatic activation step)TCMUD8 9,349,1989
other mutation test systemsoral/mouse500 mg/kgMUREAV 343,157,1995
other mutation test systems/Escherichia coli25814 µmol/LEMMUEG 19,98,1992
sex chromosome loss and nondisjunctionlung/human80 mg/LMUREAV 369,243,1996
sister chromatid exchangeovary/hamster100 mg/LSCIEAS 236,933,1987

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 71750 mg/kg/103W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NTIS** PB83-206748
oral/rat lowest published toxic dose: 108150 mg/kg/103W- intermittentTumorigenic: Neoplastic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors
NTIS** PB83-206748

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/cat lowest published toxic concentration: 17 mg/m3Behavioral: General anestheticVCVGH* -,390,1990
inhalation/mouse lowest published toxic concentration: 7500 mg/m3/2HBehavioral: General anestheticVCVGH* -,307,1990
inhalation/mouse Lowest published lethal concentration: 35000 mg/m3/2HVCVGH* -,390,1990
inhalation/rat lethal concentration (50 percent kill): 4238 ppm/2H85JCAE -,97,1986
intravenous/Dog lowest published lethal dose: 100 mg/kgQJPPAL 7,205,1934
oral/Dog lowest published lethal dose: 500 mg/kgBehavioral: Sleep

Liver: Hepatitis (hepatocellular necrosis), zonal

Liver: Fatty liver degeneration
AJHYA2 16,325,1932
oral/rat lethal dose (50 percent kill): 920 mg/kgBehavioral: Altered sleep time (including change in righting reflex)

Behavioral: Ataxia

Liver: Other changes
SRTCAC 36(1-4),10,1989
subcutaneous/rabbit lowest published lethal dose: 700 mg/kgQJPPAL 7,205,1934

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 32500 mg/kg/13W- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTPTR* NTP-TR-232,1982
oral/mouse lowest published toxic dose: 14 gm/kg/14D- continuousRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTPTR* NTP-TR-232,1982
oral/rat lowest published toxic dose: 7 gm/kg/14D- continuousRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTPTR* NTP-TR-232,1982

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMEMDT 41,99,1986
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMEMDT 71,1519,1999
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 41,99,1986
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 71,1519,1999
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMEMDT 71,1519,1999
TOXICOLOGY REVIEWAIHAAP 40(3),A46,1979
TOXICOLOGY REVIEWMUTAEX 14,5,1999
TOXICOLOGY REVIEWMUTAEX 14,271,1999
TOXICOLOGY REVIEWMUREAV 628,67,2007
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWMUREAV 721,27,2011
TOXICOLOGY REVIEWMUREAV 769,34,2014
TOXICOLOGY REVIEWMUREAV 802,1,2016

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-AUSTRIAMAK-TMW 5 ppm (40 mg/m3);KZW 20 ppm (160 mg/m3), 2007
Occupational Exposure Limit-DENMARKtime-weighted average 5 ppm (40 mg/m3), skin, carc, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 5 ppm (42 mg/m3), short term exposure limit 10 ppm (84 mg/m3), NOV2011
Occupational Exposure Limit-GERMANYMAK 5 ppm (42 mg/m3), 2011
Occupational Exposure Limit-ICELANDtime-weighted average 5 ppm (40 mg/m3), skin, NOV2011
Occupational Exposure Limit-NORWAYtime-weighted average 5 ppm (40 mg/m3), JAN1999
Occupational Exposure Limit-SWITZERLANDMAK-week 5 ppm (40 mg/m3), KZG-week 10 ppm (80 mg/m3), carc 3, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 40 mg/m3, 2003
Occupational Exposure Limit-TURKEYtime-weighted average 5 ppm (40 mg/m3), JAN1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PENTACHLOROETHANE-airHandle with cautionNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code X6173; Number of Industries 1; Total Number of Facilities 3; Number of Occupations 7; Total Number of Employees Exposed 232; Total Number of Female Employees Exposed 3

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (gavage);clear evidence:mouse
NCI Carcinogenesis Studies (gavage);equivocal evidence:rat
NIOSH Analytical Method, 1994: Pentachloroethane, 2517
NIOSH CURRENT INTELLIGENCE BULLETIN 27, 1978
NTP Toxicity studies, RPT# TOX-45, October 2000
On EPA IRIS database
Page last reviewed: November 16, 2018