Disulfide, bis(diethylthiocarbamoyl)
RTECS #
JO1225000
CAS #
Updated
March 2019
Molecular Weight
296.56
Molecular Formula
C10H20N2S4
Synonyms
1,1'-Dithiobis(N,N-diethylthioformamide)
Abstensil
Abstinil
Abstinyl
Alcophobin
Antabus
Antabuse
Antaenyl
Antaethyl
Antalcol
Antetan
Antetil
Anti-ethyl
Antietil
Antikol
Antivitium
Aversan
Averzan
Bis((diethylamino)thioxomethyl)disulphide
Bis(diethylthiocarbamoyl) disulfide
Bis(diethylthiocarbamoyl)disulphide
Bis(N,N-diethylthiocarbamoyl) disulfide
Bis(N,N-diethylthiocarbamoyl)disulphide
Contralin
Cronetal
Dicupral
Disulfiram
Disulfiram (ACGIH)
Disulfuram
Disulphuram
Dupon 4472
Dupont fungicide 4472
Ekagom TEDS
ENT 27,340
Ephorran
Espenal
Esperal
Etabus
Ethyl thiram
Ethyl thiurad
Ethyl tuads
Ethyl TUEX
Ethyldithiourame
Ethyldithiurame
Exhoran
Formamide, 1,1'-dithiobis(N,N-diethylthio-
HOCA
Krotenal
N,N,N',N'-Tetraethylthiuram disulphide
NCI-C02959
Nocbin
Noxal
NSC 190940
Refusal
Ro-Sulfiram
Stopetyl
Tenurid
Tenutex
TETD
Tetidis
Tetradin
Tetradine
Tetraethylthioperoxydicarbonic diamide
Tetraethylthiram disulphide
Tetraethylthiuram
Tetraethylthiuram disulfide
Tetraethylthiuram disulphide
Tetraetil
Teturam
Teturamin
Thiuram disulfide, tetraethyl-
Thiuram E
Thiuranide
USAF B-33
Abstensil
Abstinil
Abstinyl
Alcophobin
Antabus
Antabuse
Antaenyl
Antaethyl
Antalcol
Antetan
Antetil
Anti-ethyl
Antietil
Antikol
Antivitium
Aversan
Averzan
Bis((diethylamino)thioxomethyl)disulphide
Bis(diethylthiocarbamoyl) disulfide
Bis(diethylthiocarbamoyl)disulphide
Bis(N,N-diethylthiocarbamoyl) disulfide
Bis(N,N-diethylthiocarbamoyl)disulphide
Contralin
Cronetal
Dicupral
Disulfiram
Disulfiram (ACGIH)
Disulfuram
Disulphuram
Dupon 4472
Dupont fungicide 4472
Ekagom TEDS
ENT 27,340
Ephorran
Espenal
Esperal
Etabus
Ethyl thiram
Ethyl thiurad
Ethyl tuads
Ethyl TUEX
Ethyldithiourame
Ethyldithiurame
Exhoran
Formamide, 1,1'-dithiobis(N,N-diethylthio-
HOCA
Krotenal
N,N,N',N'-Tetraethylthiuram disulphide
NCI-C02959
Nocbin
Noxal
NSC 190940
Refusal
Ro-Sulfiram
Stopetyl
Tenurid
Tenutex
TETD
Tetidis
Tetradin
Tetradine
Tetraethylthioperoxydicarbonic diamide
Tetraethylthiram disulphide
Tetraethylthiuram
Tetraethylthiuram disulfide
Tetraethylthiuram disulphide
Tetraetil
Teturam
Teturamin
Thiuram disulfide, tetraethyl-
Thiuram E
Thiuranide
USAF B-33
Skin and Eye Irritation and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
eye /rabbit | 0.1 gm | mild | HPV407 -,-,2001 |
Mutation Data and Reference
System Test | Route/Organism/Tissue | Dose | Reference |
---|---|---|---|
DNA inhibition | HeLa cell/human | 100 µmol/L | CRNGDP 13,2389,1992 |
DNA inhibition | embryo/mouse | 10 mg/L | JJATDK 5,1,1985 |
DNA inhibition | embryo/chicken | 120 nmol/L | BBACAQ 519,65,1978 |
morphological transform | embryo/hamster | 20 µg/L | MUREAV 356,85,1996 |
morphological transform | oral/rat | 12600 mg/kg/6W | CRNGDP 9,387,1988 |
mutation in mammalian somatic cells | other cell types/mouse | 4100 µg/L (-enzymatic activation step) | HPV407 ,,2001 |
mutation in microorganisms | /Salmonella typhimurium | 25 µg/plate (+enzymatic activation step) | CBINA8 49,329,1984 |
mutation in microorganisms | /Salmonella typhimurium | 20 µg/plate (-enzymatic activation step) | PCBRD2 141,407,1984 |
other mutation test systems | embryo/chicken | 120 nmol/L | BBACAQ 519,65,1978 |
sister chromatid exchange | ovary/hamster | 5 µmol/L | SWEHDO 9(Suppl 2),27,1983 |
sister chromatid exchange | oral/mouse | 200 mg/kg | FCTOD7 37,757,1999 |
specific locus test | lymphocyte/mouse | 16 µg/L | EMMUEG 17,196,1991 |
Reproductive Effects Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
oral/rat | 5 gm/kg (3-12D pregnant) | Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | JRPFA4 39,375,1974 |
oral/rat | 310 mg/kg (31D male) | Reproductive: Paternal effects: Testes, epididymis, sperm duct | TXAPA9 107,164,1991 |
oral/mouse | 13200 mg/kg (15D prior to copulation/1-18D pregnant) | Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) | JJATDK 5,1,1985 |
oral/mouse | 39200 mg/kg (7-14D pregnant) | Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) | NTIS** PB86-197605 |
oral/rat | 2800 mg/kg (14D male) | Reproductive: Effects on newborn: Biochemical and metabolic | FATOAO 48,86,1985 |
parenteral/rat | 400 mg/kg (4-11D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Effects on embryo or fetus: Fetal death | BEXBAN 93,107,1982 |
parenteral/rat | 800 mg/kg (2D male/2D prior to copulation) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Effects on embryo or fetus: Fetal death | BEXBAN 93,107,1982 |
subcutaneous/mouse | 1278 mg/kg (6-14D pregnant) | Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | NTIS** PB223-160 |
subcutaneous/mouse | 1278 mg/kg (6-14D pregnant) | Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) Reproductive: Specific developmental abnormalities: Musculoskeletal system | NTIS** PB223-160 |
Tumorigenic Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
oral/mouse | lowest published toxic dose: 35 gm/kg/78W- intermittent | Tumorigenic: Neoplastic by RTECS criteria Liver: Tumors | NTIS** PB223-159 |
subcutaneous/mouse | lowest published toxic dose: 1000 mg/kg | Tumorigenic: Neoplastic by RTECS criteria Lung, Thorax, or Respiration: Tumors Blood: Tumors | NTIS** PB223-159 |
Acute Toxicity Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
In Vitro/Hamster, lung fibroblast | Inhibitor Concentration Low: 200 µmol/L/1H | In Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc. In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases | TXAPA9 248,210,2010 |
In Vitro/Hamster, lung fibroblast | Inhibitor Concentration Low: 100 µmol/L/1H | In Vitro Toxicity Studies: Other assays | TXAPA9 248,210,2010 |
In Vitro/Human, liver tumor | Inhibitor Concentration Low: 20 µmol/L | In Vitro Toxicity Studies: Other assays | TIVIEQ 27,1719,2013 |
In Vitro/Human, liver tumor | Inhibitor Concentration (50 percent kill): 119.6 µmol/L/24H | In Vitro Toxicity Studies: Cell metabolic activity: Alamar Blue assay etc. | TIVIEQ 29,582,2015 |
In Vitro/Mouse, fibroblast | Inhibitor Concentration (50 percent kill): >100 µmol/L/24H | In Vitro Toxicity Studies: Cell metabolic activity: Alamar Blue assay etc. | TIVIEQ 30,429,2015 |
In Vitro/mtb | Inhibitor Concentration (50 percent kill): 0.54 µmol/L/6H | In Vitro Toxicity Studies: Other assays | TIVIEQ 32,287,2016 |
In Vitro/Pig, spermatozoa | Inhibitor Concentration (50 percent kill): 0.5 µmol/L/30M | In Vitro Toxicity Studies: Other assays | TIVIEQ 29,582,2015 |
intraperitoneal/mouse | lethal dose (50 percent kill): 75 mg/kg | NTIS** AD691-490 | |
intraperitoneal/rat | lethal dose (50 percent kill): 248 mg/kg | Behavioral: Change in motor activity (specific assay) Nutritional and Gross Metabolic: Body temperature decrease | JNPHAG 9,35,1978 |
oral/child | lowest published toxic dose: 150 mg/kg | Behavioral: Somnolence (general depressed activity) Behavioral: Hallucinations, distorted perceptions Gastrointestinal: Nausea or vomiting | 34ZIAG -,230,1969 |
oral/Dog | lowest published lethal dose: 3500 mg/kg | Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral: Ataxia Nutritional and Gross Metabolic: Body temperature decrease | APTOA6 8,305,1952 |
oral/human | lowest published toxic dose: 14 mg/kg | Endocrine: Change in gonadotropins | SWEHDO 4,66,1978 |
oral/human | lowest published toxic dose: 18 mg/kg | Endocrine: Change in gonadotropins Endocrine: Change in LH | SWEHDO 4,66,1978 |
oral/human | lowest published lethal dose: 160 mg/kg | Behavioral: Coma Gastrointestinal: Ulceration or bleeding from large intestine Liver: Hepatitis, fibrous (cirrhosis, post- necrotic scarring) | BMJOAE 2,94,1977 |
oral/man | lowest published toxic dose: 450 mg/kg/6W- intermittent | Brain and Coverings: Encephalitis Liver: Hepatitis (hepatocellular necrosis), diffuse Skin: After systemic exposure: Dermatitis, other | AJGAAR 93,830,1998 |
oral/man | lowest published toxic dose: 150 mg/kg/6W- intermittent | Musculoskeletal: Joints | ARHEAW 25,1494,1982 |
oral/man | lowest published lethal dose: 150 mg/kg/6W- intermittent | Liver: Hepatitis (hepatocellular necrosis), diffuse | AIMDAP 143,1271,1983 |
oral/mouse | lethal dose (50 percent kill): 1.013 mg/kg | TCMUD8 22,83,2001 | |
oral/rabbit | lethal dose (50 percent kill): 1800 mg/kg | Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral: Ataxia Nutritional and Gross Metabolic: Body temperature decrease | APTOA6 8,305,1952 |
oral/rat | lowest published toxic dose: 200 mg/kg | Brain and Coverings: Other degenerative changes Cardiac: Cardiomyopathy including infarction Liver: Multiple effects | FATOAO 50,52,1987 |
oral/rat | lethal dose (50 percent kill): 500 mg/kg | HPV407 -,-,2001 | |
oral/rat | lowest published toxic dose: 178.5 mg/kg | Reproductive: Paternal effects: Testes, epididymis, sperm duct Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases | FCTOD7 105,44,2017 |
oral/woman | lowest published toxic dose: 140 mg/kg/2W | Behavioral: Hallucinations, distorted perceptions Behavioral: Convulsions or effect on seizure threshold | SMJOAV 80,1577,1987 |
oral/woman | lowest published toxic dose: 90 mg/kg/18D- intermittent | Liver: Jaundice, other or unclassified | JCLPDE 46,67,1985 |
oral/woman | lowest published lethal dose: 90 mg/kg/18D- intermittent | Behavioral: Coma Liver: Jaundice, other or unclassified Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) | DMWOAX 118,1355,1993 |
skin/rabbit | lethal dose (50 percent kill): >2000 mg/kg | HPV407 -,-,2001 | |
subcutaneous/mouse | lethal dose (50 percent kill): 2600 mg/kg | NIIRDN -,523,1995 | |
subcutaneous/rat | Lethal dose: >4 gm/kg | APTOA6 8,305,1952 | |
Tank with water/Daphnia | Lowest published lethal concentration: 3.2 µg/L/21D | AQUTO* 7,165,1985 | |
Tank with water/Zebrafish | lowest published toxic concentration: 32.62 µg/L/48H | Reproductive: Other developmental abnormalities | NETEEC 34,413,2012 |
Tank with water/Zebrafish | lowest published toxic concentration: 80 µg/L/6D | Reproductive: Specific developmental abnormalities: Musculoskeletal system | TXAPA9 268,221,2013 |
Tank with water/Zebrafish | lethal concentration (50 percent kill): 0.48 mg/L/48H | TXAPA9 268,221,2013 | |
Tank with water/Zebrafish | lethal concentration (50 percent kill): 0.45 mg/L/96H | TXAPA9 268,221,2013 | |
Tank with water/Zebrafish | lethal concentration (50 percent kill): 0.36 mg/L/6D | TXAPA9 268,221,2013 |
Other Multiple Dose Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
intraperitoneal/rat | lowest published toxic dose: 375 mg/kg/5D- intermittent | Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation) | ARTODN 83,571,2009 |
ocular/rat | lowest published toxic dose: 58.75 mg/kg/47D- intermittent | Eye: Other eye effects Nutritional and Gross Metabolic: Changes in: Ca Biochemical: Metabolism (intermediary): Lipids including transport | BPBLEO 31,981,2008 |
ocular/rat | lowest published toxic dose: 82.5 mg/kg/33D- intermittent | Eye: Other eye effects Biochemical: Metabolism (intermediary): Lipids including transport Biochemical: Metabolism (intermediary): Effect on active transport | BPBLEO 31,981,2008 |
ocular/rat | lowest published toxic dose: 41.25 mg/kg/33D- intermittent | Eye: Other eye effects Biochemical: Metabolism (intermediary): Lipids including transport | BPBLEO 31,981,2008 |
oral/Dog | lowest published toxic dose: 1750 mg/kg/7D- intermittent | Autonomic Nervous System: Other (direct) parasympathomimetic Liver: Hepatitis (hepatocellular necrosis), zonal Blood: Changes in spleen | APTOA6 8,305,1952 |
oral/man | lowest published toxic dose: 39.3 mg/kg/11D- intermittent | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) | BCPHBM 53,155,2002 |
oral/mouse | lowest published toxic dose: 3200 mg/kg/16D- intermittent | Tumorigenic: Active as anti-cancer agent | MOCAT* 3,1049,2004 |
oral/rabbit | lowest published toxic dose: 280 mg/kg/18D- intermittent | Spinal Cord: Demyelination Autonomic Nervous System: Other (direct) parasympathomimetic Liver: Hepatitis (hepatocellular necrosis), zonal | APTOA6 8,305,1952 |
oral/rat | lowest published toxic dose: 91250 mg/kg/2Y- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | HPV407 -,-,2001 |
oral/rat | lowest published toxic dose: 11200 mg/kg/28D- intermittent | Eye: Other eye effects Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other hydrolases | TXCYAC 197,177,2004 |
oral/rat | lowest published toxic dose: 5250 mg/kg/1W- intermittent | Behavioral: Change in motor activity (specific assay) Nutritional and Gross Metabolic: Weight loss or decreased weight gain | TOXID9 66,44,2002 |
oral/rat | lowest published toxic dose: 31.5 gm/kg/6W- intermittent | Musculoskeletal: Other changes | TOXID9 66,44,2002 |
oral/rat | lowest published toxic dose: 40500 mg/kg/9W- intermittent | Musculoskeletal: Other changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain | TOXID9 60,33,2001 |
oral/rat | lowest published toxic dose: 7 gm/kg/7D- intermittent | Autonomic Nervous System: Other (direct) parasympathomimetic Gastrointestinal: Ulceration or bleeding from stomach Blood: Changes in spleen | APTOA6 8,305,1952 |
oral/rat | lowest published toxic dose: 6750 mg/kg/6W- intermittent | Brain and Coverings: Other degenerative changes Nutritional and Gross Metabolic: Changes in: Other metals | TOLED5 75,235,1995 |
oral/rat | lowest published toxic dose: 7770 mg/kg/3W- intermittent | Peripheral Nerve and Sensation: Recording from peripheral motor nerve Nutritional and Gross Metabolic: Weight loss or decreased weight gain | APTOA6 55,339,1984 |
oral/rat | lowest published toxic dose: 6545 mg/kg/13W- intermittent | Autonomic Nervous System: Parasympatholytic Gastrointestinal: Contraction (isolated tissue) Nutritional and Gross Metabolic: Weight loss or decreased weight gain | APTOA6 55,339,1984 |
oral/rat | lowest published toxic dose: 720 mg/kg/60D- intermittent | Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases | EPEPEG 292,89,1994 |
oral/rat | lowest published toxic dose: 44640 mg/kg/2Y- continuous | Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | JPMSAE 59,1267,1970 |
oral/rat | lowest published toxic dose: 535.5 mg/kg/3D- intermittent | Reproductive: Paternal effects: Testes, epididymis, sperm duct Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases | FCTOD7 105,44,2017 |
oral/woman | lowest published toxic dose: 150 mg/kg/5D- intermittent | Gastrointestinal: Nausea or vomiting Liver: Jaundice (or hyperbilirubinemia) hepatocellular Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects | JHEPT* 21,853,1994 |
oral/woman | lowest published toxic dose: 3000 mg/kg/8W- intermittent | Peripheral Nerve and Sensation: Sensory change involving peripheral nerve Peripheral Nerve and Sensation: Paresthesia | JTCTDW 46,314,2008 |
oral/woman | lowest published toxic dose: 760 mg/kg/91D- intermittent | Tumorigenic: Active as anti-cancer agent | MOCAT* 3,1049,2004 |
Reviews
Organization | Standard | Reference |
---|---|---|
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 2 mg/m3 | DTLVS* TLV/BEI,2013 |
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Not classifiable as a human carcinogen | DTLVS* TLV/BEI,2013 |
International Agency for Research on Cancer (IARC) | Cancer Review:Animal Inadequate Evidence | IMEMDT 12,85,1976 |
International Agency for Research on Cancer (IARC) | Cancer Review:Human No Adequate Data | IMEMDT 12,85,1976 |
International Agency for Research on Cancer (IARC) | Cancer Review:Group 3 | IMSUDL 7,56,1987 |
TOXICOLOGY REVIEW | CRTXB2 2,365,1973 | |
TOXICOLOGY REVIEW | JHEPT* 21,853,1994 | |
TOXICOLOGY REVIEW | AINCM* 7,63,2006 | |
TOXICOLOGY REVIEW | DIMON* 39,678,1993 | |
TOXICOLOGY REVIEW | JHEPT* 44,791,2006 | |
TOXICOLOGY REVIEW | ENTOX* -,84,2005 | |
TOXICOLOGY REVIEW | MUREAV 584,1,2005 | |
TOXICOLOGY REVIEW | DERCL* 27,289,2009 | |
TOXICOLOGY REVIEW | NBREV* 3,179,1979 | |
TOXICOLOGY REVIEW | NEUCL* 23,377,2005 | |
TOXICOLOGY REVIEW | NBREV* 9,299,1985 | |
TOXICOLOGY REVIEW | TXAPA9 243,225,2010 | |
TOXICOLOGY REVIEW | NTAPM* -,671,1995 | |
TOXICOLOGY REVIEW | MUREAV 727,42,2011 | |
TOXICOLOGY REVIEW | MUREAV 750,1,2012 | |
TOXICOLOGY REVIEW | MUREAV 795,7,2016 | |
TOXICOLOGY REVIEW | MUREAV 802,1,2016 | |
TOXICOLOGY REVIEW | MUREAV 769,19,2016 | |
TOXICOLOGY REVIEW | MUTAEX 32,491,2017 | |
TOXICOLOGY REVIEW | RTOPDW 59,364,2011 | |
TOXICOLOGY REVIEW | SFDRA* 38,523,2016 |
Standards and Regulations
NIOSH Documentation and Surveillance
Organization | Standard | Reference |
---|---|---|
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DISULFIRAM-air | 10H time-weighted average 2 mg/m3 | NIOSH* DHHS #95-121,1995 |
National Occupational Exposure Survey 1983 | Hazard Code 80219; Number of Industries 28; Total Number of Facilities 2688; Number of Occupations 51; Total Number of Employees Exposed 53525; Total Number of Female Employees Exposed 6305 | |
National Occupational Hazard Survey 1974 | Hazard Code 80219; Number of Industries 4; Total Number of Facilities 209; Number of Occupations 24; Total Number of Employees Exposed 4441 |
Status in Federal Agencies
Organization | Reference |
---|---|
EPA GENETOX PROGRAM 1988, Negative: Carcinogenicity-mouse/rat | |
EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
EPA TSCA Section 8(d) unpublished health/safety studies | |
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 | |
NCI Carcinogenesis Bioassay (feed);no evidence:mouse,rat | NCITR* NCI-TR-166,1979 |
NIOSH CURRENT INTELLIGENCE BULLETIN 23, 1978 |
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health