Diphenylamine
RTECS #
JJ7800000
CAS #
Updated
December 2018
Molecular Weight
169.24
Molecular Formula
C12H11N
Synonyms
Aniline, N-phenyl-
Anilinobenzene
Benzenamine, N-phenyl- (9CI)
Benzene, (phenylamino)-
Benzene, anilino-
Big Dipper
C.I. 10355
Deccoscald 282
DFA
Difenylamin (Czech)
Diphenylamine (ACGIH:OSHA)
N,N-Diphenylamine
Naugalube 428L
N-Fenylanilin (Czech)
No-Scald
No-Scald DPA 283
N-Phenylaniline
N-Phenylbenzenamine
Scaldip
Shield DPA
Anilinobenzene
Benzenamine, N-phenyl- (9CI)
Benzene, (phenylamino)-
Benzene, anilino-
Big Dipper
C.I. 10355
Deccoscald 282
DFA
Difenylamin (Czech)
Diphenylamine (ACGIH:OSHA)
N,N-Diphenylamine
Naugalube 428L
N-Fenylanilin (Czech)
No-Scald
No-Scald DPA 283
N-Phenylaniline
N-Phenylbenzenamine
Scaldip
Shield DPA
Reproductive Effects Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| oral/rat | 7500 mg/kg (17-22D pregnant) | Reproductive: Specific developmental abnormalities: Urogenital system | PEREBL 4,448,1970 |
| oral/rat | 12645 mg/kg (multigeneration) | Reproductive: Other effects on female Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | HPV386 -,-,2001 |
| unreported route/mammal (species unspecified) | 131 mg/kg (multigenerations) | Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | FEREAC 64,25845,1999 |
| unreported route/mammal (species unspecified) | 448 mg/kg (multigenerations) | Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) | FEREAC 64,25845,1999 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| oral/guinea pig | lethal dose (50 percent kill): 300 mg/kg | HPV386 -,-,2001 | |
| oral/mammal (species unspecified) | lethal dose (50 percent kill): 3200 mg/kg | Lung, Thorax, or Respiration: Cyanosis | GISAAA 40(10),114,1975 |
| oral/mouse | lethal dose (50 percent kill): 1230 mg/kg | Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Respiratory depression Blood: Methemoglobinemia- Carboxhemoglobinemia | STGNBT -,104,1999 |
| oral/mouse | lethal dose (50 percent kill): 1750 mg/kg | HPV386 -,-,2001 | |
| oral/rat | lethal dose (50 percent kill): 1120 mg/kg | Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Respiratory depression Blood: Methemoglobinemia- Carboxhemoglobinemia | STGNBT -,104,1999 |
| oral/rat | lethal dose (50 percent kill): 1165 mg/kg | HPV386 -,-,2001 | |
| skin/rabbit | lethal dose (50 percent kill): >5000 mg/kg | HPV386 -,-,2001 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| intraperitoneal/gerbil | lowest published toxic dose: 150 mg/kg/3D- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | HPV386 -,-,2001 |
| intraperitoneal/hamster | lowest published toxic dose: 1200 mg/kg/3D- intermittent | Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, and Bladder: Other changes | HPV386 -,-,2001 |
| intraperitoneal/hamster | lowest published toxic dose: 2400 mg/kg/3D- intermittent | Gastrointestinal: Ulceration or bleeding from stomach Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Blood: Changes in spleen | HPV386 -,-,2001 |
| intraperitoneal/hamster | lowest published toxic dose: 1200 mg/kg/3D- intermittent | Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) | VTPHAK 27,171,1990 |
| intraperitoneal/rat | lowest published toxic dose: 1200 mg/kg/3D- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | HPV386 -,-,2001 |
| oral/Dog | lowest published toxic dose: 553680 mg/kg/96W- intermittent | Blood: Normocytic anemia Liver: Changes in liver weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain | HPV386 -,-,2001 |
| oral/hamster | lowest published toxic dose: 1200 mg/kg/3D- intermittent | Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) | HPV386 -,-,2001 |
| oral/hamster | lowest published toxic dose: 1800 mg/kg/3D- intermittent | Gastrointestinal: Ulceration or bleeding from stomach Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) | HPV386 -,-,2001 |
| oral/hamster | lowest published toxic dose: 1200 mg/kg/3D- intermittent | Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Blood: Other changes Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | VTPHAK 27,171,1990 |
| oral/mouse | lowest published toxic dose: 1750 mg/kg/10D- intermittent | Blood: Methemoglobinemia- Carboxhemoglobinemia Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | STGNBT -,104,1999 |
| oral/mouse | lowest published toxic dose: 24080 mg/kg/80W- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | HPV386 -,-,2001 |
| oral/mouse | lowest published toxic dose: 80080 mg/kg/80W- intermittent | Blood: Changes in spleen Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | HPV386 -,-,2001 |
| oral/mouse | lowest published toxic dose: 399840 mg/kg/80W- intermittent | Liver: Other changes Blood: Changes in spleen Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | HPV386 -,-,2001 |
| oral/mouse | lowest published toxic dose: 2800 mg/kg/2D- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | HPV386 -,-,2001 |
| oral/rat | lowest published toxic dose: 25 mg/kg/30D- intermittent | Gastrointestinal: Alteration in gastric secretion Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, and Bladder: Proteinuria | STGNBT -,104,1999 |
| oral/rat | lowest published toxic dose: 309 mg/kg/26W- intermittent | Kidney, Ureter, and Bladder: Other changes in urine composition Blood: Other changes | STGNBT -,104,1999 |
| oral/rat | lowest published toxic dose: 213120 mg/kg/640D- intermittent | Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, and Bladder: Interstitial nephritis | HPV386 -,-,2001 |
| oral/rat | lowest published toxic dose: 426880 mg/kg/640D- intermittent | Behavioral: Food intake (animal) Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, and Bladder: Interstitial nephritis | HPV386 -,-,2001 |
| oral/rat | lowest published toxic dose: 221711 mg/kg/19W- intermittent | Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) | HPV386 -,-,2001 |
| oral/rat | lowest published toxic dose: 20010 mg/kg/30D- intermittent | Kidney, Ureter, and Bladder: Other changes Blood: Changes in spleen | HPV386 -,-,2001 |
| oral/rat | lowest published toxic dose: 4732 mg/kg/14D- intermittent | Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, and Bladder: Urine volume increased Kidney, Ureter, and Bladder: Renal function tests depressed | HPV386 -,-,2001 |
| oral/rat | lowest published toxic dose: 1800 mg/kg/3D- intermittent | Kidney, Ureter, and Bladder: Other changes | HPV386 -,-,2001 |
| oral/rat | lowest published toxic dose: 2400 mg/kg/3D- intermittent | Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, and Bladder: Interstitial nephritis Kidney, Ureter, and Bladder: Other changes | HPV386 -,-,2001 |
| oral/rat | lowest published toxic dose: 4662 mg/kg/14D- intermittent | Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Endocrine: Changes in spleen weight | HPV386 -,-,2001 |
| skin/rabbit | lowest published toxic dose: 21000 mg/kg/21D- intermittent | Gastrointestinal: Other changes | FEREAC 71,70703,2006 |
| unreported route/rat | lowest published toxic dose: 2082 mg/kg/3D- intermittent | Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, and Bladder: Other changes Blood: Other hemolysis with or without anemia | HPV386 -,-,2001 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 10 mg/m3 | DTLVS* TLV/BEI,2013 |
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Not classifiable as a human carcinogen | DTLVS* TLV/BEI,2013 |
| TOXICOLOGY REVIEW | EVHPAZ 15,121,1976 | |
| TOXICOLOGY REVIEW | CMSHAF 53,809,2003 | |
| TOXICOLOGY REVIEW | FEREAC 71,70703,2006 | |
| TOXICOLOGY REVIEW | HTOPA* 1,595,2002 | |
| TOXICOLOGY REVIEW | FCTOD7 55,596,2013 | |
| TOXICOLOGY REVIEW | RTOPDW 55,43,2009 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION | FEREAC 54,7740,1989 | |
| Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES | RED Completed | RBREV* -,177,1998 |
| Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 10 mg/m3 | DTLVS* 3,95,1971 |
| Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
| Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
| Occupational Exposure Limit-AUSTRALIA | time-weighted average 10 mg/m3, JUL2008 | |
| Occupational Exposure Limit-AUSTRIA | MAK-TMW 0.7 ppm (5 mg/m3);KZW 1.4 ppm (10 mg/m3), inhal, skin, 2007 | |
| Occupational Exposure Limit-BELGIUM | time-weighted average 10 mg/m3, MAR2002 | |
| Occupational Exposure Limit-DENMARK | time-weighted average 5 mg/m3, MAY2011 | |
| Occupational Exposure Limit-FINLAND | time-weighted average 5 mg/m3, short term exposure limit 10 mg/m3, NOV2011 | |
| Occupational Exposure Limit-FRANCE | VME 10 mg/m3, FEB2006 | |
| Occupational Exposure Limit-ICELAND | time-weighted average 5 mg/m3, NOV2011 | |
| Occupational Exposure Limit-KOREA | time-weighted average 10 mg/m3, 2006 | |
| Occupational Exposure Limit-MEXICO | time-weighted average 10 mg/m3;short term exposure limit 20 mg/m3, 2004 | |
| Occupational Exposure Limit-NEW ZEALAND | time-weighted average 10 mg/m3, JAN2002 | |
| Occupational Exposure Limit-NORWAY | time-weighted average 5 mg/m3, JAN1999 | |
| Occupational Exposure Limit-PERU | time-weighted average 10 mg/m3, JUL2005 | |
| Occupational Exposure Limit-SWEDEN | time-weighted average 4 mg/m3;short term exposure limit 12 mg/m3, JUN2005 | |
| Occupational Exposure Limit-SWITZERLAND | MAK-week 10 mg/m3, inhal, JAN2011 | |
| Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 0.7 mg/m3, 2003 | |
| Occupational Exposure Limit-UNITED KINGDOM | time-weighted average 10 mg/m3;short term exposure limit 20 mg/m3, OCT2007 | |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 10 mg/m3 | CFRGBR 29,1926.55,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 10 mg/m3 | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DIPHENYLAMINE-air | 10H time-weighted average 10 mg/m3 | NIOSH* DHHS #92-100,1992 |
| National Occupational Exposure Survey 1983 | Hazard Code 27615; Number of Industries 97; Total Number of Facilities 10880; Number of Occupations 78; Total Number of Employees Exposed 155673; Total Number of Female Employees Exposed 20837 | |
| National Occupational Hazard Survey 1974 | Hazard Code 27615; Number of Industries 71; Total Number of Facilities 3217; Number of Occupations 55; Total Number of Employees Exposed 50967 |
Status in Federal Agencies
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health