Diethylenetriamine

RTECS #

IE1225000

CAS #

111-40-0
See: NMAM or OSHA Methods

Updated

December 2018

Molecular Weight

103.20

Molecular Formula

C₄H₁₃N₃

Synonyms

1,2-Ethanediamine, N-(2-aminoethyl)-
1,4,7-Triazaheptane
2,2'-Diaminodiethylamine
2,2'-Iminobis(ethanamine)
3-Azapentane-1,5-diamine
Aminoethylethandiamine
Bis(2-aminoethyl)amine
Bis(beta-aminoethyl)amine
ChS-P 1
Diethylamine, 2,2'-diamino-
Diethylenetriamine (ACGIH:OSHA)
Ethylamine, 2,2'-iminobis-
Ethylenediamine, N-(2-aminoethyl)-

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
skin /rabbit	500 mg open irritation test	moderate	UCDS** 12/30/1971
skin /rabbit	500 mg		IYKEDH 6,170,1975

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
In Vitro/Human, leukemia cells	Inhibitor Concentration (5 percent kill): 127 mg/L/30M	In Vitro Toxicity Studies: Cell counting	TIVIEQ 27,857,2013
In Vitro/Human, leukemia cells	Inhibitor Concentration Low: 110 mg/L/30M	In Vitro Toxicity Studies: Other assays	TIVIEQ 27,857,2013
In Vitro/Human, leukemia cells	Inhibitor Concentration (25 percent kill): 1221.6 mg/L/24H	In Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc.	TIVIEQ 26,1150,2012
In Vitro/Human, lymphocyte	Inhibitor Concentration (30 percent kill): >200 mg/L/45H	In Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc.	TIVIEQ 29,901,2015
In Vitro/Human, lymphocyte	Inhibitor Concentration (50 percent kill): >200 mg/L/45H	In Vitro Toxicity Studies: Other assays	TIVIEQ 29,901,2015
In Vitro/Human, skin	Inhibitor Concentration (50 percent kill): >2000 µmol/L/48H	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	TXAPA9 245,281,2010
In Vitro/Human, skin	Inhibitor Concentration (50 percent kill): 1259.4 µmol/L/48H	In Vitro Toxicity Studies: Other assays	TXAPA9 245,281,2010
inhalation/rat	Lowest published lethal concentration: 70 mg/m³/4H		NTIS** OTS0556409
intraperitoneal/mouse	lethal dose (50 percent kill): 71 mg/kg	Behavioral: Convulsions or effect on seizure threshold Gastrointestinal: Peritonitis	AMIHAB 17,129,1958
intraperitoneal/rat	lethal dose (50 percent kill): 74 mg/kg	Behavioral: Convulsions or effect on seizure threshold Gastrointestinal: Peritonitis	AMIHAB 17,129,1958
oral/rat	lethal dose (50 percent kill): 1080 mg/kg	Behavioral: Convulsions or effect on seizure threshold	AMIHAB 17,129,1958
skin/guinea pig	lethal dose (50 percent kill): 170 µL/kg		JIHTAB 26,269,1944
skin/rabbit	lethal dose (50 percent kill): 1090 mg/kg		JIHTAB 31,60,1949
unreported route/guinea pig	lethal dose (50 percent kill): 600 mg/kg		GISAAA 37(7),103,1972
unreported route/mouse	lethal dose (50 percent kill): 970 mg/kg		GISAAA 37(7),103,1972
unreported route/rabbit	lethal dose (50 percent kill): 970 mg/kg		GISAAA 37(7),103,1972
unreported route/rat	lethal dose (50 percent kill): 970 mg/kg		GISAAA 37(7),103,1972

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
oral/rabbit	lowest published toxic dose: 1820 mg/kg/26W- intermittent	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases	GISAAA 37(7),103,1972

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 1 ppm (skin)	DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEW		JJOMDZ 15,808,1973
TOXICOLOGY REVIEW		FCTOD7 55,596,2013
TOXICOLOGY REVIEW		RTOPDW 55,43,2009

Standards and Regulations

Organization	Standard	Reference
Mine Safety and Health Administration (MSHA) STANDARD-air	time-weighted average 1 ppm (4 mg/m³) (skin)	DTLWS* 3,85,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 1 ppm (4.2 mg/m³), JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 1 ppm (4 mg/m³), sen, 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 1 ppm (4.3 mg/m³), Skin, MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 1 ppm (4 mg/m³), skin, MAY2011
Occupational Exposure Limit-FINLAND	time-weighted average 0.46 ppm (2 mg/m³), skin, NOV2011
Occupational Exposure Limit-FRANCE	VME 1 ppm (4 mg/m³), FEB2006
Occupational Exposure Limit-HUNGARY	time-weighted average 4 mg/m³, short term exposure limit 4 mg/m³, Skin, SEP2000
Occupational Exposure Limit-ICELAND	time-weighted average 1 ppm (4 mg/m³), skin, sen, NOV2011
Occupational Exposure Limit-KOREA	time-weighted average 1 ppm (4 mg/m³), skin, 2006
Occupational Exposure Limit-MEXICO	time-weighted average 1 ppm (4.2 mg/m³) (skin), 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 1 ppm (4.2 mg/m³), skin, JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 1 ppm (4 mg/m³), JAN1999
Occupational Exposure Limit-PERU	time-weighted average 1 ppm (4.2 mg/m³), JUL2005
Occupational Exposure Limit-RUSSIA	short term exposure limit 0.3 mg/m³, Skin, JUN2003
Occupational Exposure Limit-SWEDEN	time-weighted average 1 ppm (4.5 mg/m³);short term exposure limit 2 ppm (10 mg/m³), Skin, Sen, JUN2005
Occupational Exposure Limit-SWITZERLAND	MAK-week 1 ppm (4 mg/m³), skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 4 mg/m³, 2003
Occupational Exposure Limit-UNITED KINGDOM	time-weighted average 1 ppm (4.3 mg/m³), skin, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	ceiling concentration 10 ppm (42 mg/m³) (skin)	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	ceiling concentration 10 ppm (42 mg/m³) (skin)	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DIETHYLENE TRIAMINE-air	10H time-weighted average 1 ppm (Sk)	NIOSH* DHHS #95-121,1995
National Occupational Exposure Survey 1983	Hazard Code 25210; Number of Industries 78; Total Number of Facilities 2978; Number of Occupations 74; Total Number of Employees Exposed 94517; Total Number of Female Employees Exposed 15589
National Occupational Hazard Survey 1974	Hazard Code 25210; Number of Industries 66; Total Number of Facilities 2804; Number of Occupations 56; Total Number of Employees Exposed 38557

Status in Federal Agencies

Organization	Reference
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE	FEREAC 47,26992,82
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Diethylenetriamine, 2540
OSHA ANALYTICAL METHOD #ID-60

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health